R K Ganju

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases
    C K Ullrich
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1438-42. 2000
  2. ncbi request reprint Slit: a roadblock for chemotaxis
    A Z Fernandis
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Sci STKE 2001:pe1. 2001
  3. ncbi request reprint Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk
    R K Ganju
    Division of Experimental Medicine, Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:17263-8. 2000
  4. ncbi request reprint SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways
    R D Chernock
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 97:608-15. 2001
  5. ncbi request reprint Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK
    R K Ganju
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 91:791-7. 1998
  6. ncbi request reprint Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways
    R P Cherla
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3067-74. 2001
  7. ncbi request reprint HIV-1 Tat induces microvascular endothelial apoptosis through caspase activation
    I W Park
    Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:2766-71. 2001
  8. pmc Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells
    R K Ganju
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Virol 72:6131-7. 1998
  9. pmc RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes
    R K Ganju
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Exp Med 185:1055-63. 1997
  10. ncbi request reprint Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    A Preet
    Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Oncogene 27:339-46. 2008

Collaborators

  • M A Shipp
  • H Avraham
  • L Wu
  • J E Groopman
  • A Preet
  • R P Cherla
  • C K Ullrich
  • R D Chernock
  • A Z Fernandis
  • I W Park
  • J F Wang
  • E Schoenberger
  • S Avraham
  • Z Y Liu

Detail Information

Publications12

  1. ncbi request reprint HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases
    C K Ullrich
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1438-42. 2000
    ..Blood. 2000;96:1438-1442)..
  2. ncbi request reprint Slit: a roadblock for chemotaxis
    A Z Fernandis
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Sci STKE 2001:pe1. 2001
    ..Fernandis and Ganju discuss the therapeutic potential of Slit as an antiviral agent and in the treatment of inflammatory diseases, autoimmune disorders, and cancer...
  3. ncbi request reprint Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk
    R K Ganju
    Division of Experimental Medicine, Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:17263-8. 2000
    ..Taken together, these results suggest that MIP1beta stimulation mediated by CCR5 induces the formation of a signaling complex consisting of RAFTK, Syk, SHP1, and Grb2...
  4. ncbi request reprint SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways
    R D Chernock
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 97:608-15. 2001
    ..Our results suggest that CXCR4-mediated signaling is regulated by SHP2 and cbl, which collectively participate in the formation of a multimeric signaling complex...
  5. ncbi request reprint Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK
    R K Ganju
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 91:791-7. 1998
    ..Thus, RAFTK appears to provide a functional "bridge" for the transmission of CCR5 receptor signaling to the cytoskeleton and nucleus, primary sites of chemotaxis and growth regulation...
  6. ncbi request reprint Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways
    R P Cherla
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3067-74. 2001
    ..These studies suggest that NO-related signaling pathways may mediate SDF1 alpha-induced chemotaxis, but not mitogen-activated protein kinase activation...
  7. ncbi request reprint HIV-1 Tat induces microvascular endothelial apoptosis through caspase activation
    I W Park
    Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:2766-71. 2001
    ..Taken together, these data demonstrate that HIV-1 Tat is able to activate apoptosis in microvascular endothelium by a mechanism distinct from TNF secretion or the Fas pathway...
  8. pmc Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells
    R K Ganju
    Divisions of Experimental Medicine and Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Virol 72:6131-7. 1998
    ..These studies reveal that Tat stimulation activates a number of signal transduction pathways that are associated with cell growth and migration...
  9. pmc RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes
    R K Ganju
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Exp Med 185:1055-63. 1997
    ..These observations indicate that RAFTK participates in T cell receptor signaling and may act to link signals from the cell surface to the cytoskeleton and thereby affect the host immune response...
  10. ncbi request reprint Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
    A Preet
    Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Oncogene 27:339-46. 2008
    ..Our study suggests that cannabinoids like THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers...
  11. ncbi request reprint Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor
    J F Wang
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood 90:3507-15. 1997
    ..VRP-mediated activation of RAFTK may facilitate signal transduction to the cytoskeleton and downstream to the JNK pathway in FLT4-expressing blood cells...
  12. ncbi request reprint CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase
    R K Ganju
    Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 88:4159-65. 1996
    ..Taken together, these data indicate that CD10/NEP is itself phosphorylated by CKII and that CD10/NEP co-associates with additional tyrosine phosphoproteins including lyn...