Neil J Ganem

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Linking abnormal mitosis to the acquisition of DNA damage
    Neil J Ganem
    Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 199:871-81. 2012
  2. pmc A mechanism linking extra centrosomes to chromosomal instability
    Neil J Ganem
    Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 460:278-82. 2009
  3. pmc DNA breaks and chromosome pulverization from errors in mitosis
    Karen Crasta
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA
    Nature 482:53-8. 2012
  4. ncbi request reprint Limiting the proliferation of polyploid cells
    Neil J Ganem
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:437-40. 2007
  5. pmc Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
    Mijung Kwon
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 22:2189-203. 2008
  6. ncbi request reprint Tetraploidy, aneuploidy and cancer
    Neil J Ganem
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Genet Dev 17:157-62. 2007

Collaborators

Detail Information

Publications6

  1. pmc Linking abnormal mitosis to the acquisition of DNA damage
    Neil J Ganem
    Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 199:871-81. 2012
    ..Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis...
  2. pmc A mechanism linking extra centrosomes to chromosomal instability
    Neil J Ganem
    Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Boston, Massachusetts 02115, USA
    Nature 460:278-82. 2009
    ..These findings provide a direct mechanistic link between extra centrosomes and CIN, two common characteristics of solid tumours. We propose that this mechanism may be a common underlying cause of CIN in human cancer...
  3. pmc DNA breaks and chromosome pulverization from errors in mitosis
    Karen Crasta
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02115, USA
    Nature 482:53-8. 2012
    ..Pulverization of chromosomes in micronuclei may also be one explanation for 'chromothripsis' in cancer and developmental disorders, where isolated chromosomes or chromosome arms undergo massive local DNA breakage and rearrangement...
  4. ncbi request reprint Limiting the proliferation of polyploid cells
    Neil J Ganem
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 131:437-40. 2007
    ..Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells...
  5. pmc Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
    Mijung Kwon
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 22:2189-203. 2008
    ..Thus, morphological features of cancer cells can be linked to unique genetic requirements for survival...
  6. ncbi request reprint Tetraploidy, aneuploidy and cancer
    Neil J Ganem
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Genet Dev 17:157-62. 2007
    ..Therefore, abnormal division of tetraploid cells might facilitate genetic changes that lead to aneuploid cancers...