Bruce Furie

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Interactions of platelets, blood-borne tissue factor, and fibrin during arteriolar thrombus formation in vivo
    Derek Sim
    Center for Hemostasis and Thrombosis Research, Harvard Medical School, Boston, MA 02115, USA
    Microcirculation 12:301-11. 2005
  2. doi request reprint Formation of the clot
    Bruce Furie
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Thromb Res 130:S44-6. 2012
  3. ncbi request reprint Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation
    Bruce Furie
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 10:171-8. 2004
  4. ncbi request reprint Cancer-associated thrombosis
    Bruce Furie
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Blood Cells Mol Dis 36:177-81. 2006
  5. pmc Thrombus formation in vivo
    Bruce Furie
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 115:3355-62. 2005
  6. ncbi request reprint Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development
    Peter L Gross
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Medicine, 330 Brookline Avenue, Boston, MA 02215, USA
    J Leukoc Biol 78:1318-26. 2005
  7. pmc Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin
    Shahrokh Falati
    Center for Hemostasis and Thrombosis Research, Research East 319, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Exp Med 197:1585-98. 2003
  8. pmc Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
    Qing Huai
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Struct Mol Biol 15:422-3. 2008
  9. pmc Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
    Christophe Dubois
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 117:953-60. 2007
  10. pmc Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins
    Jaehyung Cho
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Blood 120:647-55. 2012

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Interactions of platelets, blood-borne tissue factor, and fibrin during arteriolar thrombus formation in vivo
    Derek Sim
    Center for Hemostasis and Thrombosis Research, Harvard Medical School, Boston, MA 02115, USA
    Microcirculation 12:301-11. 2005
    ..This review discusses the role of platelet intracellular signaling, P-selectin expression on platelets, and tissue factor-bearing microparticles in thrombus formation...
  2. doi request reprint Formation of the clot
    Bruce Furie
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Thromb Res 130:S44-6. 2012
    ..Inhibition of these thiol isomerases blocks platelet aggregation and fibrin generation. Pharmaceuticals directed against these thiol isomerases offers a novel approach to antithrombotic therapy...
  3. ncbi request reprint Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation
    Bruce Furie
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 10:171-8. 2004
    ....
  4. ncbi request reprint Cancer-associated thrombosis
    Bruce Furie
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Blood Cells Mol Dis 36:177-81. 2006
    ..Exploration of a potential role of microparticles in cancer-associated thrombosis indicates that tissue factor microparticles are present in a spectrum of cancer patients known to have a high incidence of thromboembolic complications...
  5. pmc Thrombus formation in vivo
    Bruce Furie
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 115:3355-62. 2005
    ..The study of biochemistry and cell biology in a living animal offers new understanding of physiology and pathology in complex biologic systems...
  6. ncbi request reprint Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development
    Peter L Gross
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Medicine, 330 Brookline Avenue, Boston, MA 02215, USA
    J Leukoc Biol 78:1318-26. 2005
    ..These results indicate that tissue factor derived from hematopoietic cells is delivered by microparticles during the initial phase of thrombus development in vivo...
  7. pmc Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin
    Shahrokh Falati
    Center for Hemostasis and Thrombosis Research, Research East 319, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Exp Med 197:1585-98. 2003
    ..We propose that PSGL-1 plays a role in blood coagulation in addition to its known role in leukocyte trafficking...
  8. pmc Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
    Qing Huai
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Struct Mol Biol 15:422-3. 2008
    ..These results provide a structural understanding of one receptor binding to two ligands...
  9. pmc Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
    Christophe Dubois
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 117:953-60. 2007
    ..In the tissue factor-mediated pathway, vWF plays a role in platelet accumulation during thrombus formation but is not required for platelet activation in vivo...
  10. pmc Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins
    Jaehyung Cho
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Blood 120:647-55. 2012
    ..These results indicate that both endothelial and platelet β3 integrins contribute to extracellular PDI binding at the vascular injury site...
  11. pmc Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans
    Laurence Panicot-Dubois
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3708-19. 2007
    ..We conclude that BSDL plays a role in optimal platelet activation and thrombus formation by interacting with CXCR4 on platelets...
  12. pmc Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents
    Reema Jasuja
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 122:2104-13. 2012
    ..Thus, PDI is a viable target for small molecule inhibition of thrombus formation, and its inhibition may prove to be a useful adjunct in refractory thrombotic diseases that are not controlled with conventional antithrombotic agents...
  13. pmc Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII
    Lin Lin
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    J Mol Biol 371:717-24. 2007
    ..The C2 domain of lactadherin may serve as a marker of cell surface phosphatidylserine exposure and may have potential as a unique anti-thrombotic agent...
  14. pmc Peritoneal macrophages express both P-selectin and PSGL-1
    Boris Tchernychev
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    J Cell Biol 163:1145-55. 2003
    ..This is the first description of a leukocyte shown to express both P-selectin and PSGL-1...
  15. ncbi request reprint Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation
    Janet Chou
    Center for Hemostasis and Thrombosis Research, Vascular Biology Center, 330 Brookline Ave, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 104:3190-7. 2004
    ..This demonstrates that blood-borne TF associated with hematopoietic cell-derived microparticles contributes to thrombus propagation...
  16. ncbi request reprint The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M
    Marianne A Grant
    Center for Hemostasis, Thrombosis, and Vascular Biology, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32464-73. 2004
    ..Taken together these data identify that glacontryphan-M possesses the canonical contryphan intercysteine loop structure, yet possesses critical determinants necessary for a calcium-induced functionally required conformation...
  17. ncbi request reprint In vivo models of platelet function and thrombosis: study of real-time thrombus formation
    Shahrokh Falati
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 272:187-97. 2004
  18. pmc Laser-induced endothelial cell activation supports fibrin formation
    Ben T Atkinson
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 116:4675-83. 2010
    ..Thus laser injury leads to rapid endothelial cell activation. The laser activated endothelial cells can support formation of tenase and prothrombinase and may be a source of activated tissue factor as well...
  19. pmc Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
    Erik R Vandendries
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:288-92. 2007
    ....
  20. pmc A critical role for extracellular protein disulfide isomerase during thrombus formation in mice
    Jaehyung Cho
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 118:1123-31. 2008
    ..These results indicate that PDI is required in vivo in mice for both fibrin generation and platelet thrombus formation...
  21. ncbi request reprint Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels
    Derek S Sim
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 103:2127-34. 2004
    ..Thus, the status of the intracellular signaling machinery prior to engagement of platelet receptors influences the rate of platelet accumulation during thrombus formation...
  22. ncbi request reprint Role of P-selectin and PSGL-1 in coagulation and thrombosis
    Erik R Vandendries
    Center for Hemostasis, Thrombosis, and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Thromb Haemost 92:459-66. 2004
    ..The P-selectin- and PSGL-1-dependent delivery of circulating microparticles to thrombi appears to be important for normal tissue factor accumulation and fibrin generation in thrombi...
  23. ncbi request reprint Thrombus formation in a living mouse
    Bruce Furie
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and HarvardMedical School, Boston, Massachusetts 02215, USA
    Pathophysiol Haemost Thromb 35:1-4. 2006
  24. pmc Platelet PECAM-1 inhibits thrombus formation in vivo
    Shahrokh Falati
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 107:535-41. 2006
    ..In PECAM-1-deficient mice the time to 75% vessel occlusion was significantly shorter than in control mice. These data provide evidence for the involvement of platelet PECAM-1 in the negative regulation of thrombus formation...
  25. pmc Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo
    Christophe Dubois
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, 840 Memorial Drive, Cambridge, MA 02139, USA
    Blood 107:3902-6. 2006
    ..It may thus be important when considering targets for antithrombotic therapy to use multiple animal models with diverse pathways to thrombus formation...
  26. doi request reprint Mechanisms of thrombus formation
    Bruce Furie
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA
    N Engl J Med 359:938-49. 2008
  27. pmc Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy
    Jeffrey I Zwicker
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Clin Cancer Res 15:6830-40. 2009
    ..We evaluated the hypothesis that tumor-derived tissue factor-bearing microparticles in plasma contribute to cancer-associated thrombosis...
  28. doi request reprint Tissue factor-bearing microparticles and thrombus formation
    Jeffrey I Zwicker
    Division of Hemostasis, Harvard Medical School, Thrombosis Beth Israel Deaconess Medical Center, 330 Brookline Ave E CLS 903, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 31:728-33. 2011
    ..Only a subpopulation of these microparticles expresses tissue factor...
  29. ncbi request reprint Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse
    Shahrokh Falati
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 8:1175-81. 2002
    ..Subsequently tissue factor was associated with the interior of the thrombus. Tissue factor was biologically active, and was associated with fibrin generation within the thrombus...
  30. ncbi request reprint Real time in vivo imaging of tissue factor-induced thrombus formation
    Bruce Furie
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Pathophysiol Haemost Thromb 33:26-7. 2003
  31. doi request reprint Measurement of platelet microparticles
    Jeffrey I Zwicker
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 788:127-39. 2012
    ..We describe methodology for light scatter-based flow cytometry as well as impedance-based flow cytometry for the enumeration and characterization of platelet microparticles...
  32. ncbi request reprint Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody
    Mingdong Huang
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:14338-46. 2004
    ..We conclude that this antibody is directed at the membrane binding site in the omega loop of Factor IX and blocks Factor IX function by inhibiting its interaction with membranes...
  33. pmc Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking
    Steven R Barthel
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:19491-6. 2009
    ..These results indicate that alpha1,3 FTs could enhance metastatic efficiency of PCa by triggering an E-selectin-dependent trafficking mechanism...
  34. pmc Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo
    Reema Jasuja
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 116:4665-74. 2010
    ..These results indicate that, although both platelets and endothelial cells secrete PDI after laser-induced injury, PDI from endothelial cells is required for fibrin generation in vivo...
  35. ncbi request reprint Tissue factor pathway vs. collagen pathway for in vivo platelet activation
    Barbara C Furie
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Blood Cells Mol Dis 36:135-8. 2006
    ..Understanding of the response to insult in thrombosis models deepens our understanding of the process and provides a firm foundation for evaluation of anti-thrombotic therapy in these models...
  36. ncbi request reprint Structure of human urokinase plasminogen activator in complex with its receptor
    Qing Huai
    Division of Hemostasis and Thrombosis, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 311:656-9. 2006
    ..The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists...
  37. pmc Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study)
    Jeffrey I Zwicker
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Br J Haematol 160:530-7. 2013
    ..Enoxaparin demonstrated a clear trend towards reducing the rate of VTE in patients with elevated levels of TFMP, with an overall rate of VTE similar in magnitude to the lower TFMP group...
  38. ncbi request reprint Cancer-associated thrombosis
    Jeffrey I Zwicker
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and the Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
    Crit Rev Oncol Hematol 62:126-36. 2007
    ....
  39. ncbi request reprint Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins
    Mingdong Huang
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Struct Biol 10:751-6. 2003
    ..Increasingly Gla domains are being identified in proteins unrelated to blood coagulation. Thus, this membrane-binding mechanism may be important in other physiologic processes...
  40. ncbi request reprint P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
    Takako Hirata
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Immunol 169:4307-13. 2002
    ..P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin...
  41. ncbi request reprint Thiol isomerases in thrombus formation
    Bruce Furie
    From the Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
    Circ Res 114:1162-73. 2014
    ....
  42. ncbi request reprint The blood coagulation cascade
    Monica Schenone
    Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Hematol 11:272-7. 2004
    ....
  43. pmc β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model
    Ariela Arad
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Blood 117:3453-9. 2011
    ..These results indicate that anti-β(2)-GP1 IgG autoantibodies in antiphospholipid syndrome patient sera are not only a marker of antiphospholipid syndrome but are directly involved in the pathogenesis of thrombosis...
  44. ncbi request reprint Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons
    Jianrong Li
    Department of Neurology, Division of Neuroscience, Children s Hospital, Boston, MA 02115, USA
    J Neurosci 23:5816-26. 2003
    ....
  45. ncbi request reprint P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice
    Britta Engelhardt
    Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
    J Immunol 175:1267-75. 2005
    ..Taken together, our findings demonstrate that PSGL-1 is not required for the pathogenesis of EAE...
  46. ncbi request reprint P-selectin and blood coagulation: it's not only about inflammation any more
    Bruce Furie
    Arterioscler Thromb Vasc Biol 25:877-8. 2005
  47. ncbi request reprint P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes
    Nari Harakawa
    Department of Internal Medicine, Osaka Dental University, Hirakata, Osaka, Japan
    Int Immunol 19:321-9. 2007
    ..Taken together, these results indicate that the interaction of PSGL-1 with P-selectin constitutes a second mechanism of leukocyte rolling in the HEVs of peripheral LNs...
  48. pmc Microparticles and a P-selectin-mediated pathway of blood coagulation
    Alessandro Celi
    Laboratorio di Biologia Cellulare Respiratoria, Dipartimento Cardiotoracico dell Università di Pisa, Pisa, Italy
    Dis Markers 20:347-52. 2004
  49. ncbi request reprint Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcgamma receptor IIA
    Jean G Sathish
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Thromb Haemost 92:598-605. 2004
    ..The calcium rise is mediated primarily by induction of a calcium entry mechanism involving the Na(+)-Ca(2+) exchanger operating in reverse mode, since it was blocked by inhibitors of Na(+)-Ca(2+) exchange, bepridil and 5 mM NiCl(2)...
  50. ncbi request reprint PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin
    Yoshio Katayama
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1079, New York, NY 10029
    Blood 102:2060-7. 2003
    ..Our results thus underscore a major difference between mature myeloid cells and immature stem/progenitor cells in that E-selectin ligands cooperate with alpha4 integrin rather than P-selectin ligands...
  51. ncbi request reprint Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile
    Eva Czerwiec
    Marine Biological Laboratory, Woods Hole, MA, USA
    Eur J Biochem 269:6162-72. 2002
    ....
  52. ncbi request reprint The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus
    Karin Hansson
    Department of Clinical Chemistry, Lund University, University Hospital, Malmo, S 205 02 Malmo, Sweden
    J Biol Chem 279:32453-63. 2004
    ..Glacontryphan-M is the first contryphan reported to modulate the activity of L-type calcium ion channels...
  53. pmc PTP-1B is an essential positive regulator of platelet integrin signaling
    Elena Garcia Arias-Salgado
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 170:837-45. 2005
    ..Thus, PTP-1B is an essential positive regulator of the initiation of outside-in alphaIIbbeta3 signaling in platelets...

Research Grants32

  1. Cancer, venous thromboembolic disease and tissue factor-bearing microparticles
    Bruce Furie; Fiscal Year: 2010
    ..abstract_text> ..
  2. INTRAVITAL VIDEO-RATE CONFOCAL MICROSCOPE
    Bruce Furie; Fiscal Year: 2001
    ..The BioRad RTS2000 real-time laser confocal system, fitted to a Nikon E600FN microscope, will provide a group of investigators with instrumentation to significantly advance their fields. ..
  3. Factor lXa-Factor Vllla complexes in blood coagulation
    Bruce Furie; Fiscal Year: 2004
    ..abstract_text> ..
  4. SELECTIN LIGANDS IN LEUKOCYTE BIOLOGY AND INFLAMMATION
    Bruce Furie; Fiscal Year: 2005
    ..Finally, we propose to use the PSGL-1 null mouse to establish whether the absence of PSGL-1 will block or mitigate graft versus host disease following bone marrow transplantation in a mouse model. ..
  5. Factor lXa-Factor Vllla complexes in blood coagulation
    Bruce Furie; Fiscal Year: 2005
    ..abstract_text> ..
  6. SELECTIN LIGANDS IN LEUKOCYTE BIOLOGY AND INFLAMMATION
    Bruce Furie; Fiscal Year: 2006
    ..Finally, we propose to use the PSGL-1 null mouse to establish whether the absence of PSGL-1 will block or mitigate graft versus host disease following bone marrow transplantation in a mouse model. ..
  7. Factor lXa-Factor Vllla complexes in blood coagulation
    Bruce Furie; Fiscal Year: 2006
    ..abstract_text> ..
  8. SELECTIN LIGANDS IN LEUKOCYTE BIOLOGY AND INFLAMMATION
    Bruce Furie; Fiscal Year: 2007
    ..Finally, we propose to use the PSGL-1 null mouse to establish whether the absence of PSGL-1 will block or mitigate graft versus host disease following bone marrow transplantation in a mouse model. ..
  9. Factor lXa-Factor Vllla complexes in blood coagulation
    Bruce Furie; Fiscal Year: 2007
    ..abstract_text> ..
  10. PROGRAM IN BLOOD COAGULATION AND VASCULAR BIOLOGY
    Bruce Furie; Fiscal Year: 2007
    ..Dr. Bruce Furie is the Program Director and Dr. Barbara C. Furie is the Associate Program Director...
  11. Cancer, venous thromboembolic disease and tissue factor-bearing microparticles
    Bruce Furie; Fiscal Year: 2009
    ..abstract_text> ..
  12. Role of selectins and selectin ligands in the pathobiol*
    Bruce Furie; Fiscal Year: 2004
    ..To prove the physiologic importance of this pathway, we will attempt to rescue homozygous protein C deficient mice from fatal thrombosis by PSGL-1 deficiency. ..
  13. SELECTIN LIGANDS IN LEUKOCYTE BIOLOGY AND INFLAMMATION
    Bruce Furie; Fiscal Year: 2004
    ..Finally, we propose to use the PSGL-1 null mouse to establish whether the absence of PSGL-1 will block or mitigate graft versus host disease following bone marrow transplantation in a mouse model. ..
  14. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 1999
    ..The grant proposal is officially a new grant, but it is actually the competitive renewal of Project V of Program Project Grant HL42443 (Membrane Proteins in Blood Coagulation). ..
  15. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2000
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  16. BIOSYNTHESIS OF BLOOD CLOTTING PROTEINS
    Bruce Furie; Fiscal Year: 1999
    ..Detailed knowledge of these processes will improve our understanding of the biology of these proteins and has potential for improvements in hemophilia therapy. ..
  17. BIOSYNTHESIS OF BLOOD CLOTTING PROTEINS
    Bruce Furie; Fiscal Year: 2000
    ..Detailed knowledge of these processes will improve our understanding of the biology of these proteins and has potential for improvements in hemophilia therapy. ..
  18. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2001
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  19. BIOSYNTHESIS OF BLOOD CLOTTING PROTEINS
    Bruce Furie; Fiscal Year: 2001
    ..Detailed knowledge of these processes will improve our understanding of the biology of these proteins and has potential for improvements in hemophilia therapy. ..
  20. Role of selectins and selectin ligands in the pathobiol*
    Bruce Furie; Fiscal Year: 2001
    ..To prove the physiologic importance of this pathway, we will attempt to rescue homozygous protein C deficient mice from fatal thrombosis by PSGL-1 deficiency. ..
  21. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2002
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  22. Role of selectins and selectin ligands in the pathobiol*
    Bruce Furie; Fiscal Year: 2002
    ..To prove the physiologic importance of this pathway, we will attempt to rescue homozygous protein C deficient mice from fatal thrombosis by PSGL-1 deficiency. ..
  23. PLATELET CELL ADHESION MOLECULES
    Bruce Furie; Fiscal Year: 2003
    ..These studies will contribute to our understanding of the physiologically relevant receptors and counterreceptors that define cell-cell interaction during inflammation. ..
  24. Role of selectins and selectin ligands in the pathobiol*
    Bruce Furie; Fiscal Year: 2003
    ..To prove the physiologic importance of this pathway, we will attempt to rescue homozygous protein C deficient mice from fatal thrombosis by PSGL-1 deficiency. ..