Research Topics
| Anne B FultonSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Development of rod function in term born and former preterm subjectsAnne B Fulton
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Optom Vis Sci 86:E653-8. 2009..To provide an overview of some of our electroretinographic (ERG) and psychophysical studies of normal development of rod function and their application to retinopathy of prematurity (ROP)...- The cone electroretinogram in retinopathy of prematurityAnne B Fulton
Department of Ophthalmology, Children s Hospital and Harvard Medical School Boston, MA 02115, USA
Invest Ophthalmol Vis Sci 49:814-9. 2008..To test the hypothesis that retinopathy of prematurity (ROP) affects the cone photoreceptors less than the rod photoreceptors... - Retinal degenerative and hypoxic ischemic diseaseAnne B Fulton
Department of Ophthalmology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA
Doc Ophthalmol 118:55-61. 2009..Beneficial pharmaceutical interventions may be measured in improved visual outcome as well as lessening of the vascular abnormalities... 
Multifocal ERG in subjects with a history of retinopathy of prematurityAnne B Fulton
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Doc Ophthalmol 111:7-13. 2005..Investigate the function of the central retina in subjects with a history of retinopathy of prematurity (ROP)...- The neurovascular retina in retinopathy of prematurityAnne B Fulton
Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115 5737, USA
Prog Retin Eye Res 28:452-82. 2009..The data from human subjects and rat models identify photoreceptor and post-receptor targets for interventions that promise improved outcomes for children at risk for ROP... 
Visual cycle modulation in neurovascular retinopathyJames D Akula
Department of Ophthalmology, Children s Hospital Boston, Boston, MA 02115 5724, USA
Exp Eye Res 91:153-61. 2010..There was no evidence of negative alteration of photoreceptor function consequent to VCM treatment. This finding implicates the rods as a possible therapeutic target in neurovascular diseases such as ROP...- The oscillatory potentials of the dark-adapted electroretinogram in retinopathy of prematurityJames D Akula
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 48:5788-97. 2007..To study the development of the electroretinographic (ERG) oscillatory potentials (OPs) in two rat models of ROP and in human subjects with a history of ROP... - Retinal degeneration in children: dark adapted visual threshold and arteriolar diameterRonald M Hansen
Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Vision Res 48:325-31. 2008..Higher DATs were associated with narrower arterioles. Such non-invasive procedures can document the natural history of these retinal diseases and have the potential to assess response to future treatment... - The anatomy of the rat eye with oxygen-induced retinopathyJames D Akula
Department of Ophthalmology, Children s Hospital Boston, Boston, MA 02115, USA
Doc Ophthalmol 120:41-50. 2010..The ratio of anterior to posterior axial-lengths ranged from 0.45 in controls through 0.37 in the 75 model to 0.32 in the 50/10 model. Thus, eye growth is altered in these rat models of ROP... - Development of the electroretinographic oscillatory potentials in normal and ROP ratsKegao Liu
Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 47:5447-52. 2006..In ROP rats, marked attenuation of early OPs was consistent with persistent dysfunction of photoreceptors, and significant attenuation of the late OP5 was evidence of compromised function of inner retinal circuitry... - Long-term effects of retinopathy of prematurity (ROP) on rod and rod-driven functionMaureen E Harris
Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Doc Ophthalmol 122:19-27. 2011..The data are evidence that sensitivity of the post-receptor retina improves in those with a history of mild ROP. We speculate that beneficial reorganization of the post-receptor neural circuitry occurs in mild but not in severe ROP... - The neurovascular relation in oxygen-induced retinopathyJames D Akula
Department of Ophthalmology, Children s Hospital Boston, Boston, MA 02115, USA
Mol Vis 14:2499-508. 2008.... - Electroretinographic (ERG) responses in pediatric patients using vigabatrinAnne Moskowitz
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Doc Ophthalmol 124:197-209. 2012..We caution against over-reliance on the ERG to monitor pediatric patients for VGB toxicity and recommend further development of a reliable test of peripheral vision to supplant ERG testing... - Deactivation of the rod response in retinopathy of prematurityRonald M Hansen
Department of Ophthalmology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Doc Ophthalmol 121:29-35. 2010..Prolonged deactivation in these mature ROP subjects may indicate lack of maturation of the deactivation process (t(50)) or progressive compromise of retinal function with increasing age... - Rod photoreceptor function predicts blood vessel abnormality in retinopathy of prematurityJames D Akula
Department of Ophthalmology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 48:4351-9. 2007..To test the hypothesis that early rod dysfunction predicts the blood vessel abnormalities that are the clinical hallmark of retinopathy of prematurity (ROP)... - Rod and rod-driven function in achromatopsia and blue cone monochromatismAnne Moskowitz
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 50:950-8. 2009..To evaluate rod photoreceptor and postreceptor retinal function in pediatric patients with achromatopsia (ACHR) and blue cone monochromatism (BCM) using contemporary electroretinographic (ERG) procedures... - Development of scotopic visual thresholds in retinopathy of prematurityAmber M Barnaby
Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 48:4854-60. 2007..To test the hypothesis that the late-maturing parafoveal rod photoreceptors are more vulnerable than peripheral rods to the effects of retinopathy of prematurity (ROP)... - The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurityKegao Liu
Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 47:2639-47. 2006..However, vascular and neural abnormalities did not correlate... - ERG oscillatory potentials in infantsAnne Moskowitz
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, MA, USA
Doc Ophthalmol 110:265-70. 2005..Study the scotopic and photopic oscillatory potentials (OPs) of the electroretinogram (ERG) in 10-week old infants... - Recovery of the rod photoresponse in infant ratsAnne B Fulton
Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Vision Res 43:3081-5. 2003..The kinetics of rod cell recovery are likely the same in infants and adults... - Recovery of the rod photoresponse in infantsRonald M Hansen
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 46:764-8. 2005..Rhodopsin content increases and scales the parameters of the activation of rod phototransduction as rods develop. However, little is known about the kinetics of deactivation in the rods of young infants... - Cone ERG responses in patients with Smith-Lemli-Opitz Syndrome (SLOS)Deirdre Garry
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Doc Ophthalmol 121:85-91. 2010..To evaluate cone and cone-driven retinal function in patients with Smith-Lemli-Opitz syndrome (SLOS), a condition characterized by low cholesterol. Rod and rod-driven function in patients with SLOS are known to be abnormal... - Retinal function in carriers of Bardet-Biedl syndromeGerald F Cox
Department of Medicine, Children's Hospital, Boston, Mass, USA
Arch Ophthalmol 121:804-10. 2003..CONCLUSIONS: Diminished P2 sensitivity is characteristic of the carriers of BBS. The site of the primary defect in the BBS rod pathway appears to be proximal to the outer segments, most likely before the rod-bipolar cell synapse... - Multifocal ERG responses in infantsRonald M Hansen
Department of Ophthalmology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 50:470-5. 2009..To assess function of the central retina in 10-week-old infants, multifocal electroretinograms (mfERGs) were recorded. mfERG responses represent postreceptor retinal activity... - Development of the cone ERG in infantsRonald M Hansen
Department of Ophthalmology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Invest Ophthalmol Vis Sci 46:3458-62. 2005..To assess cone photoreceptor and cone-mediated postreceptoral retinal function in infants... - Rod photoreceptor function in children with mitochondrial disordersLinda L Cooper
Department of Ophthalmology, Children's Hospital Boston and Harvard Medical School, Mass 02115, USA
Arch Ophthalmol 120:1055-62. 2002..From a practical perspective, ERG testing can contribute to diagnosis of mitochondrial disorders... - Background adaptation in a rat model of retinopathy of prematurityJohn Chunguang Jiang
Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
Doc Ophthalmol 104:97-105. 2002..The effect of the background light is consistent with receptoral disease causing low dark adapted b-wave sensitivity in ROP rats... - Maculopathy and retinal degeneration in cobalamin C methylmalonic aciduria and homocystinuriaEfthymia K Tsina
Department of Ophthalmology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Arch Ophthalmol 123:1143-6. 2005 - Development of ERG responses: the ISCEV rod, maximal and cone responses in normal subjectsAnne B Fulton
Department of Ophthalmology, The Children s Hospital, Boston, MA 02115, USA
Doc Ophthalmol 107:235-41. 2003..Summarize ISCEV ERG responses from normal infants and children... - Rod photoreceptor responses in children with Smith-Lemli-Opitz syndromeEllen R Elias
Departments of Ophthalmology and Medicine, Children's Hospital, New England College of Optometry, Boston, Massachusetts, USA
Arch Ophthalmol 121:1738-43. 2003..Investigation of other membrane-bound signaling systems may be warranted in the quest to understand development and phenotype of individuals with SLOS... - Development of visual acuity in children with cerebral visual impairmentMira Lim
Department of Ophthalmology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Arch Ophthalmol 123:1215-20. 2005..CONCLUSIONS: Modest increases in PL and VEP grating acuity occur during early childhood in many of these patients. The rate of increase is lower than normal... - Diagnosis of plus disease in retinopathy of prematurity using Retinal Image multiScale AnalysisRony Gelman
Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 46:4734-8. 2005..911 for arterioles, 0.824 for venules). CONCLUSIONS: The strong performance of RISA parameters in this sample suggests that RISA may be useful for diagnosing plus disease in preterm infants with ROP... - Visual fields in young children treated with vigabatrinShivi Agrawal
Department of Ophthalmology, Children s Hospital, Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Optom Vis Sci 86:767-73. 2009..VGB is an antiepileptic medication that is associated with visual field constriction... - Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography studyDaniel X Hammer
Physical Sciences Inc, 20 New England Business Center, Andover, MA 01810, USA
Invest Ophthalmol Vis Sci 49:2061-70. 2008..To describe the fine structure of the fovea in subjects with a history of mild retinopathy of prematurity (ROP) using adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT)... - Effects of desferoxamine on retinal and visual functionMing Lu
Arch Ophthalmol 125:1581-2. 2007
Research Grants
- PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITYAnne Fulton; Fiscal Year: 2007..This information may, in the future, change management of ROP in infancy and in children with a history of ROP. ..
- A System for Study of Pediatric Visual PathwaysAnne Fulton; Fiscal Year: 2004..With these studies as a whole, we expect to obtain new knowledge about the processes that govern vision and its development in these pediatric disorders. ..
- PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITYAnne Fulton; Fiscal Year: 2004..This project, based on an entirely new perspective of ROP, will lead not only to much more information about retinal and visual function in ROP, but also to new knowledge about fundamental ROP disease processes. ..
- Retcam 120 Wide Field Digital Imaging SystemAnne Fulton; Fiscal Year: 2002..The minor users will take advantage of the wide field images as well as the highly magnified views of the macula and optic nerve head (optic disc), including the fluorescein capability. ..
- DEVELOPMENT OF PHOTORECEPTOR FUNCTIONAnne Fulton; Fiscal Year: 1999..Longitudinal measures of the visual thresholds at 10 degree and 30 degree eccentricities will test the hypothesis that the near central threshold has an abnormally slow course of development in those with a history of ROP. ..
- PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITYAnne B Fulton; Fiscal Year: 2010..This information may, in the future, change management of ROP in infancy and in children with a history of ROP. ..