Tudor A Fulga
Affiliation: Harvard University
- Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivoTudor A Fulga
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
Nat Cell Biol 9:139-48. 2007..These findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in Alzheimer's disease and related disorders...
- Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivoVikram Khurana
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 6:e1001026. 2010..Thus, caspase cleavage of tau may be a molecular mechanism through which lysosomal dysfunction and neurodegeneration are causally linked in Alzheimer's disease...
- Oxidative stress mediates tau-induced neurodegeneration in DrosophilaDora Dias-Santagata
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 117:236-45. 2007..In summary, our study identifies oxidative stress as a causal factor in tau-induced neurodegeneration in Drosophila...
- Tau phosphorylation sites work in concert to promote neurotoxicity in vivoMichelle L Steinhilb
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Biol Cell 18:5060-8. 2007..These findings suggest that serine-proline/threonine-proline sites cooperate to mediate neurodegeneration in vivo...
- Transgenic microRNA inhibition with spatiotemporal specificity in intact organismsCarlos M Loya
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
Nat Methods 6:897-903. 2009..Given that miR-SPs rely on a bipartite modular expression system, they could be used to elucidate the endogenous function of microRNAs in any species in which conditional expression can be achieved...
- A neuroprotective role for the DNA damage checkpoint in tauopathyVikram Khurana
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Aging Cell 11:360-2. 2012..Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies...
- Understanding neuronal connectivity through the post-transcriptional toolkitCarlos M Loya
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 24:625-35. 2010..In this review, we describe recent advances in understanding how post-transcriptional regulatory mechanisms refine the proteomic complexity required for the assembly of intricate and specific neural networks...
- Synapses and growth cones on two sides of a highwireTudor A Fulga
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Neuron 57:339-44. 2008....
- Senseless makes sense for spinocerebellar ataxia-1Vikram Khurana
Nat Neurosci 8:1422-4. 2005
- Invasive cell migration is initiated by guided growth of long cellular extensionsTudor A Fulga
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nat Cell Biol 4:715-9. 2002..We discuss similarities between LCEs and axons and the use of LCE-like structures as a general mechanism for initiating invasive migration in vivo...