Tudor A Fulga

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
    Tudor A Fulga
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Nat Cell Biol 9:139-48. 2007
  2. pmc Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1001026. 2010
  3. pmc Oxidative stress mediates tau-induced neurodegeneration in Drosophila
    Dora Dias-Santagata
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:236-45. 2007
  4. pmc Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
    Michelle L Steinhilb
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 18:5060-8. 2007
  5. pmc Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms
    Carlos M Loya
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 6:897-903. 2009
  6. doi A neuroprotective role for the DNA damage checkpoint in tauopathy
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 11:360-2. 2012
  7. pmc Understanding neuronal connectivity through the post-transcriptional toolkit
    Carlos M Loya
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 24:625-35. 2010
  8. doi Synapses and growth cones on two sides of a highwire
    Tudor A Fulga
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 57:339-44. 2008
  9. ncbi Senseless makes sense for spinocerebellar ataxia-1
    Vikram Khurana
    Nat Neurosci 8:1422-4. 2005
  10. ncbi Invasive cell migration is initiated by guided growth of long cellular extensions
    Tudor A Fulga
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:715-9. 2002

Detail Information

Publications10

  1. ncbi Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
    Tudor A Fulga
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Nat Cell Biol 9:139-48. 2007
    ..These findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in Alzheimer's disease and related disorders...
  2. pmc Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1001026. 2010
    ..Thus, caspase cleavage of tau may be a molecular mechanism through which lysosomal dysfunction and neurodegeneration are causally linked in Alzheimer's disease...
  3. pmc Oxidative stress mediates tau-induced neurodegeneration in Drosophila
    Dora Dias-Santagata
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:236-45. 2007
    ..In summary, our study identifies oxidative stress as a causal factor in tau-induced neurodegeneration in Drosophila...
  4. pmc Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
    Michelle L Steinhilb
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 18:5060-8. 2007
    ..These findings suggest that serine-proline/threonine-proline sites cooperate to mediate neurodegeneration in vivo...
  5. pmc Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms
    Carlos M Loya
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 6:897-903. 2009
    ..Given that miR-SPs rely on a bipartite modular expression system, they could be used to elucidate the endogenous function of microRNAs in any species in which conditional expression can be achieved...
  6. doi A neuroprotective role for the DNA damage checkpoint in tauopathy
    Vikram Khurana
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Aging Cell 11:360-2. 2012
    ..Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies...
  7. pmc Understanding neuronal connectivity through the post-transcriptional toolkit
    Carlos M Loya
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 24:625-35. 2010
    ..In this review, we describe recent advances in understanding how post-transcriptional regulatory mechanisms refine the proteomic complexity required for the assembly of intricate and specific neural networks...
  8. doi Synapses and growth cones on two sides of a highwire
    Tudor A Fulga
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 57:339-44. 2008
    ....
  9. ncbi Senseless makes sense for spinocerebellar ataxia-1
    Vikram Khurana
    Nat Neurosci 8:1422-4. 2005
  10. ncbi Invasive cell migration is initiated by guided growth of long cellular extensions
    Tudor A Fulga
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:715-9. 2002
    ..We discuss similarities between LCEs and axons and the use of LCE-like structures as a general mechanism for initiating invasive migration in vivo...