Research Topics
| W R FronteraSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Strength training in older women: early and late changes in whole muscle and single cellsWalter R Frontera
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
Muscle Nerve 28:601-8. 2003..Later, cellular adaptations in specific force track closely whole muscle changes...- Single muscle fiber size and contractility after spinal cord injury in ratsWalter R Frontera
Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
Muscle Nerve 34:101-4. 2006..SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality... - Aging of skeletal muscle: a 12-yr longitudinal studyW R Frontera
Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02114, USA
J Appl Physiol 88:1321-6. 2000.... - Skeletal muscle fiber quality in older men and womenW R Frontera
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, Massachusetts, USA
Am J Physiol Cell Physiol 279:C611-8. 2000..An intrinsic defect in contractile proteins could explain weakness in single fibers from OM. Sex-related differences exist at the whole muscle and single fiber levels... - Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and healthV A Hughes
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
J Gerontol A Biol Sci Med Sci 56:B209-17. 2001.... - Age- and gender-related differences in maximum shortening velocity of skeletal muscle fibersL S Krivickas
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Phys Med Rehabil 80:447-455; quiz 456-7. 2001..Age- and gender-related differences in Vo may partially explain the impairments in muscle function that occur with aging and the greater impairment in muscle function observed in OW compared with that observed in OM... - Contractile properties of adjacent segments of single human muscle fibersJ T Wilkins
Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
Muscle Nerve 24:1319-26. 2001..Possible explanations for nonuniformity of contractile properties include random variations in physiological systems or variability of protein expression among nuclear domains... - The reproducibility of the Bruce protocol exercise test for the determination of aerobic capacity in older womenR A Fielding
Human Physiology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Med Sci Sports Exerc 29:1109-13. 1997..The mean differences between tests and the high level of agreement between repeated tests suggests that a single measurement of VO2max can be performed to assess functional aerobic capacity in this population... - Contractile properties of single muscle fibers in myotonic dystrophyL S Krivickas
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, Massachusetts 02114, USA
Muscle Nerve 23:529-37. 2000..The results further suggest that reduction in force-generating capacity at the cellular level develops prior to clinical weakness... - Muscle fatigue and muscle injuryS A Dugan
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA
Phys Med Rehabil Clin N Am 11:385-403. 2000..Beyond illustrating what is currently known about muscle fatigue, the authors hope this review inspires the reader to solve problems of great clinical importance to patients and athletes alike... - IKKbeta/NF-kappaB activation causes severe muscle wasting in miceDongsheng Cai
Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Cell 119:285-98. 2004.... - Impact of muscle power and force on gait speed in disabled older men and womenAnthony Cuoco
Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Science, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
J Gerontol A Biol Sci Med Sci 59:1200-6. 2004..Because HGV is highly predictive of subsequent disability, future studies should evaluate the determinants of muscle power output at low external resistances... - Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosisYang D Teng
Department of Neurosurgery, Harvard Medical School Children s Hospital Boston, MA, USA
Neurosci Lett 397:155-8. 2006..Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration... - Sex differences in single muscle fiber power in older adultsLisa S Krivickas
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02114, USA
Med Sci Sports Exerc 38:57-63. 2006..This study was conducted to determine whether differences in power at the single muscle fiber level contribute to sex differences in whole muscle power production in the elderly... - Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old ageJulien Ochala
Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA, USA
Pflugers Arch 452:464-70. 2006.... - Tai Chi versus brisk walking in elderly womenJoseph F Audette
Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, 125 Nashua Street, Boston, MA 02114, USA
Age Ageing 35:388-93. 2006..to compare the effects of a short style of Tai Chi versus brisk walking training programme on aerobic capacity, heart rate variability (HRV), strength, flexibility, balance, psychological status and quality of life in elderly women... - Exercise in the elderly: research and clinical practiceJason E Frankel
New England Sinai Hospital and Rehabilitation Center, Department of Physical Medicine and Rehabilitation, Stoughton, MA 02072, and Department of Physical Medicine and Rehabilitation, Tufts New England Medical Center, Boston, MA 02111, USA
Clin Geriatr Med 22:239-56; vii. 2006..Where available, it discusses specific recommendations for prescribing exercise modalities. Finally, it presents suggestions for developing integrated exercise programs and enhancing patient compliance... - Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cellsYang D Teng
Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
Regen Med 1:763-76. 2006.... - Is stair climb power a clinically relevant measure of leg power impairments in at-risk older adults?Jonathan F Bean
Department of PM and R, Harvard Medical School, Boston, MA, USA
Arch Phys Med Rehabil 88:604-9. 2007..To test the clinical relevance of the stair climb power test (SCPT) as a measure of leg power impairments in mobility-limited older adults... 
Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticityDeniz Konya
Division of SCI Research, VA Boston Healthcare System, Boston, MA 02132, USA
Regen Med 3:309-27. 2008....- Single skeletal muscle fiber elastic and contractile characteristics in young and older menJulien Ochala
Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, and Harvard Medical School, Boston, Massachusetts, USA
J Gerontol A Biol Sci Med Sci 62:375-81. 2007..e., reduced specific force and unloaded shortening velocity) in type I and IIa fibers. However, the changes in fiber stiffness may not directly influence contractile characteristics alterations... - Effects of robotic therapy on motor impairment and recovery in chronic strokeSusan E Fasoli
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Arch Phys Med Rehabil 84:477-82. 2003..To examine whether robotic therapy can reduce motor impairment and enhance recovery of the hemiparetic arm in persons with chronic stroke... - Increased Velocity Exercise Specific to Task (InVEST) training: a pilot study exploring effects on leg power, balance, and mobility in community-dwelling older womenJonathan F Bean
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Am Geriatr Soc 52:799-804. 2004..To evaluate a dynamic form of weighted vest exercise suitable for home use and designed to enhance muscle power, balance, and mobility... - Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious ratsHoward Choi
Department of Neurosurgery, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
J Neurosci 25:4550-9. 2005..p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT1A agonists for post-SCI respiratory disorders... - Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosisLisa S Krivickas
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, Massachusetts 02114, USA
Muscle Nerve 26:636-43. 2002..A needle biopsy obtained at the time of ALS diagnosis may assist with predicting rate of disease progression... - Longitudinal changes in body composition in older men and women: role of body weight change and physical activityVirginia A Hughes
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 76:473-81. 2002..Estimates of body-composition change in older adults are mostly derived from cross-sectional data... - Weighted stair climbing in mobility-limited older people: a pilot studyJonathan Bean
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Am Geriatr Soc 50:663-70. 2002..To evaluate weighted stair climbing exercise (SCE) as a means of increasing lower extremity muscle power in mobility-limited older people... - Benefits of exercise for community-dwelling older adultsJonathan F Bean
Spaulding Cambridge Rehabilitation Center, Cambridge, MA 02138, USA
Arch Phys Med Rehabil 85:S31-42; quiz S43-4. 2004..OVERALL ARTICLE OBJECTIVE: To summarize the current knowledge regarding the therapeutic benefits of exercise for community-dwelling older adults... - The relationship between leg power and physical performance in mobility-limited older peopleJonathan F Bean
Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
J Am Geriatr Soc 50:461-7. 2002..The purpose of this study was to assess the influence of leg power and leg strength on the physical performance of community-dwelling mobility-limited older people... - Assessment of lower extremity muscle power in functionally-limited eldersDamien Callahan
Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston Univerisity, Boston, MA, USA
Aging Clin Exp Res 19:194-9. 2007..The purpose of this study was to assess the reliability and concurrent validity of a new methodology to evaluate lower extremity muscle power in older, functionally limited men and women... - Motions or muscles? Some behavioral factors underlying robotic assistance of motor recoveryNeville Hogan
Newman Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Rehabil Res Dev 43:605-18. 2006..Together these results indicate that movement coordination rather than muscle activation may be the most appropriate focus for robotic therapy... - Resistance training improves muscle function and body composition in patients with hyperthyroidismKelb Bousquet-Santos
Department of Physiology and Pharmacology, Universidade Federal Fluminense, Niteroi, RJ, Brazil
Arch Phys Med Rehabil 87:1123-30. 2006..CONCLUSIONS: Resistance training accelerates the recovery of skeletal muscle function and promotes weight gain based on muscle mass improvement in patients with medically treated hyperthyroidism... - Anthropometric assessment of 10-y changes in body composition in the elderlyVirginia A Hughes
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Am J Clin Nutr 80:475-82. 2004..Waist and thigh girths, rather than skinfold thicknesses, should be considered for use in longitudinal studies in the elderly because the changes in these girths capture increased abdominal adiposity and sarcopenia, respectively... - Movement smoothness changes during stroke recoveryBrandon Rohrer
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 22:8297-304. 2002..This pattern was reproduced in a computer simulation of recovery based on submovement blending, suggesting that progressive blending of submovements underlies stroke recovery... - Robotic therapy for chronic motor impairments after stroke: Follow-up resultsSusan E Fasoli
Department of Mechanical Engineering, Massachusetts Institute of Technology, Room 3 147, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Arch Phys Med Rehabil 85:1106-11. 2004..To study the effects of robotic rehabilitation in persons with chronic motor impairments after stroke and to examine whether improvements in motor abilities were sustained 4 months after the end of therapy... - High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivorsMichelle M Ouellette
Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, Mass 02215, USA
Stroke 35:1404-9. 2004..CONCLUSIONS: High-intensity PRT improves both paretic and nonparetic lower extremity strength after stroke, and results in reductions in functional limitations and disability... - Single muscle fiber physiology in neuromuscular diseaseLisa S Krivickas
Harvard Medical School, Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, MA 02114, USA
Phys Med Rehabil Clin N Am 16:951-65, ix. 2005 - Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patientsSusan D Driscoll
Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02144-2696, USA
AIDS 18:465-73. 2004..Combined treatment was safe, well tolerated and may be a useful strategy to decrease cardiovascular risk in this population... - Preservation of in vitro muscle fiber function in dermatomyositis and inclusion body myositis: a single fiber studyLisa S Krivickas
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, MA 02114, USA
Neuromuscul Disord 15:349-54. 2005.... - Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patientsSusan D Driscoll
Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 89:2171-8. 2004..Reduction in muscle adiposity may be an important mechanism by which exercise improves hyperinsulinemia in this population... - Comparison of two techniques of robot-aided upper limb exercise training after strokeJoel Stein
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts 02114, USA
Am J Phys Med Rehabil 83:720-8. 2004..Individuals with better motor control at baseline experienced greater increases in motor control with robotic training... 
Muscle fiber size and function in elderly humans: a longitudinal studyWalter R Frontera
Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
J Appl Physiol 105:637-42. 2008..This suggests that surviving fibers compensate to partially correct muscle size deficits in an attempt to maintain optimal force-generating capacity...