W R Frontera

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Strength training in older women: early and late changes in whole muscle and single cells
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Muscle Nerve 28:601-8. 2003
  2. ncbi request reprint Single muscle fiber size and contractility after spinal cord injury in rats
    Walter R Frontera
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 34:101-4. 2006
  3. ncbi request reprint Aging of skeletal muscle: a 12-yr longitudinal study
    W R Frontera
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02114, USA
    J Appl Physiol 88:1321-6. 2000
  4. ncbi request reprint Skeletal muscle fiber quality in older men and women
    W R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, Massachusetts, USA
    Am J Physiol Cell Physiol 279:C611-8. 2000
  5. ncbi request reprint Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health
    V A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 56:B209-17. 2001
  6. ncbi request reprint Age- and gender-related differences in maximum shortening velocity of skeletal muscle fibers
    L S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Phys Med Rehabil 80:447-455; quiz 456-7. 2001
  7. ncbi request reprint Contractile properties of adjacent segments of single human muscle fibers
    J T Wilkins
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 24:1319-26. 2001
  8. ncbi request reprint The reproducibility of the Bruce protocol exercise test for the determination of aerobic capacity in older women
    R A Fielding
    Human Physiology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Med Sci Sports Exerc 29:1109-13. 1997
  9. ncbi request reprint Contractile properties of single muscle fibers in myotonic dystrophy
    L S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, Massachusetts 02114, USA
    Muscle Nerve 23:529-37. 2000
  10. ncbi request reprint Muscle fatigue and muscle injury
    S A Dugan
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA
    Phys Med Rehabil Clin N Am 11:385-403. 2000

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Strength training in older women: early and late changes in whole muscle and single cells
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Muscle Nerve 28:601-8. 2003
    ..Later, cellular adaptations in specific force track closely whole muscle changes...
  2. ncbi request reprint Single muscle fiber size and contractility after spinal cord injury in rats
    Walter R Frontera
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 34:101-4. 2006
    ..SCI thus appears to affect various contractile properties of single muscle fibers differently. Normal cage activity may partially restore function but new interventions are needed to restore muscle fiber quality...
  3. ncbi request reprint Aging of skeletal muscle: a 12-yr longitudinal study
    W R Frontera
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02114, USA
    J Appl Physiol 88:1321-6. 2000
    ....
  4. ncbi request reprint Skeletal muscle fiber quality in older men and women
    W R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, Massachusetts, USA
    Am J Physiol Cell Physiol 279:C611-8. 2000
    ..An intrinsic defect in contractile proteins could explain weakness in single fibers from OM. Sex-related differences exist at the whole muscle and single fiber levels...
  5. ncbi request reprint Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health
    V A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Gerontol A Biol Sci Med Sci 56:B209-17. 2001
    ....
  6. ncbi request reprint Age- and gender-related differences in maximum shortening velocity of skeletal muscle fibers
    L S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Phys Med Rehabil 80:447-455; quiz 456-7. 2001
    ..Age- and gender-related differences in Vo may partially explain the impairments in muscle function that occur with aging and the greater impairment in muscle function observed in OW compared with that observed in OM...
  7. ncbi request reprint Contractile properties of adjacent segments of single human muscle fibers
    J T Wilkins
    Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, Massachusetts 02114, USA
    Muscle Nerve 24:1319-26. 2001
    ..Possible explanations for nonuniformity of contractile properties include random variations in physiological systems or variability of protein expression among nuclear domains...
  8. ncbi request reprint The reproducibility of the Bruce protocol exercise test for the determination of aerobic capacity in older women
    R A Fielding
    Human Physiology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Med Sci Sports Exerc 29:1109-13. 1997
    ..The mean differences between tests and the high level of agreement between repeated tests suggests that a single measurement of VO2max can be performed to assess functional aerobic capacity in this population...
  9. ncbi request reprint Contractile properties of single muscle fibers in myotonic dystrophy
    L S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, Massachusetts 02114, USA
    Muscle Nerve 23:529-37. 2000
    ..The results further suggest that reduction in force-generating capacity at the cellular level develops prior to clinical weakness...
  10. ncbi request reprint Muscle fatigue and muscle injury
    S A Dugan
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA
    Phys Med Rehabil Clin N Am 11:385-403. 2000
    ..Beyond illustrating what is currently known about muscle fatigue, the authors hope this review inspires the reader to solve problems of great clinical importance to patients and athletes alike...
  11. ncbi request reprint IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    Dongsheng Cai
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Cell 119:285-98. 2004
    ....
  12. ncbi request reprint Impact of muscle power and force on gait speed in disabled older men and women
    Anthony Cuoco
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Science, Boston University, 635 Commonwealth Ave, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 59:1200-6. 2004
    ....
  13. ncbi request reprint Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston, MA, USA
    Neurosci Lett 397:155-8. 2006
    ..Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration...
  14. ncbi request reprint Sex differences in single muscle fiber power in older adults
    Lisa S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA 02114, USA
    Med Sci Sports Exerc 38:57-63. 2006
    ..This study was conducted to determine whether differences in power at the single muscle fiber level contribute to sex differences in whole muscle power production in the elderly...
  15. ncbi request reprint Single skeletal muscle fiber behavior after a quick stretch in young and older men: a possible explanation of the relative preservation of eccentric force in old age
    Julien Ochala
    Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, MA, USA
    Pflugers Arch 452:464-70. 2006
    ....
  16. ncbi request reprint Tai Chi versus brisk walking in elderly women
    Joseph F Audette
    Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, Harvard Medical School, 125 Nashua Street, Boston, MA 02114, USA
    Age Ageing 35:388-93. 2006
    ..to compare the effects of a short style of Tai Chi versus brisk walking training programme on aerobic capacity, heart rate variability (HRV), strength, flexibility, balance, psychological status and quality of life in elderly women...
  17. ncbi request reprint Exercise in the elderly: research and clinical practice
    Jason E Frankel
    New England Sinai Hospital and Rehabilitation Center, Department of Physical Medicine and Rehabilitation, Stoughton, MA 02072, and Department of Physical Medicine and Rehabilitation, Tufts New England Medical Center, Boston, MA 02111, USA
    Clin Geriatr Med 22:239-56; vii. 2006
    ..Where available, it discusses specific recommendations for prescribing exercise modalities. Finally, it presents suggestions for developing integrated exercise programs and enhancing patient compliance...
  18. ncbi request reprint Physical activity-mediated functional recovery after spinal cord injury: potential roles of neural stem cells
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital and Children s Hospital Boston, Boston, MA 02115, USA
    Regen Med 1:763-76. 2006
    ....
  19. ncbi request reprint Is stair climb power a clinically relevant measure of leg power impairments in at-risk older adults?
    Jonathan F Bean
    Department of PM and R, Harvard Medical School, Boston, MA, USA
    Arch Phys Med Rehabil 88:604-9. 2007
    ..To test the clinical relevance of the stair climb power test (SCPT) as a measure of leg power impairments in mobility-limited older adults...
  20. doi request reprint Functional recovery in T13-L1 hemisected rats resulting from peripheral nerve rerouting: role of central neuroplasticity
    Deniz Konya
    Division of SCI Research, VA Boston Healthcare System, Boston, MA 02132, USA
    Regen Med 3:309-27. 2008
    ....
  21. ncbi request reprint Single skeletal muscle fiber elastic and contractile characteristics in young and older men
    Julien Ochala
    Muscle Cell Physiology Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Gerontol A Biol Sci Med Sci 62:375-81. 2007
    ..e., reduced specific force and unloaded shortening velocity) in type I and IIa fibers. However, the changes in fiber stiffness may not directly influence contractile characteristics alterations...
  22. ncbi request reprint Effects of robotic therapy on motor impairment and recovery in chronic stroke
    Susan E Fasoli
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Arch Phys Med Rehabil 84:477-82. 2003
    ..To examine whether robotic therapy can reduce motor impairment and enhance recovery of the hemiparetic arm in persons with chronic stroke...
  23. ncbi request reprint Increased Velocity Exercise Specific to Task (InVEST) training: a pilot study exploring effects on leg power, balance, and mobility in community-dwelling older women
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 52:799-804. 2004
    ..To evaluate a dynamic form of weighted vest exercise suitable for home use and designed to enhance muscle power, balance, and mobility...
  24. ncbi request reprint Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats
    Howard Choi
    Department of Neurosurgery, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 25:4550-9. 2005
    ..p.) given 20 min before 8-OH DPAT negated the effect of 8-OH DPAT. These results imply a potential clinical use of 5-HT1A agonists for post-SCI respiratory disorders...
  25. ncbi request reprint Skeletal muscle fiber function and rate of disease progression in amyotrophic lateral sclerosis
    Lisa S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, Massachusetts 02114, USA
    Muscle Nerve 26:636-43. 2002
    ..A needle biopsy obtained at the time of ALS diagnosis may assist with predicting rate of disease progression...
  26. ncbi request reprint Longitudinal changes in body composition in older men and women: role of body weight change and physical activity
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:473-81. 2002
    ..Estimates of body-composition change in older adults are mostly derived from cross-sectional data...
  27. ncbi request reprint Weighted stair climbing in mobility-limited older people: a pilot study
    Jonathan Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 50:663-70. 2002
    ..To evaluate weighted stair climbing exercise (SCE) as a means of increasing lower extremity muscle power in mobility-limited older people...
  28. ncbi request reprint Benefits of exercise for community-dwelling older adults
    Jonathan F Bean
    Spaulding Cambridge Rehabilitation Center, Cambridge, MA 02138, USA
    Arch Phys Med Rehabil 85:S31-42; quiz S43-4. 2004
    ....
  29. ncbi request reprint The relationship between leg power and physical performance in mobility-limited older people
    Jonathan F Bean
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA
    J Am Geriatr Soc 50:461-7. 2002
    ..The purpose of this study was to assess the influence of leg power and leg strength on the physical performance of community-dwelling mobility-limited older people...
  30. ncbi request reprint Assessment of lower extremity muscle power in functionally-limited elders
    Damien Callahan
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston Univerisity, Boston, MA, USA
    Aging Clin Exp Res 19:194-9. 2007
    ..The purpose of this study was to assess the reliability and concurrent validity of a new methodology to evaluate lower extremity muscle power in older, functionally limited men and women...
  31. ncbi request reprint Motions or muscles? Some behavioral factors underlying robotic assistance of motor recovery
    Neville Hogan
    Newman Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Rehabil Res Dev 43:605-18. 2006
    ..Together these results indicate that movement coordination rather than muscle activation may be the most appropriate focus for robotic therapy...
  32. ncbi request reprint Resistance training improves muscle function and body composition in patients with hyperthyroidism
    Kelb Bousquet-Santos
    Department of Physiology and Pharmacology, Universidade Federal Fluminense, Niteroi, RJ, Brazil
    Arch Phys Med Rehabil 87:1123-30. 2006
    ..To evaluate the effect of resistance training on skeletal muscle performance and body composition in patients with medically treated hyperthyroidism...
  33. ncbi request reprint Anthropometric assessment of 10-y changes in body composition in the elderly
    Virginia A Hughes
    Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Am J Clin Nutr 80:475-82. 2004
    ..An increased central distribution of fat with advancing age is associated with chronic metabolic and cardiovascular abnormalities. Little is known about the magnitude or pattern of fat distribution and its association with healthy aging...
  34. ncbi request reprint Movement smoothness changes during stroke recovery
    Brandon Rohrer
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 22:8297-304. 2002
    ..This pattern was reproduced in a computer simulation of recovery based on submovement blending, suggesting that progressive blending of submovements underlies stroke recovery...
  35. ncbi request reprint Robotic therapy for chronic motor impairments after stroke: Follow-up results
    Susan E Fasoli
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Room 3 147, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Arch Phys Med Rehabil 85:1106-11. 2004
    ..To study the effects of robotic rehabilitation in persons with chronic motor impairments after stroke and to examine whether improvements in motor abilities were sustained 4 months after the end of therapy...
  36. ncbi request reprint High-intensity resistance training improves muscle strength, self-reported function, and disability in long-term stroke survivors
    Michelle M Ouellette
    Human Physiology Laboratory, Department of Health Sciences, Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, Mass 02215, USA
    Stroke 35:1404-9. 2004
    ..To evaluate the efficacy of supervised high-intensity progressive resistance training (PRT) on lower extremity strength, function, and disability in older, long-term stroke survivors...
  37. ncbi request reprint Single muscle fiber physiology in neuromuscular disease
    Lisa S Krivickas
    Harvard Medical School, Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, MA 02114, USA
    Phys Med Rehabil Clin N Am 16:951-65, ix. 2005
  38. ncbi request reprint Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients
    Susan D Driscoll
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02144 2696, USA
    AIDS 18:465-73. 2004
    ..To determine whether exercise training in combination with metformin improves cardiovascular risk indices and insulin in comparison to metformin alone among HIV-infected patients...
  39. ncbi request reprint Preservation of in vitro muscle fiber function in dermatomyositis and inclusion body myositis: a single fiber study
    Lisa S Krivickas
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, 125 Nashua St, Boston, MA 02114, USA
    Neuromuscul Disord 15:349-54. 2005
    ....
  40. ncbi request reprint Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients
    Susan D Driscoll
    Program in Nutritional Metabolism, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:2171-8. 2004
    ..Reduction in muscle adiposity may be an important mechanism by which exercise improves hyperinsulinemia in this population...
  41. ncbi request reprint Comparison of two techniques of robot-aided upper limb exercise training after stroke
    Joel Stein
    Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts 02114, USA
    Am J Phys Med Rehabil 83:720-8. 2004
    ..This study examined whether incorporating progressive resistive training into robot-aided exercise training provides incremental benefits over active-assisted robot-aided exercise for the upper limb after stroke...
  42. pmc Muscle fiber size and function in elderly humans: a longitudinal study
    Walter R Frontera
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Appl Physiol 105:637-42. 2008
    ..This suggests that surviving fibers compensate to partially correct muscle size deficits in an attempt to maintain optimal force-generating capacity...