R M Friedlander

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease
    Yu Zhang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Neurochem 87:1184-92. 2003
  2. pmc Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston Brigham and Women s Hospital, Boston, and SCI Laboratory, VA Boston Healthcare System, MA, USA
    Proc Natl Acad Sci U S A 101:3071-6. 2004
  3. ncbi request reprint Apoptosis and caspases in neurodegenerative diseases
    Robert M Friedlander
    Neuroapoptosis Laboratory, Division of Cerebrovascular Surgery, Department of Neurosurgery, Brigham and Women s Hospital and Harvard Medical School, Boston 02115, USA
    N Engl J Med 348:1365-75. 2003
  4. ncbi request reprint Nortriptyline delays disease onset in models of chronic neurodegeneration
    Hongyan Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 113, Boston, MA 02115, USA
    Eur J Neurosci 26:633-41. 2007
  5. pmc Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:10483-7. 2003
  6. pmc Complement in neuroprotection and neurodegeneration
    Vijay Yanamadala
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Mol Med 16:69-76. 2010
  7. ncbi request reprint Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
    Wenhua Zhang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 53:267-70. 2003
  8. ncbi request reprint Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    Shan Zhu
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 417:74-8. 2002
  9. ncbi request reprint Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    R O Sanchez Mejia
    Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 48:1393-9; discussion 1399-401. 2001
  10. pmc Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    Xin Wang
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Stroke 40:1877-85. 2009

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease
    Yu Zhang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Neurochem 87:1184-92. 2003
    ..Understanding the chronology of apoptotic events provides important information for appropriate therapeutic targeting in this devastating and untreatable disease...
  2. pmc Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    Yang D Teng
    Department of Neurosurgery, Harvard Medical School Children s Hospital Boston Brigham and Women s Hospital, Boston, and SCI Laboratory, VA Boston Healthcare System, MA, USA
    Proc Natl Acad Sci U S A 101:3071-6. 2004
    ..Minocycline, with its proven clinical safety, capability to cross the blood-brain barrier, and demonstrated efficacy during a clinically relevant therapeutic window, may become an effective therapy for acute SCI...
  3. ncbi request reprint Apoptosis and caspases in neurodegenerative diseases
    Robert M Friedlander
    Neuroapoptosis Laboratory, Division of Cerebrovascular Surgery, Department of Neurosurgery, Brigham and Women s Hospital and Harvard Medical School, Boston 02115, USA
    N Engl J Med 348:1365-75. 2003
  4. ncbi request reprint Nortriptyline delays disease onset in models of chronic neurodegeneration
    Hongyan Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 113, Boston, MA 02115, USA
    Eur J Neurosci 26:633-41. 2007
    ..In addition, our data suggested a role for mPT in chronic neurodegeneration, particularly at the early rather than the advanced disease stages...
  5. pmc Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:10483-7. 2003
    ..Our results further delineate the mechanism by which minocycline mediates its remarkably broad neuroprotective effects...
  6. pmc Complement in neuroprotection and neurodegeneration
    Vijay Yanamadala
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Mol Med 16:69-76. 2010
    ..Here, we review these novel neuroprotective roles of the complement cascade, focusing on signaling pathways that might provide new therapeutic targets in acute neuronal injury...
  7. ncbi request reprint Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
    Wenhua Zhang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 53:267-70. 2003
    ..Adding relevancy to our findings, minocycline and creatine, are relatively safe, cross the blood-brain barrier, and are currently available for human evaluation...
  8. ncbi request reprint Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    Shan Zhu
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 417:74-8. 2002
    ..Because of the safety record of minocycline, and its ability to penetrate the blood-brain barrier, this drug may be a novel therapy for ALS...
  9. ncbi request reprint Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    R O Sanchez Mejia
    Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 48:1393-9; discussion 1399-401. 2001
    ..These results provide an experimental rationale for the evaluation of minocycline in human trauma patients...
  10. pmc Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    Xin Wang
    Department of Neurosurgery, Neuroapoptosis Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Stroke 40:1877-85. 2009
    ..We demonstrate that methazolamide and melatonin are protective in cellular and in vivo models of neuronal hypoxia...
  11. ncbi request reprint Depletion of wild-type huntingtin in mouse models of neurologic diseases
    Yu Zhang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurochem 87:101-6. 2003
    ..We propose that in HD, in addition to a toxic gain-of-function of mutant huntingtin, a parallel depletion of wild-type huntingtin results in a detrimental loss-of-function, playing an important role in disease progression...
  12. ncbi request reprint Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice
    Ying jun Guan
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 102:1125-38. 2007
    ..Further studies will determine if this endogenous regenerative process can be enhanced and directed so as to slow or even reverse the natural progression of this devastating disease...
  13. pmc Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury
    Wen Hua Zhang
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 113, Boston, MA 02115, USA
    Stroke 39:455-62. 2008
    ..Because mitochondrial permeability transition and consequent mitochondrial dysfunction have been implicated in acute neuronal death, we proposed to investigate the possible neuroprotective effects of nortriptyline in cerebral ischemia...
  14. ncbi request reprint Caspases in Huntington's disease
    R O Sanchez Mejia
    Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuroscientist 7:480-9. 2001
    ..In HD-transgenic mice, caspase inhibition resulted in a delayed onset of symptoms, a slowed progression, and prolonged survival. Caspase inhibition is a therapeutic strategy that merits evaluation in humans with HD...
  15. ncbi request reprint Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice
    Shan Zhu
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:5909-12. 2004
    ..Prophylactic creatine supplementation, similar to what is recommended for an agent such as aspirin, may be considered for patients in high stroke-risk categories...
  16. ncbi request reprint Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death
    Xin Wang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, LMRC 123, Boston, MA 02115, USA
    Biochim Biophys Acta 1762:742-54. 2006
    ..Cop, as an inhibitor of an important apical caspase cell death axis, may provide a tool for modulating pathological cell death...
  17. ncbi request reprint Promethazine: a novel application as a neuroprotectant that reduces ischemia-mediated injury by inhibiting mitochondrial dysfunction
    Malini V Narayanan
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard University Medical School, Boston, Massachusetts, USA
    Clin Neurosurg 51:102-7. 2004
  18. ncbi request reprint Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease
    Xin Wang
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:11645-54. 2005
    ....
  19. pmc Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease
    Xin Wang
    Neuroapoptosis Laboratory and Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:9473-85. 2008
    ..Given that many of these compounds have been approved by the Food and Drug Administration for clinical usage and cross the blood-brain barrier, these drugs may lead to trials in patients...
  20. ncbi request reprint Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice
    Edward C Stack
    Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, MA 01730, USA
    Biochim Biophys Acta 1762:373-80. 2006
    ..These data suggest that combined minocycline and CoQ10 treatment may offer therapeutic benefit to patients suffering from HD...
  21. ncbi request reprint The mitochondrial permeability transition as a target for neuroprotection
    Bruce S Kristal
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, New York 10605, USA
    J Bioenerg Biomembr 36:309-12. 2004
    ..g., in stroke) and are modulated by diseases of the central nervous system (e.g., Huntington's). Evidence of neuroprotection seen with compounds such as N -Met-Val cyclosporine also support this possibility...
  22. ncbi request reprint Minocycline is protective in a mouse model of Huntington's disease
    Steven Hersch
    Ann Neurol 54:841; author reply 842-3. 2003
  23. ncbi request reprint Caspase cascades in human immunodeficiency virus-associated neurodegeneration
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:4015-24. 2002
    ..These findings suggest that pharmacologic interventions aimed at the caspase enzyme pathways may be beneficial for the prevention or treatment of HAD...
  24. ncbi request reprint Cytochrome C and caspase-9 expression in Huntington's disease
    Tamara Kiechle
    Geriatric Research Education and Clinical Center, Bedford VA Medical Center, MA 01730, USA
    Neuromolecular Med 1:183-95. 2002
    ....
  25. ncbi request reprint Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS
    Christelle Guegan
    Department of Neurology, Columbia University, New York, New York 10032, USA
    Mol Cell Neurosci 20:553-62. 2002
    ....
  26. pmc Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology
    Irina G Stavrovskaya
    Dementia Research Service, Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA
    J Exp Med 200:211-22. 2004
    ....
  27. ncbi request reprint Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases
    Suhayl Dhib-Jalbut
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901, and The Cleveland Clinic, OH, USA
    J Neuroimmunol 176:198-215. 2006
    ..Elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroprotective and neurorestorative strategies...
  28. ncbi request reprint Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice
    Vanessa C Wheeler
    Molecular Neurogenetics Unit and Molecular Neuropathology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Hum Mol Genet 11:633-40. 2002
    ..Thus, potential HD therapies in man might be directed at different levels: preventing the disease-initiating mechanism or slowing the subsequent progression of pathogenesis...
  29. pmc Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death
    Wen Hua Zhang
    Department of Neurosurgery, Qilu Hospital, Shandong University, 250012, People s Republic of China
    Proc Natl Acad Sci U S A 100:16012-7. 2003
    ....