F Fregni

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Phrenic paresis and respiratory insufficiency associated with cervical spondylotic myelopathy
    F Fregni
    Neurology Division, Hospital das Clinicas, Sao Paulo University, Sao Paulo, Brazil
    Acta Neurochir (Wien) 146:309-12; discussion 312. 2004
  2. ncbi request reprint Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation
    F Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Eur J Neurol 13:996-1001. 2006
  3. ncbi request reprint Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Neuropsychopharmacol 9:641-54. 2006
  4. ncbi request reprint Immediate placebo effect in Parkinson's disease--is the subjective relief accompanied by objective improvement?
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
    Eur Neurol 56:222-9. 2006
  5. ncbi request reprint Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression
    Felipe Fregni
    Center for Noninvasive Brain Stimulation, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, KS 452, Boston, MA 02215, USA
    Exp Neurol 204:462-6. 2007
  6. pmc Placebo response of non-pharmacological and pharmacological trials in major depression: a systematic review and meta-analysis
    Andre Russowsky Brunoni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    PLoS ONE 4:e4824. 2009
  7. pmc Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology
    Andre R Brunoni
    Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 5:e9479. 2010
  8. pmc Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability
    Andre R Brunoni
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Ther Clin Risk Manag 5:897-910. 2009
  9. pmc Using non-invasive brain stimulation to augment motor training-induced plasticity
    Nadia Bolognini
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    J Neuroeng Rehabil 6:8. 2009
  10. ncbi request reprint Homeostatic effects of plasma valproate levels on corticospinal excitability changes induced by 1Hz rTMS in patients with juvenile myoclonic epilepsy
    Felipe Fregni
    Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, KS 452, Boston, MA 02215, USA
    Clin Neurophysiol 117:1217-27. 2006

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Phrenic paresis and respiratory insufficiency associated with cervical spondylotic myelopathy
    F Fregni
    Neurology Division, Hospital das Clinicas, Sao Paulo University, Sao Paulo, Brazil
    Acta Neurochir (Wien) 146:309-12; discussion 312. 2004
    ..This case report suggests that one pathophysiology of clinical phrenic nerve paresis may be segmental damage to the anterior horns caused by cervical spondylosis...
  2. ncbi request reprint Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation
    F Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Eur J Neurol 13:996-1001. 2006
    ..These effects were short lasting. These results replicate the findings of the previous study and, in addition, show preliminary evidence that anodal tDCS of LTA induces a similar transient tinnitus reduction as high-frequency rTMS...
  3. ncbi request reprint Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Neuropsychopharmacol 9:641-54. 2006
    ..In conclusion TMS antidepressant therapy in younger and less treatment-resistant patients is associated with better outcome...
  4. ncbi request reprint Immediate placebo effect in Parkinson's disease--is the subjective relief accompanied by objective improvement?
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
    Eur Neurol 56:222-9. 2006
    ....
  5. ncbi request reprint Effects of transcranial direct current stimulation coupled with repetitive electrical stimulation on cortical spreading depression
    Felipe Fregni
    Center for Noninvasive Brain Stimulation, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, KS 452, Boston, MA 02215, USA
    Exp Neurol 204:462-6. 2007
    ....
  6. pmc Placebo response of non-pharmacological and pharmacological trials in major depression: a systematic review and meta-analysis
    Andre Russowsky Brunoni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    PLoS ONE 4:e4824. 2009
    ..We proposed to assess placebo responses in two categories of MDD trials: pharmacological (antidepressant drugs) and non-pharmacological (device- rTMS) trials...
  7. pmc Changes in clinical trials methodology over time: a systematic review of six decades of research in psychopharmacology
    Andre R Brunoni
    Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 5:e9479. 2010
    ..As methodological flaws in trials can lead to false-negative or false-positive results, the objective of our study was to evaluate the impact of methodological changes in psychopharmacology clinical research over the past 60 years...
  8. pmc Pharmacological and combined interventions for the acute depressive episode: focus on efficacy and tolerability
    Andre R Brunoni
    Department and Institute of Psychiatry, University of Sao Paulo, Brazil
    Ther Clin Risk Manag 5:897-910. 2009
    ..In addition the optimal augmentation strategy is still not clear when dealing with treatment-resistant depression, a condition that affects 15% to 40% of depressed patients...
  9. pmc Using non-invasive brain stimulation to augment motor training-induced plasticity
    Nadia Bolognini
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    J Neuroeng Rehabil 6:8. 2009
    ..In this review we discuss how these techniques can enhance the effects of a behavioural intervention and the clinical evidence to date...
  10. ncbi request reprint Homeostatic effects of plasma valproate levels on corticospinal excitability changes induced by 1Hz rTMS in patients with juvenile myoclonic epilepsy
    Felipe Fregni
    Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, KS 452, Boston, MA 02215, USA
    Clin Neurophysiol 117:1217-27. 2006
    ..Therefore, we aimed to study the effects of 1 Hz rTMS on corticospinal excitability in patients with juvenile myoclonic epilepsy (JME) in two different conditions: low- or high-plasma valproate levels...
  11. ncbi request reprint Hand motor recovery after stroke: tuning the orchestra to improve hand motor function
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cogn Behav Neurol 19:21-33. 2006
    ..This paper reviews the stroke characteristics that can predict a good recovery and compensations across brain areas that can be implemented after a stroke to accelerate motor function recovery...
  12. ncbi request reprint Cortical stimulation of the prefrontal cortex with transcranial direct current stimulation reduces cue-provoked smoking craving: a randomized, sham-controlled study
    Felipe Fregni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    J Clin Psychiatry 69:32-40. 2008
    ....
  13. ncbi request reprint A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pain 122:197-209. 2006
    ..We discuss potential mechanisms for pain amelioration after tDCS, such as a secondary modulation of thalamic nuclei activity...
  14. ncbi request reprint A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 452, Boston, MA 02215, U S A
    Epilepsia 47:335-42. 2006
    ..To study the effects of cathodal DC polarization in patients with refractory epilepsy and malformations of cortical development (MCDs) as indexed by seizure frequency and epileptiform EEG discharges...
  15. ncbi request reprint Effects of antidepressant treatment with rTMS and fluoxetine on brain perfusion in PD
    F Fregni
    Harvard Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neurology 66:1629-37. 2006
    ..Although depression is highly prevalent in Parkinson disease (PD), little is known about the neural correlates associated with depression and antidepressant treatment in PD...
  16. pmc Transcranial direct current stimulation of the prefrontal cortex modulates the desire for specific foods
    Felipe Fregni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue KS 454, Boston, MA, 02215, USA
    Appetite 51:34-41. 2008
    ..These changes were not related to mood changes after any type of tDCS treatment. The effects of tDCS on food craving might be related to a modulation of neural circuits associated with reward and decision-making...
  17. ncbi request reprint A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, KS 452, Boston, Massachusetts 02215, USA
    Stroke 37:2115-22. 2006
    ..We therefore conducted a randomized, sham-controlled, phase II trial to evaluate whether five sessions of low-frequency rTMS can increase the magnitude and duration of these effects and whether this approach is safe...
  18. ncbi request reprint Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques
    Felipe Fregni
    Center for Non Invasive Brain Stimulation, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02115, USA
    Lancet Neurol 6:188-91. 2007
    ..However, recent advancements in the techniques of non-invasive brain stimulation have enhanced their modulatory effects and thus become a new, attractive alternative for chronic pain treatment...
  19. ncbi request reprint A randomized clinical trial of repetitive transcranial magnetic stimulation in patients with refractory epilepsy
    Felipe Fregni
    Center for Non Invasive Brain Stimulation, Beth Israel Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 60:447-55. 2006
    ..To study the antiepileptic effects of rTMS in patients with refractory epilepsy and malformations of cortical development in a randomized, double-blind, sham-controlled trial...
  20. ncbi request reprint A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia
    Felipe Fregni
    Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 54:3988-98. 2006
    ....
  21. ncbi request reprint Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mov Disord 21:1693-702. 2006
    ..These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD...
  22. ncbi request reprint Lasting accelerative effects of 1 Hz and 20 Hz electrical stimulation on cortical spreading depression: relevance for clinical applications of brain stimulation
    Felipe Fregni
    Harvard Center for Non invasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    Eur J Neurosci 21:2278-84. 2005
    ..Furthermore, the effects are found to be long lasting. We believe that these findings have strong relevance to support the clinical application of therapies involving electrical stimulation for diseases of reduced cortical excitability...
  23. ncbi request reprint Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330, Brookline Avenue, KS 452, Boston, MA 02215, USA
    Exp Brain Res 166:23-30. 2005
    ..Furthermore, this effect depends on the stimulation polarity and is specific to the site of stimulation. This result may be helpful to develop future interventions aiming at clinical benefits...
  24. ncbi request reprint Antiepileptic effects of repetitive transcranial magnetic stimulation in patients with cortical malformations: an EEG and clinical study
    Felipe Fregni
    Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Stereotact Funct Neurosurg 83:57-62. 2005
    ..To study the effects of repetitive transcranial magnetic stimulation (rTMS) on epileptic EEG discharges in patients with refractory epilepsy and malformations of cortical development (MCDs)...
  25. pmc Clinical effects and brain metabolic correlates in non-invasive cortical neuromodulation for visceral pain
    Felipe Fregni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Eur J Pain 15:53-60. 2011
    ..Therefore approaches aiming at modulation of brain activity are attractive candidates to control visceral pain...
  26. pmc Repetitive transcranial magnetic stimulation is as effective as fluoxetine in the treatment of depression in patients with Parkinson's disease
    F Fregni
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurol Neurosurg Psychiatry 75:1171-4. 2004
    ..To study the efficacy of 15 Hz repetitive transcranial magnetic stimulation (rTMS) in treating depression in patients with Parkinson's disease...
  27. ncbi request reprint Transcranial magnetic stimulation treatment for epilepsy: can it also improve depression and vice versa?
    Felipe Fregni
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    Epilepsy Behav 7:182-9. 2005
    ..This article reviews these data and explores further the question of whether depression and epilepsy can be simultaneously treated with TMS for optimal therapeutic impact...
  28. ncbi request reprint Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Neuroreport 16:1551-5. 2005
    ..These results suggest that the appropriate modulation of bihemispheric brain structures can promote motor function recovery...
  29. ncbi request reprint Transcranial magnetic stimulation for the treatment of depression in neurologic disorders
    Felipe Fregni
    Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 452, Boston, MA 02215, USA
    Curr Psychiatry Rep 7:381-90. 2005
    ..Lastly, a framework that includes the parameters of stimulation (intensity, frequency, number of pulses, and site of stimulation) for the treatment of depression in neurologic diseases is proposed...
  30. ncbi request reprint Modulation in motor threshold after a severe episode of gastrointestinal distress
    Felipe Fregni
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J ECT 20:50-1. 2004
  31. pmc Non-invasive brain stimulation for Parkinson's disease: a systematic review and meta-analysis of the literature
    F Fregni
    Harvard Center for Noninvasive Brain Stimulation, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Neurol Neurosurg Psychiatry 76:1614-23. 2005
    ..TMS, across applied stimulation sites and parameters, can exert a significant, albeit modest, positive effect on the motor function of patients with PD. ECT also may exert a significant effect on motor function in PD patients...
  32. ncbi request reprint A sham stimulation-controlled trial of rTMS of the unaffected hemisphere in stroke patients
    C G Mansur
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 64:1802-4. 2005
    ..Patients showed a significant decrease in simple and choice reaction time and improved performance of the Purdue Pegboard test with their affected hand after rTMS of the motor cortex in the intact hemisphere as compared with sham rTMS...
  33. doi request reprint Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the Major Depressive Episode: findings from a naturalistic study
    A R Brunoni
    Clinical Research Center, University Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Eur Psychiatry 28:356-61. 2013
    ..Transcranial direct current stimulation (tDCS) is a non-invasive, neuromodulatory technique with an emerging role for treating major depression...
  34. doi request reprint Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers
    P S Boggio
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Eur J Neurol 15:1124-30. 2008
    ..We aimed to evaluate whether transcranial direct current stimulation (tDCS) is effective in modulating sensory and pain perception thresholds in healthy subjects as to further explore mechanisms of tDCS in pain relief...
  35. doi request reprint Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease
    P S Boggio
    Center for Health and Biological Sciences, Mackenzie Presbyterian University, Sao Paulo, Brazil
    J Neurol Neurosurg Psychiatry 80:444-7. 2009
    ..As far as is known, this is the first trial showing that tDCS can enhance a component of recognition memory. The potential mechanisms of action and the implications of these results are discussed...
  36. ncbi request reprint Effects of repetitive transcranial magnetic stimulation on voice and speech in Parkinson's disease
    A E Dias
    Department of Neurology and Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Acta Neurol Scand 113:92-9. 2006
    ..To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on vocal function in Parkinson's disease (PD)...
  37. ncbi request reprint rTMS treatment for depression in Parkinson's disease increases BOLD responses in the left prefrontal cortex
    Ellison Fernando Cardoso
    NIF, LIM 44, Department of Radiology, University of Sao Paulo, Sao Paulo, Brazil
    Int J Neuropsychopharmacol 11:173-83. 2008
    ..Our findings show that antidepressant effects of rTMS and fluoxetine in PD are associated with changes in different areas of the depression-related neural network...
  38. doi request reprint Differential modulatory effects of transcranial direct current stimulation on a facial expression go-no-go task in males and females
    Paulo Sergio Boggio
    Programa de Pós Graduação em Distúrbios do Desenvolvimento e Núcleo de Neurociências do Comportamento, Centro de Ciencias Biologicas e da Saude, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil
    Neurosci Lett 447:101-5. 2008
    ..Our results confirmed the notion that performance to facial expression recognition is increased in females compared with males and that modulation of temporal cortex with tDCS leads to differential effects according to gender...
  39. doi request reprint Interhemispheric modulation induced by cortical stimulation and motor training
    Julie A Williams
    Department of Neurology, Harvard Medical School, Boston, Massachusetts 02215, USA
    Phys Ther 90:398-410. 2010
    ..One recently revisited technique that has been shown to be effective in improving motor function in people with stroke using interhemispheric modulation is transcranial direct current stimulation (tDCS)...
  40. ncbi request reprint Has repetitive transcranial magnetic stimulation (rTMS) treatment for depression improved? A systematic review and meta-analysis comparing the recent vs. the earlier rTMS studies
    M Gross
    Department of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil
    Acta Psychiatr Scand 116:165-73. 2007
    ..To investigate whether the recent repetitive transcranial magnetic stimulation (rTMS) studies on depression using new parameters of stimulation have shown improved clinical results...
  41. doi request reprint Transcranial magnetic stimulation: a historical evaluation and future prognosis of therapeutically relevant ethical concerns
    Jared C Horvath
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave KS 158, Boston, MA 02215, USA
    J Med Ethics 37:137-43. 2011
    ..This article provides an overview of the history of TMS and highlights the ethical questions that are likely arise as the therapeutic use of TMS continues to expand...
  42. doi request reprint Inhibition of motor cortex excitability with 15Hz transcranial alternating current stimulation (tACS)
    Soroush Zaghi
    Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, 125 Nashua Street 727, Boston, MA 02114, USA
    Neurosci Lett 479:211-4. 2010
    ..We propose that tACS may have a dampening effect on cortical networks and perhaps interfere with the temporal and spatial summation of weak subthreshold electric potentials...
  43. doi request reprint Impaired interhemispheric interactions in patients with major depression
    Sami Bajwa
    Berenson Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Nerv Ment Dis 196:671-7. 2008
    ..Our findings showing a decreased interhemispheric modulation in patients with major depression are consistent with the notion that mood disorders are associated with slow interhemispheric switching mechanisms...
  44. ncbi request reprint The plastic human brain cortex
    Alvaro Pascual-Leone
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Annu Rev Neurosci 28:377-401. 2005
    ..The challenge we face is to learn enough about the mechanisms of plasticity to modulate them to achieve the best behavioral outcome for a given subject...
  45. pmc Neuromodulation of decision-making in the addictive brain
    Shirley Fecteau
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Subst Use Misuse 45:1766-86. 2010
    ..We propose a neurocognitive model that can account for our findings and suggests a promising therapeutic role of brain stimulation in the treatment of substance abuse and addictive behavior disorders...
  46. ncbi request reprint Exploring a novel therapeutic approach with noninvasive cortical stimulation for vulvodynia
    Sofia Barros Cecilio
    Centro de Neurocirurgia Funcional e Dor, Hospital 9 de Julho, Sao Paulo, Brazil
    Am J Obstet Gynecol 199:e6-7. 2008
    ..We report a case of severe, medically refractory vulvodynia that responded remarkably to treatment with transcranial direct current stimulation...
  47. ncbi request reprint Site-specific effects of transcranial direct current stimulation on sleep and pain in fibromyalgia: a randomized, sham-controlled study
    Suely Roizenblatt
    Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Pain Pract 7:297-306. 2007
    ....
  48. pmc Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study
    Tim Wagner
    Division of Health Sciences and Technology, Harvard Medical School Massachusetts Institute of Technology, Boston, MA, USA
    Exp Brain Res 186:539-50. 2008
    ..Clinical applications of TMS should be carefully considered in light of these findings...
  49. ncbi request reprint Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 27:662-77. 2006
    ..This enhancement effect is not present in neutral pictures and might parallel accentuated subjective feeling states...
  50. ncbi request reprint Updates on the use of non-invasive brain stimulation in physical and rehabilitation medicine
    Julie A Williams
    Department of Neurology, Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    J Rehabil Med 41:305-11. 2009
    ..These new approaches need to be tested in larger clinical trials in order to determine whether they offer significant clinical effects...
  51. doi request reprint Abnormal visual activation in Parkinson's disease patients
    Ellison Fernando Cardoso
    NIF, LIM 44, Department of Radiology, University of Sao Paulo, Sao Paulo, Brazil
    Mov Disord 25:1590-6. 2010
    ..Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD...
  52. pmc Improved naming after TMS treatments in a chronic, global aphasia patient--case report
    Margaret A Naeser
    Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, Massachusetts 02130, USA
    Neurocase 11:182-93. 2005
    ..One year after her TMS treatments, she entered speech therapy with continued improvement. TMS may have modulated activity in the remaining left and right hemisphere neural network for naming...
  53. pmc Noninvasive brain stimulation with high-frequency and low-intensity repetitive transcranial magnetic stimulation treatment for posttraumatic stress disorder
    Paulo Sergio Boggio
    Programa de Pós Graduação em Distúrbios do Desenvolvimento e Núcleo de Neurociências do Comportamento, Centro de Ciencias Biologicas e da Saude, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil
    J Clin Psychiatry 71:992-9. 2010
    ....
  54. ncbi request reprint Technology insight: noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS
    Felipe Fregni
    Harvard Medical School and the Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Clin Pract Neurol 3:383-93. 2007
    ..We review randomized controlled studies, in focal epilepsy, Parkinson's disease, recovery from stroke, and chronic pain, to illustrate these principles, and we present evidence for the clinical effects of these two techniques...
  55. ncbi request reprint Impact of 5-HTTLPR and BDNF polymorphisms on response to sertraline versus transcranial direct current stimulation: implications for the serotonergic system
    A R Brunoni
    Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil University of São Paulo Medical School, Sao Paulo, Brazil Centro de Atenção Integrada em Saúde Mental, Faculdade de Ciências Médicas da Santa Casa de Misericórdia de São Paulo, Sao Paulo, Brazil Electronic address
    Eur Neuropsychopharmacol 23:1530-40. 2013
    ....
  56. doi request reprint A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
    Andre Russowsky Brunoni
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Int J Neuropsychopharmacol 11:1169-80. 2008
    ..34, 95% CI 0.02-0.66). Our results show that BDNF levels are associated with clinical changes in depression; supporting the notion that depression improvement is associated with neuroplastic changes...
  57. ncbi request reprint Hand function improvement with low-frequency repetitive transcranial magnetic stimulation of the unaffected hemisphere in a severe case of stroke
    Paulo S Boggio
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Phys Med Rehabil 85:927-30. 2006
    ....
  58. doi request reprint Can the 'yin and yang' BDNF hypothesis be used to predict the effects of rTMS treatment in neuropsychiatry?
    Andre Russowsky Brunoni
    Berenson Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 430, Boston, MA 02215, USA
    Med Hypotheses 71:279-82. 2008
    ..In this article, we review the initial studies combining measurements of BDNF in rTMS clinical trials and discuss the results and potential usefulness of this instrument in the field of rTMS...
  59. pmc Noninvasive brain stimulation for Parkinson's disease and dystonia
    Allan D Wu
    Department of Neurology, University of California, Los Angeles, California 90095, USA
    Neurotherapeutics 5:345-61. 2008
    ..Nonetheless, the noninvasive nature, minimal side effects, positive effects in preliminary clinical studies, and increasing evidence for rational mechanisms make rTMS and tDCS attractive for ongoing investigation...
  60. ncbi request reprint Modulating the healthy and affected motor cortex with repetitive transcranial magnetic stimulation in stroke: development of new strategies for neurorehabilitation
    Dylan Edwards
    Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    NeuroRehabilitation 23:3-14. 2008
  61. pmc rTMS over the intraparietal sulcus disrupts numerosity processing
    Marinella Cappelletti
    Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Exp Brain Res 179:631-42. 2007
    ....
  62. doi request reprint Modulation of emotions associated with images of human pain using anodal transcranial direct current stimulation (tDCS)
    Paulo S Boggio
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neuropsychologia 47:212-7. 2009
    ..Our results also suggest that the mechanism of tDCS in modulating emotional pain involve pathways that are independent of those modulating the somatosensory perception of pain...
  63. ncbi request reprint [Transcranial magnetic stimulation in neuropsychology: new horizons for brain research]
    Paulo Sergio Boggio
    Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Bras Psiquiatr 28:44-9. 2006
    ....
  64. pmc Pain in chronic pancreatitis: a salutogenic mechanism or a maladaptive brain response?
    Felipe Fregni
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pancreatology 7:411-22. 2007
    ..Furthermore, we consider these aspects in light of a new approach to treat visceral pain: transcranial magnetic stimulation, a noninvasive method of brain stimulation...
  65. doi request reprint Noninvasive brain stimulation with low-intensity electrical currents: putative mechanisms of action for direct and alternating current stimulation
    Soroush Zaghi
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neuroscientist 16:285-307. 2010
    ..Here the authors review what is known about DC and AC stimulation, and they discuss features that remain to be investigated...
  66. ncbi request reprint Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: role of stimulation site and depression severity
    Felix Bermpohl
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Psychiatry Res 141:1-13. 2006
    ..Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology...
  67. ncbi request reprint Diminishing risk-taking behavior by modulating activity in the prefrontal cortex: a direct current stimulation study
    Shirley Fecteau
    Berenson Allen Center for Noninvasive Brain Stimulation, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 27:12500-5. 2007
    ....
  68. ncbi request reprint Transcranial magnetic stimulation as a complementary treatment for aphasia
    Paula I Martin
    Boston University School of Medicine and VA Boston Healthcare System, Neuroimaging Aphasia Research, Transcranial Magnetic Stimulation Aphasia Research and Harold Goodglass Aphasia Research Center, Boston, Massachusetts 02130, USA
    Semin Speech Lang 25:181-91. 2004
    ..Following 10 rTMS treatments, significant improvement in naming pictures was observed. This form of rTMS may provide a novel, complementary treatment for aphasia...
  69. ncbi request reprint Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study
    Margaret A Naeser
    Department of Neurology, Harold Goodglass Boston University Aphasia Research Center, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Brain Lang 93:95-105. 2005
    ..This preliminary, open trial suggests that rTMS may provide a novel treatment approach for aphasia by possibly modulating the distributed, bi-hemispheric language network...
  70. pmc Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS
    Paula I Martin
    Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine and the Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Brain Lang 111:20-35. 2009
    ..The fMRI data of our patient who had good response following TMS support the notion that restoration of the LH language network is linked in part, to better recovery of naming and phrase length in nonfluent aphasia...
  71. pmc Imaging correlates of motor recovery from cerebral infarction and their physiological significance in well-recovered patients
    Dinesh G Nair
    Department of Neurology, Palmer 127, Beth Israel Deaconess Medical Center Harvard Medical School, 330, Brookline Avenue, Boston, MA 02215, USA
    Neuroimage 34:253-63. 2007
    ..Disinhibition of the contralesional hemisphere observed in a subgroup of our patients suggests persistent alterations in intracortical and transcallosal (interhemispheric) interactions, despite complete functional recovery...
  72. doi request reprint Depression in Parkinson's disease: convergence from voxel-based morphometry and functional magnetic resonance imaging in the limbic thalamus
    Ellison Fernando Cardoso
    NIF, LIM 44, Department of Radiology, University of Sao Paulo, Sao Paulo, Brazil
    Neuroimage 47:467-72. 2009
    ..In addition this data supports the link between neurodegenerative alterations and mood regulation...
  73. ncbi request reprint Dissociable networks for the expectancy and perception of emotional stimuli in the human brain
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02132, USA
    Neuroimage 30:588-600. 2006
    ..This dissociation may reflect a distinction between anticipatory and perceptive components of emotional stimulus processing...
  74. pmc Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia
    Catarina Freitas
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Schizophr Res 108:11-24. 2009
    ..A growing body of evidence suggests that repetitive transcranial magnetic stimulation (rTMS) can alleviate negative and positive symptoms of refractory schizophrenia. However, trials to date have been small and results are mixed...
  75. doi request reprint Novelty seeking modulates medial prefrontal activity during the anticipation of emotional stimuli
    Felix Bermpohl
    Berenson Allen Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 164:81-5. 2008
    ..BOLD responses to emotional expectancy were positively correlated with novelty-seeking scores in the medial prefrontal cortex. This correlation was strongest for the sub-dimension of exploratory excitability...
  76. ncbi request reprint Activation of prefrontal cortex by transcranial direct current stimulation reduces appetite for risk during ambiguous decision making
    Shirley Fecteau
    Berenson Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 27:6212-8. 2007
    ..The ability to modify risk-taking behavior may be translated into therapeutic interventions for disorders such as drug abuse, overeating, or pathological gambling...
  77. ncbi request reprint Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression
    Paulo S Boggio
    Department of Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil
    J Affect Disord 101:91-8. 2007
    ..We aimed to extend this previous investigation testing whether one session of anodal transcranial direct current stimulation (tDCS) of the left DLPFC, as compared with anodal occipital and sham tDCS, affects this AGN task performance...
  78. ncbi request reprint After-effects of transcranial direct current stimulation (tDCS) on cortical spreading depression
    David Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Robert Koch Strasse 40, 37099 Gottingen, Germany
    Neurosci Lett 398:85-90. 2006
    ....
  79. ncbi request reprint Transcranial direct stimulation and fluoxetine for the treatment of depression
    Sergio P Rigonatti
    Eur Psychiatry 23:74-6. 2008
  80. ncbi request reprint Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and concurrent depression
    Paulo S Boggio
    Department of Experimental Psychology, Institute of Psychology, University of Sao Paulo, Sao Paulo, SP, Brazil
    Mov Disord 20:1178-84. 2005
    ..The results show that rTMS could improve some aspects of cognition in PD patients similar to that of fluoxetine. The mechanisms for this cognitive improvement are unclear, but it is in the context of mood improvement...
  81. ncbi request reprint Motor cortex stimulation for chronic pain: systematic review and meta-analysis of the literature
    Moises C Lima
    Department of Rehabilitation, University of Sao Paulo, Brazil
    Neurology 70:2329-37. 2008
    ..To conduct a systematic review and meta-analysis to quantify the efficacy of invasive and noninvasive brain stimulation for the treatment of chronic pain...
  82. pmc A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression
    Paulo S Boggio
    Nucleo de Neurociencias, Centro de Ciencias Biologicas e da Saude, Universidade Presbiteriana Mackenzie, Sao Paulo, Brazil
    Int J Neuropsychopharmacol 11:249-54. 2008
    ..Our findings support further investigation on the effects of this novel potential therapeutic approach - tDCS - for the treatment of major depression...
  83. ncbi request reprint Transient disruption of ventrolateral prefrontal cortex during verbal encoding affects subsequent memory performance
    Itamar Kahn
    Department of Psychology and Neuroscience Program, Stanford University, California, USA
    J Neurophysiol 94:688-98. 2005
    ..In contrast, disruption of correlated mechanisms in right pVLPFC facilitates encoding, perhaps by inducing a functional shift in the mechanisms engaged during learning...
  84. ncbi request reprint Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study
    Demetrio Ortega Rumi
    Institute of Psychiatry, University of Sao Paulo, Faculty of Medicine, Sao Paulo SP, Brazil
    Biol Psychiatry 57:162-6. 2005
    ..Three recent meta analyses strongly suggest its benefits in the treatment of depression. The present study investigates whether repetitive TMS (rTMS) accelerates the onset of action and increases the therapeutic effects of amitriptyline...
  85. ncbi request reprint Low and high frequency repetitive transcranial magnetic stimulation for the treatment of spasticity
    Angela C Valle
    Department of Pathology, University of Sao Paulo, Sao Paulo, Brazil
    Dev Med Child Neurol 49:534-8. 2007
    ..Results of this trial provide initial evidence to support further trials exploring the use of cortical stimulation in the treatment of spasticity...
  86. ncbi request reprint New insights into neuromodulatory approaches for the treatment of pain
    Mark P Jensen
    Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6490, USA
    J Pain 9:193-9. 2008
    ....
  87. ncbi request reprint Treatment of major depression with transcranial direct current stimulation
    Felipe Fregni
    Bipolar Disord 8:203-4. 2006
  88. ncbi request reprint Towards novel treatments for paediatric stroke: is transcranial magnetic stimulation beneficial?
    Felipe Fregni
    Lancet Neurol 7:472-3. 2008
  89. ncbi request reprint Comparison of repetitive transcranial magnetic stimulation and electroconvulsive therapy in unipolar non-psychotic refractory depression: a randomized, single-blind study
    Moacyr Alexandro Rosa
    Institute of Psychiatry, University of Sao Paulo, Sao Paulo SP, Brazil
    Int J Neuropsychopharmacol 9:667-76. 2006
    ....
  90. ncbi request reprint Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression
    Felipe Fregni
    Depress Anxiety 23:482-4. 2006
  91. ncbi request reprint Prefrontal cortex modulation using transcranial DC stimulation reduces alcohol craving: a double-blind, sham-controlled study
    Paulo S Boggio
    Nucleo de Neurociencias, Mackenzie University, Sao Paulo, SP, Brazil
    Drug Alcohol Depend 92:55-60. 2008
    ..We tested whether modulation of DLPFC using transcranial direct current stimulation (tDCS) could alter alcohol craving in patients with alcohol dependence while being exposed to alcohol cues...
  92. ncbi request reprint Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease
    Paulo S Boggio
    Department of Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil Núcleo de Neurociências, Mackenzie University, Sao Paulo, Brazil
    J Neurol Sci 249:31-8. 2006
    ....
  93. ncbi request reprint Enhancement of non-dominant hand motor function by anodal transcranial direct current stimulation
    Paulo S Boggio
    Department of Experimental Psychology, University of Sao Paulo, Brazil
    Neurosci Lett 404:232-6. 2006
    ..We speculate that the under-use of the non-dominant hand with its associated consequences in cortical plasticity might be one of the reasons to explain motor performance enhancement in the non-dominant hand only...
  94. ncbi request reprint Cardiovascular effects of anesthesia in ECT: a randomized, double-blind comparison of etomidate, propofol, and thiopental
    Moacyr Alexandro Rosa
    Clinical Hospital, Institute of Psychiatry, University of Sao Paulo, Brazil
    J ECT 23:6-8. 2007
    ..The results showed that etomidate, propofol, and thiopental were associated with similar cardiovascular effects...
  95. ncbi request reprint Focusing effect of acetylcholine on neuroplasticity in the human motor cortex
    Min Fang Kuo
    Department of Clinical Neurophysiology, Georg August University Gottingen, 37075 Gottingen, Germany
    J Neurosci 27:14442-7. 2007
    ..These findings are in line with a cholinergic focusing effect that optimizes the detection of relevant signals during information processing in humans...
  96. ncbi request reprint rTMS combined with motor learning training in healthy subjects
    James R Carey
    Program in Physical Therapy, University of Minnesota, Minneapolis, MN 55455, USA
    Restor Neurol Neurosci 24:191-9. 2006
    ..This study explored the effects of motor learning training combined with repetitive transcranial magnetic stimulation (rTMS) on motor performance in healthy subjects...
  97. ncbi request reprint Left prefrontal repetitive transcranial magnetic stimulation impairs performance in affective go/no-go task
    Felix Bermpohl
    Psychiatry and Psychology Institute, University of Sao Paulo, Brazil
    Neuroreport 16:615-9. 2005
    ..Our findings demonstrate a functionally relevant lateralization of the prefrontal contribution to affective go/no-go tasks...