R Freeman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue
    William B Farquhar
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 282:H66-71. 2002
  2. ncbi request reprint Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome
    Istvan Bonyhay
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 110:3193-8. 2004
  3. ncbi request reprint Autonomic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 365:1259-70. 2005
  4. doi request reprint Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs
    Roy Freeman
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA Electronic address
    Pain 155:367-76. 2014
  5. doi request reprint Testing the autonomic nervous system
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Electronic address
    Handb Clin Neurol 115:115-36. 2013
  6. doi request reprint New and developing drugs for the treatment of neuropathic pain in diabetes
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Diab Rep 13:500-8. 2013
  7. pmc Autoimmune autonomic ganglionopathy with reversible cognitive impairment
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Boston, MA 02215, USA
    Arch Neurol 69:461-6. 2012
  8. doi request reprint Clinical practice. Neurogenic orthostatic hypotension
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 358:615-24. 2008
  9. ncbi request reprint Topiramate and physiologic measures of nerve function in polyneuropathy
    R Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Acta Neurol Scand 115:222-31. 2007
  10. ncbi request reprint Autonomic peripheral neuropathy
    Roy Freeman
    Department of Neurology, Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Neurol Clin 25:277-301. 2007

Research Grants

  1. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2009
  2. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
  3. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2006
  4. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2001
  5. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2010

Detail Information

Publications63

  1. ncbi request reprint Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue
    William B Farquhar
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 282:H66-71. 2002
    ..These variables were highly related in both subject groups, indicating that blood volume is a strong physiological correlate of peak oxygen consumption in patients with CFS...
  2. ncbi request reprint Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome
    Istvan Bonyhay
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 110:3193-8. 2004
    ..Little is known about sympathetic nerve outflow and its role in hemodynamic control in this disorder...
  3. ncbi request reprint Autonomic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 365:1259-70. 2005
    ..Autonomic dysfunction can occur in association with specific infections. The availability of sensitive and reproducible measures of autonomic function has improved physicians' ability to diagnose these disorders...
  4. doi request reprint Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs
    Roy Freeman
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA Electronic address
    Pain 155:367-76. 2014
    ..These "trans-etiological" profiles may reflect distinct pathophysiological mechanisms and therefore, potential differential responses to treatment. ..
  5. doi request reprint Testing the autonomic nervous system
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Electronic address
    Handb Clin Neurol 115:115-36. 2013
    ..Frequency domain analyses of heart rate and blood pressure variability, microneurography, and baroreflex assessment are currently research tools but may find a place in the clinical assessment of autonomic function in the future. ..
  6. doi request reprint New and developing drugs for the treatment of neuropathic pain in diabetes
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Diab Rep 13:500-8. 2013
    ..Mechanisms of action, preclinical supporting data, clinical trial evidence, and adverse effects will be reviewed. ..
  7. pmc Autoimmune autonomic ganglionopathy with reversible cognitive impairment
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Boston, MA 02215, USA
    Arch Neurol 69:461-6. 2012
    ..Some patients with AAG report cognitive impairment of unclear etiology despite treatment of autonomic symptoms...
  8. doi request reprint Clinical practice. Neurogenic orthostatic hypotension
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 358:615-24. 2008
  9. ncbi request reprint Topiramate and physiologic measures of nerve function in polyneuropathy
    R Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Acta Neurol Scand 115:222-31. 2007
    ..To evaluate topiramate treatment on nerve function using electrophysiologic methods and a non-inferiority clinical trial design...
  10. ncbi request reprint Autonomic peripheral neuropathy
    Roy Freeman
    Department of Neurology, Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Neurol Clin 25:277-301. 2007
    ..The features associated with an autonomic neuropathy include impairment of cardiovascular, gastrointestinal, urogenital, thermoregulatory, sudomotor, and pupillomotor autonomic function...
  11. ncbi request reprint Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Med Res Opin 23:147-61. 2007
    ..To examine the efficacy and safety of tramadol/acetaminophen (APAP) for the management of painful diabetic peripheral neuropathy (DPN)...
  12. ncbi request reprint Cardiovascular manifestations of autonomic epilepsy
    Roy Freeman
    Autonomic and Peripheral Nerve Laboratory, Harvard Medical School, Dept of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 16:12-7. 2006
    ..Awareness of the diverse autonomic manifestations of epilepsy will enhance diagnosis and lead to more effective therapy of these patients...
  13. ncbi request reprint The treatment of neuropathic pain
    Roy Freeman
    Department of Neurology, Harvard Medical School, Boston, MA 02215, USA
    CNS Spectr 10:698-706. 2005
    ..Recent advances in the understanding of pain mechanisms at multiple central nervous system levels should pave the way toward more effective treatment modalities...
  14. ncbi request reprint Assessment of cardiovascular autonomic function
    Roy Freeman
    Anatomic and Peripheral Neerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Neurophysiol 117:716-30. 2006
    ....
  15. ncbi request reprint Newer agents for the treatment of painful diabetic peripheral neuropathy
    Roy Freeman
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Curr Diab Rep 5:409-16. 2005
    ..Recent advances in the understanding of pain mechanisms at multiple central nervous system levels should pave the way toward more effective treatment modalities with less prominent side effects...
  16. ncbi request reprint Assessment of cardiovascular autonomic function
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Suppl Clin Neurophysiol 57:369-75. 2004
  17. pmc Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 31:1448-54. 2008
    ....
  18. doi request reprint Current pharmacologic treatment for orthostatic hypotension
    Roy Freeman
    Dept of Neurology Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 18:14-8. 2008
    ..If unsuccessful there are several supplementary agents with different mechanisms of action that may provide an additive effect...
  19. ncbi request reprint Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy
    Roy Freeman
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Diab Rep 9:423-31. 2009
    ..Prospective studies to investigate the prevalence of other disorders that might be responsible for a peripheral neuropathy in individuals with diabetes are warranted...
  20. ncbi request reprint Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Appl Physiol (1985) 93:636-44. 2002
    ..Reduced compliance may limit the dynamic response to orthostatic change and thereby contribute to symptoms of orthostatic intolerance in this population group...
  21. ncbi request reprint Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 60:465-70. 2003
    ..To differentiate the quantitative sensory testing (QST) results of subjects simulating small and large fiber sensory loss from those of normal subjects and subjects with sensory peripheral neuropathy...
  22. ncbi request reprint Autonomic function and human immunodeficiency virus infection
    R Freeman
    Division of Neurology, New England Deaconess Hospital, Boston, MA 02215
    Neurology 40:575-80. 1990
    ..Autonomic dysfunction occurs more frequently and with greater severity in patients with AIDS; however, it may be present in the early stages of HIV infection and appears to progress during the illness...
  23. ncbi request reprint The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial
    R Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Neurology 53:2151-7. 1999
    ..To study the therapeutic effect and mechanism of action of 3,4-DL-threodihydroxyphenylserine (DL-DOPS) in neurogenic orthostatic hypotension...
  24. ncbi request reprint Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
    ..Midodrine hydrochloride, an alpha-agonist, could improve orthostatic BP by increasing vasomotor and venomotor tone...
  25. ncbi request reprint The evaluation of small fiber function-autonomic and quantitative sensory testing
    Christopher Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurol Clin 22:683-702, vii. 2004
    ..The severity of dysfunction also can be determined to guide therapy and aid in prognostication for individual patients...
  26. pmc Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control
    Gail K Adler
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes 58:360-6. 2009
    ..We tested the hypothesis that prior exposure to hypoglycemia leads to impaired cardiovascular autonomic function...
  27. pmc Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 67:534-41. 2010
    ..To describe the natural history, clinical, neurophysiological, and histological features, and outcomes of diabetic patients presenting with acute painful neuropathy associated with glycemic control, also referred to as insulin neuritis...
  28. ncbi request reprint The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine
    R Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Hebrew Rehabilitation Center for the Aged, Boston, MA, USA
    Neurology 47:1414-20. 1996
    ....
  29. ncbi request reprint Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 67:28-32. 2006
    ..To investigate the prevalence, symptoms, and neurophysiologic features of delayed orthostatic hypotension (OH)...
  30. ncbi request reprint Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome
    Istvan Bonyhay
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Neurol 61:332-9. 2007
    ..To elucidate the mechanisms whereby postural tachycardia syndrome (POTS) patients maintain orthostatic blood pressure and explain the greater prevalence of female cases in POTS cohorts...
  31. ncbi request reprint Human studies of recombinant human nerve growth factor and diabetic peripheral neuropathy
    R Freeman
    Harvard Medical School, Boston, Mass, USA
    Eur Neurol 41:20-6. 1999
    ..Two pivotal 12-month phase III trials are underway in diabetic patients with symptomatic peripheral neuropathy to confirm the therapeutic effects of rhNGF. Results from these trials are expected in 2000...
  32. ncbi request reprint Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial
    Andrew C Ahn
    Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA
    Acupunct Med 25:11-7. 2007
    ..The TCM style improved nerve sensation according to quantitative sensory testing while the Japanese style had a more equivocal effect. No evident changes were observed in glucose control or heart rate variability in either group...
  33. pmc Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:2629-34. 2010
    ..To determine the relationships among large, small, and autonomic fiber neurophysiological measures in a cross-sectional study of patients with diabetes...
  34. ncbi request reprint The treatment of orthostatic hypotension with dihydroxyphenylserine
    R Freeman
    Division of Neurology, New England Deaconess Hospital, Boston, MA 02215
    Clin Neuropharmacol 14:296-304. 1991
    ..We review the biochemistry, pharmacokinetics, and possible mechanisms of action and clinical utility of this agent in the treatment of neurogenic orthostatic hypotension...
  35. pmc Autonomic neuropathy and coeliac disease
    C H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    J Neurol Neurosurg Psychiatry 76:579-81. 2005
    ..These four patients comprised 2.4% of patients referred for autonomic testing in one year. Thus the frequency of coeliac disease is similar to that reported in idiopathic peripheral neuropathy...
  36. doi request reprint Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Arch Neurol 65:213-7. 2008
    ..Symptomatic and immunomodulatory therapy has provided limited clinical benefit in small uncontrolled studies...
  37. ncbi request reprint Treatment of orthostatic hypotension
    Roy Freeman
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Semin Neurol 23:435-42. 2003
    ..There are rare patients who will require additional agents to treat their symptoms. A small group of patients remain refractory to all therapeutic modalities...
  38. ncbi request reprint L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy
    Christopher H Gibbons
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 65:1104-6. 2005
    ..L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies...
  39. ncbi request reprint Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration
    A Veves
    Department of Medicine, Microcirculation Lab, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabetes 47:457-63. 1998
    ..Reduced expression of ecNOS may be a major contributing factor for endothelial dysfunction. These data provide support for a close association of neuropathy and microcirculation in the pathogenesis of foot ulceration...
  40. pmc Autoimmune autonomic ganglionopathy: IgG effects on ganglionic acetylcholine receptor current
    Z Wang
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Neurology 68:1917-21. 2007
    ..Previous clinical studies and observations in animal models suggest that AAG is an antibody-mediated neurologic disorder...
  41. ncbi request reprint Levetiracetam for seizures after liver transplantation
    G A Glass
    Department of Neurology, Tufts New England Medical Center, Boston, MA 02111, USA
    Neurology 64:1084-5. 2005
    ..Treatment with levetiracetam is efficacious, and levetiracetam-treated patients require significantly lower doses of immunosuppressant medications to achieve an equivalent antirejection effect...
  42. ncbi request reprint Orthostatic dyspnea: a neglected symptom of orthostatic hypotension
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Dept of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 15:40-4. 2005
    ..05). In this study, dyspnea was frequently associated with OH. Ventilation perfusion mismatch, due to inadequate perfusion of ventilated lung apices may be the most likely underlying cause of orthostatic dyspnea in patients with OH...
  43. doi request reprint Phantom sweating: a novel autonomic paresthesia
    Lindsey Lair
    Autonomic and Peripheral Nerve Laboratory, Dept of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Clin Auton Res 18:352-4. 2008
    ..To describe the biology of phantom sweating, a novel autonomic neuropathy symptom, based on a description of a patient with a small fiber and autonomic neuropathy...
  44. pmc Quantification of sweat gland innervation: a clinical-pathologic correlation
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Neurology 72:1479-86. 2009
    ....
  45. doi request reprint Hypoglycemia increases serum interleukin-6 levels in healthy men and women
    Sarah Dotson
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes Care 31:1222-3. 2008
    ..Because hypoglycemia is also associated with adverse outcomes, we tested the hypothesis that hypoglycemia increases IL-6...
  46. pmc Quantification of sudomotor innervation: a comparison of three methods
    Christopher H Gibbons
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, Boston, Massachusetts 02215, USA
    Muscle Nerve 42:112-9. 2010
    ..Our results suggest that sudomotor fibers can be rapidly and reproducibly quantified, and results correlate well with physical exam findings...
  47. ncbi request reprint Endothelial dysfunction precedes C-fiber abnormalities in primary (AL) amyloidosis
    Martin Berghoff
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Ann Neurol 53:725-30. 2003
    ..At this stage, C-fiber and smooth muscle function are still preserved. These data suggest that endothelial abnormalities precede and may contribute to the pathogenesis of the neuropathy associated with AL amyloidosis...
  48. ncbi request reprint Syncope and the history of nervous influences on the heart
    Frederick Nahm
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, USA
    Arch Neurol 60:282-7. 2003
  49. ncbi request reprint Surgical decompression for diabetic sensorimotor polyneuropathy
    David R Cornblath
    Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Diabetes Care 30:421-2. 2007
  50. ncbi request reprint A biphasic model of limb venous compliance: a comparison with linear and exponential models
    Marcelo R Risk
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol 95:1207-15. 2003
    ..The steep low-pressure phase of the compliance curve extends to higher pressures in the calf than in the forearm, thereby enlarging the range of pressures over which hemodynamic regulation by the calf venous circulation occurs...
  51. ncbi request reprint Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function
    Roy Freeman
    Neurology 65:1517. 2005
  52. ncbi request reprint Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy
    Martin Berghoff
    Department of Neurology, University of Munster, Munster, Germany
    Muscle Nerve 33:494-9. 2006
    ..These findings suggest that the functional abnormalities in diabetic peripheral neuropathy are not homogeneous and that C-fiber subclasses are differentially affected in type 1 and 2 diabetes mellitus...
  53. ncbi request reprint Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 14:363-8. 2004
    ....
  54. ncbi request reprint Nonpharmacological treatment of reflex syncope
    Wouter Wieling
    Dept of Internal Medicine, Academic Medical Center University of Amsterdam Room F4 221, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Clin Auton Res 14:62-70. 2004
    ..Preliminary data suggest that water drinking may improve orthostatic tolerance. Abdominal belts may also be effective in highly symptomatic subjects with reflex syncope...
  55. ncbi request reprint Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
    ..In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture...
  56. ncbi request reprint Pure autonomic failure: an immaculate misconception?
    Roy Freeman
    Neurology 63:953-4. 2004
  57. ncbi request reprint Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Care 26:1553-79. 2003
    ..Finally, knowledge of early autonomic dysfunction can encourage patient and physician to improve metabolic control and to use therapies such as ACE inhibitors and beta-blockers, proven to be effective for patients with CAN...
  58. ncbi request reprint Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    Semin Neurol 23:365-72. 2003
    ..There are studies in progress that suggest that autonomic nerves can be induced to regenerate, and the future for patients with diabetic autonomic neuropathy is brighter...
  59. ncbi request reprint Pharmacological treatment of reflex syncope
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Clin Auton Res 14:71-5. 2004
    ..None of these agents has shown a consistent therapeutic benefit in clinical trials...
  60. ncbi request reprint The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes
    Roy Freeman
    Clin Auton Res 12:231-3. 2002
  61. ncbi request reprint A treatment for neurally mediated syncope? (Don't) hold your breath
    Roy Freeman
    Ann Neurol 63:265-7. 2008
  62. ncbi request reprint The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis
    Raelene E Maser
    Department of Medical Technology, University of Delaware, Newark, Delaware 19716, USA
    Diabetes Care 26:1895-901. 2003
    ..To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes...
  63. ncbi request reprint Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005

Research Grants16

  1. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2009
    ..We will measure the response to therapy and the role played by neuropathy and nitric oxide in determining this response. ..
  2. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  3. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2006
    ..The relationships between these variables and role of covariates such as the level of physical activity and psychiatric state, determined with standardized instruments, will be analyzed using multivariate statistics. ..
  4. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2001
    ..The relationships between these variables and the role of covariates such as the level of physical activity and psychiatric state, determined with standardized instruments, are to be analyzed using multivariate statistics. ..
  5. ORTHOSTATIC INTOLERANCE IN CFS
    Roy Freeman; Fiscal Year: 2010
    ..We will measure the response to therapy and the role played by neuropathy and nitric oxide in determining this response. ..