S D Freedman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Fatty acids in cystic fibrosis
    S D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Pulm Med 6:530-2. 2000
  2. ncbi request reprint Association of cystic fibrosis with abnormalities in fatty acid metabolism
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 350:560-9. 2004
  3. ncbi request reprint Characterization of LPS-induced lung inflammation in cftr-/- mice and the effect of docosahexaenoic acid
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Appl Physiol 92:2169-76. 2002
  4. ncbi request reprint Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis
    S D Freedman
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 121:950-7. 2001
  5. pmc A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice
    S D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 96:13995-4000. 1999
  6. ncbi request reprint Mechanisms to explain pancreatic dysfunction in cystic fibrosis
    S D Freedman
    Pancreas Center, Beth Israel Deaconess Medical Center, Boston, Massachussachusetts, USA
    Med Clin North Am 84:657-64, x. 2000
  7. ncbi request reprint Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells
    S D Freedman
    Division of Gastroenterology, Charles A Dana Research Institute, Boston, Massachusetts
    Am J Physiol 267:G40-51. 1994
  8. ncbi request reprint GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin
    E M Parker
    The Pancreas Center, Beth Israel Deaconess Medical Center, Harvard Medical Schlool, Boston, Massachusetts 02215, USA
    Pancreas 21:219-25. 2000
  9. pmc The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study
    C R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Aliment Pharmacol Ther 35:255-65. 2012
  10. pmc GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney
    S Fukuoka
    Laboratory of Cell and Molecular Biology, Charles A Dana Research Institute, Thorndike Laboratory, Boston, MA 02215
    Proc Natl Acad Sci U S A 89:1189-93. 1992

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Fatty acids in cystic fibrosis
    S D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Pulm Med 6:530-2. 2000
    ..In addition, DHA therapy reverses the increased neutrophil infiltration in the lungs of CF knock-out mice. Further studies are required to determine the mechanism by which CF gene mutations lead to this lipid abnormality...
  2. ncbi request reprint Association of cystic fibrosis with abnormalities in fatty acid metabolism
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 350:560-9. 2004
    ..In this study we determined whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid defect in tissues expressing CFTR...
  3. ncbi request reprint Characterization of LPS-induced lung inflammation in cftr-/- mice and the effect of docosahexaenoic acid
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Appl Physiol 92:2169-76. 2002
    ..In contrast, neutrophils and eicosanoids were decreased in cftr-/- but not in WT mice treated with DHA, indicating that the effects of DHA on these inflammatory parameters may be related to correction of the membrane lipid defect...
  4. ncbi request reprint Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis
    S D Freedman
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 121:950-7. 2001
    ....
  5. pmc A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice
    S D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 96:13995-4000. 1999
    ..These results strongly suggest that certain phenotypic manifestations of CF may result from remediable alterations in phospholipid-bound arachidonic acid and DHA levels...
  6. ncbi request reprint Mechanisms to explain pancreatic dysfunction in cystic fibrosis
    S D Freedman
    Pancreas Center, Beth Israel Deaconess Medical Center, Boston, Massachussachusetts, USA
    Med Clin North Am 84:657-64, x. 2000
    ..Any of these abnormalities alone or in combination may explain the development of pancreatic exocrine insufficiency...
  7. ncbi request reprint Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells
    S D Freedman
    Division of Gastroenterology, Charles A Dana Research Institute, Boston, Massachusetts
    Am J Physiol 267:G40-51. 1994
    ....
  8. ncbi request reprint GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin
    E M Parker
    The Pancreas Center, Beth Israel Deaconess Medical Center, Harvard Medical Schlool, Boston, Massachusetts 02215, USA
    Pancreas 21:219-25. 2000
    ..This suggests that in pancreatic acini, GP2 may exist in a complex with src kinases, caveolin, and an 85-kDa phosphorylated substrate to regulate endocytosis at the APM...
  9. pmc The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study
    C R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Aliment Pharmacol Ther 35:255-65. 2012
    ..Since CFTR dysfunction leads to altered fatty acid metabolism, specifically reduced docosahexaenoic acid (DHA), we hypothesised that DHA supplementation might be an effective therapy for patients with PSC...
  10. pmc GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney
    S Fukuoka
    Laboratory of Cell and Molecular Biology, Charles A Dana Research Institute, Thorndike Laboratory, Boston, MA 02215
    Proc Natl Acad Sci U S A 89:1189-93. 1992
    ....
  11. ncbi request reprint A sham-controlled trial of a 5-day course of repetitive transcranial magnetic stimulation of the unaffected hemisphere in stroke patients
    Felipe Fregni
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, KS 452, Boston, Massachusetts 02215, USA
    Stroke 37:2115-22. 2006
    ..We therefore conducted a randomized, sham-controlled, phase II trial to evaluate whether five sessions of low-frequency rTMS can increase the magnitude and duration of these effects and whether this approach is safe...
  12. ncbi request reprint A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pain 122:197-209. 2006
    ..We discuss potential mechanisms for pain amelioration after tDCS, such as a secondary modulation of thalamic nuclei activity...
  13. ncbi request reprint Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice
    Harpreet Pall
    Division of Pediatric Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr Gastroenterol Nutr 42:275-81. 2006
    ..As proof of concept that CFTR dysfunction plays a role in PSC, induction of colitis in cftr mice results in bile duct injury that can be prevented by pretreatment with docosahexaenoic acid (DHA)...
  14. ncbi request reprint A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, KS 452, Boston, MA 02215, U S A
    Epilepsia 47:335-42. 2006
    ..To study the effects of cathodal DC polarization in patients with refractory epilepsy and malformations of cortical development (MCDs) as indexed by seizure frequency and epileptiform EEG discharges...
  15. ncbi request reprint Ethanol administration to cystic fibrosis knockout mice results in increased fatty acid ethyl ester production
    Paola G Blanco
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Alcohol Clin Exp Res 29:2039-45. 2005
    ....
  16. ncbi request reprint Evidence of increased flux to n-6 docosapentaenoic acid in phospholipids of pancreas from cftr-/- knockout mice
    Mario Ollero
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 55:1192-200. 2006
    ..This suggests an enhanced flux through the n-6 pathway beyond arachidonate. This study provides a more in-depth understanding of the fatty acid alterations found in CF, as reflected by the cftr(-/-) mouse model...
  17. ncbi request reprint Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis
    Satti Beharry
    Program in Integrative Biology, The Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G839-48. 2007
    ..The potential therapeutic benefits of DHA in severe CF-associated liver disease remain to be explored...
  18. ncbi request reprint A randomized, sham-controlled, proof of principle study of transcranial direct current stimulation for the treatment of pain in fibromyalgia
    Felipe Fregni
    Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 54:3988-98. 2006
    ....
  19. ncbi request reprint Primary sclerosing cholangitis in childhood is associated with abnormalities in cystic fibrosis-mediated chloride channel function
    Harpreet Pall
    Division of Pediatric Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr 151:255-9. 2007
    ..To determine whether primary sclerosing cholangitis (PSC) in childhood is associated with abnormalities in cystic fibrosis transmembrane conductance regulator (CFTR)...
  20. ncbi request reprint Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages
    Charlotte Andersson
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston 02215, MA, United States
    J Cyst Fibros 7:68-78. 2008
    ..Since PPARs and LXRs are important regulators of inflammation and fatty acid metabolism in macrophages, we hypothesized that these pathways are dysregulated in CF macrophages and are corrected with DHA treatment...
  21. ncbi request reprint Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis
    M Rabie Al-Turkmani
    Department of Pathology, Harvard Medical School, Massachusetts General Hospital, GRB 235, 55 Fruit Street, Boston, MA 02114, USA
    Prostaglandins Leukot Essent Fatty Acids 77:309-18. 2007
    ..It is recommended that future trials include a larger population of CF patients and measure multiple clinical outcomes...
  22. pmc Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism
    Charlotte Andersson
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Lipid Res 49:1692-700. 2008
    ..In conclusion, these data demonstrate that CFTR dysfunction is associated with altered fatty acid metabolism in cultured airway epithelial cells...
  23. ncbi request reprint The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis
    Michele D Bishop
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Medicine, Boston, MA, USA
    Hum Genet 118:372-81. 2005
    ..We concluded that extensive genotyping and ion channel testing are useful to confirm or exclude the diagnosis of CF in the majority of patients with idiopathic pancreatitis...
  24. ncbi request reprint Transcranial direct current stimulation of the unaffected hemisphere in stroke patients
    Felipe Fregni
    Harvard Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Neuroreport 16:1551-5. 2005
    ..These results suggest that the appropriate modulation of bihemispheric brain structures can promote motor function recovery...
  25. ncbi request reprint Analysis of lipid abnormalities in CF mice
    Steven D Freedman
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Methods Mol Med 70:517-24. 2002
  26. ncbi request reprint An enteral therapy containing medium-chain triglycerides and hydrolyzed peptides reduces postprandial pain associated with chronic pancreatitis
    Julie C Shea
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Pancreatology 3:36-40. 2003
    ....
  27. pmc Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes
    Marina N Chernova
    Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Physiol 549:3-19. 2003
    ..Thus, pharmacological modulation of DRA might be a useful adjunct treatment of cystic fibrosis...
  28. ncbi request reprint Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis
    Sunil Sheth
    Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Dana 532, 330 Brookline Avenue, Boston, MA 02215, USA
    Hum Genet 113:286-92. 2003
    ....
  29. ncbi request reprint Laboratory tests for the diagnosis of cystic fibrosis
    Lan Wang
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Pathol 117:S109-15. 2002
    ..Recently, a 2-tiered newborn screening protocol including CFTR genotyping has become popular, increasing the likelihood of early diagnosis...
  30. ncbi request reprint Induction of colitis in cftr-/- mice results in bile duct injury
    Paola G Blanco
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, Dana 501, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 287:G491-6. 2004
    ..0006). Pretreatment with oral docosahexaenoic acid decreased both histological evidence of bile duct injury and serum alkaline phosphatase levels. In the setting of colitis, loss of CFTR function leads to bile duct injury...
  31. ncbi request reprint Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses
    Paola G Blanco
    Departments of Medicine and Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Obstet Gynecol 190:1369-74. 2004
    ..Our purpose was to determine whether docosahexaenoic acid increased surfactant production, as reflected by increased dipalmitoyl phosphatidylcholine, in mouse fetal lung and amniotic fluid...
  32. ncbi request reprint Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis
    Andres Gelrud
    Division of Gastroenterology and Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Gastroenterol 99:1557-62. 2004
    ..The aim of this study was to determine if CFTR function is abnormal in patients with pancreas divisum and recurrent acute pancreatitis (PD/RAP)...
  33. pmc Interleukin 8 secretion from monocytes of subjects heterozygous for the deltaF508 cystic fibrosis transmembrane conductance regulator gene mutation is altered
    Munir M Zaman
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Diagn Lab Immunol 11:819-24. 2004
    ..This is not a result of increased LPS receptor expression but, rather, is associated with alterations in MAPK signaling...
  34. ncbi request reprint Lasting accelerative effects of 1 Hz and 20 Hz electrical stimulation on cortical spreading depression: relevance for clinical applications of brain stimulation
    Felipe Fregni
    Harvard Center for Non invasive Brain Stimulation and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    Eur J Neurosci 21:2278-84. 2005
    ..Furthermore, the effects are found to be long lasting. We believe that these findings have strong relevance to support the clinical application of therapies involving electrical stimulation for diseases of reduced cortical excitability...
  35. ncbi request reprint Novel therapeutic approaches to the treatment of chronic abdominal visceral pain
    Franca Patrizi
    Department of Medicine and Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
    ScientificWorldJournal 6:472-90. 2006
    ..This paper will present an overview of the pathophysiology and the available therapies for CAVP, focusing on the recent advances in the treatment of this pathology...
  36. pmc A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA
    M Rabie Al-Turkmani
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Lipid Res 49:1946-54. 2008
    ..In conclusion, the evidence suggests that low LA level in cultured CF cells is due to its increased metabolism, and this increased LA metabolism is corrected by DHA supplementation...
  37. ncbi request reprint Treatment of chronic visceral pain with brain stimulation
    Felipe Fregni
    Ann Neurol 58:971-2. 2005
  38. doi request reprint A 21-year-old man with chronic pancreatitis
    Mark P Callery
    Harvard Medical School, and Division of General Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    JAMA 299:1588-94. 2008
    ..We address the patient's concerns regarding chronic pancreatitis, including what he should expect over the next several years, whether endoscopic or surgical therapies should be considered, and whether there are any cures...
  39. pmc Treatment of cancer pain with noninvasive brain stimulation
    Gisele Silva
    J Pain Symptom Manage 34:342-5. 2007
  40. pmc Pain in chronic pancreatitis: a salutogenic mechanism or a maladaptive brain response?
    Felipe Fregni
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pancreatology 7:411-22. 2007
    ..Furthermore, we consider these aspects in light of a new approach to treat visceral pain: transcranial magnetic stimulation, a noninvasive method of brain stimulation...
  41. ncbi request reprint Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion
    Isabel Calvo Del Castillo
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Surg Res 110:338-43. 2003
    ..We investigated the effect of various fatty acids on electrogenic chloride secretion in T84 cells, a model for intestinal epithelium...
  42. ncbi request reprint Decreased expression of peroxisome proliferator activated receptor gamma in cftr-/- mice
    Mario Ollero
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Physiol 200:235-44. 2004
    ..These changes may be related to the loss of function of CFTR and may be relevant to the pathogenesis of metabolic abnormalities associated with cystic fibrosis in humans...
  43. ncbi request reprint Survey of breast-feeding practices and outcomes in the cystic fibrosis population
    Eliza M Parker
    Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, Massachusetts 01655, USA
    Pediatr Pulmonol 37:362-7. 2004
    ..This survey indicates that breast-feeding is not harmful to children with CF, and may be beneficial...
  44. ncbi request reprint Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis
    Ibrahim Batal
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:78-84. 2007
    ..An altered distribution of fatty acids in cells and tissues is found in patients with cystic fibrosis (CF). In this study, we assessed the potential role of plasma fatty acid analysis in the diagnosis of CF...