A S Freedman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission
    A S Freedman
    Division of Hematologic Malignancies and Biostatistics, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 16:13-8. 1998
  2. ncbi request reprint Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells
    A Astier
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Philadelphia, PA, USA
    Leuk Lymphoma 28:65-72. 1997
  3. ncbi request reprint The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1
    A Astier
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:19719-24. 1997
  4. ncbi request reprint Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2
    S N Manie
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:15636-41. 1997
  5. ncbi request reprint Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
    S N Manie
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:4230-6. 1997
  6. ncbi request reprint Studies of in vitro activated CD5+ B cells
    A S Freedman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 73:202-8. 1989
  7. ncbi request reprint The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma
    J W Friedberg
    Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 7:446-53. 2001
  8. ncbi request reprint CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donors
    R J Soiffer
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 19:1152-9. 2001
  9. pmc (90)Y-ibritumomab tiuxetan followed by reduced-intensity conditioning and allo-SCT in patients with advanced follicular lymphoma
    K E Abou-Nassar
    Lymphoma Program, Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115 6084, USA
    Bone Marrow Transplant 46:1503-9. 2011
  10. ncbi request reprint MCP-1 modulates chemotaxis by follicular lymphoma cells
    H Husson
    Department of Medicine, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA
    Br J Haematol 115:554-62. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission
    A S Freedman
    Division of Hematologic Malignancies and Biostatistics, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 16:13-8. 1998
    ....
  2. ncbi request reprint Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells
    A Astier
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Philadelphia, PA, USA
    Leuk Lymphoma 28:65-72. 1997
    ....
  3. ncbi request reprint The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1
    A Astier
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:19719-24. 1997
    ..These data suggest that RAFTK itself is sufficient for HEF1 phosphorylation, whereas a cooperation between RAFTK and Src kinases is required for the complete phosphorylation of p130(Cas)...
  4. ncbi request reprint Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2
    S N Manie
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:15636-41. 1997
    ..These data implicate Fyn and SHP2 as potential modulators of Cas signaling complexes in B cells...
  5. ncbi request reprint Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
    S N Manie
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:4230-6. 1997
    ..These associations implicate HEF1 and Cas as important components in a cytoskeleton-linked signaling pathway initiated by ligation of beta1 integrin or BCR on human B cells...
  6. ncbi request reprint Studies of in vitro activated CD5+ B cells
    A S Freedman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 73:202-8. 1989
    ..These phenotypic and functional studies are consistent with the notion that TPA-induced CD5+ B cells are a subset of in vitro activated B lymphocytes...
  7. ncbi request reprint The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma
    J W Friedberg
    Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 7:446-53. 2001
    ..Future work should explore alternative conditioning strategies and altered timing of XRT, in an attempt to limit these late toxicities...
  8. ncbi request reprint CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donors
    R J Soiffer
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 19:1152-9. 2001
    ..Herein, we report results in the first 48 recipients of unrelated marrow using CD6+ TCD as the sole form of GVHD prophylaxis...
  9. pmc (90)Y-ibritumomab tiuxetan followed by reduced-intensity conditioning and allo-SCT in patients with advanced follicular lymphoma
    K E Abou-Nassar
    Lymphoma Program, Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115 6084, USA
    Bone Marrow Transplant 46:1503-9. 2011
    ..Two-year OS and PFS were 83% (±11%) and 74% (±13%), respectively. This treatment is associated with favorable outcomes including acceptable rates of GVHD and relapse in advanced FL patients, and warrants prospective studies...
  10. ncbi request reprint MCP-1 modulates chemotaxis by follicular lymphoma cells
    H Husson
    Department of Medicine, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA
    Br J Haematol 115:554-62. 2001
    ..We found that cultured FDCs produced MCP-1, and this production was enhanced by tumour necrosis factor. These data implicate MCP-1 in the migration and localization of FL cells...
  11. ncbi request reprint B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells
    G J Freeman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 143:2714-22. 1989
    ..These results demonstrate that the B7 gene encodes a unique molecule belonging to the Ig superfamily and that B7 expression is limited to normal activated B cells and noncirculating B cell malignancies...
  12. pmc A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome
    E D Jacobsen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Ann Oncol 22:1608-13. 2011
    ..The prognosis for patients with most forms of T-cell lymphoma is poor. Allogeneic hematopoietic stem-cell transplantation (HSCT) may improve the outcome...
  13. ncbi request reprint Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1
    A S Freedman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 79:206-12. 1992
    ..Therefore, an understanding of the adhesive interaction of follicular NHL cells with GCs may provide insight into the clinical and biologic behavior of these diseases...
  14. ncbi request reprint TGFbeta-mediated activation of Smad1 in B-cell non-Hodgkin's lymphoma and effect on cell proliferation
    O Munoz
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Leukemia 18:2015-25. 2004
    ..This work opens new insights into aberrant Smad pathways and their pathophysiological role in FL and in other non-Hodgkin lymphomas...
  15. ncbi request reprint Expression and regulation of CD5 on in vitro activated human B cells
    A S Freedman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Eur J Immunol 19:849-55. 1989
    ..The role of the T cell-derived lymphokine IL4 in regulating CD5 expression may be important in the disease states characterized by increased numbers of CD5+ B cells...
  16. ncbi request reprint Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells
    O Spertini
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Leukemia 5:300-8. 1991
    ..Thus, most CLL cells and some non-Hodgkin's lymphoma cells express a functionally active LAM-1 molecule which may correlate with their capacity to migrate through the circulation and disseminate into peripheral LN...
  17. pmc Response to low-dose involved-field radiotherapy in patients with non-Hodgkin's lymphoma
    S K Luthy
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Ann Oncol 19:2043-7. 2008
    ..The purpose of this study was to analyze response to palliative low-dose involved-field radiotherapy (LD-IF-RT) (two 2-Gy fractions), explore factors predicting for response, and determine the time course to subsequent treatment...
  18. ncbi request reprint The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas
    A Astier
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:228-32. 1997
    ..Although the function of RAFTK remains unknown, these data suggest that RAFTK may have a significant function in integrin-mediated signaling pathways in B cells...
  19. ncbi request reprint The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21
    G J Freeman
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Blood 79:489-94. 1992
    ..The mapping of B7 may permit further insight into disease states associated with aberrant lymphocyte activation and lymphokine synthesis...