Research Topics
Genomes and GenesSpecies | A S FreedmanSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remissionA S Freedman
Division of Hematologic Malignancies and Biostatistics, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 16:13-8. 1998....- Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cellsA Astier
Division of Hematologic Malignancies, Dana Farber Cancer Institute, Philadelphia, PA, USA
Leuk Lymphoma 28:65-72. 1997.... - The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1A Astier
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:19719-24. 1997..These data suggest that RAFTK itself is sufficient for HEF1 phosphorylation, whereas a cooperation between RAFTK and Src kinases is required for the complete phosphorylation of p130(Cas)... - Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2S N Manie
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:15636-41. 1997..These data implicate Fyn and SHP2 as potential modulators of Cas signaling complexes in B cells... - Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cellsS N Manie
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:4230-6. 1997..These associations implicate HEF1 and Cas as important components in a cytoskeleton-linked signaling pathway initiated by ligation of beta1 integrin or BCR on human B cells... - Studies of in vitro activated CD5+ B cellsA S Freedman
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
Blood 73:202-8. 1989..These phenotypic and functional studies are consistent with the notion that TPA-induced CD5+ B cells are a subset of in vitro activated B lymphocytes... - The impact of external beam radiation therapy prior to autologous bone marrow transplantation in patients with non-Hodgkin's lymphomaJ W Friedberg
Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Blood Marrow Transplant 7:446-53. 2001..Future work should explore alternative conditioning strategies and altered timing of XRT, in an attempt to limit these late toxicities... - CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donorsR J Soiffer
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 19:1152-9. 2001..Herein, we report results in the first 48 recipients of unrelated marrow using CD6+ TCD as the sole form of GVHD prophylaxis... 
(90)Y-ibritumomab tiuxetan followed by reduced-intensity conditioning and allo-SCT in patients with advanced follicular lymphomaK E Abou-Nassar
Lymphoma Program, Department of Medical Oncology, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115 6084, USA
Bone Marrow Transplant 46:1503-9. 2011..Two-year OS and PFS were 83% (±11%) and 74% (±13%), respectively. This treatment is associated with favorable outcomes including acceptable rates of GVHD and relapse in advanced FL patients, and warrants prospective studies...- MCP-1 modulates chemotaxis by follicular lymphoma cellsH Husson
Department of Medicine, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA
Br J Haematol 115:554-62. 2001..We found that cultured FDCs produced MCP-1, and this production was enhanced by tumour necrosis factor. These data implicate MCP-1 in the migration and localization of FL cells... - B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cellsG J Freeman
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
J Immunol 143:2714-22. 1989..These results demonstrate that the B7 gene encodes a unique molecule belonging to the Ig superfamily and that B7 expression is limited to normal activated B cells and noncirculating B cell malignancies... - A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndromeE D Jacobsen
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Ann Oncol 22:1608-13. 2011..The prognosis for patients with most forms of T-cell lymphoma is poor. Allogeneic hematopoietic stem-cell transplantation (HSCT) may improve the outcome... - Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1A S Freedman
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
Blood 79:206-12. 1992..Therefore, an understanding of the adhesive interaction of follicular NHL cells with GCs may provide insight into the clinical and biologic behavior of these diseases... - TGFbeta-mediated activation of Smad1 in B-cell non-Hodgkin's lymphoma and effect on cell proliferationO Munoz
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Leukemia 18:2015-25. 2004..This work opens new insights into aberrant Smad pathways and their pathophysiological role in FL and in other non-Hodgkin lymphomas... - Expression and regulation of CD5 on in vitro activated human B cellsA S Freedman
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
Eur J Immunol 19:849-55. 1989..The role of the T cell-derived lymphokine IL4 in regulating CD5 expression may be important in the disease states characterized by increased numbers of CD5+ B cells... - Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cellsO Spertini
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
Leukemia 5:300-8. 1991..Thus, most CLL cells and some non-Hodgkin's lymphoma cells express a functionally active LAM-1 molecule which may correlate with their capacity to migrate through the circulation and disseminate into peripheral LN... - Response to low-dose involved-field radiotherapy in patients with non-Hodgkin's lymphomaS K Luthy
Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
Ann Oncol 19:2043-7. 2008..The purpose of this study was to analyze response to palliative low-dose involved-field radiotherapy (LD-IF-RT) (two 2-Gy fractions), explore factors predicting for response, and determine the time course to subsequent treatment... - The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130casA Astier
Division of Hematologic Malignancies, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 272:228-32. 1997..Although the function of RAFTK remains unknown, these data suggest that RAFTK may have a significant function in integrin-mediated signaling pathways in B cells... - The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21G J Freeman
Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
Blood 79:489-94. 1992..The mapping of B7 may permit further insight into disease states associated with aberrant lymphocyte activation and lymphokine synthesis...