Laura E Fredenburgh
Affiliation: Harvard University
Fredenburgh L, Merz A, Cheng S. Haeme oxygenase signalling pathway: implications for cardiovascular disease. Eur Heart J. 2015;36:1512-8 pubmed publisher
Fredenburgh L, Kraft B, Hess D, Harris R, Wolf M, Suliman H, et al
. Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. Am J Physiol Lung Cell Mol Physiol. 2015;309:L834-46 pubmed publisher
Kuethe D, Filipczak P, Hix J, Gigliotti A, EstÃ©par R, Washko G, et al
. Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2016;311:L208-18 pubmed publisher
..Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI. ..
Fredenburgh L, Ma J, Perrella M. Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Trends Cardiovasc Med. 2009;19:31-7 pubmed publisher
..Here, we discuss our recent data demonstrating the adverse consequences of COX-2 inhibition on pulmonary vascular remodeling and PASMC contractility. ..
Fredenburgh L, Velandia M, Ma J, Olszak T, Cernadas M, Englert J, et al
. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011;187:5255-67 pubmed publisher
..Taken together, our results suggest that epithelial expression of COX-2 in the ileum is a critical modulator of tight junction protein expression and intestinal barrier function during sepsis...
Sicard D, Fredenburgh L, Tschumperlin D. Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions. J Mech Behav Biomed Mater. 2017;74:118-127 pubmed publisher
Dieffenbach P, Haeger C, Coronata A, Choi K, Varelas X, Tschumperlin D, et al
. Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2. Am J Physiol Lung Cell Mol Physiol. 2017;313:L628-L647 pubmed publisher
..The ability to interrupt this critical mechanobiological feedback loop and enhance local prostaglandin activity via manipulation of YAP/TAZ signaling presents a highly attractive novel strategy for the treatment of PH. ..