T F Franke

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    T F Franke
    ABL Basic Research Program, National Cancer Institute Frederick Cancer Research Facility and Development Center NCI FCRFDC, Frederick, MD 21702, USA
    Science 275:665-8. 1997
  2. ncbi request reprint Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    T Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:330-5. 2001
  3. ncbi request reprint Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
    H G Wang
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 284:339-43. 1999
  4. ncbi request reprint Regulation of cell death protease caspase-9 by phosphorylation
    M H Cardone
    Program on Apoptosis and Cell Death Research, The Burnham Institute, La Jolla, CA 92037, USA
    Science 282:1318-21. 1998
  5. pmc Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    D Fulton
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 399:597-601. 1999
  6. ncbi request reprint The AKT kinase is activated in multiple myeloma tumor cells
    J Hsu
    Department of Medicine and Pathology, West Los Angeles Veterans Administration Medical Center and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90073, USA
    Blood 98:2853-5. 2001
  7. pmc AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
    K Datta
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Mol Cell Biol 15:2304-10. 1995
  8. ncbi request reprint The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    T F Franke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell 81:727-36. 1995
  9. pmc Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
    A H Kim
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 21:893-901. 2001
  10. pmc Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt
    O Zugasti
    , CNRS UMR5535, F-34293 Montpellier Cedex 5, France
    Mol Cell Biol 21:6706-17. 2001

Collaborators

  • A Toker
  • L C Cantley
  • P N Tsichlis
  • J C Reed
  • A Papapetropoulos
  • William Sessa
  • D R Kaplan
  • Yigong Shi
  • S G Lee
  • J Hsu
  • T Matsui
  • A H Kim
  • O S Bang
  • J M Angelastro
  • O Zugasti
  • S Krajewski
  • H G Wang
  • Z Z Su
  • D Fulton
  • P B Fisher
  • L Emdad
  • D Sarkar
  • M H Cardone
  • S I Yang
  • K Datta
  • C Peyssonnaux
  • L Li
  • M V Chao
  • M Fisher
  • E K Park
  • S S Kang
  • S Renner
  • G Khursigara
  • R J Hajjar
  • D X Liu
  • A Lichtenstein
  • K H Lee
  • A Eychene
  • A S Yang
  • A Rosenzweig
  • U Hibner
  • L A Greene
  • J Tao
  • P Fort
  • M Picard
  • N Y Moon
  • T L Force
  • S R Lee
  • W Rul
  • X Sun
  • P Roux
  • F del Monte
  • F McKeon
  • J P Gratton
  • K Walsh
  • F Shibasaki
  • J Fontana
  • T Bobo
  • I M Ethell
  • Y Fujio
  • Y Yamaguchi
  • N Pathan
  • T J McCabe
  • N Roy
  • E Stanbridge
  • H R Stennicke
  • S Frisch
  • G S Salvesen
  • A Bellacosa
  • J Q Cheng
  • T O Chan
  • T Taguchi
  • D K Morrison
  • J R Testa
  • E A Golemis
  • A Makris
  • J Gardner
  • M E Gonzalez-Portal
  • A K Godwin
  • T C Hamilton

Detail Information

Publications16

  1. ncbi request reprint Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    T F Franke
    ABL Basic Research Program, National Cancer Institute Frederick Cancer Research Facility and Development Center NCI FCRFDC, Frederick, MD 21702, USA
    Science 275:665-8. 1997
    ..Thus, Akt is apparently regulated by the direct interaction of PtdIns-3,4-P2 with the Akt PH domain...
  2. ncbi request reprint Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    T Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:330-5. 2001
    ..Akt may represent an important nodal target for therapy in ischemic and other heart disease...
  3. ncbi request reprint Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
    H G Wang
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 284:339-43. 1999
    ..Thus, a Ca2+-inducible mechanism for apoptosis induction operates by regulating BAD phosphorylation and localization in cells...
  4. ncbi request reprint Regulation of cell death protease caspase-9 by phosphorylation
    M H Cardone
    Program on Apoptosis and Cell Death Research, The Burnham Institute, La Jolla, CA 92037, USA
    Science 282:1318-21. 1998
    ..Mutant pro-Casp9(Ser196Ala) was resistant to Akt-mediated phosphorylation and inhibition in vitro and in cells, resulting in Akt-resistant induction of apoptosis. Thus, caspases can be directly regulated by protein phosphorylation...
  5. pmc Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    D Fulton
    Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 399:597-601. 1999
    ..Thus, eNOS is a newly described Akt substrate linking signal transduction by Akt to the release of the gaseous second messenger NO...
  6. ncbi request reprint The AKT kinase is activated in multiple myeloma tumor cells
    J Hsu
    Department of Medicine and Pathology, West Los Angeles Veterans Administration Medical Center and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90073, USA
    Blood 98:2853-5. 2001
    ..These results indicate that activation of the AKT kinase is a characteristic of MM cells and suggest that AKT activity is important for MM cell expansion...
  7. pmc AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
    K Datta
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Mol Cell Biol 15:2304-10. 1995
    ..Addition of maltose-binding protein-AH/PH fusion recombinant protein, which is expected to bind Akt, to the immunoprecipitates from serum-starved cells induced the activation of the Akt kinase...
  8. ncbi request reprint The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    T F Franke
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cell 81:727-36. 1995
    ..These results identify Akt as a novel target of PI 3-kinase and suggest that the Akt PH domain may be a mediator of PI 3-kinase signaling...
  9. pmc Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
    A H Kim
    Molecular Neurobiology Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 21:893-901. 2001
    ..These results provide the first direct link between Akt and the family of stress-activated kinases...
  10. pmc Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt
    O Zugasti
    , CNRS UMR5535, F-34293 Montpellier Cedex 5, France
    Mol Cell Biol 21:6706-17. 2001
    ..Our data demonstrate that the GTPases of the Rho family control three major components of cellular signal transduction, namely, p53, Akt, and Erks, which collaborate in the induction of apoptosis due to the loss of anchorage...
  11. ncbi request reprint Characterization of a novel isoform of caspase-9 that inhibits apoptosis
    J M Angelastro
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 276:12190-200. 2001
    ..Taken together, our observations indicate that casp-9-CTD acts as a dominant-negative variant. Its expression in various tissues indicates a physiological role in regulating cell death...
  12. ncbi request reprint Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells
    O S Bang
    Department of Biology, College of Natural Sciences, Kyungpook National University, Taegu 702-701, Korea
    J Cell Sci 114:81-88. 2001
    ..In summary, our results indicate that Akt overrides the growth-arresting effect of NGF and thereby, negatively regulates neuronal differentiation...
  13. pmc AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
    J Q Cheng
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111
    Proc Natl Acad Sci U S A 89:9267-71. 1992
    ..We conclude that AKT2 belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains and that alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas...
  14. ncbi request reprint Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications
    A Bellacosa
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Oncogene 8:745-54. 1993
    ..c-akt was mapped by fluorescence in situ hybridization (FISH) to mouse chromosome 12 and rat chromosome 6 in close proximity to the Igh locus...
  15. ncbi request reprint The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1
    T F Franke
    Fox Chase Cancer Center, Philadelphia, PA 19111
    Oncogene 9:141-8. 1994
    ..The high degree of homology between the catalytic domains of Dkt1 and the three known members of the Drosophila PKC family suggests an evolutionarily conserved functional relationship between the members of the two families...
  16. ncbi request reprint Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling
    S G Lee
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA
    Oncogene 27:1114-21. 2008
    ..Activation of survival pathways may be one mechanism by which AEG-1 exerts its oncogenic properties...