John V Frangioni

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
  2. doi request reprint The impact of greed on academic medicine and patient care
    John V Frangioni
    Beth Israel Deaconess Medical Center and the Harvard Medical School, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 26:503-7. 2008
  3. pmc Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex
    Fangbing Liu
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e38589. 2012
  4. pmc Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy
    Yoshitomo Ashitate
    Department of Medicine, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Surg Res 176:7-13. 2012
  5. pmc Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer
    J Sven D Mieog
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 18:2483-91. 2011
  6. ncbi request reprint In vivo tracking of stem cells for clinical trials in cardiovascular disease
    John V Frangioni
    Division of Hematology Oncology, Department of Radiology, and Molecular Imaging Center, Beth Israel Deaconess Medical Center, 330 Brookline Ave, SL B05, Boston, Mass 02215, USA
    Circulation 110:3378-83. 2004
  7. ncbi request reprint Translating in vivo diagnostics into clinical reality
    John V Frangioni
    Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Room SL B05, Boston, MA 02215, USA
    Nat Biotechnol 24:909-13. 2006
  8. ncbi request reprint In vivo near-infrared fluorescence imaging
    John V Frangioni
    SL B05 Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Opin Chem Biol 7:626-34. 2003
  9. pmc New technologies for human cancer imaging
    John V Frangioni
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rm SL B05, Boston, MA 02215, USA
    J Clin Oncol 26:4012-21. 2008
  10. pmc The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping
    Susan L Troyan
    Breast Care Center, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Surg Oncol 16:2943-52. 2009

Detail Information

Publications108 found, 100 shown here

  1. pmc Renal clearance of quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 25:1165-70. 2007
    ..5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications...
  2. doi request reprint The impact of greed on academic medicine and patient care
    John V Frangioni
    Beth Israel Deaconess Medical Center and the Harvard Medical School, 330 Brookline Avenue, Room SL B05, Boston, Massachusetts 02215, USA
    Nat Biotechnol 26:503-7. 2008
    ..To what extent is the increasing emphasis on profit generation at US academic institutions shackling intellectual freedom and compromising healthcare?..
  3. pmc Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex
    Fangbing Liu
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e38589. 2012
    ..We developed a novel animal model system to study the molecular mechanisms of TSC/LAM pathogenesis and tumorigenesis and provide a platform for drug testing...
  4. pmc Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy
    Yoshitomo Ashitate
    Department of Medicine, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Surg Res 176:7-13. 2012
    ..We hypothesized that two independent wavelengths of near-infrared (NIR) fluorescent light could be used to identify bile ducts and hepatic arteries simultaneously, and intraoperatively...
  5. pmc Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer
    J Sven D Mieog
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 18:2483-91. 2011
    ..Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers...
  6. ncbi request reprint In vivo tracking of stem cells for clinical trials in cardiovascular disease
    John V Frangioni
    Division of Hematology Oncology, Department of Radiology, and Molecular Imaging Center, Beth Israel Deaconess Medical Center, 330 Brookline Ave, SL B05, Boston, Mass 02215, USA
    Circulation 110:3378-83. 2004
    ..We review the many contrast agents and detectors that have been proposed for stem cell tracking during clinical trials, define the characteristics of an ideal imaging technology, and suggest future directions for research...
  7. ncbi request reprint Translating in vivo diagnostics into clinical reality
    John V Frangioni
    Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Room SL B05, Boston, MA 02215, USA
    Nat Biotechnol 24:909-13. 2006
  8. ncbi request reprint In vivo near-infrared fluorescence imaging
    John V Frangioni
    SL B05 Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Opin Chem Biol 7:626-34. 2003
    ..Recent examples of in vivo near-infrared fluorescence imaging of animals and humans are presented, including imaging of normal and diseased vasculature, tissue perfusion, protease activity, hydroxyapatite and cancer...
  9. pmc New technologies for human cancer imaging
    John V Frangioni
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, Rm SL B05, Boston, MA 02215, USA
    J Clin Oncol 26:4012-21. 2008
    ..This review explores these emerging technologies and considers their potential impact on clinical care. Finally, those cancers that are currently difficult to image and quantify, such as ovarian cancer and acute leukemia, are discussed...
  10. pmc The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping
    Susan L Troyan
    Breast Care Center, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Surg Oncol 16:2943-52. 2009
    ..The FLARE imaging system overcomes this major obstacle...
  11. pmc Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99(m) technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients
    Joost R van der Vorst
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 19:4104-11. 2012
    ..We performed a randomized clinical trial to assess the value of blue dyes when used in combination with NIR fluorescence. We also preliminarily examined the possibility of performing SLN mapping without radiotracers...
  12. pmc Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots
    Edward G Soltesz
    Division of Cardiac Surgery, Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 79:269-77; discussion 269-77. 2005
    ..Our objective was to develop an optical noninvasive imaging tool that would permit intraoperative SLN mapping and provide real-time visual feedback for image-guided localization and resection...
  13. pmc Identification of metastatic nodal disease in a phase 1 dose-escalation trial of intraoperative sentinel lymph node mapping in non-small cell lung cancer using near-infrared imaging
    Denis M Gilmore
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:562-70; discussion 569-70. 2013
    ....
  14. ncbi request reprint Sentinel lymph node mapping of the gastrointestinal tract by using invisible light
    Edward G Soltesz
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Ann Surg Oncol 13:386-96. 2006
    ..Our goal was to develop a method for patient-specific intraoperative sentinel lymph node mapping of the GI tract by using invisible near-infrared light...
  15. pmc Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer
    Merlijn Hutteman
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Am J Obstet Gynecol 206:89.e1-5. 2012
    ..Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed...
  16. pmc Design considerations for tumour-targeted nanoparticles
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Nanotechnol 5:42-7. 2010
    ..This study suggests a set of design rules for the clinical translation of targeted nanoparticles that can be eliminated through the kidneys...
  17. pmc Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer
    Boudewijn E Schaafsma
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Gynecol Oncol 127:126-30. 2012
    ..The current randomized study aims to determine whether ICG:HSA offers advantages over using ICG alone...
  18. pmc Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients
    Joost R van der Vorst
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Oral Oncol 49:15-9. 2013
    ..This feasibility study explored the use of indocyanine green adsorbed to human serum albumin (ICG:HSA) for SLN mapping in head and neck cancer patients...
  19. pmc Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging
    Cherie P Parungo
    Cardiac Surgery Research Laboratory, Brigham and Women s Hospital, Division of Hematology Oncology, Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Thorac Cardiovasc Surg 129:844-50. 2005
    ..Our purpose was to develop an intraoperative method for identifying sentinel lymph nodes of the esophagus with high-sensitivity near-infrared fluorescence imaging...
  20. pmc Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue
    Yoshitomo Ashitate
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Plast Surg 70:360-5. 2013
    ..In the validation set, this threshold provided a prediction sensitivity of 95.3% and a specificity of 98.0%. We demonstrate that a single intraoperative near-infrared measurement can predict submental flap outcome at 72 hours...
  21. pmc Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents
    Aya Matsui
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Surgery 148:87-95. 2010
    ....
  22. ncbi request reprint Nerve-highlighting fluorescent contrast agents for image-guided surgery
    Summer L Gibbs-Strauss
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mol Imaging 10:91-101. 2011
    ..These results lay the foundation for the development of ideal nerve-highlighting fluorophores for image-guided surgery...
  23. pmc First-in-human pilot study of a spatial frequency domain oxygenation imaging system
    Sylvain Gioux
    Beth Israel Deaconess Medical Center, Division of Hematology Oncology, Department of Medicine, Boston, Massachusetts 02215, USA
    J Biomed Opt 16:086015. 2011
    ..Overall, this study lays the foundation for clinical translation of endogenous contrast imaging using SFDI...
  24. pmc Humoral bone morphogenetic protein 2 is sufficient for inducing breast cancer microcalcification
    Fangbing Liu
    Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Mol Imaging 7:175-86. 2008
    ....
  25. pmc Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light
    Joshua H Winer
    Department of Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Ann Surg Oncol 17:1094-100. 2010
    ..Our hypothesis is that a near-infrared (NIR) fluorophore exhibiting uptake in insulinoma could provide high-sensitivity detection intraoperatively...
  26. doi request reprint A novel pilot study using spatial frequency domain imaging to assess oxygenation of perforator flaps during reconstructive breast surgery
    John T Nguyen
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Plast Surg 71:308-15. 2013
    ..Spatial frequency domain imaging (SFDI) is a promising new technology that provides oxygenation images over a large field of view. The goal of this clinical pilot study is to use SFDI in perforator flap breast reconstruction...
  27. pmc Intraoperative near-infrared fluorescence imaging in perforator flap reconstruction: current research and early clinical experience
    Bernard T Lee
    Division of Plastic and Reconstructive Surgery, Boston, Massachusetts, USA
    J Reconstr Microsurg 26:59-65. 2010
    ..In this article, we review our preclinical and clinical data, as well as literature describing the use of similar NIR fluorescence imaging systems in plastic and reconstructive surgery...
  28. pmc Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients
    Joost R van der Vorst
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Int J Gynecol Cancer 21:1472-8. 2011
    ..Near-infrared fluorescence imaging is based on invisible NIR light and can provide high sensitivity, high-resolution, and real-time image guidance during surgery...
  29. pmc Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients
    Merlijn Hutteman
    Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Breast Cancer Res Treat 127:163-70. 2011
    ..With these optimized parameters that eliminate the necessity of HSA, larger trials can now be performed to determine patient benefit...
  30. ncbi request reprint In vivo tracking in cardiac stem cell-based therapy
    Kozo Hoshino
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Prog Cardiovasc Dis 49:414-20. 2007
    ..Herein, we review current in vivo imaging techniques and future directions for tracking the effects of cell-based therapy...
  31. ncbi request reprint Effective low-dose escalation of indocyanine green for near-infrared fluorescent sentinel lymph node mapping in melanoma
    Denis M Gilmore
    Department of Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Ann Surg Oncol 20:2357-63. 2013
    ..Near-infrared imaging (NIR) may utilize indocyanine green (ICG) to improve SLN identification. The safety, feasibility and optimal dose of albumin-bound ICG (ICG:HSA) was assessed by NIR to improve SLN mapping in patients with melanoma...
  32. pmc Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green
    Joost R van der Vorst
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Surg Res 174:266-71. 2012
    ..The current study aims to optimize dosage and timing of ICG administration...
  33. pmc Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging
    Boudewijn E Schaafsma
    Department of Surgery, University Medical Center, Leiden, The Netherlands
    J Surg Res 183:253-7. 2013
    ..The aim of this study was to assess the added value of near-infrared (NIR) fluorescence imaging to conventional blue dye staining for ex vivo sentinel lymph node mapping...
  34. pmc A dose- and time-controllable syngeneic animal model of breast cancer microcalcification
    Fangbing Liu
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Breast Cancer Res Treat 122:87-94. 2010
    ..This animal model lays the foundation for the development of novel diagnostic radiotracers for breast cancer...
  35. pmc Lymphatic drainage of the peritoneal space: a pattern dependent on bowel lymphatics
    Cherie P Parungo
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Ann Surg Oncol 14:286-98. 2007
    ..Sentinel lymph nodes (SLNs) have been identified for solid organs and the pleural space. Our purpose was to determine whether the peritoneal space has a predictable lymph node drainage pattern...
  36. pmc Intraoperative near infrared fluorescence guided identification of the ureters using low dose methylene blue: a first in human experience
    Floris P R Verbeek
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Urol 190:574-9. 2013
    ..Furthermore, we assessed the optimal timing and dose of methylene blue...
  37. pmc Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light
    Eiichi Tanaka
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Surgery 144:39-48. 2008
    ..We hypothesized that with an appropriate fluorophore and imaging system, invisible near-infrared (NIR) light could be used for image-guided procedures on the extrahepatic bile ducts...
  38. pmc Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging
    Eiichi Tanaka
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Thorac Cardiovasc Surg 138:133-40. 2009
    ..Our objective was to determine whether methylene blue, already US Food and Drug Administration approved for other indications, has useful near-infrared fluorescence properties for image-guided cardiac surgery...
  39. pmc Image-guided quantification of cardioplegia delivery during cardiac surgery
    Edward G Soltesz
    Division of Cardiac Surgery, Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Heart Surg Forum 10:E381-6. 2007
    ..Such a system would permit instantaneous imaging of jeopardized myocardium and allow immediate, intraoperative corrective measures...
  40. pmc Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light
    Merlijn Hutteman
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 18:1006-14. 2011
    ..We hypothesized that the combination of invisible near-infrared (NIR) fluorescent light and ex vivo injection could solve remaining problems of SLN mapping in colorectal cancer...
  41. pmc Quantitative assessment of nipple perfusion with near-infrared fluorescence imaging
    Yoshitomo Ashitate
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Plast Surg 70:149-53. 2013
    ..05). Based on our findings, radial incisions for nipple-sparing mastectomy may be preferable due to higher perfusion; however, clinical trials are necessary for further assessment...
  42. pmc Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light
    Floris P R Verbeek
    Department of Surgery, University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands
    J Hepatobiliary Pancreat Sci 19:626-37. 2012
    ..g., sensitive detection and demarcation of tumours and vital structures) and function (e.g., assessment of luminal flow and tissue perfusion) during both open and minimally invasive surgeries...
  43. pmc Near-infrared fluorescence-guided resection of colorectal liver metastases
    Joost R van der Vorst
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Cancer 119:3411-8. 2013
    ....
  44. pmc Bone flap perfusion assessment using near-infrared fluorescence imaging
    John T Nguyen
    Division of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Surg Res 178:e43-50. 2012
    ..The present pilot study investigated the ability of NIR imaging to assess the perfusion of vascularized bone flaps...
  45. pmc Sentinel lymph node mapping of the pleural space
    Cherie P Parungo
    Division of Cardiac Surgery, Brigham and Women s Hospital, Boston, MA, USA
    Chest 127:1799-804. 2005
    ..The purpose of this study was to determine whether the pleural space has an SLN group...
  46. pmc Image-guided oncologic surgery using invisible light: completed pre-clinical development for sentinel lymph node mapping
    Eiichi Tanaka
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Surg Oncol 13:1671-81. 2006
    ..In this study, we complete pre-clinical development of the technology for sentinel lymph node (SLN) mapping using a large animal model of spontaneous melanoma...
  47. pmc The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in perforator flap breast reconstruction
    Bernard T Lee
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Plast Reconstr Surg 126:1472-81. 2010
    ..In this study, the authors demonstrate the use of an intraoperative, near-infrared fluorescence imaging system for evaluation of perforator location and flap perfusion...
  48. pmc The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery
    Boudewijn E Schaafsma
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Surg Oncol 104:323-32. 2011
    ..Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery...
  49. pmc Image-guided perforator flap design using invisible near-infrared light and validation with x-ray angiography
    Aya Matsui
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Ann Plast Surg 63:327-30. 2009
    ..The technology we describe provides high-sensitivity real-time image guidance throughout perforator dissection, and permits patient-specific flap design...
  50. pmc Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery
    Yoshitomo Ashitate
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Thorac Cardiovasc Surg 142:31-8.e1-2. 2011
    ..We hypothesized that near-infrared fluorescent light could provide sensitive, real-time, high-resolution intraoperative imaging of thoracic duct anatomy and function...
  51. pmc Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue
    Aya Matsui
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Surgery 148:78-86. 2010
    ..S. Food and Drug Administration for other indications, could be exploited for real-time, intra-operative identification of the ureters...
  52. pmc Rapid translocation of nanoparticles from the lung airspaces to the body
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Biotechnol 28:1300-3. 2010
    ..We discuss the importance of these findings for drug delivery, air pollution and carcinogenesis...
  53. pmc Predictive capability of near-infrared fluorescence angiography in submental perforator flap survival
    Aya Matsui
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Plast Reconstr Surg 126:1518-27. 2010
    ..This study evaluates the predictive capability of near-infrared fluorescence angiography for flap survival in submental flap reconstruction...
  54. pmc Structure-activity relationship of nerve-highlighting fluorophores
    Summer L Gibbs
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e73493. 2013
    ..Two new DSB fluorophores with the highest nerve to muscle ratio were tested in pigs to confirm scalability. ..
  55. pmc Targeted zwitterionic near-infrared fluorophores for improved optical imaging
    Hak Soo Choi
    Department of Medicine, Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Biotechnol 31:148-53. 2013
    ..1 with IRDye800-CW and 2.7 with Cy5.5. Our results suggest that introducing zwitterionic properties into targeted fluorophores may be a general strategy for improving the SBR in diagnostic and therapeutic applications...
  56. pmc Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems
    Yoshitomo Ashitate
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Vasc Surg 56:171-80. 2012
    ....
  57. pmc Submental perforator flap design with a near-infrared fluorescence imaging system: the relationship among number of perforators, flap perfusion, and venous drainage
    Aya Matsui
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Plast Reconstr Surg 124:1098-104. 2009
    ..The impact of the number of preserved perforator arteries on flap perfusion and venous drainage was quantified...
  58. pmc Real-time intraoperative ureteral guidance using invisible near-infrared fluorescence
    Eiichi Tanaka
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Urol 178:2197-202. 2007
    ..Our hypothesis was that near-infrared fluorescence imaging would enable visualization of the ureteral anatomy and flow intraoperatively and in real time...
  59. pmc Detection of breast cancer microcalcifications using a dual-modality SPECT/NIR fluorescent probe
    Kumar R Bhushan
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Chem Soc 130:17648-9. 2008
    ..Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized...
  60. pmc Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light
    Onkar Khullar
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Semin Thorac Cardiovasc Surg 21:309-15. 2009
    ..This review provides a theoretic and empiric framework for developing the next generation of diagnostic and therapeutic agents for lung cancer...
  61. pmc Motion-gated acquisition for in vivo optical imaging
    Sylvain Gioux
    Boston University, 48 Cummington Street, Boston, Massachusetts 02215, USA
    J Biomed Opt 14:064038. 2009
    ..This gating device should help to enable the clinical translation of promising new optical imaging technologies...
  62. pmc Sentinel lymph node mapping with type-II quantum dots
    John V Frangioni
    Division of Hematology Oncology, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 374:147-59. 2007
    ..They contain a CdTe core, CdSe shell, and a highly anionic, oligomeric phosphine organic coating. We also describe how to utilize such QDs in animal model systems of SLN mapping...
  63. pmc Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source
    Sylvain Gioux
    Boston University, 48 Cummington Street, Boston, Massachusetts 02215, USA
    J Biomed Opt 15:026005. 2010
    ..Taken together, our study offers an alternative to laser diodes for clinical translation of FLi and explores the use of relatively low frequency modulation for in vivo imaging...
  64. pmc Real-time visualization and quantification of retrograde cardioplegia delivery using near infrared fluorescent imaging
    Aravind T Rangaraj
    Division of Cardiac Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Card Surg 23:701-8. 2008
    ..In this study, we evaluate the feasibility of near infrared (NIR) imaging for real-time visualization of cardioplegia distribution in a porcine model...
  65. pmc Near-infrared imaging of face transplants: are both pedicles necessary?
    John T Nguyen
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Surg Res 184:714-21. 2013
    ..As it remains unclear whether perfusion can be based off a single pedicle, this study was designed to assess perfusion patterns of facial transplant allografts using near-infrared (NIR) fluorescence imaging...
  66. pmc Nanoparticle migration and delivery of Paclitaxel to regional lymph nodes in a large animal model
    Onkar V Khullar
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Coll Surg 214:328-37. 2012
    ..The aim of this study was to demonstrate feasibility of migration and in situ chemotherapy delivery to regional lymph nodes (LN) in a large animal model using an expansile polymer nanoparticle (eNP) delivery system...
  67. pmc Localization and quantification of platelet-rich thrombi in large blood vessels with near-infrared fluorescence imaging
    Robert Flaumenhaft
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Circulation 115:84-93. 2007
    ..Near-infrared light, with its superior tissue penetration and reduced scatter, could potentially solve this problem...
  68. pmc Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots
    Hak Soo Choi
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nano Lett 9:2354-9. 2009
    ..We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body...
  69. doi request reprint MRI contrast using solid-state, B1-distorting, microelectromechanical systems (MEMS) microresonant devices (MRDs)
    Razvan Ciocan
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Magn Reson Med 61:860-6. 2009
    ..When implanted subcutaneously in the flank of a mouse, only MRDs tuned to the resonant frequency of protons generated a measurable in vivo B(1) field. This study lays the foundation for a new class of solid-state contrast agents for MRI...
  70. pmc High-throughput screening of small molecule ligands targeted to live bacteria surface
    Jeong Heon Lee
    Center for Molecular Imaging, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, United States
    Anal Chem 85:3508-14. 2013
    ..The technology we describe could form the foundation for developing new classes of antibiotics...
  71. pmc An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives
    Valerie Humblet
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Contrast Media Mol Imaging 1:196-211. 2006
    ..Taken together, our study should expedite the development of disease-targeted, multimodality diagnostic and therapeutic agents...
  72. pmc cGMP-Compatible preparative scale synthesis of near-infrared fluorophores
    Hoon Hyun
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Contrast Media Mol Imaging 7:516-24. 2012
    ..Finally, we report the unique in vivo properties of ZW800-1 in large animals approaching the size of humans, thus laying the foundation for rapid clinical translation of these methods...
  73. ncbi request reprint Organic alternatives to quantum dots for intraoperative near-infrared fluorescent sentinel lymph node mapping
    Shunsuke Ohnishi
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 4:172-81. 2005
    ..This preclinical study, performed on large animals approaching the size of humans, should serve as a foundation for future clinical studies...
  74. pmc High-resolution computed tomography of single breast cancer microcalcifications in vivo
    Kazumasa Inoue
    Division of Hematology Oncology and Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 10:295-304. 2011
    ..Taken together, this study provides an in vivo "gold standard" for the development of calcification-specific contrast agents and a model system for studying the mechanism of breast cancer microcalcification...
  75. pmc Synthesis of conjugatable bisphosphonates for molecular imaging of large animals
    Kumar R Bhushan
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Avenue, SLB 05, Boston, MA 02215, USA
    Angew Chem Int Ed Engl 46:7969-71. 2007
  76. pmc Optical clearing of the skin for near-infrared fluorescence image-guided surgery
    Aya Matsui
    Beth Israel Deaconess Medical Center, Department of Medicine, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
    J Biomed Opt 14:024019. 2009
    ..In conclusion, topically applied hyperosmotic agents are ineffective for image-guided surgery of living subjects...
  77. ncbi request reprint High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen
    Valerie Humblet
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 4:448-62. 2005
    ..We also discuss chemical strategies for improving performance even further. Taken together, this study describes nearly complete preclinical development of an optically based small-molecule contrast agent for image-guided surgery...
  78. pmc Optimization of coded aperture radioscintigraphy for sentinel lymph node mapping
    Hirofumi Fujii
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging Biol 14:173-82. 2012
    ..Radioscintigraphic imaging during sentinel lymph node (SLN) mapping could potentially improve localization; however, parallel-hole collimators have certain limitations. In this study, we explored the use of coded aperture (CA) collimators...
  79. pmc First-in-human clinical trials of imaging devices: an example from optical imaging
    Summer L Gibbs-Strauss
    Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL B05, Boston, MA 02215, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2001-4. 2009
    ....
  80. pmc Optical imaging of hydroxyapatite in the calcified vasculature of transgenic animals
    Atif Zaheer
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 26:1132-6. 2006
    ..To detect the hydroxyapatite component of vascular calcification in vivo so that the process of calcium deposition can be studied in transgenic model systems...
  81. pmc Tissue-like phantoms for near-infrared fluorescence imaging system assessment and the training of surgeons
    Alec M De Grand
    Beth Israel Deaconess Medical Center, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
    J Biomed Opt 11:014007. 2006
    ..We demonstrate how these phantoms can be used to calibrate and compare imaging systems, and to train surgeons to operate under NIR fluorescence image guidance...
  82. pmc High-power, computer-controlled, light-emitting diode-based light sources for fluorescence imaging and image-guided surgery
    Sylvain Gioux
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mol Imaging 8:156-65. 2009
    ..0 mW/cm2 of 760 nm NIR fluorescence excitation light over a 15 cm diameter field of view. Using this light source, we demonstrated NIR fluorescence-guided surgery in a large-animal model...
  83. pmc Three-dimensional surface profile intensity correction for spatially modulated imaging
    Sylvain Gioux
    Boston University, Department of Biomedical Engineering, Boston, Massachusetts 02215, USA
    J Biomed Opt 14:034045. 2009
    ..These data lay the foundation for employing structured light for quantitative imaging during surgery...
  84. pmc Quantitative assessment of perfusion and vascular compromise in perforator flaps using a near-infrared fluorescence-guided imaging system
    Aya Matsui
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Plast Reconstr Surg 124:451-60. 2009
    ..In this study, the authors demonstrate the use of near-infrared fluorescence angiography to directly quantify normal and abnormal perfusion in perforator flaps...
  85. ncbi request reprint Molecular imaging agents specific for the annulus fibrosus of the intervertebral disk
    Summer L Gibbs-Strauss
    Division of Hematology Oncology, Department of Medicine, and Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Imaging 9:128-40. 2010
    ..FM fluorophores could be used for image-guided surgery to assist in the removal of intervertebral disk and lay the foundation for derivatives for magnetic resonance imaging and positron emission tomography...
  86. pmc Production of multimeric prostate-specific membrane antigen small-molecule radiotracers using a solid-phase 99mTc preloading strategy
    Preeti Misra
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Nucl Med 48:1379-89. 2007
    ..However, highly charged ligands are difficult to label with 99mTc and to purify. In this study, we present an adamantane-trimerized small molecule that has nanomolar binding to PSMA and also has 12 negative charges...
  87. pmc Rigid multivalent scaffolds based on adamantane
    Khaled Nasr
    Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, SL B05, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Org Chem 73:1056-60. 2008
    ..In addition, an amino group at the fourth bridgehead position provides a flexible linker for attachment of effector molecules such as contrast agents, radiotracers, or cytotoxins without interfering with the cell binding process...
  88. ncbi request reprint Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy
    Akira Nakayama
    Beth Israel Deaconess Medical Center, HIM 1023, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Imaging 1:365-77. 2002
    ..This imaging system may prove useful for the refinement of revascularization techniques, and for the administration of cardiac gene therapy...
  89. pmc High-throughput small molecule identification using MALDI-TOF and a nanolayered substrate
    Jeong Heon Lee
    Robotic Chemistry Group, Center for Molecular Imaging, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Anal Chem 83:5283-9. 2011
    ..Our study lays the foundation for improved encoderless combinatorial chemistry...
  90. pmc Nanotechnology in thoracic surgery
    Morgan D Schulz
    Division of Thoracic Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 89:S2188-90. 2010
    ..With promising preclinical results in many applications directly applicable to thoracic oncology, it is possible that the frontiers of minimally invasive thoracic surgery will eventually be explored at the nanoscale...
  91. pmc Radiolabeled and near-infrared fluorescent fibrinogen derivatives create a system for the identification and repair of obscure gastrointestinal bleeding
    Shunsuke Ohnishi
    Division of Hematology Oncology, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Surgery 140:785-92. 2006
    ..125I-FBG permits gamma ray-based preoperative or intraoperative scanning, and near-infrared (NIR) flourescent FBG (FBG800) permits real-time intraoperative visualization of active clot...
  92. ncbi request reprint Selection of quantum dot wavelengths for biomedical assays and imaging
    Yong Taik Lim
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Mol Imaging 2:50-64. 2003
    ..Taken together, our data should prove useful in designing fluorescent QD contrast agents optimized for specific biomedical applications...
  93. ncbi request reprint Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer
    Robert E Lenkinski
    Department of Radiology, Molecular Imaging Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
    Acad Radiol 10:1159-64. 2003
    ..The aim of this study was to develop a straightforward, reproducible model system that could be used to develop multimodality contrast agents for the identification of breast cancer microcalcification...
  94. ncbi request reprint IRDye78 conjugates for near-infrared fluorescence imaging
    Atif Zaheer
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mol Imaging 1:354-64. 2002
    ....
  95. ncbi request reprint Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging
    Akira Nakayama
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Mol Imaging 2:37-49. 2003
    ..Taken together, BAT perfusion can now be measured noninvasively using NIR fluorescent light, and pharmacological modulators of thermogenesis can be screened at relatively high throughput in living animals...
  96. pmc Class 1A PI3K regulates vessel integrity during development and tumorigenesis
    Tina L Yuan
    Departments of Systems Biology and Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:9739-44. 2008
    ..Furthermore, we show that a PI3K inhibitor can mimic the effects of class 1A PI3K loss, which suggests that targeting class 1A PI3K may be a promising therapy for blocking tumor angiogenesis...
  97. ncbi request reprint In vivo optical imaging of pleural space drainage to lymph nodes of prognostic significance
    Cherie P Parungo
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Surg Oncol 11:1085-92. 2004
    ..The purpose of this study was to identify the in vivo pattern of drainage from the pleural space to prognostic lymph node stations...
  98. ncbi request reprint An integrated vector system for cellular studies of phage display-derived peptides
    Stephan D Voss
    Department of Pediatric Radiology, Children s Hospital Medical Center, Boston, MA 02115, USA
    Anal Biochem 308:364-72. 2002
    ..Taken together, this system of vectors should facilitate the development of phage display-derived peptides into useful biomolecules...
  99. pmc Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
    Sungjee Kim
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 22:93-7. 2004
    ..Taken together, the chemical, optical and in vivo data presented in this study demonstrate the potential of near-infrared quantum dots for biomedical imaging...
  100. pmc Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging
    John P Zimmer
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA
    J Am Chem Soc 128:2526-7. 2006
    ..The biological utility of these fluorescent probes resulted from our intentional choice to match the semiconductor material and water-soluble ligand with a desired final hydrodynamic diameter and emission wavelength...
  101. ncbi request reprint Improved chemical strategies for the targeted therapy of cancer
    Wolfgang Maison
    Institut fur Organische Chemie, Universitat Hamburg, Martin Luther King Platz 6, 20146 Hamburg, Germany
    Angew Chem Int Ed Engl 42:4726-8. 2003

Research Grants21

  1. Intraoperative Near-Infrared Fluorescence Imaging
    John V Frangioni; Fiscal Year: 2010
    ....
  2. Objective Flap Assessment During Reconstructive Surgery
    JOHN FRANGIONI; Fiscal Year: 2009
    ..With the completion of these studies, we foresee being able to solve major clinical problems in reconstructive surgery using real-time, intraoperative objective assessment. ..
  3. Near-Infrared Quantum Dots for In Vivo Imaging
    JOHN FRANGIONI; Fiscal Year: 2006
    ..If completed, the specific aims of this proposal will generate a clinically useful set of contrast agents, and a more complete understanding of the in vivo behavior of fluorescent semiconductor nanocrystals. ..
  4. Objective Flap Assessment During Reconstructive Surgery
    JOHN FRANGIONI; Fiscal Year: 2006
    ..With the completion of these studies, we foresee being able to solve major clinical problems in reconstructive surgery using real-time, intraoperative objective assessment. ..
  5. MOLECULAR IMAGING OF ADVANCED BLADDER CANCER
    JOHN FRANGIONI; Fiscal Year: 2002
    ..We believe that bladder cancer-specific, low-molecular weight ligands will someday be clinically useful reagents for improved detection and guided therapy of transitional cell carcinoma of the bladder. ..
  6. Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided Surger
    JOHN V contact FRANGIONI; Fiscal Year: 2010
    ..The goal of this grant is to develop a new class of ideal near-infrared fluorophores that can be injected into the bloodstream. These fluorophores would "stick" to tumors and other diseased tissue, but not to normal tissue. ..
  7. Objective Flap Assessment During Reconstructive Surgery
    JOHN FRANGIONI; Fiscal Year: 2007
    ..With the completion of these studies, we foresee being able to solve major clinical problems in reconstructive surgery using real-time, intraoperative objective assessment. ..
  8. Intraoperative Near-Infrared Fluorescence Imaging
    JOHN FRANGIONI; Fiscal Year: 2007
    ..Taken together, this BRP application describes an academic/industrial partnership engineered for successful translation of a general-purpose optical imaging technology to the clinic. ..
  9. A Platform for Cancer Biomarker Validation: Image Fusion Using NIR Fluorescence
    Ali Kamen; Fiscal Year: 2010
    ..This study also leverages a unique prostate cancer tissue bank that provides paired DCE-MRI and histological whole mounts from individual prostate cancer patients. ..
  10. Intraoperative Near-Infrared Fluorescence Imaging
    JOHN FRANGIONI; Fiscal Year: 2009
    ..Taken together, this BRP application describes an academic/industrial partnership engineered for successful translation of a general-purpose optical imaging technology to the clinic. ..
  11. A Platform for Cancer Biomarker Validation: Image Fusion Using NIR Fluorescence
    JOHN FRANGIONI; Fiscal Year: 2009
    ..This study also leverages a unique prostate cancer tissue bank that provides paired DCE-MRI and histological whole mounts from individual prostate cancer patients. ..
  12. FLEX TM microPET/SPECT/CT to Support Cancer Research at Harvard Medical School
    JOHN FRANGIONI; Fiscal Year: 2006
    ..Thus, this single investment in the densely-populated LMA would fulfill the goal of PAR-05-124 by having a "significant impact on biomedical/behavioral research and contribute to the advancement of human health." ..
  13. Intraoperative Near-Infrared Fluorescence Imaging
    JOHN FRANGIONI; Fiscal Year: 2006
    ..Taken together, this BRP application describes an academic/industrial partnership engineered for successful translation of a general-purpose optical imaging technology to the clinic. ..
  14. Spatially Modulated Near-Infrared Light for Image-Guided Cancer Surgery
    JOHN FRANGIONI; Fiscal Year: 2007
    ..Successful completion of the specific aims in this application will ensure that a novel optical imaging technology for image-guided surgical interventions is translated efficiently to the clinic. ..
  15. Intraoperative Near-Infrared Fluorescence Imaging
    JOHN FRANGIONI; Fiscal Year: 2005
    ..Taken together, this BRP application describes an academic/industrial partnership engineered for successful translation of a general-purpose optical imaging technology to the clinic. ..
  16. LOW-MOLECULAR WEIGHT LIGANDS FOR PROSTATE CANCER
    JOHN FRANGIONI; Fiscal Year: 2003
    ..We believe that prostate- specific, low-molecular weight ligands will someday be clinically useful reagents for improved prostate cancer detection and guided therapy. ..