J W Francis

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: a potential vector for delivering heterologous proteins to neurons
    J W Francis
    Cecil B Day Center for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Neurochem 74:2528-36. 2000
  2. ncbi request reprint Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNS
    J W Francis
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th St, Room 3125, Charlestown, MA 02129, USA
    Brain Res 1011:7-13. 2004

Detail Information

Publications2

  1. ncbi request reprint Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: a potential vector for delivering heterologous proteins to neurons
    J W Francis
    Cecil B Day Center for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Neurochem 74:2528-36. 2000
    ..These results suggest that a catalytically inactive form of DAB(389)TTC may be useful as a nonviral vehicle to deliver exogenous proteins to the cytosolic compartment of neurons...
  2. ncbi request reprint Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNS
    J W Francis
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th St, Room 3125, Charlestown, MA 02129, USA
    Brain Res 1011:7-13. 2004
    ..We conclude that TTC may be a useful vector to enhance neuronal delivery of potentially therapeutic enzymes or trophic factors following direct injection into the brain...