J W Francis
Affiliation: Harvard University
- Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: a potential vector for delivering heterologous proteins to neuronsJ W Francis
Cecil B Day Center for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Neurochem 74:2528-36. 2000..These results suggest that a catalytically inactive form of DAB(389)TTC may be useful as a nonviral vehicle to deliver exogenous proteins to the cytosolic compartment of neurons...
- Tetanus toxin fragment C as a vector to enhance delivery of proteins to the CNSJ W Francis
Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th St, Room 3125, Charlestown, MA 02129, USA
Brain Res 1011:7-13. 2004..We conclude that TTC may be a useful vector to enhance neuronal delivery of potentially therapeutic enzymes or trophic factors following direct injection into the brain...