MARIA FRANCESCHINI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Noninvasive measurement of neuronal activity with near-infrared optical imaging
    Maria Angela Franceschini
    Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 21:372-86. 2004
  2. pmc The effect of different anesthetics on neurovascular coupling
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 51:1367-77. 2010
  3. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
  4. pmc Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging
    Maria Angela Franceschini
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 40:548-60. 2003
  5. pmc Assessment of infant brain development with frequency-domain near-infrared spectroscopy
    Maria Angela Franceschini
    Athinoula A Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Pediatr Res 61:546-51. 2007
  6. pmc Coupling between somatosensory evoked potentials and hemodynamic response in the rat
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street Bldg 149 room 2301, Charlestown, MA 02129, USA
    Neuroimage 41:189-203. 2008
  7. ncbi request reprint Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy
    David A Boas
    Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 23:S275-88. 2004
  8. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
  9. pmc Study of neurovascular coupling by modulating neuronal activity with GABA
    Harsha Radhakrishnan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Brain Res 1372:1-12. 2011
  10. pmc Fast optical signal not detected in awake behaving monkeys
    Harsha Radhakrishnan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
    Neuroimage 45:410-9. 2009

Research Grants

  1. Optical monitoring of cerebral oxygenation in infants
    Maria Angela Franceschini; Fiscal Year: 2010
  2. Optical monitoring of cerebral oxygenation in infants
    MARIA FRANCESCHINI; Fiscal Year: 2009
  3. Non Ivasive Optical Imaging of the Human Brain
    MARIA FRANCESCHINI; Fiscal Year: 2007
  4. Optical monitoring of cerebral oxygenation in infants
    MARIA FRANCESCHINI; Fiscal Year: 2005
  5. NON-INVASIVE OPTICAL IMAGING OF THE HUMAN BRAIN
    MARIA FRANCESCHINI; Fiscal Year: 2002
  6. Noninvasive Optical Imaging of the Human Brain
    Maria Angela Franceschini; Fiscal Year: 2010

Detail Information

Publications24

  1. pmc Noninvasive measurement of neuronal activity with near-infrared optical imaging
    Maria Angela Franceschini
    Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 21:372-86. 2004
    ..The relative changes in intensity associated with the fast signal were approximately 0.07% and the latency of the signal was approximately 100 ms...
  2. pmc The effect of different anesthetics on neurovascular coupling
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 51:1367-77. 2010
    ..Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used...
  3. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
    ....
  4. pmc Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging
    Maria Angela Franceschini
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 40:548-60. 2003
    ..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging...
  5. pmc Assessment of infant brain development with frequency-domain near-infrared spectroscopy
    Maria Angela Franceschini
    Athinoula A Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Pediatr Res 61:546-51. 2007
    ..FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development...
  6. pmc Coupling between somatosensory evoked potentials and hemodynamic response in the rat
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street Bldg 149 room 2301, Charlestown, MA 02129, USA
    Neuroimage 41:189-203. 2008
    ..The N1 and P2 components, and not P1, need to be considered to correctly interpret neurovascular coupling...
  7. ncbi request reprint Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy
    David A Boas
    Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 23:S275-88. 2004
    ....
  8. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
    ..Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs...
  9. pmc Study of neurovascular coupling by modulating neuronal activity with GABA
    Harsha Radhakrishnan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Brain Res 1372:1-12. 2011
    ..These results suggest that the hemodynamic response is predominantly driven by cortico-cortical interactions and not by the initial thalamocortical activity in layer IV...
  10. pmc Fast optical signal not detected in awake behaving monkeys
    Harsha Radhakrishnan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
    Neuroimage 45:410-9. 2009
    ..Based on these negative results, despite the optimal experimental conditions, we doubt the usefulness of non-invasive fast optical signal measurements with NIRS...
  11. pmc Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life
    Nadege Roche-Labarbe
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, 02129, USA
    Hum Brain Mapp 31:341-52. 2010
    ..A stable CBV-CBF relationship may not be valid for premature neonates...
  12. pmc Increased cerebral blood volume and oxygen consumption in neonatal brain injury
    P Ellen Grant
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 29:1704-13. 2009
    ....
  13. ncbi request reprint Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
    Danny K Joseph
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
    Appl Opt 45:8142-51. 2006
    ..Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging...
  14. ncbi request reprint Physiological system identification with the Kalman filter in diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Med Image Comput Comput Assist Interv 8:649-56. 2005
    ..Cardiovascular dynamics also affect the blood oxygen dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This Kalman filter framework for DOT may be adapted for BOLD fMRI analysis and multimodal studies...
  15. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
    ..This state-space approach to DOT analysis could be extended to BOLD fMRI analysis, multimodal studies and real-time analysis...
  16. ncbi request reprint Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters
    Gary Strangman
    Neural Systems Group, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 18:865-79. 2003
    ....
  17. ncbi request reprint Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation
    Juliette Selb
    Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 10:11013. 2005
    ..Finally, we use the time-gated measurements to resolve in depth the brain activation during the motor stimulus...
  18. ncbi request reprint Time-series estimation of biological factors in optical diffusion tomography
    Simon Prince
    Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 113576
    Phys Med Biol 48:1491-504. 2003
    ..It is argued that the application of these time-series techniques improves both the fidelity and temporal resolution of reconstruction in optical tomography...
  19. ncbi request reprint Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy
    Francesco Fabbri
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Brain Res 992:193-204. 2003
    ..These findings provide indications about the cerebral hemodynamic/metabolic mechanisms associated with ECT, and may lead to useful parameters to predict the individual clinical outcome of ECT...
  20. ncbi request reprint Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy
    Valentina Quaresima
    University of L Aquila, Department of Biomedical Sciences and Technologies, 67100 L Aquila, Italy
    J Biomed Opt 9:413-20. 2004
    ..These data confirm that frequency-domain tissue oximeters are noninvasive, powerful tools to investigate the spatial and temporal features of muscle blood flow and oxygenation, with potential applications in areas of pathophysiology...
  21. ncbi request reprint Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging
    Yiheng Zhang
    Northeastern University, Electrical and Computer Engineering Department, Boston, Massachusetts 02115, USA
    J Biomed Opt 10:11014. 2005
    ..By projecting the data onto the orthogonal nullspace of these eigenvectors, we can obtain more localized response, as reflected in improved contrast-to-noise ratio and correlation coefficient maps...
  22. ncbi request reprint Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin
    Joseph P Culver
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 27:947-59. 2005
    ..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms...
  23. pmc Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects
    Maria Angela Franceschini
    Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford, Massachusetts 02155 6013, USA
    J Appl Physiol 92:372-84. 2002
    ..Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline...
  24. ncbi request reprint Characterization of spatial and temporal variations in the optical properties of tissuelike media with diffuse reflectance imaging
    Francesco Fabbri
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    Appl Opt 42:3063-72. 2003
    ..In the case of media with optical properties similar to those of tissue in the near infrared, we found that the changes mu(a)/mu(s)' should occur over a volume approximately 2 mm deep and 4 mm x 4 mm wide to apply this expression...

Research Grants14

  1. Optical monitoring of cerebral oxygenation in infants
    Maria Angela Franceschini; Fiscal Year: 2010
    ....
  2. Optical monitoring of cerebral oxygenation in infants
    MARIA FRANCESCHINI; Fiscal Year: 2009
    ....
  3. Non Ivasive Optical Imaging of the Human Brain
    MARIA FRANCESCHINI; Fiscal Year: 2007
    ..The long-term objective of this project is to apply DOI to the study of normal brain development in infants, and to the diagnosis and follow-up of cerebrovascular diseases and psychiatric syndromes in adults and children. ..
  4. Optical monitoring of cerebral oxygenation in infants
    MARIA FRANCESCHINI; Fiscal Year: 2005
    ..continuous monitoring of cerebral oxygenation in neonates. ..
  5. NON-INVASIVE OPTICAL IMAGING OF THE HUMAN BRAIN
    MARIA FRANCESCHINI; Fiscal Year: 2002
    ..abstract_text> ..
  6. Noninvasive Optical Imaging of the Human Brain
    Maria Angela Franceschini; Fiscal Year: 2010
    ..This knowledge will benefit basic and clinical neuroscience applications of fMRI and DOI. ..