S M Fortune

..The results further suggest that discerning the nature of the interaction and the structure of macromolecular complexes will provide insights into both an alternative mechanism of protein secretion and mycobacterial virulence...

..This method can be readily applied to other organisms at either the single pathway level, as described here, or at the system level to define quantitative genetic interaction networks...

..From these data, we have estimated the rate of MIRU variation in the host environment, providing a benchmark rate for future epidemiologic work...

..Our analysis suggests that the methodologies employed undoubtedly shape the results. It is clear, however, that the question is not which method is better but which provides the data most suited to a given question...

..Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores...

..The implications of these findings should be considered in all models of antigen presentation during M. tuberculosis infection and in vaccine development...

..Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of the secretion system itself...

..tuberculosis without inhibiting production of NO. These results imply that inhibition of macrophage responses to IFN-gamma may contribute to the inability of an apparently effective immune response to eradicate M. tuberculosis...

..The interaction between these two peptidoglycan hydrolases at the septum suggests a role for the complex in cell division, possibly during reactivation...

..tuberculosis genes required for inhibition of IFN-gamma and IL-12 signaling by screening a transposon mutagenized library of M. tuberculosis; and 3) to characterize the genes identified in these screens. ..

..This work will provide a foundation for understanding the role of these proteins in the interaction between M. tuberculosis and the infected host. ..