S M Fortune

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Mutually dependent secretion of proteins required for mycobacterial virulence
    S M Fortune
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:10676-81. 2005
  2. pmc Characterization of mycobacterial virulence genes through genetic interaction mapping
    Swati M Joshi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:11760-5. 2006
  3. pmc The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
    Mark N Ragheb
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    BMC Genomics 14:145. 2013
  4. ncbi request reprint Dividing oceans into pools: strategies for the global analysis of bacterial genes
    Sarah M Fortune
    Division of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Longwood Avenue, Boston, MA 02115, USA
    Microbes Infect 8:1631-6. 2006
  5. pmc Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
    M Sloan Siegrist
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18792-7. 2009
  6. pmc Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10
    Joshua S Woodworth
    Division of Rheumatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 76:4199-205. 2008
  7. doi request reprint Regulation of protein secretion by ... protein secretion?
    Krishnamohan Atmakuri
    Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 4:190-1. 2008
  8. ncbi request reprint Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
    Sarah M Fortune
    Division of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 172:6272-80. 2004
  9. ncbi request reprint A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis
    Erik C Hett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Mol Microbiol 66:658-68. 2007

Research Grants

  1. M tuberculosis evasion of the innate immune response
    Sarah Fortune; Fiscal Year: 2005
  2. PE and PPE Function
    Sarah Fortune; Fiscal Year: 2007

Collaborators

  • JoAnne L Flynn
  • Philana Ling Lin
  • Samuel Behar
  • Joel D Ernst
  • Eric J Rubin
  • Mark N Ragheb
  • M Sloan Siegrist
  • Joshua S Woodworth
  • Krishnamohan Atmakuri
  • Erik C Hett
  • Swati M Joshi
  • Michael R Chase
  • Christopher B Ford
  • Noman Siddiqi
  • Mark Borowsky
  • D Branch Moody
  • Matthew J McConnell
  • Meera Unnikrishnan
  • Tan Yun Cheng
  • Michael C Chao
  • Lynn L Deng
  • Adrie J Steyn
  • Nicole Capite
  • Christopher M Sassetti
  • Amit K Pandey

Detail Information

Publications9

  1. pmc Mutually dependent secretion of proteins required for mycobacterial virulence
    S M Fortune
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:10676-81. 2005
    ..The results further suggest that discerning the nature of the interaction and the structure of macromolecular complexes will provide insights into both an alternative mechanism of protein secretion and mycobacterial virulence...
  2. pmc Characterization of mycobacterial virulence genes through genetic interaction mapping
    Swati M Joshi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:11760-5. 2006
    ..This method can be readily applied to other organisms at either the single pathway level, as described here, or at the system level to define quantitative genetic interaction networks...
  3. pmc The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
    Mark N Ragheb
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    BMC Genomics 14:145. 2013
    ..From these data, we have estimated the rate of MIRU variation in the host environment, providing a benchmark rate for future epidemiologic work...
  4. ncbi request reprint Dividing oceans into pools: strategies for the global analysis of bacterial genes
    Sarah M Fortune
    Division of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Longwood Avenue, Boston, MA 02115, USA
    Microbes Infect 8:1631-6. 2006
    ..Our analysis suggests that the methodologies employed undoubtedly shape the results. It is clear, however, that the question is not which method is better but which provides the data most suited to a given question...
  5. pmc Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
    M Sloan Siegrist
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18792-7. 2009
    ..Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores...
  6. pmc Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10
    Joshua S Woodworth
    Division of Rheumatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 76:4199-205. 2008
    ..The implications of these findings should be considered in all models of antigen presentation during M. tuberculosis infection and in vaccine development...
  7. doi request reprint Regulation of protein secretion by ... protein secretion?
    Krishnamohan Atmakuri
    Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 4:190-1. 2008
    ..Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of the secretion system itself...
  8. ncbi request reprint Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
    Sarah M Fortune
    Division of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 172:6272-80. 2004
    ..tuberculosis without inhibiting production of NO. These results imply that inhibition of macrophage responses to IFN-gamma may contribute to the inability of an apparently effective immune response to eradicate M. tuberculosis...
  9. ncbi request reprint A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis
    Erik C Hett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Mol Microbiol 66:658-68. 2007
    ..The interaction between these two peptidoglycan hydrolases at the septum suggests a role for the complex in cell division, possibly during reactivation...

Research Grants3

  1. M tuberculosis evasion of the innate immune response
    Sarah Fortune; Fiscal Year: 2005
    ..tuberculosis genes required for inhibition of IFN-gamma and IL-12 signaling by screening a transposon mutagenized library of M. tuberculosis; and 3) to characterize the genes identified in these screens. ..
  2. PE and PPE Function
    Sarah Fortune; Fiscal Year: 2007
    ..This work will provide a foundation for understanding the role of these proteins in the interaction between M. tuberculosis and the infected host. ..