S M Fortune

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Mutually dependent secretion of proteins required for mycobacterial virulence
    S M Fortune
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:10676-81. 2005
  2. pmc Characterization of mycobacterial virulence genes through genetic interaction mapping
    Swati M Joshi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:11760-5. 2006
  3. pmc DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis
    Scarlet S Shell
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Pathog 9:e1003419. 2013
  4. pmc Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis
    Christopher B Ford
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Nat Genet 45:784-90. 2013
  5. pmc Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
    Christopher B Ford
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 43:482-6. 2011
  6. pmc EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity
    Alejandra Garces
    Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000957. 2010
  7. pmc The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
    Mark N Ragheb
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    BMC Genomics 14:145. 2013
  8. ncbi request reprint Dividing oceans into pools: strategies for the global analysis of bacterial genes
    Sarah M Fortune
    Division of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Longwood Avenue, Boston, MA 02115, USA
    Microbes Infect 8:1631-6. 2006
  9. pmc Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
    M Sloan Siegrist
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18792-7. 2009
  10. doi request reprint Regulation of protein secretion by ... protein secretion?
    Krishnamohan Atmakuri
    Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 4:190-1. 2008

Research Grants

  1. M tuberculosis evasion of the innate immune response
    Sarah Fortune; Fiscal Year: 2005
  2. PE and PPE Function
    Sarah Fortune; Fiscal Year: 2007

Collaborators

  • JoAnne L Flynn
  • Philana Ling Lin
  • Joel D Ernst
  • Samuel Behar
  • Christopher B Ford
  • Rupal R Shah
  • Michael R Chase
  • Joshua S Woodworth
  • Krishnamohan Atmakuri
  • Eric J Rubin
  • Mark N Ragheb
  • Scarlet S Shell
  • Marc Lipsitch
  • Alejandra Garces
  • Christopher M Sassetti
  • M Sloan Siegrist
  • Erik C Hett
  • Swati M Joshi
  • Sebastien Gagneux
  • Seung Hun Baek
  • Peter C Dedon
  • James C Johnston
  • Megan B Murray
  • Midori Kato Maeda
  • Erin G Prestwich
  • Ted Cohen
  • Jennifer Gardy
  • James Galagan
  • James C Sacchettini
  • Oleg Iartchouk
  • Nilofar Mohaideen
  • Thomas R Ioerger
  • David A Sarracino
  • Alissa C Rothchild
  • Mary F Lopez
  • Bryan Krastins
  • Talia L Ramsdell
  • Matthew J McConnell
  • Noman Siddiqi
  • Mark Borowsky
  • D Branch Moody
  • Meera Unnikrishnan
  • Tan Yun Cheng
  • Adrie J Steyn
  • Lynn L Deng
  • Michael C Chao
  • Amit K Pandey
  • Nicole Capite

Detail Information

Publications13

  1. pmc Mutually dependent secretion of proteins required for mycobacterial virulence
    S M Fortune
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:10676-81. 2005
    ..The results further suggest that discerning the nature of the interaction and the structure of macromolecular complexes will provide insights into both an alternative mechanism of protein secretion and mycobacterial virulence...
  2. pmc Characterization of mycobacterial virulence genes through genetic interaction mapping
    Swati M Joshi
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 103:11760-5. 2006
    ..This method can be readily applied to other organisms at either the single pathway level, as described here, or at the system level to define quantitative genetic interaction networks...
  3. pmc DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis
    Scarlet S Shell
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Pathog 9:e1003419. 2013
    ..Our results indicate that MamA influences gene expression in M. tuberculosis and plays an important but strain-specific role in fitness during hypoxia...
  4. pmc Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant tuberculosis
    Christopher B Ford
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    Nat Genet 45:784-90. 2013
    ..These data suggest that interventions to prevent the emergence of drug-resistant tuberculosis should target bacterial as well as treatment-related risk factors. ..
  5. pmc Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
    Christopher B Ford
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 43:482-6. 2011
    ..We show that Mtb continues to acquire mutations during disease latency, which may explain why isoniazid monotherapy for latent tuberculosis is a risk factor for the emergence of isoniazid resistance...
  6. pmc EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity
    Alejandra Garces
    Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, Massachusetts, United States of America
    PLoS Pathog 6:e1000957. 2010
    ..We propose that ESX1 and EspA play central roles in the virulence of Mtb in vivo because they alter the integrity of the mycobacterial cell wall...
  7. pmc The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
    Mark N Ragheb
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    BMC Genomics 14:145. 2013
    ..From these data, we have estimated the rate of MIRU variation in the host environment, providing a benchmark rate for future epidemiologic work...
  8. ncbi request reprint Dividing oceans into pools: strategies for the global analysis of bacterial genes
    Sarah M Fortune
    Division of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Longwood Avenue, Boston, MA 02115, USA
    Microbes Infect 8:1631-6. 2006
    ..Our analysis suggests that the methodologies employed undoubtedly shape the results. It is clear, however, that the question is not which method is better but which provides the data most suited to a given question...
  9. pmc Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
    M Sloan Siegrist
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18792-7. 2009
    ..Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores...
  10. doi request reprint Regulation of protein secretion by ... protein secretion?
    Krishnamohan Atmakuri
    Harvard School of Public Health, Boston, MA 02115, USA
    Cell Host Microbe 4:190-1. 2008
    ..Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of the secretion system itself...
  11. pmc Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10
    Joshua S Woodworth
    Division of Rheumatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 76:4199-205. 2008
    ..The implications of these findings should be considered in all models of antigen presentation during M. tuberculosis infection and in vaccine development...
  12. ncbi request reprint A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis
    Erik C Hett
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Mol Microbiol 66:658-68. 2007
    ..The interaction between these two peptidoglycan hydrolases at the septum suggests a role for the complex in cell division, possibly during reactivation...
  13. ncbi request reprint Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
    Sarah M Fortune
    Division of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 172:6272-80. 2004
    ..tuberculosis without inhibiting production of NO. These results imply that inhibition of macrophage responses to IFN-gamma may contribute to the inability of an apparently effective immune response to eradicate M. tuberculosis...

Research Grants3

  1. M tuberculosis evasion of the innate immune response
    Sarah Fortune; Fiscal Year: 2005
    ..tuberculosis genes required for inhibition of IFN-gamma and IL-12 signaling by screening a transposon mutagenized library of M. tuberculosis; and 3) to characterize the genes identified in these screens. ..
  2. PE and PPE Function
    Sarah Fortune; Fiscal Year: 2007
    ..This work will provide a foundation for understanding the role of these proteins in the interaction between M. tuberculosis and the infected host. ..