A C Forster

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid
    A C Forster
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Anal Biochem 297:60-70. 2001
  2. pmc Programming peptidomimetic syntheses by translating genetic codes designed de novo
    Anthony C Forster
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6353-7. 2003
  3. ncbi request reprint Pure translation display
    Anthony C Forster
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Anal Biochem 333:358-64. 2004
  4. ncbi request reprint De novo genetic codes and pure translation display
    Zhongping Tan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Methods 36:279-90. 2005
  5. ncbi request reprint Amino acid backbone specificity of the Escherichia coli translation machinery
    Zhongping Tan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    J Am Chem Soc 126:12752-3. 2004
  6. pmc Towards synthesis of a minimal cell
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Syst Biol 2:45. 2006
  7. pmc Specificity of translation for N-alkyl amino acids
    Baolin Zhang
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Avenue, Nashville, Tennessee 37232, USA
    J Am Chem Soc 129:11316-7. 2007

Research Grants

  1. DRUG DISCOVERY BY MIRROR IMAGE LIGAND DISPLAY
    ANTHONY FORSTER; Fiscal Year: 2003
  2. Directed evolution of inhibitors of anthrax toxin
    ANTHONY FORSTER; Fiscal Year: 2007

Collaborators

  • Zhongping Tan
  • Virginia W Cornish
  • Baolin Zhang
  • Stephen C Blacklow
  • Lucas Gartenmann Dickson
  • Madhavi N L Nalam

Detail Information

Publications7

  1. ncbi request reprint A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid
    A C Forster
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
    Anal Biochem 297:60-70. 2001
    ..The recombinant clones can be exploited to prepare initiation factors and initiation complexes for structural studies, to study initiation and elongation in ribosomal peptide synthesis, and to screen for eubacterial-specific drugs...
  2. pmc Programming peptidomimetic syntheses by translating genetic codes designed de novo
    Anthony C Forster
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6353-7. 2003
    ..Genetic programming of peptidomimetic synthesis should facilitate mechanistic studies of translation and may ultimately enable the directed evolution of small molecules with desirable catalytic or pharmacological properties...
  3. ncbi request reprint Pure translation display
    Anthony C Forster
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Anal Biochem 333:358-64. 2004
    ..Pure translation display should enable the directed evolution of peptide analogs with desirable catalytic or pharmacological properties...
  4. ncbi request reprint De novo genetic codes and pure translation display
    Zhongping Tan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    Methods 36:279-90. 2005
    ..Toward this goal, we have demonstrated the display of polypeptides on their mRNAs in a purified translation system, termed "pure translation display."..
  5. ncbi request reprint Amino acid backbone specificity of the Escherichia coli translation machinery
    Zhongping Tan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA
    J Am Chem Soc 126:12752-3. 2004
    ..They further support the substrate plasticity of the ribosomal biosynthetic machinery and provide immediate candidates for ribosomally encoded polymer synthesis...
  6. pmc Towards synthesis of a minimal cell
    Anthony C Forster
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mol Syst Biol 2:45. 2006
    ..Our proposed minimal genome is 113 kbp long and contains 151 genes. We detail building blocks already in place and major hurdles to overcome for completion...
  7. pmc Specificity of translation for N-alkyl amino acids
    Baolin Zhang
    Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, 2222 Pierce Avenue, Nashville, Tennessee 37232, USA
    J Am Chem Soc 129:11316-7. 2007

Research Grants2

  1. DRUG DISCOVERY BY MIRROR IMAGE LIGAND DISPLAY
    ANTHONY FORSTER; Fiscal Year: 2003
    ..3. To apply this strategy for drug discovery to other potential therapeutic targets, including the gp41 subunit of the HIV envelope glycoprotein and the breast-cancer specific, cell- surface glycoprotein MUC1. ..
  2. Directed evolution of inhibitors of anthrax toxin
    ANTHONY FORSTER; Fiscal Year: 2007
    ..Furthermore, the technology developed will have potential utility in diagnosis, target validation and treatment of any disease. ..