Genomes and Genes
Affiliation: Harvard Medical School
- Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatmentAnne L Fletcher
Immune Regeneration Laboratory, Monash University, Clayton, Australia
J Immunol 183:823-31. 2009..Together, these data show that Aire(+) mTECs are highly sensitive to damage and that mTEC regeneration follows a conserved pattern regardless of the treatment regimen used...
- Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunityAdrian Liston
John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
J Exp Med 200:1015-26. 2004....
- Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodesVeronika Lukacs-Kornek
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Nat Immunol 12:1096-104. 2011..Notably, in vivo expression of NOS2 by FRCs and LECs regulated the size of the activated T cell pool. Our study elucidates an as-yet-unrecognized role for the lymph node stromal niche in controlling T cell responses...
- Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responsesMaliha A Alikhan
Monash Immunology and Stem Cell Laboratories MISCL, Monash University, Melbourne, Australia
Am J Pathol 179:1243-56. 2011..Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury...
- Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humansHuijuan Lv
Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Clin Invest 121:1561-73. 2011..These results thus support a role for T cell-specific therapies for myocarditis...
- Lymph node stroma broaden the peripheral tolerance paradigmAnne L Fletcher
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, USA
Trends Immunol 32:12-8. 2011..These findings, we suggest, necessitate a broadening of peripheral tolerance theory to include steady-state presentation of clinically relevant PTA to naïve CD8 T cells by lymph node-resident stroma...
- Intronic miR-211 assumes the tumor suppressive function of its host gene in melanomaCarmit Levy
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 40:841-9. 2010..These data implicate miR-211 as a suppressor of melanoma invasion whose expression is silenced or selected against via suppression of the entire melastatin locus during human melanoma progression...
- Aire controls mesenchymal stem cell-mediated suppression in chronic colitisBiju Parekkadan
Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, USA
Mol Ther 20:178-86. 2012..We propose that Aire represents an early molecular switch imposing a suppressive MSC phenotype via regulation of Eta-1. Monitoring Aire expression in MSCs may thus be a critical parameter for clinical use...
- Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditionsAnne L Fletcher
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Exp Med 207:689-97. 2010..Collectively, these data show that diverse stromal cell types have evolved to constitutively express PTAs, and that exposure to viral products alters the interaction between T cells and LNSCs...
- AIRE in the thymus and beyondJames M Gardner
Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143 0540, USA
Curr Opin Immunol 21:582-9. 2009..The detection of both Aire and TSA expression by cell populations outside of the thymus raises the possibility that such expression may play a relevant role in the maintenance of self-tolerance...
- Localization of Idd11 is not associated with thymus and nkt cell abnormalities in NOD miceThomas C Brodnicki
Genetics and Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050 Australia
Diabetes 54:3453-7. 2005....
- The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organsShannon J Turley
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nat Rev Immunol 10:813-25. 2010..Recent studies have shown that SLO-resident stromal cells also have a crucial role in tolerance induction in the periphery. In this Review, we discuss the roles of SLO-resident DCs and stromal cells in shaping T cell responses...
- Reduced thymic Aire expression and abnormal NF-kappa B2 signaling in a model of systemic autoimmunityAnne L Fletcher
Immune Regeneration Laboratory, Monash University, Clayton, Victoria, Australia
J Immunol 182:2690-9. 2009....
- The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cellsNatalie Seach
Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
J Immunol 180:5384-92. 2008..Thus, we propose a broader role for LTalpha1beta2-LTbetaR signaling in the maintenance of the thymic microenvironments, specifically by regulating TRA and chemokine expression in mTEC(low) for efficient induction of central tolerance...
- The contribution of thymic stromal abnormalities to autoimmune diseaseAnne L Fletcher
Monash Immunology and Stem Cell Laboratories, Monash University, Melbourne, Australia
Crit Rev Immunol 31:171-87. 2011..Paradoxically, immunodeficiency and age-related immunosenescence are also linked with increased autoimmunity. Here we discuss the theoretical basis and the evidence gathered thus far to support these associations...
- Unbiased analysis, enrichment and purification of thymic stromal cellsDaniel H D Gray
Monash Immunology and Stem Cell Laboratories, Level 3, STRIP, Building 75, Monash University, Wellington Road, Clayton, Victoria, 3800, Australia
J Immunol Methods 329:56-66. 2008..This three-step procedure represents a rapid, reproducible method for the unbiased purification of the stromal cells that direct thymic T-cell differentiation...