M C Fishman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Fashioning the vertebrate heart: earliest embryonic decisions
    M C Fishman
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 124:2099-117. 1997
  2. ncbi request reprint gridlock, an HLH gene required for assembly of the aorta in zebrafish
    T P Zhong
    Cardiovascular Research Center, Massachusetts General Hospital Harvard Medical School, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA
    Science 287:1820-4. 2000
  3. ncbi request reprint Vessel patterning in the embryo of the zebrafish: guidance by notochord
    B Fouquet
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Dev Biol 183:37-48. 1997
  4. ncbi request reprint Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation
    J N Chen
    Cardiovascular Research Center, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Development 122:3809-16. 1996
  5. ncbi request reprint Gridlock signalling pathway fashions the first embryonic artery
    T P Zhong
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Nature 414:216-20. 2001
  6. ncbi request reprint Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    Z Huang
    Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129
    Science 265:1883-5. 1994
  7. ncbi request reprint Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
    J N Chen
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 124:4373-82. 1997
  8. ncbi request reprint A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms
    E W Knapik
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:451-60. 1996
  9. ncbi request reprint Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activity
    U Mende
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Neurosci Res 54:263-72. 1998
  10. ncbi request reprint Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
    I A Drummond
    Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
    Development 125:4655-67. 1998

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Fashioning the vertebrate heart: earliest embryonic decisions
    M C Fishman
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 124:2099-117. 1997
    ..Genetic analyses in mouse and zebrafish may provide one entrance to these pathways...
  2. ncbi request reprint gridlock, an HLH gene required for assembly of the aorta in zebrafish
    T P Zhong
    Cardiovascular Research Center, Massachusetts General Hospital Harvard Medical School, 149 13th Street, 4th Floor, Charlestown, MA 02129, USA
    Science 287:1820-4. 2000
    ..These results suggest that the arterial endothelial identity is established even before the onset of blood flow and implicate the grl gene in assignment of vessel-specific cell fate...
  3. ncbi request reprint Vessel patterning in the embryo of the zebrafish: guidance by notochord
    B Fouquet
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Dev Biol 183:37-48. 1997
    ..This suggests that signals from the notochord may guide angioblasts in the fashioning of the dorsal aorta. The notochord seems to be less important for the formation of the vein...
  4. ncbi request reprint Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation
    J N Chen
    Cardiovascular Research Center, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Development 122:3809-16. 1996
    ..5 is likely to be but one step in the determination of cardiac myocyte cell fate. Its overexpression increases heart size, perhaps by bringing cells on the edge of the field to a threshold level for initiation of cardiac differentiation...
  5. ncbi request reprint Gridlock signalling pathway fashions the first embryonic artery
    T P Zhong
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown 02129, USA
    Nature 414:216-20. 2001
    ..Thus, a notch-grl pathway controls assembly of the first embryonic artery, apparently by adjudicating an arterial versus venous cell fate decision...
  6. ncbi request reprint Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase
    Z Huang
    Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129
    Science 265:1883-5. 1994
    ..Hence, neuronal NO production appears to exacerbate acute ischemic injury, whereas vascular NO protects after middle cerebral artery occlusion. The data emphasize the importance of developing selective inhibitors of the neuronal isoform...
  7. ncbi request reprint Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
    J N Chen
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 124:4373-82. 1997
    ..Thus, the pattern of cardiac BMP4 appears to be in the pathway by which the heart interprets lateralizing signals from the midline...
  8. ncbi request reprint A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms
    E W Knapik
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:451-60. 1996
    ....
  9. ncbi request reprint Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activity
    U Mende
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Neurosci Res 54:263-72. 1998
    ..We propose that alpha(o) and its associated betagamma are sequestered in a distinct pool of membranes that does not contribute to the regulation of adenylyl cyclase...
  10. ncbi request reprint Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function
    I A Drummond
    Renal Unit, Massachusetts General Hospital, Charlestown MA 02129, USA
    Development 125:4655-67. 1998
    ..These studies reveal the similarity of normal pronephric development to kidney organogenesis in all vertebrates and allow for a genetic dissection of genes needed to establish the earliest renal function...
  11. ncbi request reprint Zebrafish: the complete cardiovascular compendium
    C A Macrae
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cold Spring Harb Symp Quant Biol 67:301-7. 2002
  12. ncbi request reprint Targeted disruption of the neuronal nitric oxide synthase gene
    P L Huang
    Cardiovascular Research Center, Massachusetts General Hospital, Boston 02129
    Cell 75:1273-86. 1993
    ..This phenotype resembles the human disorder infantile pyloric stenosis, in which gastric outlet obstruction is associated with the lack of NDP neurons in the pylorus...
  13. ncbi request reprint A novel transmembrane semaphorin can bind c-src
    F Eckhardt
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129, USA
    Mol Cell Neurosci 9:409-19. 1997
    ....
  14. pmc Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission
    H Mashimo
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, 02114, USA
    J Clin Invest 98:8-13. 1996
    ....
  15. ncbi request reprint Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression
    E H Lo
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    Stroke 27:1381-5. 1996
    ....
  16. ncbi request reprint Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling
    J Chan
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Dev Biol 234:470-82. 2001
    ..Our observations suggest Eph/ephrin B signaling plays an essential role in regulating cell movements during gastrulation...
  17. ncbi request reprint Mutations affecting development of zebrafish digestive organs
    M Pack
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:321-8. 1996
    ..These gastrointestinal mutations may be informative with regard to patterning and crucial lineage decisions during organogenesis, and may be relevant to diabetes, congenital dysmorphogenesis and disorders of cell proliferation...
  18. ncbi request reprint Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul
    R T Peterson
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 11:1481-91. 2001
    ..What guides this transformation to organotypic form is not known...
  19. ncbi request reprint Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit
    W Rottbauer
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dev Cell 1:265-75. 2001
    ..Thus, calcium signaling via C-LTCC can regulate heart growth independently of contraction, and plays distinctive roles in fashioning both form and function of the two developing chambers...
  20. pmc Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury
    R M Friedlander
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    J Exp Med 185:933-40. 1997
    ..Our data suggest that genetic manipulation using ICE family dominant negative inhibitors can ameliorate the extent of ischemia-induced brain injury and preserve neurological function...
  21. ncbi request reprint A microsatellite genetic linkage map for zebrafish (Danio rerio)
    E W Knapik
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Nat Genet 18:338-43. 1998
    ..These markers will provide an initial infrastructure for the positional cloning of the nearly 600 zebrafish genes identified as crucial to vertebrate development,and will become the anchor for the physical map of the zebrafish genome...
  22. pmc Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene
    F C Serluca
    Cardiovascular Research Center and Developmental Biology Laboratory, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02119, USA
    Genome Res 11:1625-31. 2001
    ..The duplications are accompanied by acquisition of clear functional specialization, consistent with the DDC model of genome evolution...
  23. ncbi request reprint Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression
    H Mashimo
    Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114, USA
    Biochem Biophys Res Commun 210:31-7. 1995
    ....
  24. ncbi request reprint Semaphorin III is needed for normal patterning and growth of nerves, bones and heart
    O Behar
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129, USA
    Nature 383:525-8. 1996
    ..Thus, semaphorin III might serve as a signal that restrains growth in several developing organs...
  25. ncbi request reprint Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
    D Y Stainier
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:285-92. 1996
    ..The mutations identified in this screen point to discrete and critical steps in the formation and function of the heart and vasculature...
  26. ncbi request reprint Regional cerebral blood flow response to vibrissal stimulation in mice lacking type I NOS gene expression
    J Ma
    Neurosurgical Services and Neurology Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Physiol 270:H1085-90. 1996
    ....
  27. ncbi request reprint Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice
    J B Schulz
    Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital, Boston, 02114, USA
    J Neurochem 67:430-3. 1996
    ..These findings show that NO. produced by nNOS results in generation of peroxynitrite, which plays a role in malonate neurotoxicity...
  28. ncbi request reprint L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice
    J Ma
    Department of Neurosurgery and Neurology, Massachusetts General Hospital, Charlestown, USA
    Am J Physiol 271:H1717-9. 1996
    ..L-NNA superfusion (1 mM) inhibited this increase by approximately 60% in both strains. Hence, synthesis of NO by the constitutively expressed type I NOS contributes to blood flow augmentation during hypercapnia...
  29. pmc G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart
    D Valenzuela
    Laboratory of Developmental Biology and Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Proc Natl Acad Sci U S A 94:1727-32. 1997
    ..Other cardiac G alpha subunits cannot substitute...
  30. ncbi request reprint Hematopoietic mutations in the zebrafish
    B M Weinstein
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Development 123:303-9. 1996
    ..Some cause defects in precursor generation, others defects in differentiation, and others an increase in cellular photosensitivity...
  31. ncbi request reprint Hypertension in mice lacking the gene for endothelial nitric oxide synthase
    P L Huang
    Cardiovascular Research Center, Medical Services, Massachusetts General Hospital, Boston 02129, USA
    Nature 377:239-42. 1995
    ..Thus eNOS mediates basal vasodilation. Responses to NOS blockade in the mutant mice suggest that non-endothelial isoforms of NOS may be involved in maintaining blood pressure...
  32. ncbi request reprint MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice
    R T Matthews
    Neurochemistry Laboratory, Massachusetts General Hospital, Boston, USA
    Neurobiol Dis 4:114-21. 1997
    ..These results provide further evidence that neuronally derived NO and peroxynitrite play a role in MPP+ neurotoxicity...
  33. ncbi request reprint Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    W Steudel
    Department of Anaesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Circ Res 81:34-41. 1997
    ..We conclude that NOS 3 is a key enzyme responsible for providing basal pulmonary NO release. Congenital NOS 3 deficiency produces mild pulmonary hypertension in mice...
  34. ncbi request reprint Gridlock, a localized heritable vascular patterning defect in the zebrafish
    B M Weinstein
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129, USA
    Nat Med 1:1143-7. 1995
    ..The grl defect resembles coarctation of the aorta, a human congenital cardiovascular malformation of unknown aetiology, in the location of the lesion and its consequences and in the mutants' dependence on collateral vessels for survival...
  35. ncbi request reprint Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
    H Mashimo
    Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Jackson 7, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Science 274:262-5. 1996
    ..ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa...
  36. ncbi request reprint The slow mo mutation reduces pacemaker current and heart rate in adult zebrafish
    K S Warren
    Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Physiol Heart Circ Physiol 281:H1711-9. 2001
    ..It is clear that zebrafish may be used for genetic dissection of selected physiological mechanisms in the adult...
  37. ncbi request reprint Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria
    S Childs
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown 02129, USA
    Curr Biol 10:1001-4. 2000
    ..The mutant phenotype, which shows light-dependent hemolysis and liver disease, is similar to that seen in humans with erythropoietic protoporphyria, a disorder of ferrochelatase...
  38. ncbi request reprint Zebrafish genetic map with 2000 microsatellite markers
    N Shimoda
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Genomics 58:219-32. 1999
    ..2-cM average resolution. One centimorgan in zebrafish is about 0. 74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks...
  39. ncbi request reprint Pre-pattern in the pronephric kidney field of zebrafish
    F C Serluca
    Cardiovascular Research Center and Developmental Biology Laboratory, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02129, USA
    Development 128:2233-41. 2001
    ..1 and sim1, but not wt1. Thus, there is a field for the pronephric kidney with classical attributes of defined border, pre-pattern and regulation. The pattern of the fate map reflects particular combinations of transcription factors...
  40. ncbi request reprint Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase
    H Son
    Howard Hughes Medical Institute and Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 87:1015-23. 1996
    ..They further suggest that there is also a NOS-independent component of LTP in stratum radiatum and that LTP in stratum oriens is largely NOS independent...
  41. pmc Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes
    M Park
    Department of Biology, University of Michigan, 830 N University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 95:9366-71. 1998
    ....
  42. ncbi request reprint Cyclooxygenase-2 mediates increased renal renin content induced by low-sodium diet
    P Harding
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202, USA
    Hypertension 29:297-302. 1997
    ..Thus, increased renal renin content in response to dietary sodium restriction appears to require the induction of cyclooxygenase-2, while neuronal nitric oxide synthase appears to affect basal but not stimulated renal renin content...
  43. pmc Calcium extrusion is critical for cardiac morphogenesis and rhythm in embryonic zebrafish hearts
    A M Ebert
    Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
    Proc Natl Acad Sci U S A 102:17705-10. 2005
    ..Thus, the inhibition of NCX1h versus SERCA2 activity differentially affects the pathophysiology of rhythm in the developing heart and suggests that relative levels of NCX1 and SERCA2 function are essential for normal development...
  44. ncbi request reprint Renal abnormalities in mutant mice
    C Carpenter
    Nature 380:292. 1996