B Fischl

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc FreeSurfer
    Bruce Fischl
    Athinoula A Martinos Center, Dept of Radiology, MGH, Harvard Medical School, MA USA
    Neuroimage 62:774-81. 2012
  2. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
  3. pmc Predicting the location of entorhinal cortex from MRI
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 47:8-17. 2009
  4. ncbi request reprint Sequence-independent segmentation of magnetic resonance images
    Bruce Fischl
    Department of Radiology, MGH, Athinoula A Martinos Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 23:S69-84. 2004
  5. ncbi request reprint Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex
    B Fischl
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    IEEE Trans Med Imaging 20:70-80. 2001
  6. pmc Phase maps reveal cortical architecture
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 104:11513-4. 2007
  7. pmc Cortical folding patterns and predicting cytoarchitecture
    Bruce Fischl
    Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 18:1973-80. 2008
  8. ncbi request reprint Age-related changes in prefrontal white matter measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
    Ann N Y Acad Sci 1064:37-49. 2005
  9. pmc Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129 2060, USA
    Neuroimage 54:1795-802. 2011
  10. ncbi request reprint Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
    H D Rosas
    Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:745-7. 2005

Detail Information

Publications89

  1. pmc FreeSurfer
    Bruce Fischl
    Athinoula A Martinos Center, Dept of Radiology, MGH, Harvard Medical School, MA USA
    Neuroimage 62:774-81. 2012
    ..It is freely available, runs on a wide variety of hardware and software platforms, and is open source...
  2. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  3. pmc Predicting the location of entorhinal cortex from MRI
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 47:8-17. 2009
    ....
  4. ncbi request reprint Sequence-independent segmentation of magnetic resonance images
    Bruce Fischl
    Department of Radiology, MGH, Athinoula A Martinos Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 23:S69-84. 2004
    ..This sequence has the added benefit of allowing the explicit estimation of T2* and of reducing test-retest intensity variability...
  5. ncbi request reprint Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex
    B Fischl
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    IEEE Trans Med Imaging 20:70-80. 2001
    ....
  6. pmc Phase maps reveal cortical architecture
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 104:11513-4. 2007
  7. pmc Cortical folding patterns and predicting cytoarchitecture
    Bruce Fischl
    Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 18:1973-80. 2008
    ..These results further highlight the significance of cortical folding patterns and suggest a common mechanism for the development of the folds and the cytoarchitectonic fields...
  8. ncbi request reprint Age-related changes in prefrontal white matter measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
    Ann N Y Acad Sci 1064:37-49. 2005
    ..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures...
  9. pmc Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129 2060, USA
    Neuroimage 54:1795-802. 2011
    ..Such changes are associated with traditional imaging metrics of degeneration and may provide a unique biomarker of the tissue loss that occurs as a result of AD...
  10. ncbi request reprint Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
    H D Rosas
    Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:745-7. 2005
    ..They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD...
  11. ncbi request reprint Neuroimaging H.M.: a 10-year follow-up examination
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Hippocampus 16:936-45. 2006
    ..Most of these alterations were not apparent in his prior scans, suggesting that they are of recent origin. Advanced age and hypertension likely contributed to these new findings...
  12. ncbi request reprint Cortical mechanisms specific to explicit visual object recognition
    M Bar
    Massachusetts General Hospital, NMR Center, Charlestown, MA 02129, USA
    Neuron 29:529-35. 2001
    ..The results presented here provide new insights into the processes underlying explicit object recognition, as well as the analysis that takes place immediately before and after recognition is possible...
  13. ncbi request reprint Atlas renormalization for improved brain MR image segmentation across scanner platforms
    Xiao Han
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 26:479-86. 2007
    ....
  14. pmc Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease
    Rahul S Desikan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Brain 132:2048-57. 2009
    ....
  15. pmc Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA
    Med Image Comput Comput Assist Interv 11:235-43. 2008
    ..We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals...
  16. ncbi request reprint Cortical surface-based analysis. I. Segmentation and surface reconstruction
    A M Dale
    Massachusetts General Hosp Harvard Medical School, Building 149, Charlestown, Massachusetts, 02129, USA
    Neuroimage 9:179-94. 1999
    ..Automated routines for unfolding and flattening the cortical surface are described in a companion paper. These procedures allow for the routine use of cortical surface-based analysis and visualization methods in functional brain imaging...
  17. pmc Local and global attention are mapped retinotopically in human occipital cortex
    Y Sasaki
    NMR Center, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 98:2077-82. 2001
    ..Instead, local attention and global attention appear to be special cases of visual spatial attention, which are mapped consistently with the maps of retinotopy and spatial frequency tuning, in multiple visual cortical areas...
  18. pmc Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast
    D H Salat
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 48:21-8. 2009
    ..These results demonstrate that there are strong regional changes in neural tissue properties with aging and tissue intensity measures may serve as an important biomarker of degeneration...
  19. ncbi request reprint Cerebral cortex thickness in 15-year-old adolescents with low birth weight measured by an automated MRI-based method
    M Martinussen
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Brain 128:2588-96. 2005
    ....
  20. ncbi request reprint Age-related alterations in white matter microstructure measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 26:1215-27. 2005
    ..These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration...
  21. ncbi request reprint Regional and progressive thinning of the cortical ribbon in Huntington's disease
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
    Neurology 58:695-701. 2002
    ....
  22. pmc Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 39:10-8. 2008
    ....
  23. pmc White matter pathology isolates the hippocampal formation in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
    Neurobiol Aging 31:244-56. 2010
    ..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways...
  24. ncbi request reprint Geometry driven volumetric registration
    Gheorghe Postelnicu
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Inf Process Med Imaging 20:675-86. 2007
    ..The result is a volumetric warp that aligns the folding patterns...
  25. ncbi request reprint Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 37:599-610. 2007
    ..Moreover, they suggest that anterior cingulate white matter abnormalities contribute to slower performance of volitional saccades and to inter-individual variability of saccadic latency in chronic, medicated schizophrenia...
  26. ncbi request reprint A role for the human dorsal anterior cingulate cortex in fear expression
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 62:1191-4. 2007
    ..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)...
  27. pmc Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults
    Elizabeth C Leritz
    Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, MA 02130, USA
    Neuroimage 54:2659-71. 2011
    ....
  28. ncbi request reprint Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccade
    Dara S Manoach
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Neurosci 27:1791-8. 2007
    ..More generally, these results highlight the importance of trial history as a source of variability in both behavioral and neuroimaging studies...
  29. pmc Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity
    H Diana Rosas
    Center for Neuro imaging of Aging and Neurodegenerative Diseases, 149 13th Street Room 2275, Charlestown, MA 02129, USA
    Brain 131:1057-68. 2008
    ....
  30. pmc Laminar analysis of 7T BOLD using an imposed spatial activation pattern in human V1
    Jonathan R Polimeni
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 52:1334-46. 2010
    ....
  31. pmc The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
    ....
  32. pmc Improved tractography alignment using combined volumetric and surface registration
    Lilla Zollei
    Martinos Center for Biomedical Imaging, MGH, Boston, MA, USA
    Neuroimage 51:206-13. 2010
    ..Together these results imply a clear advantage to aligning anatomy as opposed to lower resolution DWI data even when the final goal is diffusion analysis...
  33. pmc Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 49:2995-3004. 2010
    ..Our findings provide evidence for early degeneration of commissural pyramidal neurons in the neocortex, loss of cortico-cortical connectivity, and functional compromise of associative cortical processing...
  34. pmc Automated MRI measures predict progression to Alzheimer's disease
    Rahul S Desikan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurobiol Aging 31:1364-74. 2010
    ....
  35. pmc Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI
    Koen Van Leemput
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hippocampus 19:549-57. 2009
    ..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies...
  36. pmc Target-specific contrast agents for magnetic resonance microscopy
    Megan L Blackwell
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129
    Neuroimage 46:382-93. 2009
    ..Our results suggest target-specific contrast agents will enable more detailed MR images with applications in imaging pathological ex vivo samples and constructing better MR atlases from ex vivo brains...
  37. pmc Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype
    Ciprian Catana
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Nucl Med 51:1431-8. 2010
    ....
  38. pmc Combined volumetric and surface registration
    Gheorghe Postelnicu
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02176 USA
    IEEE Trans Med Imaging 28:508-22. 2009
    ..The result is a combined surface and volume morph (CVS) that accurately registers both cortical and subcortical regions, establishing a single coordinate system suitable for the entire brain...
  39. pmc Regional white matter volume differences in nondemented aging and Alzheimer's disease
    David H Salat
    Department of Radiology, Massachusetts General Hospital, Boston MA, USA
    Neuroimage 44:1247-58. 2009
    ..Overall, these results demonstrate the utility of automated regional WM measures in revealing the distinct patterns of age and AD associated volume loss that may contribute to cognitive decline...
  40. pmc Selective disruption of the cerebral neocortex in Alzheimer's disease
    Rahul S Desikan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 5:e12853. 2010
    ..However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown...
  41. pmc Accurate and robust brain image alignment using boundary-based registration
    Douglas N Greve
    Martinos Center for Biomedical Imaging, 143 13th Street, Charlestown, MA, USA
    Neuroimage 48:63-72. 2009
    ..Even in the limit of registering a single slice, we show the BBR results to be robust and accurate...
  42. pmc Brain morphometry with multiecho MPRAGE
    Andre J W van der Kouwe
    Department of Radiology, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 40:559-69. 2008
    ..Since acquisition time is the same for MEMPR as for MPRAGE, and it has better distortion properties and additional T2* information, MEMPR is recommended for morphometry studies...
  43. ncbi request reprint Orbitofrontal thickness, retention of fear extinction, and extraversion
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 16:1909-12. 2005
    ..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality...
  44. ncbi request reprint Regionally localized thinning of the cerebral cortex in schizophrenia
    Gina R Kuperberg
    Department of Psychiatry, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Charlestown, 02129, USA
    Arch Gen Psychiatry 60:878-88. 2003
    ....
  45. ncbi request reprint Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging
    Nikos Makris
    Massachusetts General Hospital, USA
    J Cogn Neurosci 15:584-99. 2003
    ..The SAP technique makes it possible to represent multimodal structural and functional imaging data on the flattened surface of the cerebellar cortex as illustrated in one functional MRI experiment...
  46. ncbi request reprint Thinning of the cerebral cortex in aging
    David H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Cereb Cortex 14:721-30. 2004
    ..These findings demonstrate that cortical thinning occurs by middle age and spans widespread cortical regions that include primary as well as association cortex...
  47. pmc Meditation experience is associated with increased cortical thickness
    Sara W Lazar
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Neuroreport 16:1893-7. 2005
    ..Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice...
  48. ncbi request reprint Comparison of manual and automatic section positioning of brain MR images
    Thomas Benner
    Department of Radiology and General Clinical Research Center, Massachusetts General Hospital, Athinoula A Martinos Center, Harvard Medical School, 149 13th St, Rm 2301, Charlestown, MA 02129, USA
    Radiology 239:246-54. 2006
    ..001). Automatic section prescription leads to improved reproducibility of imaging orientations for intra- and intersubject series in clinical practice...
  49. ncbi request reprint Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data
    Jorge Jovicich
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149, 13th Street, Radiology CNY149 Room 2301, Charlestown, MA 02129, USA
    Neuroimage 30:436-43. 2006
    ..We provide the source code for the gradient distortion algorithm together with the phantom data...
  50. ncbi request reprint Human cerebral cortex: a system for the integration of volume- and surface-based representations
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 33:139-53. 2006
    ..This system of topographical analysis of the cerebral cortex is consistent with current views of cortical development and neural systems organization of the human and non-human primate brain...
  51. ncbi request reprint On-line automatic slice positioning for brain MR imaging
    Andre J W van der Kouwe
    Department of Radiology, MGH, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 27:222-30. 2005
    ..Translations and rotations relative to the atlas can be set so that planning can be done in anatomical space, rather than scanner coordinates, and stored as part of the protocol allowing standardization of slice orientations...
  52. ncbi request reprint A hybrid approach to the skull stripping problem in MRI
    F Segonne
    Athinoula A Martinos Center MGH NMR Center, Charlestown, MA 02129, USA
    Neuroimage 22:1060-75. 2004
    ..Studies by our group and others outperform other publicly available skull-stripping tools...
  53. pmc Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:10706-11. 2005
    ..e., greater extinction memory). These results suggest that the size of the vmPFC might explain individual differences in the ability to modulate fear among humans...
  54. doi request reprint In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: a surface-based analysis
    J Cohen-Adad
    AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 57:55-62. 2011
    ..Our data support the presence of disseminated subpial increases in T2* signal in subjects with MS, which may reflect the diffuse subpial pathology described in neuropathology...
  55. pmc Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia
    Z Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 123:153-9. 2010
    ..This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia...
  56. ncbi request reprint Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer
    Xiao Han
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuroimage 32:180-94. 2006
    ....
  57. pmc Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI
    Jonathan J Wisco
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
    Schizophr Res 94:317-27. 2007
    ..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia...
  58. pmc Mechanisms of migraine aura revealed by functional MRI in human visual cortex
    N Hadjikhani
    Nuclear Magnetic Resonance Center and Stroke and Neurovascular Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 98:4687-92. 2001
    ..These data strongly suggest that an electrophysiological event such as CSD generates the aura in human visual cortex...
  59. ncbi request reprint Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain
    Bruce Fischl
    Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Rm 2328, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuron 33:341-55. 2002
    ..The technique is shown to be comparable in accuracy to manual labeling, and of sufficient sensitivity to robustly detect changes in the volume of noncortical structures that presage the onset of probable Alzheimer's disease...
  60. ncbi request reprint Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniques
    Susanne Knake
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Suppl Clin Neurophysiol 57:494-502. 2004
  61. pmc Cortical thickness is influenced by regionally specific genetic factors
    Lars M Rimol
    Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
    Biol Psychiatry 67:493-9. 2010
    ..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes...
  62. ncbi request reprint Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary results
    Mitsuhiro Nishida
    Center for Morphometric Analysis, Department of Neurology, Massachusetts General Hospital, 34 Fruit Street, Boston, MA 02114, USA
    Neuroimage 32:1041-9. 2006
    ..These preliminary results are consistent with the heterochronous nature of cerebral development and provide initial estimates of regional brain growth and therefore regional vulnerability in the perinatal time period...
  63. ncbi request reprint A magnetic resonance imaging study of cortical thickness in animal phobia
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital East, 2nd Floor, Building 149, 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 55:946-52. 2004
    ....
  64. ncbi request reprint Changes in cerebral cortex of children treated for medulloblastoma
    Arthur K Liu
    Harvard Combined Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 68:992-8. 2007
    ..Using high-resolution magnetic resonance imaging, we measured the thickness of the cerebral cortex in a group of medulloblastoma patients and a group of normally developing children...
  65. pmc Accurate prediction of V1 location from cortical folds in a surface coordinate system
    Oliver P Hinds
    Department of Cognitive and Neural Systems, Boston University, MA 02215, USA
    Neuroimage 39:1585-99. 2008
    ....
  66. ncbi request reprint Regional cortical thickness matters in recall after months more than minutes
    Kristine B Walhovd
    University of Oslo, Department of Psychology, POB 1094 Blindern, 0317 Oslo, Norway
    Neuroimage 31:1343-51. 2006
    ..This supports a unique and critical role of the thickness of distinct cortical areas in recall after months, more than after minutes...
  67. ncbi request reprint The functional and structural significance of the frontal shift in the old/new ERP effect
    Kristine B Walhovd
    University of Oslo, Institute of Psychology, P B 1094 Blindern, 0317 Oslo, Norway
    Brain Res 1081:156-70. 2006
    ..The functional correlates need not be restricted to the older age groups...
  68. pmc A technique for the deidentification of structural brain MR images
    Amanda Bischoff-Grethe
    Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, La Jolla, USA
    Hum Brain Mapp 28:892-903. 2007
    ..Analyses support this algorithm as a viable method to allow data sharing with minimal data alteration within large-scale multisite projects...
  69. ncbi request reprint Cortical surface shape analysis based on spherical wavelets
    Peng Yu
    Harvard MIT Division of Health Sciences and Technology HST, Massachusetts Institute of Technology MIT, Cambridge, MA 02139 USA
    IEEE Trans Med Imaging 26:582-97. 2007
    ..The cortical folding development model provides quantitative anatomic information regarding macroscopic cortical folding development and may be of potential use as a biomarker for early diagnosis of neurologic deficits in newborns...
  70. ncbi request reprint Focal thinning of the cerebral cortex in multiple sclerosis
    Michael Sailer
    Otto von Guericke University Magdeburg, Leipzigerstrasse 44, 39120 Magdeburg, Germany
    Brain 126:1734-44. 2003
    ..The data provide new insight into the cortical pathology in multiple sclerosis patients, revealing focal cortical thinning beside an overall reduction of the cortical thickness with disease progression...
  71. ncbi request reprint Selective increase of cortical thickness in high-performing elderly--structural indices of optimal cognitive aging
    Anders M Fjell
    University of Oslo, Department of Psychology, Norway
    Neuroimage 29:984-94. 2006
    ..Further analyses showed that the latter was a result of a complex aging pattern, differing between the two performance groups, with decades of cortical thickening and subsequent thinning...
  72. ncbi request reprint Geometrically accurate topology-correction of cortical surfaces using nonseparating loops
    Florent Segonne
    CERTIS Laboratory, ENPC, 19 rue Nobel Cité Descartes, Champs sur Marne 77455, France
    IEEE Trans Med Imaging 26:518-29. 2007
    ..Applied to real data, our method provides topological corrections similar to those made by a trained operator...
  73. pmc Mapping an intrinsic MR property of gray matter in auditory cortex of living humans: a possible marker for primary cortex and hemispheric differences
    Irina S Sigalovsky
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, and Harvard MIT Division of Health Sciences and Technology, Speech and Hearing Bioscience and Technology Program, Cambridge, MA 02139, USA
    Neuroimage 32:1524-37. 2006
    ..These results indicate that in vivo R1 mapping can provide new insights into the structure of human cortical gray matter and its relation to function...
  74. ncbi request reprint Cognitive function, P3a/P3b brain potentials, and cortical thickness in aging
    Anders M Fjell
    Department of Psychology, University of Oslo, Norway
    Hum Brain Mapp 28:1098-116. 2007
    ..It is concluded that thickness in specific cortical areas correlates with scalp recorded P3a/P3b in elderly, and that these relationships differentially mediate higher cognitive function...
  75. ncbi request reprint Cortical atrophy is relevant in multiple sclerosis at clinical onset
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Dept of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    J Neurol 254:1212-20. 2007
    ....
  76. ncbi request reprint A genetic algorithm for the topology correction of cortical surfaces
    Florent Segonne
    MIT C S A I L
    Inf Process Med Imaging 19:393-405. 2005
    ..Applied to synthetic and real data, our method generates optimal topological corrections with only a few iterations...
  77. ncbi request reprint Permutation tests for classification: towards statistical significance in image-based studies
    Polina Golland
    Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Inf Process Med Imaging 18:330-41. 2003
    ..We demonstrate the method on examples of both structural and functional neuroimaging studies...
  78. ncbi request reprint Age does not increase rate of forgetting over weeks--neuroanatomical volumes and visual memory across the adult life-span
    Anders M Fjell
    Institute of Psychology, University of Oslo, 0317 Oslo, Norway
    J Int Neuropsychol Soc 11:2-15. 2005
    ..While neuroanatomical volumetric differences can explain some of the differences in memory functioning between younger and older persons, the hippocampus does not seem to be unique in this respect...
  79. pmc Effects of registration regularization and atlas sharpness on segmentation accuracy
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Lab, MIT, USA
    Med Image Comput Comput Assist Interv 10:683-91. 2007
    ..The optimal parcellation in all three cases corresponds to a unique balance of atlas "sharpness" and warp regularization that yield statistically significant improvements over the previously demonstrated parcellation results...
  80. pmc Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants
    Roy H Perlis
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 65:882-92. 2008
    ....
  81. ncbi request reprint An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    Rahul S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
    Neuroimage 31:968-80. 2006
    ....
  82. ncbi request reprint Effects of age on volumes of cortex, white matter and subcortical structures
    Kristine B Walhovd
    University of Oslo, Department of Psychology, P O Box 1094 Blindern, 0317 Oslo, Norway
    Neurobiol Aging 26:1261-70; discussion 1275-8. 2005
    ..In general, the findings point to global and large effects of age across brain volumes...
  83. pmc Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice location
    Christine Fennema-Notestine
    Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, California 92093, USA
    Hum Brain Mapp 27:99-113. 2006
    ..The results of this study may direct users towards a method appropriate to their T1-weighted datasets and improve the efficiency of processing for large, multisite neuroimaging studies...
  84. pmc Location and spatial profile of category-specific regions in human extrastriate cortex
    Mona Spiridon
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hum Brain Mapp 27:77-89. 2006
    ....
  85. ncbi request reprint Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study
    Aaron L Goldman
    Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 63:475-83. 2008
    ..Currently available data on the heritability of these structural changes are inconsistent...
  86. ncbi request reprint Cortical volume and speed-of-processing are complementary in prediction of performance intelligence
    Kristine B Walhovd
    Institute of Psychology, University of Oslo, P B 1094, Blindern, 0317 Oslo, Norway
    Neuropsychologia 43:704-13. 2005
    ..The main conclusion from the study is that speed and size are complementary in prediction of performance intelligence, and the theoretical implications are discussed...
  87. ncbi request reprint Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type
    Brian T Gold
    Department of Anatomy and Neurobiology, University of Kentucky, MN214 Chandler Medical Center, Lexington, KY 40536 0298, USA
    Neuropsychologia 43:833-46. 2005
    ....
  88. pmc Effects of registration regularization and atlas sharpness on segmentation accuracy
    B T Thomas Yeo
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Med Image Anal 12:603-15. 2008
    ..Our experiments also suggest that segmentation accuracy is tolerant up to a small mismatch between atlas sharpness and warp smoothness...
  89. ncbi request reprint Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy data
    Christine Fennema-Notestine
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive 0841, La Jolla, CA 92093 0841, USA
    Neuroinformatics 5:235-45. 2007
    ..These expected findings support the feasibility of combining legacy data to investigate novel scientific questions...

Research Grants16

  1. Tools for Analyzing Cortical Structure and Connectivity
    Bruce Fischl; Fiscal Year: 2010
    ..abstract_text> ..
  2. Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal Lobe
    Bruce Fischl; Fiscal Year: 2010
    ..The ability to more accurately localize these cortical regions would be a critical step in the early diagnosis of AD, and in the assessment of the efficacy of potential clinical interventions. ..
  3. Tools for Analyzing Cortical Structure and Connectivity
    Bruce Fischl; Fiscal Year: 2009
    ..abstract_text> ..
  4. Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal Lobe
    Bruce Fischl; Fiscal Year: 2007
    ..The ability to more accurately localize these cortical regions would be a critical step in the early diagnosis of AD, and in the assessment of the efficacy of potential clinical interventions. ..
  5. Tools for Analyzing Cortical Structure and Connectivity
    Bruce Fischl; Fiscal Year: 2007
    ....
  6. Automated Analysis of Healthy and Diseased Brain Tissue
    Bruce Fischl; Fiscal Year: 2005
    ..Upon completion of tool development they will be applied to the study of a variety of disorders, focusing on schizophrenia. Alzheimer's and Huntington's disease. ..
  7. Computeserver Structural & Functional Image Analysis
    Bruce Fischl; Fiscal Year: 2004
    ..Also, this instrument enhances the performances capabilities of two Regional Resources, enabling these facilities to deliver greater computational power to their user. ..
  8. Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal Lobe
    Bruce Fischl; Fiscal Year: 2009
    ..The ability to more accurately localize these cortical regions would be a critical step in the early diagnosis of AD, and in the assessment of the efficacy of potential clinical interventions. ..