Research Topics
| B FischlSummaryAffiliation: Harvard University Country: USA Publications
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Publications
FreeSurferBruce Fischl
Athinoula A Martinos Center, Dept of Radiology, MGH, Harvard Medical School, MA USA
Neuroimage 62:774-81. 2012..It is freely available, runs on a wide variety of hardware and software platforms, and is open source...
Automatically parcellating the human cerebral cortexBruce Fischl
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
Cereb Cortex 14:11-22. 2004..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
Cortical folding patterns and predicting cytoarchitectureBruce Fischl
Department of Radiology, Harvard Medical School, Charlestown, MA 02129, USA
Cereb Cortex 18:1973-80. 2008..These results further highlight the significance of cortical folding patterns and suggest a common mechanism for the development of the folds and the cytoarchitectonic fields...- Phase maps reveal cortical architectureBruce Fischl
Athinoula A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 104:11513-4. 2007 - Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortexB Fischl
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
IEEE Trans Med Imaging 20:70-80. 2001.... - Sequence-independent segmentation of magnetic resonance imagesBruce Fischl
Department of Radiology, MGH, Athinoula A Martinos Center, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 23:S69-84. 2004..This sequence has the added benefit of allowing the explicit estimation of T2* and of reducing test-retest intensity variability... - Predicting the location of entorhinal cortex from MRIBruce Fischl
Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 47:8-17. 2009.... - Age-related changes in prefrontal white matter measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
Ann N Y Acad Sci 1064:37-49. 2005..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures... - Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129 2060, USA
Neuroimage 54:1795-802. 2011..Such changes are associated with traditional imaging metrics of degeneration and may provide a unique biomarker of the tissue loss that occurs as a result of AD... - Regional cortical thinning in preclinical Huntington disease and its relationship to cognitionH D Rosas
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 65:745-7. 2005..They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD... - Cortical mechanisms specific to explicit visual object recognitionM Bar
Massachusetts General Hospital, NMR Center, Charlestown, MA 02129, USA
Neuron 29:529-35. 2001..The results presented here provide new insights into the processes underlying explicit object recognition, as well as the analysis that takes place immediately before and after recognition is possible... - Neuroimaging H.M.: a 10-year follow-up examinationD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
Hippocampus 16:936-45. 2006..Most of these alterations were not apparent in his prior scans, suggesting that they are of recent origin. Advanced age and hypertension likely contributed to these new findings... - Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRIKoen Van Leemput
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA
Med Image Comput Comput Assist Interv 11:235-43. 2008..We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals... - Atlas renormalization for improved brain MR image segmentation across scanner platformsXiao Han
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
IEEE Trans Med Imaging 26:479-86. 2007.... - Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's diseaseRahul S Desikan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Brain 132:2048-57. 2009.... - Cortical surface-based analysis. I. Segmentation and surface reconstructionA M Dale
Massachusetts General Hosp Harvard Medical School, Building 149, Charlestown, Massachusetts, 02129, USA
Neuroimage 9:179-94. 1999..Automated routines for unfolding and flattening the cortical surface are described in a companion paper. These procedures allow for the routine use of cortical surface-based analysis and visualization methods in functional brain imaging... - Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrastD H Salat
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
Neuroimage 48:21-8. 2009..These results demonstrate that there are strong regional changes in neural tissue properties with aging and tissue intensity measures may serve as an important biomarker of degeneration... - Local and global attention are mapped retinotopically in human occipital cortexY Sasaki
NMR Center, Department of Radiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 98:2077-82. 2001..Instead, local attention and global attention appear to be special cases of visual spatial attention, which are mapped consistently with the maps of retinotopy and spatial frequency tuning, in multiple visual cortical areas... - Age-related alterations in white matter microstructure measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
Neurobiol Aging 26:1215-27. 2005..These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration... - Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengthsB C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 39:10-8. 2008.... - Regional and progressive thinning of the cortical ribbon in Huntington's diseaseH D Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
Neurology 58:695-701. 2002.... - White matter pathology isolates the hippocampal formation in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
Neurobiol Aging 31:244-56. 2010..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways... - Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophreniaDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Neuroimage 37:599-610. 2007..Moreover, they suggest that anterior cingulate white matter abnormalities contribute to slower performance of volitional saccades and to inter-individual variability of saccadic latency in chronic, medicated schizophrenia... - A role for the human dorsal anterior cingulate cortex in fear expressionMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 62:1191-4. 2007..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)... - Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adultsElizabeth C Leritz
Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, MA 02130, USA
Neuroimage 54:2659-71. 2011.... - Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccadeDara S Manoach
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosci 27:1791-8. 2007..More generally, these results highlight the importance of trial history as a source of variability in both behavioral and neuroimaging studies... - Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneityH Diana Rosas
Center for Neuro imaging of Aging and Neurodegenerative Diseases, 149 13th Street Room 2275, Charlestown, MA 02129, USA
Brain 131:1057-68. 2008.... - Geometry driven volumetric registrationGheorghe Postelnicu
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
Inf Process Med Imaging 20:675-86. 2007..The result is a volumetric warp that aligns the folding patterns... - The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009.... - Laminar analysis of 7T BOLD using an imposed spatial activation pattern in human V1Jonathan R Polimeni
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 52:1334-46. 2010.... - Improved tractography alignment using combined volumetric and surface registrationLilla Zollei
Martinos Center for Biomedical Imaging, MGH, Boston, MA, USA
Neuroimage 51:206-13. 2010..Together these results imply a clear advantage to aligning anatomy as opposed to lower resolution DWI data even when the final goal is diffusion analysis... - Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"H Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 49:2995-3004. 2010..Our findings provide evidence for early degeneration of commissural pyramidal neurons in the neocortex, loss of cortico-cortical connectivity, and functional compromise of associative cortical processing... - Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototypeCiprian Catana
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Nucl Med 51:1431-8. 2010.... - Accurate and robust brain image alignment using boundary-based registrationDouglas N Greve
Martinos Center for Biomedical Imaging, 143 13th Street, Charlestown, MA, USA
Neuroimage 48:63-72. 2009..Even in the limit of registering a single slice, we show the BBR results to be robust and accurate... - Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRIKoen Van Leemput
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hippocampus 19:549-57. 2009..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies... - Target-specific contrast agents for magnetic resonance microscopyMegan L Blackwell
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129
Neuroimage 46:382-93. 2009..Our results suggest target-specific contrast agents will enable more detailed MR images with applications in imaging pathological ex vivo samples and constructing better MR atlases from ex vivo brains... - Selective disruption of the cerebral neocortex in Alzheimer's diseaseRahul S Desikan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
PLoS ONE 5:e12853. 2010..However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown... - Combined volumetric and surface registrationGheorghe Postelnicu
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02176 USA
IEEE Trans Med Imaging 28:508-22. 2009..The result is a combined surface and volume morph (CVS) that accurately registers both cortical and subcortical regions, establishing a single coordinate system suitable for the entire brain... - Regional white matter volume differences in nondemented aging and Alzheimer's diseaseDavid H Salat
Department of Radiology, Massachusetts General Hospital, Boston MA, USA
Neuroimage 44:1247-58. 2009..Overall, these results demonstrate the utility of automated regional WM measures in revealing the distinct patterns of age and AD associated volume loss that may contribute to cognitive decline... - Automated MRI measures predict progression to Alzheimer's diseaseRahul S Desikan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neurobiol Aging 31:1364-74. 2010.... - Brain morphometry with multiecho MPRAGEAndre J W van der Kouwe
Department of Radiology, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 40:559-69. 2008..Since acquisition time is the same for MEMPR as for MPRAGE, and it has better distortion properties and additional T2* information, MEMPR is recommended for morphometry studies... - Human cerebral cortex: a system for the integration of volume- and surface-based representationsNikos Makris
Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 33:139-53. 2006..This system of topographical analysis of the cerebral cortex is consistent with current views of cortical development and neural systems organization of the human and non-human primate brain... - Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imagingNikos Makris
Massachusetts General Hospital, USA
J Cogn Neurosci 15:584-99. 2003..The SAP technique makes it possible to represent multimodal structural and functional imaging data on the flattened surface of the cerebellar cortex as illustrated in one functional MRI experiment... - Regionally localized thinning of the cerebral cortex in schizophreniaGina R Kuperberg
Department of Psychiatry, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Charlestown, 02129, USA
Arch Gen Psychiatry 60:878-88. 2003.... - Meditation experience is associated with increased cortical thicknessSara W Lazar
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
Neuroreport 16:1893-7. 2005..Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice... - Thinning of the cerebral cortex in agingDavid H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Cereb Cortex 14:721-30. 2004..These findings demonstrate that cortical thinning occurs by middle age and spans widespread cortical regions that include primary as well as association cortex... - Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human dataJorge Jovicich
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Building 149, 13th Street, Radiology CNY149 Room 2301, Charlestown, MA 02129, USA
Neuroimage 30:436-43. 2006..We provide the source code for the gradient distortion algorithm together with the phantom data... - Comparison of manual and automatic section positioning of brain MR imagesThomas Benner
Department of Radiology and General Clinical Research Center, Massachusetts General Hospital, Athinoula A Martinos Center, Harvard Medical School, 149 13th St, Rm 2301, Charlestown, MA 02129, USA
Radiology 239:246-54. 2006..001). Automatic section prescription leads to improved reproducibility of imaging orientations for intra- and intersubject series in clinical practice... - On-line automatic slice positioning for brain MR imagingAndre J W van der Kouwe
Department of Radiology, MGH, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 27:222-30. 2005..Translations and rotations relative to the atlas can be set so that planning can be done in anatomical space, rather than scanner coordinates, and stored as part of the protocol allowing standardization of slice orientations... - Orbitofrontal thickness, retention of fear extinction, and extraversionScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neuroreport 16:1909-12. 2005..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality... - Cerebral cortex thickness in 15-year-old adolescents with low birth weight measured by an automated MRI-based methodM Martinussen
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Brain 128:2588-96. 2005.... - A hybrid approach to the skull stripping problem in MRIF Segonne
Athinoula A Martinos Center MGH NMR Center, Charlestown, MA 02129, USA
Neuroimage 22:1060-75. 2004..Studies by our group and others outperform other publicly available skull-stripping tools... - Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memoryMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:10706-11. 2005..e., greater extinction memory). These results suggest that the size of the vmPFC might explain individual differences in the ability to modulate fear among humans... - In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: a surface-based analysisJ Cohen-Adad
AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 57:55-62. 2011..Our data support the presence of disseminated subpial increases in T2* signal in subjects with MS, which may reflect the diffuse subpial pathology described in neuropathology... - Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophreniaZ Kikinis
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Schizophr Res 123:153-9. 2010..This method of parcellation offers a more precise way of measuring MR-MFG that will likely be important in further documentation of DLPFC anomalies in schizophrenia... - Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRIJonathan J Wisco
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States
Schizophr Res 94:317-27. 2007..0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia... - Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturerXiao Han
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Neuroimage 32:180-94. 2006.... - Mechanisms of migraine aura revealed by functional MRI in human visual cortexN Hadjikhani
Nuclear Magnetic Resonance Center and Stroke and Neurovascular Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 98:4687-92. 2001..These data strongly suggest that an electrophysiological event such as CSD generates the aura in human visual cortex... - Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniquesSusanne Knake
Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Suppl Clin Neurophysiol 57:494-502. 2004 - Cortical thickness is influenced by regionally specific genetic factorsLars M Rimol
Department of Radiology, University of California, San Diego, La Jolla, California 92093 0738, USA
Biol Psychiatry 67:493-9. 2010..Yet, little is known about the patterning of those genetic influences, i.e., whether the same genes influence structure throughout the brain or whether there are regionally specific sets of genes... - A magnetic resonance imaging study of cortical thickness in animal phobiaScott L Rauch
Department of Psychiatry, Massachusetts General Hospital-East, 2nd Floor, Building 149, 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 55:946-52. 2004..Further research will be necessary to replicate these findings and to determine their specificity as well as their pathophysiologic significance... - Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary resultsMitsuhiro Nishida
Center for Morphometric Analysis, Department of Neurology, Massachusetts General Hospital, 34 Fruit Street, Boston, MA 02114, USA
Neuroimage 32:1041-9. 2006..These preliminary results are consistent with the heterochronous nature of cerebral development and provide initial estimates of regional brain growth and therefore regional vulnerability in the perinatal time period... - Whole brain segmentation: automated labeling of neuroanatomical structures in the human brainBruce Fischl
Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Rm. 2328, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuron 33:341-55. 2002..The technique is shown to be comparable in accuracy to manual labeling, and of sufficient sensitivity to robustly detect changes in the volume of noncortical structures that presage the onset of probable Alzheimer's disease... - Changes in cerebral cortex of children treated for medulloblastomaArthur K Liu
Harvard Combined Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 68:992-8. 2007..Using high-resolution magnetic resonance imaging, we measured the thickness of the cerebral cortex in a group of medulloblastoma patients and a group of normally developing children... - Effects of registration regularization and atlas sharpness on segmentation accuracyB T Thomas Yeo
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Med Image Anal 12:603-15. 2008..Our experiments also suggest that segmentation accuracy is tolerant up to a small mismatch between atlas sharpness and warp smoothness... - Cortical volume and speed-of-processing are complementary in prediction of performance intelligenceKristine B Walhovd
Institute of Psychology, University of Oslo, P B 1094, Blindern, 0317 Oslo, Norway
Neuropsychologia 43:704-13. 2005..The main conclusion from the study is that speed and size are complementary in prediction of performance intelligence, and the theoretical implications are discussed... - Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer typeBrian T Gold
Department of Anatomy and Neurobiology, University of Kentucky, MN214 Chandler Medical Center, Lexington, KY 40536 0298, USA
Neuropsychologia 43:833-46. 2005.... - Age does not increase rate of forgetting over weeks--neuroanatomical volumes and visual memory across the adult life-spanAnders M Fjell
Institute of Psychology, University of Oslo, 0317 Oslo, Norway
J Int Neuropsychol Soc 11:2-15. 2005..While neuroanatomical volumetric differences can explain some of the differences in memory functioning between younger and older persons, the hippocampus does not seem to be unique in this respect... - Focal thinning of the cerebral cortex in multiple sclerosisMichael Sailer
Otto von Guericke University Magdeburg, Leipzigerstrasse 44, 39120 Magdeburg, Germany
Brain 126:1734-44. 2003..The data provide new insight into the cortical pathology in multiple sclerosis patients, revealing focal cortical thinning beside an overall reduction of the cortical thickness with disease progression... - Permutation tests for classification: towards statistical significance in image-based studiesPolina Golland
Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Inf Process Med Imaging 18:330-41. 2003..We demonstrate the method on examples of both structural and functional neuroimaging studies... - Location and spatial profile of category-specific regions in human extrastriate cortexMona Spiridon
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Hum Brain Mapp 27:77-89. 2006.... - Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice locationChristine Fennema-Notestine
Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, San Diego, La Jolla, California 92093, USA
Hum Brain Mapp 27:99-113. 2006..The results of this study may direct users towards a method appropriate to their T1-weighted datasets and improve the efficiency of processing for large, multisite neuroimaging studies... - Mapping an intrinsic MR property of gray matter in auditory cortex of living humans: a possible marker for primary cortex and hemispheric differencesIrina S Sigalovsky
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, and Harvard MIT Division of Health Sciences and Technology, Speech and Hearing Bioscience and Technology Program, Cambridge, MA 02139, USA
Neuroimage 32:1524-37. 2006..These results indicate that in vivo R1 mapping can provide new insights into the structure of human cortical gray matter and its relation to function... - Cortical atrophy is relevant in multiple sclerosis at clinical onsetMassimiliano Calabrese
The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Dept of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
J Neurol 254:1212-20. 2007.... - Cognitive function, P3a/P3b brain potentials, and cortical thickness in agingAnders M Fjell
Department of Psychology, University of Oslo, Norway
Hum Brain Mapp 28:1098-116. 2007..It is concluded that thickness in specific cortical areas correlates with scalp recorded P3a/P3b in elderly, and that these relationships differentially mediate higher cognitive function... - Geometrically accurate topology-correction of cortical surfaces using nonseparating loopsFlorent Segonne
CERTIS Laboratory, ENPC, 19 rue Nobel Cité Descartes, Champs sur Marne 77455, France
IEEE Trans Med Imaging 26:518-29. 2007..Applied to real data, our method provides topological corrections similar to those made by a trained operator... - Cortical surface shape analysis based on spherical waveletsPeng Yu
Harvard MIT Division of Health Sciences and Technology HST, Massachusetts Institute of Technology MIT, Cambridge, MA 02139 USA
IEEE Trans Med Imaging 26:582-97. 2007..The cortical folding development model provides quantitative anatomic information regarding macroscopic cortical folding development and may be of potential use as a biomarker for early diagnosis of neurologic deficits in newborns... - The functional and structural significance of the frontal shift in the old/new ERP effectKristine B Walhovd
University of Oslo, Institute of Psychology, P B 1094 Blindern, 0317 Oslo, Norway
Brain Res 1081:156-70. 2006..The functional correlates need not be restricted to the older age groups... - Regional cortical thickness matters in recall after months more than minutesKristine B Walhovd
University of Oslo, Department of Psychology, POB 1094 Blindern, 0317 Oslo, Norway
Neuroimage 31:1343-51. 2006..This supports a unique and critical role of the thickness of distinct cortical areas in recall after months, more than after minutes... - An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interestRahul S Desikan
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
Neuroimage 31:968-80. 2006.... - A genetic algorithm for the topology correction of cortical surfacesFlorent Segonne
MIT C S A I L
Inf Process Med Imaging 19:393-405. 2005..Applied to synthetic and real data, our method generates optimal topological corrections with only a few iterations... - Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation studyAaron L Goldman
Neuroimaging Core Facility, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 63:475-83. 2008..Currently available data on the heritability of these structural changes are inconsistent... - Accurate prediction of V1 location from cortical folds in a surface coordinate systemOliver P Hinds
Department of Cognitive and Neural Systems, Boston University, MA 02215, USA
Neuroimage 39:1585-99. 2008.... - Selective increase of cortical thickness in high-performing elderly--structural indices of optimal cognitive agingAnders M Fjell
University of Oslo, Department of Psychology, Norway
Neuroimage 29:984-94. 2006..Further analyses showed that the latter was a result of a complex aging pattern, differing between the two performance groups, with decades of cortical thickening and subsequent thinning... - Effects of registration regularization and atlas sharpness on segmentation accuracyB T Thomas Yeo
Computer Science and Artificial Intelligence Lab, MIT, USA
Med Image Comput Comput Assist Interv 10:683-91. 2007..The optimal parcellation in all three cases corresponds to a unique balance of atlas "sharpness" and warp regularization that yield statistically significant improvements over the previously demonstrated parcellation results... - Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participantsRoy H Perlis
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Arch Gen Psychiatry 65:882-92. 2008.... - Effects of age on volumes of cortex, white matter and subcortical structuresKristine B Walhovd
University of Oslo, Department of Psychology, P O Box 1094 Blindern, 0317 Oslo, Norway
Neurobiol Aging 26:1261-70; discussion 1275-8. 2005..In general, the findings point to global and large effects of age across brain volumes... - A technique for the deidentification of structural brain MR imagesAmanda Bischoff Grethe
Laboratory of Cognitive Imaging, Department of Psychiatry, University of California, San Diego, La Jolla, USA
Hum Brain Mapp 28:892-903. 2007..Analyses support this algorithm as a viable method to allow data sharing with minimal data alteration within large-scale multisite projects... - Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy dataChristine Fennema-Notestine
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive 0841, La Jolla, CA 92093 0841, USA
Neuroinformatics 5:235-45. 2007..These expected findings support the feasibility of combining legacy data to investigate novel scientific questions...
Research Grants
- Tools for Analyzing Cortical Structure and ConnectivityBruce Fischl; Fiscal Year: 2010..abstract_text> ..
- Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal LobeBruce Fischl; Fiscal Year: 2010..The ability to more accurately localize these cortical regions would be a critical step in the early diagnosis of AD, and in the assessment of the efficacy of potential clinical interventions. ..
- Tools for Analyzing Cortical Structure and ConnectivityBruce Fischl; Fiscal Year: 2009..abstract_text> ..
- Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal LobeBruce Fischl; Fiscal Year: 2007..The ability to more accurately localize these cortical regions would be a critical step in the early diagnosis of AD, and in the assessment of the efficacy of potential clinical interventions. ..
- Tools for Analyzing Cortical Structure and ConnectivityBruce Fischl; Fiscal Year: 2007....
- Automated Analysis of Healthy and Diseased Brain TissueBruce Fischl; Fiscal Year: 2005..Upon completion of tool development they will be applied to the study of a variety of disorders, focusing on schizophrenia. Alzheimer's and Huntington's disease. ..
- Computeserver Structural & Functional Image AnalysisBruce Fischl; Fiscal Year: 2004..Also, this instrument enhances the performances capabilities of two Regional Resources, enabling these facilities to deliver greater computational power to their user. ..
- Inferring in Vivo Cytoarchitectural Borders in the Medial Temporal LobeBruce Fischl; Fiscal Year: 2009..The ability to more accurately localize these cortical regions would be a critical step in the early diagnosis of AD, and in the assessment of the efficacy of potential clinical interventions. ..