Bradford D Fischer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 58:544-50. 2010
  2. pmc Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 215:311-9. 2011
  3. ncbi Preclinical assessment of drug combinations for the treatment of pain: isobolographic and dose-addition analysis of the opioidergic system
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    CNS Neurol Disord Drug Targets 10:529-35. 2011
  4. pmc Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 337:805-11. 2011
  5. pmc Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, Massachusetts 01772 9102, USA
    Neuropharmacology 59:612-8. 2010
  6. doi Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 198:271-8. 2008
  7. ncbi Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Pain 6:425-33. 2005
  8. pmc Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys
    Nina M Shinday
    Department of Psychiatry, Division of Neuroscience, New England Primate Research Center, Beth Israel Deaconess Medical Center and Harvard Medical School, MA 01772, USA
    Neuropsychopharmacology 38:1006-14. 2013
  9. pmc Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 227:347-54. 2013
  10. ncbi Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 324:732-9. 2008

Detail Information

Publications12

  1. pmc Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropharmacology 58:544-50. 2010
    ..These results suggest that CP-55940 and LY235959 produce additive or supra-additive attenuation of morphine antinociceptive tolerance after repeated morphine administration, depending on their relative concentrations...
  2. pmc Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 215:311-9. 2011
    ..Experimental evidence suggests that the differential behavioral effects of benzodiazepines depend on their relative actions at γ-aminobutyric acid type A (GABA(A)) receptors that contain either an α1, α2, α3, or α5 subunit...
  3. ncbi Preclinical assessment of drug combinations for the treatment of pain: isobolographic and dose-addition analysis of the opioidergic system
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    CNS Neurol Disord Drug Targets 10:529-35. 2011
    ..Finally, comments on the future assessment of drug combinations for the treatment of pain-related disorders are made...
  4. pmc Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 337:805-11. 2011
    ..These results suggest that combinations of triazolam and pregnanolone may have enhanced anxiolytic effects with reduced behavioral disruption and abuse potential compared with either drug alone...
  5. pmc Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, Massachusetts 01772 9102, USA
    Neuropharmacology 59:612-8. 2010
    ..These behavioral effects suggest that the anxiolytic and rate-reducing effects of GABA(A) receptor positive modulators are dependent on their relative efficacy and affinity at different GABA(A) receptor subtypes...
  6. doi Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 198:271-8. 2008
    ..Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception...
  7. ncbi Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3270, USA
    J Pain 6:425-33. 2005
    ..These results suggest that a range of NMDA receptor antagonists potentiate morphine-induced antinociception, although the potentiation of l-methadone might be specific to the antagonist examined...
  8. pmc Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys
    Nina M Shinday
    Department of Psychiatry, Division of Neuroscience, New England Primate Research Center, Beth Israel Deaconess Medical Center and Harvard Medical School, MA 01772, USA
    Neuropsychopharmacology 38:1006-14. 2013
    ....
  9. pmc Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 227:347-54. 2013
    ..Assays of schedule-controlled responding can be used to characterize the pharmacology of benzodiazepines and other GABAA receptor modulators, and are sensitive to changes in drug effects that are related to physical dependence...
  10. ncbi Morphine in combination with metabotropic glutamate receptor antagonists on schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, CB 3270, Davie Hall, University of North Carolina, Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 324:732-9. 2008
    ..In addition, these data confirm that the behavioral effects of drug mixtures depend on the endpoint under study...
  11. pmc Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice
    Linda A Dykstra
    Behavioral Neuroscience Program, Department of Psychology, University of North Carolina, Chapel Hill, North Carolina 27599 3270, USA
    Behav Pharmacol 22:540-7. 2011
    ..These results indicate that the NR1 subunit of the NMDA receptor does not play a prominent role in μ opioid tolerance...
  12. ncbi Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception
    Bradford D Fischer
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    J Pharmacol Exp Ther 318:1300-6. 2006
    ..In addition, these data confirm that the behavioral effects of drug mixtures depend on the relative concentrations of the drugs in the mixture and on the endpoint under study...