Paolo Fiorina

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
    Mohammed Javeed I Ansari
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 126:140-7. 2008
  2. pmc Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
  3. ncbi request reprint Role of podocyte b7-1 in diabetic nephropathy
    Paolo Fiorina
    Nephrology Division, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
    J Am Soc Nephrol 25:1415-29. 2014
  4. pmc Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses
    Michele Carvello
    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:155-65. 2012
  5. pmc IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response
    Alessandra Petrelli
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:3223-34. 2011
  6. pmc Strategies to reverse endothelial progenitor cell dysfunction in diabetes
    Alessandra Petrelli
    Transplantation Research Center TRC, Nephrology Division, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Diabetes Res 2012:471823. 2012
  7. pmc Regenerative therapies for diabetic microangiopathy
    Roberto Bassi
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Diabetes Res 2012:916560. 2012
  8. pmc Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes
    Francesca D'Addio
    Corresponding author Paolo Fiorina
    Diabetes Care 37:267-76. 2014
  9. ncbi request reprint 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders Building, EN530, Boston, MA, USA
    Acta Diabetol 49:S133-9. 2012
  10. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010

Detail Information

Publications64

  1. ncbi request reprint Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
    Mohammed Javeed I Ansari
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 126:140-7. 2008
    ..We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity...
  2. pmc Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
    ..These data provide important preclinical data supporting the basis for further development of allogeneic MSC-based therapies for T1D and, potentially, for other autoimmune disorders...
  3. ncbi request reprint Role of podocyte b7-1 in diabetic nephropathy
    Paolo Fiorina
    Nephrology Division, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
    J Am Soc Nephrol 25:1415-29. 2014
    ..Taken together, these results identify B7-1 inhibition as a potential therapeutic strategy for the prevention or treatment of diabetic nephropathy. ..
  4. pmc Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses
    Michele Carvello
    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:155-65. 2012
    ..Anti-CD22/cal-mediated B-cell depletion promotes the reduction of the anti-islet immune response in various models of islet transplantation...
  5. pmc IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response
    Alessandra Petrelli
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:3223-34. 2011
    ..Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still unclear...
  6. pmc Strategies to reverse endothelial progenitor cell dysfunction in diabetes
    Alessandra Petrelli
    Transplantation Research Center TRC, Nephrology Division, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Diabetes Res 2012:471823. 2012
    ..Finally, we review preclinical and clinical strategies that aim to revert diabetes-induced dysfunction of endothelial progenitor cells as a means of finding new strategies to prevent diabetic complications...
  7. pmc Regenerative therapies for diabetic microangiopathy
    Roberto Bassi
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Diabetes Res 2012:916560. 2012
    ....
  8. pmc Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes
    Francesca D'Addio
    Corresponding author Paolo Fiorina
    Diabetes Care 37:267-76. 2014
    ..CONCLUSIONS ITA, despite immunosuppressive therapy, is associated with a near-normalization of hemostatic and cerebral abnormalities. ..
  9. ncbi request reprint 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders Building, EN530, Boston, MA, USA
    Acta Diabetol 49:S133-9. 2012
    ..Kidney-localized (31)P-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients...
  10. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010
    ....
  11. doi request reprint The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing
    Paolo Fiorina
    Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Transplant 19:1369-81. 2010
    ..Despite controversial data about the functional impairment of diabetic BM-PCs, in this model our data showed a residual capacity of these cells to trigger angiogenesis and cell proliferation...
  12. pmc Immunological applications of stem cells in type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Division of Nephrology, Children s Hospital Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Rev 32:725-54. 2011
    ..Finally, embryonic SCs also offer exciting prospects because they are able to generate glucose-responsive insulin-producing cells. Easy enthusiasm should be mitigated mainly because of the potential oncogenicity of SCs...
  13. pmc Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:367-74. 2012
    ..Kidney-pancreas (KP), but not kidney alone (KD), transplantation is associated with sustained normoglycemia, improvement in quality of life, and reduction of morbidity/mortality in diabetic patients with end-stage renal disease (ESRD)...
  14. pmc Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:121-31. 2011
    ..Targeting the CXCR4-CXCL12 axis thus mobilizes autologous HSCs and promotes long-term survival of islet allografts via a PD-L1-mediated mechanism...
  15. ncbi request reprint Altered kidney graft high-energy phosphate metabolism in kidney-transplanted end-stage renal disease type 1 diabetic patients: a cross-sectional analysis of the effect of kidney alone and kidney-pancreas transplantation
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy
    Diabetes Care 30:597-603. 2007
    ..The aim of this study was to ascertain the impact of kidney alone (KD) or combined kidney-pancreas (KP) transplantation on renal energy metabolism...
  16. ncbi request reprint Natural history of kidney graft survival, hypertrophy, and vascular function in end-stage renal disease type 1 diabetic kidney-transplanted patients: beneficial impact of pancreas and successful islet cotransplantation
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Diabetes Care 28:1303-10. 2005
    ..Our aim was to evaluate survival, hypertrophy, and vascular function of the kidney graft in end-stage renal disease (ESRD) type 1 diabetic patients after transplant...
  17. pmc Divergent role of donor dendritic cells in rejection versus tolerance of allografts
    Takuya Ueno
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:535-44. 2009
    ..These data indicate the importance of the CX3CR1 pathway in the generation of heart tissue dendritic cells and the divergent role of tissue/dendritic cells in rejection versus tolerance...
  18. ncbi request reprint Islet transplantation is associated with an improvement of cardiovascular function in type 1 diabetic kidney transplant patients
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Diabetes Care 28:1358-65. 2005
    ..The aim of this study was to determine whether islet transplantation can improve cardiovascular function in these patients...
  19. pmc Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes
    Mollie Jurewicz
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:3139-47. 2010
    ..Here, we examine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to reverse recent-onset type 1 diabetes in NOD mice, as well as determine the immunomodulatory effects of NOR MSCs in vivo...
  20. doi request reprint Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 85:1030-8. 2008
    ..Here, we provide evidence that lack of CCR2 could lead to the generation of functionally and phenotypically different DC, which in part could explain the benefits observed in transplanting islets in CCR2 recipients...
  21. ncbi request reprint Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants
    Paolo Fiorina
    Departments of Medicine and Surgery, San Raffaele Scientific Institute, Milan, Italy
    J Am Soc Nephrol 14:2150-8. 2003
    ..Successful islet transplantation was associated with improvements in kidney graft survival rates and function among uremic patients with type I diabetes mellitus and kidney grafts...
  22. ncbi request reprint Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantation
    Paolo Fiorina
    Department of Medicine I, San Raffaele Hospital, Milan, Italy
    Transplantation 75:1296-301. 2003
    ..The aim of this study was to evaluate the effects of islet transplantation on patient survival and diabetic vascular complications...
  23. pmc Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection
    Andrea Vergani
    Transplantation Research Center, Nephrology Division, Boston Children s Hospital and Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 62:1665-75. 2013
    ..The beneficial effects of oATP treatment revealed a role for the purinergic system in islet allograft rejection, and the targeting of P2X7R is a novel strategy to induce long-term islet allograft function...
  24. pmc Targeting CD22 reprograms B-cells and reverses autoimmune diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:3013-24. 2008
    ..To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice...
  25. ncbi request reprint Metabolic and immunological features of the failing islet-transplanted patient
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 31:436-8. 2008
    ..This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure...
  26. ncbi request reprint Kidney function after islet transplant alone in type 1 diabetes: impact of immunosuppressive therapy on progression of diabetic nephropathy
    Paola Maffi
    Department of Medicine, Transplant Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Diabetes Care 30:1150-5. 2007
    ..The aim of our study was to assess the impact of the Edmonton immunosuppressive protocol (tacrolimus-sirolimus association) on kidney function...
  27. pmc CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival
    Francesca D'Addio
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60391. 2013
    ..Thus, CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection...
  28. ncbi request reprint L-arginine-induced vasodilation of the renal vasculature is preserved in uremic type 1 diabetic patients after kidney and pancreas but not after kidney-alone transplantation
    Francesco De Cobelli
    Department of Radiology, Universita Vita e Salute San Raffaele, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 27:947-54. 2004
    ..e., curing diabetes, is expected to prevent endothelial damages. Our aim was to study L-arginine-induced vasodilation of the renal vasculature in uremic type 1 diabetic patients after KP or KD using magnetic resonance (MR)...
  29. ncbi request reprint Technique, complications, and therapeutic efficacy of percutaneous transplantation of human pancreatic islet cells in type 1 diabetes: the role of US
    Massimo Venturini
    Department of Radiology, San Raffaele Scientific Institute, Vita Salute University, Olgettina 60, 20132 Milan, Italy
    Radiology 234:617-24. 2005
    ....
  30. ncbi request reprint Successful surgical salvage of pancreas allograft
    Elena Orsenigo
    Department of Surgery, San Raffaele Scientific Hospital, Milan, Italy
    Transplantation 75:233-6. 2003
    ..The authors describe a surgical rescue technique that allows salvage of the pancreatic graft when surgical complications appear after the transplant...
  31. ncbi request reprint Urological complications after simultaneous renal and pancreatic transplantation
    Elena Orsenigo
    Department of Surgery, Universita Vita e Salute, Milan, Italy
    Eur J Surg 168:609-13. 2002
    ..To report the urological complications after simultaneous renal and pancreatic transplantation...
  32. ncbi request reprint Evaluation of polyneuropathy markers in type 1 diabetic kidney transplant patients and effects of islet transplantation: neurophysiological and skin biopsy longitudinal analysis
    Ubaldo Del Carro
    Department of Neurology and Clinical Neurophysiology, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 30:3063-9. 2007
    ....
  33. ncbi request reprint Morphological and functional differences in haemostatic axis between kidney transplanted and end-stage renal disease patients
    Paolo Fiorina
    Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy
    Transpl Int 18:1036-47. 2005
    ..Kidney transplant is associated with a better atherothrombotic profile in ESRD, platelet intracellular calcium and cytokines seem to be most influenced by the transplant, while most morphological abnormalities are retained...
  34. ncbi request reprint Importance of donor- and recipient-derived selectins in cardiac allograft rejection
    Atsushi Izawa
    Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 18:2929-36. 2007
    ..In conclusion, donor-derived selectins contribute to the development of both acute and chronic cardiac allograft rejection, and targeting donor selectins may open novel therapeutic approaches in clinical transplantation...
  35. ncbi request reprint Gastrointestinal bleeding from enterically drained transplanted pancreas
    Elena Orsenigo
    Department of Surgery, Universita Vita e Salute San Raffaele, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Transpl Int 18:296-302. 2005
    ..There were no significant differences in pancreas graft and patient survival rates between the two groups. Anastomotic hemorrhage did not influence patient and graft survival...
  36. ncbi request reprint Cross-sectional assessment of the effect of kidney and kidney-pancreas transplantation on resting left ventricular energy metabolism in type 1 diabetic-uremic patients: a phosphorous-31 magnetic resonance spectroscopy study
    Gianluca Perseghin
    Division of Internal Medicine Section of Nutrition Metabolism, Universita Vita e Salute San Raffaele, Milan, Italy
    J Am Coll Cardiol 46:1085-92. 2005
    ....
  37. ncbi request reprint Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival
    Paolo Fiorina
    Transplantation Research Center TRC, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Diabetes 56:912-20. 2007
    ..This study introduces dDCs and rDCs as two distinct types of DCs and provides novel data with clinical implications to use chemokine-based DC-depleting strategies to prolong islet allograft survival...
  38. ncbi request reprint Early increase of retinal arterial and venous blood flow velocities at color Doppler imaging in brittle type 1 diabetes after islet transplant alone
    Massimo Venturini
    Department of Radiology, San Raffaele Scientific Institute, Milan and Universita Vita e Salute San Raffaele, Milan, Italy
    Transplantation 81:1274-7. 2006
    ..46 vs. 10.12+/-1.20 cm/s, P=0.01) and veins (maxv: 3.12+/-0.28 vs. 6.12+/-1.00 cm/s, P=0.01) was found only in the ITA patients. An early, significant increase of arterial and venous retinal blood flow velocities was found after ITA...
  39. ncbi request reprint Selective intra-graft apoptosis and down-regulation of lymphocyte bcl-2, iNOs and CD95L expression in kidney-pancreas transplanted patients after anti-Thymoglobulin induction
    Paolo Fiorina
    Department of Internal Medicine I, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Transpl Int 17:603-8. 2004
    ..7+/-1.1% vs FNAB = 81.9+/-15.1%; p < 0.05) were evident in the graft than in PBL. In KP patients intra-graft apoptosis and reduced anti-apoptotic molecules were evident after ATG induction...
  40. pmc Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model
    Francesca D'Addio
    Renal Division, Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53797. 2013
    ..Clinical trials investigating B7/CD28 blockade (LEA29Y, Belatacept) in kidney transplant recipients have proven that the replacement of toxic CNI use is feasible in selected populations...
  41. pmc Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7
    Andrea Vergani
    Transplantation Research Center, Boston Children s Hospital, Harvard Medical School, Enders Building 5th floor, Rm EN530, 300 Longwood Ave, Boston, MA 02115, USA
    Circulation 127:463-75. 2013
    ..Novel clinical-grade P2X7R inhibitors are available, rendering the targeting of P2X7R a potential therapy in cardiac transplantation...
  42. doi request reprint Kidney-pancreas transplantation is associated with near-normal sexual function in uremic type 1 diabetic patients
    Andrea Salonia
    Department of Urology, University Vita Salute San Raffaele, Milan, Italy
    Transplantation 92:802-8. 2011
    ..The present study aimed to analyze sexual function in patients with T1D and ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation...
  43. doi request reprint Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection
    Yanfei Huang
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 90:1307-11. 2010
    ....
  44. ncbi request reprint Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients
    Paolo Fiorina
    Department of Internal Medicine I, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 26:1129-36. 2003
    ..Our aim was to evaluate the long-term effects of transplanted islets on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients...
  45. ncbi request reprint Normalization of multiple hemostatic abnormalities in uremic type 1 diabetic patients after kidney-pancreas transplantation
    Paolo Fiorina
    Internal Medicine, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milano, Italy
    Diabetes 53:2291-300. 2004
    ....
  46. ncbi request reprint Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells
    Francesca Galbiati
    Division of General Medicine, Unit of Endocrinology and Metabolic Disease, San Raffaele Scientific Institute, 20132 Milan, Italy
    Endocrinology 144:1832-41. 2003
    ....
  47. pmc Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes
    Reza Abdi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1759-67. 2008
    ....
  48. ncbi request reprint Mechanisms of PDL1-mediated regulation of autoimmune diabetes
    Indira Guleria
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 125:16-25. 2007
    ..These data provide strong evidence that PDL1 regulates autoimmune diabetes by limiting the expansion of CD4+ and CD8+ autoreactive T cells, and define the timing and locale of PDL1-mediated regulation of type 1 diabetes...
  49. pmc B7h (ICOS-L) maintains tolerance at the fetomaternal interface
    Leonardo V Riella
    Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 182:2204-13. 2013
    ..Taken together, these data support the hypothesis that B7h blockade abrogates tolerance at the fetomaternal interface by enhancing CD8(+) effector response and reducing local immunomodulation mediated by CD8(+) regulatory T cells...
  50. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
    ..These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes...
  51. ncbi request reprint Successful endovascular treatment for gastroduodenal artery pseudoaneurysm with an arteriovenous fistula after pancreas transplantation
    Elena Orsenigo
    Department of Surgery, University Vita Salute San Raffaele, Milan, Italy
    Transpl Int 16:694-6. 2003
    ..At 11 months of follow-up, normal pancreatic function was reported. Endovascular treatment for gastroduodenal artery pseudoaneurysm with an arteriovenous fistula after pancreas transplantation obviates the need for surgical intervention...
  52. ncbi request reprint Advantages and disadvantages of enteric versus bladder diversion in simultaneous kidney-pancreas transplantation
    Elena Orsenigo
    Department of Surgery, San Raffaele University, Milan, Italy
    Chir Ital 54:429-36. 2002
    ....
  53. ncbi request reprint Apoptotic/mytogenic pathways during human heart development
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute HSR, Milan, Via Olgettina 60, Milan 20132, Italy
    Int J Cardiol 96:409-17. 2004
    ..The aim of our study was to assess myocytes apoptosis/mitosis and associated intracellular signalling pathways during heart development...
  54. doi request reprint Impact of islet transplantation on diabetes complications and quality of life
    Roberto Bassi
    Transplantation Research Center, Nephrology Division, Children s Hospital Harvard Medical School, Boston, MA 02115, USA
    Curr Diab Rep 11:355-63. 2011
    ..The proof of concept for cellular replacement therapy in diabetes has been established with islet transplantation, it only needs to be improved and rendered widely available...
  55. pmc Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 191:2319-27. 2013
    ..These data could have significant clinical implications for Treg-based therapy in immune-mediated diseases. ..
  56. doi request reprint Modified CD4(+) T-cell response in recipients of old cardiac allografts
    Christian Denecke
    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transpl Int 25:328-36. 2012
    ..These findings contribute to a better understanding of the immune response following the engraftment of older donor organs...
  57. ncbi request reprint Pancreatic islet cell transplant for treatment of diabetes
    Paolo Fiorina
    Transplantation Medicine, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Endocrinol Metab Clin North Am 36:999-1013; ix. 2007
    ....
  58. ncbi request reprint Inhibition of the purinergic pathway prolongs mouse lung allograft survival
    Kaifeng Liu
    1 Department of Medicine Pediatrics, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts
    Am J Respir Cell Mol Biol 51:300-10. 2014
    ..This study illustrates a potential new pathway to target in hopes of prolonging survival of lung transplant recipients. ..
  59. ncbi request reprint A report of six cases of familial papillary thyroid cancer
    Elena Orsenigo
    Department of Surgery, University Vita e Salute of San Raffaele, Milan, Italy
    Eur J Surg Oncol 29:185-7. 2003
    ..Familial occurrence of papillary thyroid cancer is uncommon. The purpose of this study was review our own experience in a series of 267 papillary thyroid cancers...
  60. pmc Can existing drugs approved for other indications retard renal function decline in patients with type 1 diabetes and nephropathy?
    Alessandro Doria
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Semin Nephrol 32:437-44. 2012
    ....
  61. ncbi request reprint Antitumorigenic and antiinsulinogenic effects of calcitriol on insulinoma cells and solid beta-cell tumors
    Francesca Galbiati
    Department of Medicine, San Raffaele Scientific Institute, Milan 20132, Italy
    Endocrinology 143:4018-30. 2002
    ..Together, these findings provide the rationale for testing the efficacy of calcitriol in the treatment of patients with solid beta-cell tumors...
  62. ncbi request reprint Role of CXC chemokine receptor 3 pathway in renal ischemic injury
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:716-23. 2006
    ..It is concluded that CXCR3 plays an important role in orchestrating the recruitment of Th1 cells to the ischemic kidney and in mediating I/R injury and therefore may serve as a novel target for the therapy of I/R injury...
  63. pmc B-cell depletion improves islet allograft survival with anti-CD45RB
    Kang Mi Lee
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cell Transplant 23:51-8. 2014
    ..These findings may help elucidate the varied action of B-cells in promoting tolerance versus rejection. ..