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Genomes and Genes | Paolo FiorinaSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Role of ICOS pathway in autoimmune and alloimmune responses in NOD miceMohammed Javeed I Ansari
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Clin Immunol 126:140-7. 2008..We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity...
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetesPaolo Fiorina
Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 183:993-1004. 2009..These data provide important preclinical data supporting the basis for further development of allogeneic MSC-based therapies for T1D and, potentially, for other autoimmune disorders...
Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7Andrea Vergani
Transplantation Research Center, Nephrology Division, Boston Children s Hospital, Harvard Medical School, Enders Building 5th floor, Rm EN530, 300 Longwood Ave, Boston, MA 02115
Circulation 127:463-75. 2013..Novel clinical-grade P2X7R inhibitors are available, rendering the targeting of P2X7R a potential therapy in cardiac transplantation...- 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patientsPaolo Fiorina
Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders Building, EN530, Boston, MA, USA
Acta Diabetol 49:S133-9. 2012..Kidney-localized (31)P-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients... - Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1Paolo Fiorina
Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 186:121-31. 2011..Targeting the CXCR4-CXCL12 axis thus mobilizes autologous HSCs and promotes long-term survival of islet allografts via a PD-L1-mediated mechanism... - Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantationPaolo Fiorina
Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 35:367-74. 2012..Kidney-pancreas (KP), but not kidney alone (KD), transplantation is associated with sustained normoglycemia, improvement in quality of life, and reduction of morbidity/mortality in diabetic patients with end-stage renal disease (ESRD)... - Immunological applications of stem cells in type 1 diabetesPaolo Fiorina
Transplantation Research Center, Division of Nephrology, Children s Hospital Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
Endocr Rev 32:725-54. 2011..Finally, embryonic SCs also offer exciting prospects because they are able to generate glucose-responsive insulin-producing cells. Easy enthusiasm should be mitigated mainly because of the potential oncogenicity of SCs... - The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healingPaolo Fiorina
Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cell Transplant 19:1369-81. 2010..Despite controversial data about the functional impairment of diabetic BM-PCs, in this model our data showed a residual capacity of these cells to trigger angiogenesis and cell proliferation... - A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD miceAndrea Vergani
Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 59:2253-64. 2010.... - Divergent role of donor dendritic cells in rejection versus tolerance of allograftsTakuya Ueno
Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Am Soc Nephrol 20:535-44. 2009..These data indicate the importance of the CX3CR1 pathway in the generation of heart tissue dendritic cells and the divergent role of tissue/dendritic cells in rejection versus tolerance... - Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetesMollie Jurewicz
Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 59:3139-47. 2010..Here, we examine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to reverse recent-onset type 1 diabetes in NOD mice, as well as determine the immunomodulatory effects of NOR MSCs in vivo... - Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantationPaolo Fiorina
Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Transplantation 85:1030-8. 2008..Here, we provide evidence that lack of CCR2 could lead to the generation of functionally and phenotypically different DC, which in part could explain the benefits observed in transplanting islets in CCR2 recipients... - Targeting CD22 reprograms B-cells and reverses autoimmune diabetesPaolo Fiorina
Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 57:3013-24. 2008..To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice... - Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responsesMichele Carvello
Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 61:155-65. 2012..Anti-CD22/cal-mediated B-cell depletion promotes the reduction of the anti-islet immune response in various models of islet transplantation... - Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survivalPaolo Fiorina
Transplantation Research Center TRC, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
Diabetes 56:912-20. 2007..This study introduces dDCs and rDCs as two distinct types of DCs and provides novel data with clinical implications to use chemokine-based DC-depleting strategies to prolong islet allograft survival... - Importance of donor- and recipient-derived selectins in cardiac allograft rejectionAtsushi Izawa
Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 18:2929-36. 2007..In conclusion, donor-derived selectins contribute to the development of both acute and chronic cardiac allograft rejection, and targeting donor selectins may open novel therapeutic approaches in clinical transplantation... - Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejectionYanfei Huang
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Transplantation 90:1307-11. 2010.... - Mechanisms of PDL1-mediated regulation of autoimmune diabetesIndira Guleria
Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Clin Immunol 125:16-25. 2007..These data provide strong evidence that PDL1 regulates autoimmune diabetes by limiting the expansion of CD4+ and CD8+ autoreactive T cells, and define the timing and locale of PDL1-mediated regulation of type 1 diabetes... - Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetesReza Abdi
Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 57:1759-67. 2008.... - Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejectionAndrea Vergani
Transplantation Research Center, Nephrology Division, Boston Children s Hospital and Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts
Diabetes 62:1665-75. 2013..The beneficial effects of oATP treatment revealed a role for the purinergic system in islet allograft rejection, and the targeting of P2X7R is a novel strategy to induce long-term islet allograft function... - The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetesJamil Azzi
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 61:1509-18. 2012..These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes... - Regenerative therapies for diabetic microangiopathyRoberto Bassi
Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Exp Diabetes Res 2012:916560. 2012.... - Strategies to reverse endothelial progenitor cell dysfunction in diabetesAlessandra Petrelli
Transplantation Research Center TRC, Nephrology Division, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Exp Diabetes Res 2012:471823. 2012..Finally, we review preclinical and clinical strategies that aim to revert diabetes-induced dysfunction of endothelial progenitor cells as a means of finding new strategies to prevent diabetic complications... - IL-21 is an antitolerogenic cytokine of the late-phase alloimmune responseAlessandra Petrelli
Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 60:3223-34. 2011..Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still unclear... - CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft SurvivalFrancesca D'Addio
Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America Transplantation and Internal Medicine Division, San Raffaele Scientific Institute, Milan, Italy
PLoS ONE 8:e60391. 2013..Thus, CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection... - Modified CD4(+) T-cell response in recipients of old cardiac allograftsChristian Denecke
Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Transpl Int 25:328-36. 2012..These findings contribute to a better understanding of the immune response following the engraftment of older donor organs... - Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant modelFrancesca D'Addio
Renal Division, Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 8:e53797. 2013..Clinical trials investigating B7/CD28 blockade (LEA29Y, Belatacept) in kidney transplant recipients have proven that the replacement of toxic CNI use is feasible in selected populations... - Impact of islet transplantation on diabetes complications and quality of lifeRoberto Bassi
Transplantation Research Center, Nephrology Division, Children s Hospital Harvard Medical School, Boston, MA 02115, USA
Curr Diab Rep 11:355-63. 2011..The proof of concept for cellular replacement therapy in diabetes has been established with islet transplantation, it only needs to be improved and rendered widely available... - Role of CXC chemokine receptor 3 pathway in renal ischemic injuryPaolo Fiorina
Transplantation Research Center, Children's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
J Am Soc Nephrol 17:716-23. 2006..It is concluded that CXCR3 plays an important role in orchestrating the recruitment of Th1 cells to the ischemic kidney and in mediating I/R injury and therefore may serve as a novel target for the therapy of I/R injury...