Paolo Fiorina

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
    Mohammed Javeed I Ansari
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 126:140-7. 2008
  2. doi request reprint Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
  3. pmc Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes
    Francesca D'Addio
    Corresponding author Paolo Fiorina
    Diabetes Care 37:267-76. 2014
  4. ncbi request reprint 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders Building, EN530, Boston, MA, USA
    Acta Diabetol 49:S133-9. 2012
  5. pmc Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:367-74. 2012
  6. pmc Immunological applications of stem cells in type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Division of Nephrology, Children s Hospital Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Rev 32:725-54. 2011
  7. pmc Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:121-31. 2011
  8. doi request reprint The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing
    Paolo Fiorina
    Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Transplant 19:1369-81. 2010
  9. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010
  10. pmc Divergent role of donor dendritic cells in rejection versus tolerance of allografts
    Takuya Ueno
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:535-44. 2009

Detail Information

Publications33

  1. ncbi request reprint Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
    Mohammed Javeed I Ansari
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 126:140-7. 2008
    ..We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity...
  2. doi request reprint Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:993-1004. 2009
    ..These data provide important preclinical data supporting the basis for further development of allogeneic MSC-based therapies for T1D and, potentially, for other autoimmune disorders...
  3. pmc Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes
    Francesca D'Addio
    Corresponding author Paolo Fiorina
    Diabetes Care 37:267-76. 2014
    ..CONCLUSIONS ITA, despite immunosuppressive therapy, is associated with a near-normalization of hemostatic and cerebral abnormalities. ..
  4. ncbi request reprint 31P-magnetic resonance spectroscopy (31P-MRS) detects early changes in kidney high-energy phosphate metabolism during a 6-month Valsartan treatment in diabetic and non-diabetic kidney-transplanted patients
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Enders Building, EN530, Boston, MA, USA
    Acta Diabetol 49:S133-9. 2012
    ..Kidney-localized (31)P-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients...
  5. pmc Near normalization of metabolic and functional features of the central nervous system in type 1 diabetic patients with end-stage renal disease after kidney-pancreas transplantation
    Paolo Fiorina
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham andWomen s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:367-74. 2012
    ..Kidney-pancreas (KP), but not kidney alone (KD), transplantation is associated with sustained normoglycemia, improvement in quality of life, and reduction of morbidity/mortality in diabetic patients with end-stage renal disease (ESRD)...
  6. pmc Immunological applications of stem cells in type 1 diabetes
    Paolo Fiorina
    Transplantation Research Center, Division of Nephrology, Children s Hospital Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Rev 32:725-54. 2011
    ..Finally, embryonic SCs also offer exciting prospects because they are able to generate glucose-responsive insulin-producing cells. Easy enthusiasm should be mitigated mainly because of the potential oncogenicity of SCs...
  7. pmc Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 186:121-31. 2011
    ..Targeting the CXCR4-CXCL12 axis thus mobilizes autologous HSCs and promotes long-term survival of islet allografts via a PD-L1-mediated mechanism...
  8. doi request reprint The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing
    Paolo Fiorina
    Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Transplant 19:1369-81. 2010
    ..Despite controversial data about the functional impairment of diabetic BM-PCs, in this model our data showed a residual capacity of these cells to trigger angiogenesis and cell proliferation...
  9. pmc A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice
    Andrea Vergani
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:2253-64. 2010
    ....
  10. pmc Divergent role of donor dendritic cells in rejection versus tolerance of allografts
    Takuya Ueno
    Transplantation Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:535-44. 2009
    ..These data indicate the importance of the CX3CR1 pathway in the generation of heart tissue dendritic cells and the divergent role of tissue/dendritic cells in rejection versus tolerance...
  11. pmc Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes
    Mollie Jurewicz
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:3139-47. 2010
    ..Here, we examine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to reverse recent-onset type 1 diabetes in NOD mice, as well as determine the immunomodulatory effects of NOR MSCs in vivo...
  12. pmc Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection
    Andrea Vergani
    Transplantation Research Center, Nephrology Division, Boston Children s Hospital and Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 62:1665-75. 2013
    ..The beneficial effects of oATP treatment revealed a role for the purinergic system in islet allograft rejection, and the targeting of P2X7R is a novel strategy to induce long-term islet allograft function...
  13. doi request reprint Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 85:1030-8. 2008
    ..Here, we provide evidence that lack of CCR2 could lead to the generation of functionally and phenotypically different DC, which in part could explain the benefits observed in transplanting islets in CCR2 recipients...
  14. pmc Targeting CD22 reprograms B-cells and reverses autoimmune diabetes
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:3013-24. 2008
    ..To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice...
  15. pmc Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses
    Michele Carvello
    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:155-65. 2012
    ..Anti-CD22/cal-mediated B-cell depletion promotes the reduction of the anti-islet immune response in various models of islet transplantation...
  16. pmc CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival
    Francesca D'Addio
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60391. 2013
    ..Thus, CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection...
  17. pmc B7h (ICOS-L) maintains tolerance at the fetomaternal interface
    Leonardo V Riella
    Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 182:2204-13. 2013
    ..Taken together, these data support the hypothesis that B7h blockade abrogates tolerance at the fetomaternal interface by enhancing CD8(+) effector response and reducing local immunomodulation mediated by CD8(+) regulatory T cells...
  18. pmc Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model
    Francesca D'Addio
    Renal Division, Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e53797. 2013
    ..Clinical trials investigating B7/CD28 blockade (LEA29Y, Belatacept) in kidney transplant recipients have proven that the replacement of toxic CNI use is feasible in selected populations...
  19. pmc Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7
    Andrea Vergani
    Transplantation Research Center, Boston Children s Hospital, Harvard Medical School, Enders Building 5th floor, Rm EN530, 300 Longwood Ave, Boston, MA 02115, USA
    Circulation 127:463-75. 2013
    ..Novel clinical-grade P2X7R inhibitors are available, rendering the targeting of P2X7R a potential therapy in cardiac transplantation...
  20. ncbi request reprint Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival
    Paolo Fiorina
    Transplantation Research Center TRC, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Diabetes 56:912-20. 2007
    ..This study introduces dDCs and rDCs as two distinct types of DCs and provides novel data with clinical implications to use chemokine-based DC-depleting strategies to prolong islet allograft survival...
  21. doi request reprint Kidney-derived mesenchymal stromal cells modulate dendritic cell function to suppress alloimmune responses and delay allograft rejection
    Yanfei Huang
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transplantation 90:1307-11. 2010
    ....
  22. ncbi request reprint Importance of donor- and recipient-derived selectins in cardiac allograft rejection
    Atsushi Izawa
    Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 18:2929-36. 2007
    ..In conclusion, donor-derived selectins contribute to the development of both acute and chronic cardiac allograft rejection, and targeting donor selectins may open novel therapeutic approaches in clinical transplantation...
  23. ncbi request reprint Mechanisms of PDL1-mediated regulation of autoimmune diabetes
    Indira Guleria
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 125:16-25. 2007
    ..These data provide strong evidence that PDL1 regulates autoimmune diabetes by limiting the expansion of CD4+ and CD8+ autoreactive T cells, and define the timing and locale of PDL1-mediated regulation of type 1 diabetes...
  24. pmc Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes
    Reza Abdi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1759-67. 2008
    ....
  25. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
    ..These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes...
  26. pmc Strategies to reverse endothelial progenitor cell dysfunction in diabetes
    Alessandra Petrelli
    Transplantation Research Center TRC, Nephrology Division, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Diabetes Res 2012:471823. 2012
    ..Finally, we review preclinical and clinical strategies that aim to revert diabetes-induced dysfunction of endothelial progenitor cells as a means of finding new strategies to prevent diabetic complications...
  27. pmc Regenerative therapies for diabetic microangiopathy
    Roberto Bassi
    Nephrology Division, Transplantation Research Center, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Diabetes Res 2012:916560. 2012
    ....
  28. pmc Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 191:2319-27. 2013
    ..These data could have significant clinical implications for Treg-based therapy in immune-mediated diseases. ..
  29. doi request reprint Modified CD4(+) T-cell response in recipients of old cardiac allografts
    Christian Denecke
    Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Transpl Int 25:328-36. 2012
    ..These findings contribute to a better understanding of the immune response following the engraftment of older donor organs...
  30. pmc IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response
    Alessandra Petrelli
    Transplantation Research Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:3223-34. 2011
    ..Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still unclear...
  31. doi request reprint Impact of islet transplantation on diabetes complications and quality of life
    Roberto Bassi
    Transplantation Research Center, Nephrology Division, Children s Hospital Harvard Medical School, Boston, MA 02115, USA
    Curr Diab Rep 11:355-63. 2011
    ..The proof of concept for cellular replacement therapy in diabetes has been established with islet transplantation, it only needs to be improved and rendered widely available...
  32. doi request reprint B-Cell Depletion Improves Islet Allograft Survival With Anti-CD45RB
    Kang Mi Lee
    Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Cell Transplant 23:51-8. 2014
    ..These findings may help elucidate the varied action of B-cells in promoting tolerance versus rejection. ..
  33. ncbi request reprint Role of CXC chemokine receptor 3 pathway in renal ischemic injury
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:716-23. 2006
    ..It is concluded that CXCR3 plays an important role in orchestrating the recruitment of Th1 cells to the ischemic kidney and in mediating I/R injury and therefore may serve as a novel target for the therapy of I/R injury...