DANIEL J FINLEY

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Chaperone-mediated pathway of proteasome regulatory particle assembly
    Jeroen Roelofs
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 459:861-5. 2009
  2. pmc Hexameric assembly of the proteasomal ATPases is templated through their C termini
    SoYeon Park
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 459:866-70. 2009
  3. pmc An asymmetric interface between the regulatory and core particles of the proteasome
    Geng Tian
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 18:1259-67. 2011
  4. pmc Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins
    Amanda M Goh
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    BMC Biochem 9:4. 2008
  5. pmc Recognition and processing of ubiquitin-protein conjugates by the proteasome
    Daniel Finley
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Biochem 78:477-513. 2009

Research Grants

  1. Regulation of Proteasome Activity by Ubp6 and Hul5
    Daniel Finley; Fiscal Year: 2007
  2. UBIQUITIN-PROTEIN CONJUGATES AND FUSIONS
    Daniel Finley; Fiscal Year: 1992
  3. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2002
  4. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2000
  5. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2000
  6. Regulation of Proteasome Activity by Ubp6 and Hul5
    DANIEL J FINLEY; Fiscal Year: 2010
  7. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2004
  8. NEW, SALT-SENSITIVE COMPONENTS OF THE PROTEASOME
    Daniel Finley; Fiscal Year: 2005
  9. Regulation of Proteasome Activity by Ubp6 and Hul5
    Daniel Finley; Fiscal Year: 2007
  10. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2002

Collaborators

  • Yigong Shi
  • SoYeon Park
  • Geng Tian
  • Steven P Gygi
  • Jeroen Roelofs
  • Amanda M Goh
  • Bettina Huck
  • Christopher P Hill
  • Min Jae Lee
  • Fiona McAllister
  • Fan Zhang
  • Wilhelm Haas
  • Byung Hoon Lee
  • Jessica Robert
  • Ying Huo
  • Fiona E McAllister
  • Woong Kim
  • Marion Schmidt
  • Suzanne Elsasser
  • Kylie J Walters
  • Rati Verma
  • Raymond J Deshaies
  • Peter M Howley

Detail Information

Publications5

  1. pmc Chaperone-mediated pathway of proteasome regulatory particle assembly
    Jeroen Roelofs
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 459:861-5. 2009
    ..In addition, competition between the RP chaperones and the CP for Rpt engagement may explain the release of RP chaperones as proteasomes mature...
  2. pmc Hexameric assembly of the proteasomal ATPases is templated through their C termini
    SoYeon Park
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 459:866-70. 2009
    ..Our studies show that assembly of the proteasome base is a rapid yet highly orchestrated process...
  3. pmc An asymmetric interface between the regulatory and core particles of the proteasome
    Geng Tian
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Struct Mol Biol 18:1259-67. 2011
    ..Rpt-core particle cross-links are all sensitive to nucleotides, implying that ATP hydrolysis drives dynamic alterations at the core particle-regulatory particle interface...
  4. pmc Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins
    Amanda M Goh
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    BMC Biochem 9:4. 2008
    ....
  5. pmc Recognition and processing of ubiquitin-protein conjugates by the proteasome
    Daniel Finley
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Biochem 78:477-513. 2009
    ..Here we examine the key elements of this molecular machine and how they cooperate in the processing of proteolytic substrates...

Research Grants32

  1. Regulation of Proteasome Activity by Ubp6 and Hul5
    Daniel Finley; Fiscal Year: 2007
    ..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..
  2. UBIQUITIN-PROTEIN CONJUGATES AND FUSIONS
    Daniel Finley; Fiscal Year: 1992
    ....
  3. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2002
    ..3. To identify the ubiquitin receptor of the proteasome. 4. To demonstrate the existence of a gated axial channel in the proteasome. 5. To characterize the chaperone-like activity of the proteasome. ..
  4. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2000
    ..3. To identify the ubiquitin receptor of the proteasome. 4. To demonstrate the existence of a gated axial channel in the proteasome. 5. To characterize the chaperone-like activity of the proteasome. ..
  5. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2000
    ..3. To identify the ubiquitin receptor of the proteasome. 4. To demonstrate the existence of a gated axial channel in the proteasome. 5. To characterize the chaperone-like activity of the proteasome. ..
  6. Regulation of Proteasome Activity by Ubp6 and Hul5
    DANIEL J FINLEY; Fiscal Year: 2010
    ..A better understanding of this new pathway may potentially shed new light on a variety of disease mechanisms. ..
  7. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2004
    ..In summary, these studies seek to identify the key enzymes and substrates of the Rub2 pathway and thus provide an essential foundation for future studies of this novel protein modification system. ..
  8. NEW, SALT-SENSITIVE COMPONENTS OF THE PROTEASOME
    Daniel Finley; Fiscal Year: 2005
    ..Aim 4. To map sequences within proteasome-associated proteins that mediate their binding to proteasomes. Aim 5. To study the functions of specific proteasome-associated proteins. ..
  9. Regulation of Proteasome Activity by Ubp6 and Hul5
    Daniel Finley; Fiscal Year: 2007
    ..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..
  10. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2002
    ..In summary, these studies seek to identify the key enzymes and substrates of the Rub2 pathway and thus provide an essential foundation for future studies of this novel protein modification system. ..
  11. NEW, SALT-SENSITIVE COMPONENTS OF THE PROTEASOME
    Daniel Finley; Fiscal Year: 2006
    ..Aim 4. To map sequences within proteasome-associated proteins that mediate their binding to proteasomes. Aim 5. To study the functions of specific proteasome-associated proteins. ..
  12. NEW, SALT-SENSITIVE COMPONENTS OF THE PROTEASOME
    Daniel Finley; Fiscal Year: 2003
    ..Aim 4. To map sequences within proteasome-associated proteins that mediate their binding to proteasomes. Aim 5. To study the functions of specific proteasome-associated proteins. ..
  13. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2001
    ..3. To identify the ubiquitin receptor of the proteasome. 4. To demonstrate the existence of a gated axial channel in the proteasome. 5. To characterize the chaperone-like activity of the proteasome. ..
  14. Regulation of Proteasome Activity by Ubp6 and Hul5
    DANIEL J FINLEY; Fiscal Year: 2010
    ..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..
  15. Regulation of Proteasome Activity by Ubp6 and Hul5
    Daniel Finley; Fiscal Year: 2009
    ..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..
  16. Functional Analysis of the Proteasome Base
    Daniel Finley; Fiscal Year: 2007
    ..In summary, this proposal will combine biochemical, genetic, proteomic, and structural methods to address key questions concerning early steps in protein degradation by the proteasome. ..
  17. ATPASE PROTEINS OF THE YEAST 26S PROTEIN
    Daniel Finley; Fiscal Year: 1999
    ..In summary, the powerful combination of biochemistry and genetics proposed below will provide insights into a novel ATPase particle, and allow us to test the molecular chaperone model of 26S ATPase function. ..
  18. UBIQUITIN-PROTEIN CONJUGATES AND FUSIONS
    Daniel Finley; Fiscal Year: 1990
    ....
  19. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2003
    ..In summary, these studies seek to identify the key enzymes and substrates of the Rub2 pathway and thus provide an essential foundation for future studies of this novel protein modification system. ..
  20. NEW, SALT-SENSITIVE COMPONENTS OF THE PROTEASOME
    Daniel Finley; Fiscal Year: 2004
    ..Aim 4. To map sequences within proteasome-associated proteins that mediate their binding to proteasomes. Aim 5. To study the functions of specific proteasome-associated proteins. ..
  21. UBIQUITIN-PROTEIN CONJUGATES AND FUSIONS
    Daniel Finley; Fiscal Year: 1991
    ....
  22. A NEW PROTEIN MODIFICATION PATHWAY IN EUKARYOTES
    Daniel Finley; Fiscal Year: 2001
    ..In summary, these studies seek to identify the key enzymes and substrates of the Rub2 pathway and thus provide an essential foundation for future studies of this novel protein modification system. ..
  23. UBIQUITIN-PROTEIN CONJUGATES AND FUSIONS
    Daniel Finley; Fiscal Year: 1993
    ....
  24. ANALYSIS OF THE PROTEASOME REGULATORY PARTICLE
    Daniel Finley; Fiscal Year: 2003
    ..3. To identify the ubiquitin receptor of the proteasome. 4. To demonstrate the existence of a gated axial channel in the proteasome. 5. To characterize the chaperone-like activity of the proteasome. ..
  25. Ubiquitination and Cellular Regulation
    Daniel Finley; Fiscal Year: 2004
    ..Based on past experience, the conference will be oversubscribed by a large margin. To foster strong interactions among participants, the conference is limited to approximately 175 participants. ..