DANIEL J FINLEY

....

..Here we examine the key elements of this molecular machine and how they cooperate in the processing of proteolytic substrates...

..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..

..Based on past experience, the conference will be oversubscribed by a large margin. To foster strong interactions among participants, the conference is limited to approximately 175 participants. ..

..In summary, the powerful combination of biochemistry and genetics proposed below will provide insights into a novel ATPase particle, and allow us to test the molecular chaperone model of 26S ATPase function. ..

....

..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..

..In summary, these studies seek to identify the key enzymes and substrates of the Rub2 pathway and thus provide an essential foundation for future studies of this novel protein modification system. ..

..In summary, this proposal will combine biochemical, genetic, proteomic, and structural methods to address key questions concerning early steps in protein degradation by the proteasome. ..

..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..

..Thus, by providing a deeper understanding of this enzyme, our studies may facilitate the development of other useful drugs. ..

..Aim 4. To map sequences within proteasome-associated proteins that mediate their binding to proteasomes. Aim 5. To study the functions of specific proteasome-associated proteins. ..

..3. To identify the ubiquitin receptor of the proteasome. 4. To demonstrate the existence of a gated axial channel in the proteasome. 5. To characterize the chaperone-like activity of the proteasome. ..

..A better understanding of this new pathway may potentially shed new light on a variety of disease mechanisms. ..