C M Field

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Small molecules in an RNAi world
    Ulrike S Eggert
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biosyst 2:93-6. 2006
  2. ncbi request reprint Septins: cytoskeletal polymers or signalling GTPases?
    C M Field
    Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:387-94. 1999
  3. ncbi request reprint Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrity
    Christine M Field
    Department of Systems Biology, Harvard Medical School, Boston MA 02115, USA
    Development 132:2849-60. 2005
  4. ncbi request reprint Microtubules, membranes and cytokinesis
    A F Straight
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 10:R760-70. 2000
  5. pmc Cell polarization during monopolar cytokinesis
    Chi Kuo Hu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 181:195-202. 2008
  6. ncbi request reprint Animal cytokinesis: from parts list to mechanisms
    Ulrike S Eggert
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Biochem 75:543-66. 2006
  7. pmc Clues to CD2-associated protein involvement in cytokinesis
    Pascale Monzo
    Institut National de la Santé et de la Recherche Médicale U568, Faculte de Medecine, 06107 Nice Cedex 02, France
    Mol Biol Cell 16:2891-902. 2005
  8. pmc Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets
    Ulrike S Eggert
    Department of Systems Biology, Harvard Medical School Boston, Massachusetts, USA
    PLoS Biol 2:e379. 2004
  9. pmc Anillin binds nonmuscle myosin II and regulates the contractile ring
    Aaron F Straight
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 16:193-201. 2005
  10. ncbi request reprint The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides
    Alina M Vrabioiu
    Department of Systems Biology, Harvard University, Boston, MA 02115, USA
    J Biol Chem 279:3111-8. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Small molecules in an RNAi world
    Ulrike S Eggert
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biosyst 2:93-6. 2006
    ..In this Opinion, we compare and contrast small molecules and RNAi. We discuss the advantages and disadvantages of both technologies focusing on timing, specificity, dose and therapeutic use...
  2. ncbi request reprint Septins: cytoskeletal polymers or signalling GTPases?
    C M Field
    Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:387-94. 1999
    ....
  3. ncbi request reprint Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrity
    Christine M Field
    Department of Systems Biology, Harvard Medical School, Boston MA 02115, USA
    Development 132:2849-60. 2005
    ..Cumulatively, our data point to an important role for Anillin in scaffolding cleavage furrow components, directly stabilizing intracellular bridges, and indirectly stabilizing newly deposited plasma membrane during cellularization...
  4. ncbi request reprint Microtubules, membranes and cytokinesis
    A F Straight
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 10:R760-70. 2000
    ..Specialized microtubule structures are responsible for directing membrane vesicles to the site of cell cleavage, and vesicle fusion is required for the proper completion of cytokinesis...
  5. pmc Cell polarization during monopolar cytokinesis
    Chi Kuo Hu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 181:195-202. 2008
    ..We propose that feedback loops between cortical furrow components and microtubules promote symmetry breaking during monopolar cytokinesis and regional specialization of the cytoskeleton during normal bipolar cytokinesis...
  6. ncbi request reprint Animal cytokinesis: from parts list to mechanisms
    Ulrike S Eggert
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Biochem 75:543-66. 2006
    ..We also discuss the extent to which classic questions have been answered and identify major outstanding questions...
  7. pmc Clues to CD2-associated protein involvement in cytokinesis
    Pascale Monzo
    Institut National de la Santé et de la Recherche Médicale U568, Faculte de Medecine, 06107 Nice Cedex 02, France
    Mol Biol Cell 16:2891-902. 2005
    ..Both CD2AP and anillin were found phosphorylated early in mitosis and also CD2AP phosphorylation was coupled to its delocalization from membrane to cytosol. All these observations led us to propose CD2AP as a new player in cytokinesis...
  8. pmc Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets
    Ulrike S Eggert
    Department of Systems Biology, Harvard Medical School Boston, Massachusetts, USA
    PLoS Biol 2:e379. 2004
    ..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
  9. pmc Anillin binds nonmuscle myosin II and regulates the contractile ring
    Aaron F Straight
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Biol Cell 16:193-201. 2005
    ..We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis...
  10. ncbi request reprint The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides
    Alina M Vrabioiu
    Department of Systems Biology, Harvard University, Boston, MA 02115, USA
    J Biol Chem 279:3111-8. 2004
    ..We conclude that bound GTP and GDP play a structural, rather then regulatory, role for the majority of septins in proliferating cells as GTP does for alpha-tubulin...
  11. ncbi request reprint Self- and actin-templated assembly of Mammalian septins
    Makoto Kinoshita
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 3:791-802. 2002
    ..We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles...
  12. pmc Mammalian septins nomenclature
    Ian G Macara
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Biol Cell 13:4111-3. 2002
    ..The human and mouse septin genes will be named SEPT1-SEPT10 and Sept1-Sept10, respectively. Splice variants will be designated by an underscore followed by a lowercase "v" and a number, e.g., SEPT4_v1...
  13. ncbi request reprint Cytoskeleton: what does GTP do for septins?
    Timothy J Mitchison
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 5731, USA
    Curr Biol 12:R788-90. 2002
    ..This model cannot, however, explain the GTP-biochemistry of heteromeric septin complexes from cytosol...
  14. pmc Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization
    Jian Cao
    Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    J Cell Biol 182:301-13. 2008
    ..We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway...
  15. pmc A quantitative analysis of contractility in active cytoskeletal protein networks
    Poul M Bendix
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    Biophys J 94:3126-36. 2008
    ..Our results suggest that cellular contractility can be sensitively regulated by tuning the (local) activity of molecular motors and the cross-linker density and binding affinity...