Research Topics
Genomes and Genes | C M FieldSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Small molecules in an RNAi worldUlrike S Eggert
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Mol Biosyst 2:93-6. 2006..In this Opinion, we compare and contrast small molecules and RNAi. We discuss the advantages and disadvantages of both technologies focusing on timing, specificity, dose and therapeutic use...- Septins: cytoskeletal polymers or signalling GTPases?C M Field
Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Trends Cell Biol 9:387-94. 1999.... - Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrityChristine M Field
Department of Systems Biology, Harvard Medical School, Boston MA 02115, USA
Development 132:2849-60. 2005..Cumulatively, our data point to an important role for Anillin in scaffolding cleavage furrow components, directly stabilizing intracellular bridges, and indirectly stabilizing newly deposited plasma membrane during cellularization... - Microtubules, membranes and cytokinesisA F Straight
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 10:R760-70. 2000..Specialized microtubule structures are responsible for directing membrane vesicles to the site of cell cleavage, and vesicle fusion is required for the proper completion of cytokinesis... 
Cell polarization during monopolar cytokinesisChi Kuo Hu
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 181:195-202. 2008..We propose that feedback loops between cortical furrow components and microtubules promote symmetry breaking during monopolar cytokinesis and regional specialization of the cytoskeleton during normal bipolar cytokinesis...- Animal cytokinesis: from parts list to mechanismsUlrike S Eggert
Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Biochem 75:543-66. 2006..We also discuss the extent to which classic questions have been answered and identify major outstanding questions... - Clues to CD2-associated protein involvement in cytokinesisPascale Monzo
Institut National de la Santé et de la Recherche Médicale U568, Faculte de Medecine, 06107 Nice Cedex 02, France
Mol Biol Cell 16:2891-902. 2005..Both CD2AP and anillin were found phosphorylated early in mitosis and also CD2AP phosphorylation was coupled to its delocalization from membrane to cytosol. All these observations led us to propose CD2AP as a new player in cytokinesis... - Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targetsUlrike S Eggert
Department of Systems Biology, Harvard Medical School Boston, Massachusetts, USA
PLoS Biol 2:e379. 2004..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways... - Anillin binds nonmuscle myosin II and regulates the contractile ringAaron F Straight
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
Mol Biol Cell 16:193-201. 2005..We propose a role for anillin in spatially regulating the contractile activity of myosin II during cytokinesis... - The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotidesAlina M Vrabioiu
Department of Systems Biology, Harvard University, Boston, MA 02115, USA
J Biol Chem 279:3111-8. 2004..We conclude that bound GTP and GDP play a structural, rather then regulatory, role for the majority of septins in proliferating cells as GTP does for alpha-tubulin... - Self- and actin-templated assembly of Mammalian septinsMakoto Kinoshita
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 3:791-802. 2002..We conclude that septins alone self-assemble into rings, that adaptor proteins recruit septins to actin bundles, and that septins help organize these bundles... - Mammalian septins nomenclatureIan G Macara
Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Mol Biol Cell 13:4111-3. 2002..The human and mouse septin genes will be named SEPT1-SEPT10 and Sept1-Sept10, respectively. Splice variants will be designated by an underscore followed by a lowercase "v" and a number, e.g., SEPT4_v1... - Cytoskeleton: what does GTP do for septins?Timothy J Mitchison
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115 5731, USA
Curr Biol 12:R788-90. 2002..This model cannot, however, explain the GTP-biochemistry of heteromeric septin complexes from cytosol... - Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerizationJian Cao
Sinsheimer Laboratories, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
J Cell Biol 182:301-13. 2008..We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway... - A quantitative analysis of contractility in active cytoskeletal protein networksPoul M Bendix
School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
Biophys J 94:3126-36. 2008..Our results suggest that cellular contractility can be sensitively regulated by tuning the (local) activity of molecular motors and the cross-linker density and binding affinity...