Research Topics
Genomes and GenesSpecies | Raina FichorovaSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Biocompatibility of solid-dosage forms of anti-human immunodeficiency virus type 1 microbicides with the human cervicovaginal mucosa modeled ex vivoRadiana T Trifonova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Antimicrob Agents Chemother 50:4005-10. 2006..This study identifies immunoinflammatory biomarkers that can discriminate between formulations better than toxicity assays and should be clinically validated in relevance to the risk of HIV-1 acquisition...- Homeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicideHidemi S Yamamoto
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Microbiol 13:4. 2013.... - Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapyRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
PLoS ONE 7:e48418. 2012..Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae... - Novel vaginal microflora colonization model providing new insight into microbicide mechanism of actionRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts, USA
MBio 2:e00168-11. 2011..Our data also highlight the importance of differentiating the effects of biomedical interventions on epithelium-associated versus conventional planktonic bacterial growth when assessing vaginal mucosal health and immunity... 
Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trialsRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Cytokine 55:134-40. 2011....- Impact of T. vaginalis infection on innate immune responses and reproductive outcomeRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02155, USA
J Reprod Immunol 83:185-9. 2009..The molecular mechanisms underlying reproductive complications and epidemiologic risks associated with T. vaginalis infection remain to be elucidated... - Polyanionic microbicides modify Toll-like receptor-mediated cervicovaginal immune responsesR T Trifonova
Department of Obstetrics, Brigham and Women s Hospital, Laboratory of Genital Tract Biology, Boston, MA 02115, USA
Antimicrob Agents Chemother 53:1490-500. 2009..Further studies are warranted to determine the impact of this interference on HIV-1 transmission risk... - Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter studyRaina N Fichorova
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Anal Chem 80:4741-51. 2008..This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface... 
Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cellsR N Fichorova
Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Reprod 60:508-14. 1999....- Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptivesR N Fichorova
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Reprod 71:761-9. 2004..The described evaluation system is a valuable tool in identifying novel vaginal contraceptive microbicides, selecting out candidates that may enhance, rather than decrease, HIV transmission... - The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmissionR N Fichorova
Fearing Research Laboratory, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Thorn 217, Boston, MA 02115, USA
J Infect Dis 184:418-28. 2001..Furthermore, this study identifies in vitro and in vivo model systems for monitoring undesirable proinflammatory effects of microbicides and other vaginal products... - Anti-human immunodeficiency virus type 1 microbicide cellulose acetate 1,2-benzenedicarboxylate in a human in vitro model of vaginal inflammationR N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, 221 Longwood Ave RF468, Boston, MA 02115, USA
Antimicrob Agents Chemother 49:323-35. 2005..The described system may be useful for predicting proinflammatory side effects of other microbicide candidates for vaginal application... - The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN studyAlan Leviton
Neuroepidemiology Unit, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Pediatr 158:897-903.e1-5. 2011..To evaluate whether concentrations of inflammation-related proteins are elevated in the blood of preterm newborns who develop cerebral white matter damage... - Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cellsR N Fichorova
Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Infect Immun 69:5840-8. 2001..gonorrhoeae... - Caveolin-1 modifies the immunity to Pseudomonas aeruginosaMihaela Gadjeva
Department of Medicine, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 184:296-302. 2010..aeruginosa infection in the setting of both acute pneumonia and chronic infection typical of CF... - Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulationAlan Leviton
Neurology Department, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Cytokine 53:66-73. 2011..We wanted to assess to what extent concentrations of circulating proteins appear to be developmentally regulated, and to what extent such regulation is influenced by intra-uterine inflammation... - Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signalingRaina N Fichorova
Fearing Research Laboratory, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:2424-32. 2002..These data demonstrate that the response to N. gonorrhoeae and other Gram-negative bacteria at the mucosal surface of the female genital tract occurs in the absence of endotoxin recognition and TLR4-mediated signaling... - Preclinical assessment of the proinflammatory potential of microbicide candidatesGustavo F Doncel
CONRAD, Intramural Preclinical Research, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA 23507, USA
J Acquir Immune Defic Syndr 37:S174-80. 2004..This combined, sequential, preclinical evaluation system based on VK-2 cells in culture and a refined rabbit vaginal irritation model represents a valuable tool to assess the local safety profile of anti-HIV microbicide candidates... - Biomarkers of leukocyte traffic and activation in the vaginal mucosaRadiana T Trifonova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Biomarkers 12:608-22. 2007..These biomarkers, which were also detected in human vaginal secretions, may be used to enhance the characterization of mucosal safety of vaginally applied compounds, both in animal as well as clinical studies... - Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety studyJill L Schwartz
Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 74:133-40. 2006..Cellulose sulfate (CS) is a noncytotoxic antifertility agent that exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV... - Guiding the vaginal microbicide trials with biomarkers of inflammationRaina N Fichorova
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Acquir Immune Defic Syndr 37:S184-93. 2004.... - Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cellsRaina N Fichorova
Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, RF468, Boston, MA 02115, USA
Infect Immun 74:5773-9. 2006..These effects were dose dependent and sustained in the absence of cytotoxicity and IL-1beta release and utilized, at least in part, a signaling pathway independent from the Toll-like/IL-1 receptor adaptor protein MyD88... - Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cellsKerstin Kleine-Lowinski
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Int J Cancer 107:407-15. 2003..These observations are consistent with a model in which MCP-1 expression by infected keratinocytes, which would stimulate an immune attack on HPV-transformed cells, is suppressed for invasive cervical cancer to appear... - Detection of implantation-related cytokines in cervicovaginal secretions and peripheral blood of fertile women during ovulatory menstrual cyclesAntonio R Gargiulo
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Fertil Steril 82:1226-34. 2004..To determine whether cytokines implicated in uterine receptivity are detectable in cervicovaginal secretions and/or serum of fertile women, and whether their concentrations undergo hormonal regulation during the menstrual cycle... - Expression and function of bactericidal/permeability-increasing protein in human genital tract epithelial cellsGeraldine O Canny
Center for Experimental Therapeutics and Reperfusion Injury, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA
J Infect Dis 194:498-502. 2006..The results of the present study suggest that BPI is tightly regulated and functionally expressed by epithelial cells in the female reproductive tract and may play a role in regulating bacterial colonization in the genital mucosa...
Research Grants
- Trichomonas Lipophosphoglycan in Regulation Immune ResponsesRaina Fichorova; Fiscal Year: 2007..vaginalis infections and complications. ..
- Molecular T. vaginalis-host interactions in relevance to inflammatory sequelaeRaina Fichorova; Fiscal Year: 2009..vaginalis-host interactions in relevance to inflammatory sequelae" is to unveil molecular mechanisms of parasite-host interactions associated with inflammatory symptoms and susceptibility to infection. ..
- Molecular T. vaginalis-host interactions in relevance to inflammatory sequelaeRaina N Fichorova; Fiscal Year: 2010..vaginalis-host interactions in relevance to inflammatory sequelae" is to unveil molecular mechanisms of parasite-host interactions associated with inflammatory symptoms and susceptibility to infection. ..