Affiliation: Harvard University
- Fichorova R, Lee Y, Yamamoto H, Takagi Y, Hayes G, Goodman R, et al. Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. PLoS ONE. 2012;7:e48418 pubmed publisher..Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae...
- Lee Y, Dizzell S, Leung V, Nazli A, Zahoor M, Fichorova R, et al. Effects of Female Sex Hormones on Susceptibility to HSV-2 in Vaginal Cells Grown in Air-Liquid Interface. Viruses. 2016;8: pubmed publisher..Furthermore, under these conditions P4 was found to confer higher susceptibility to HSV-2 infection in vaginal cells. The vaginal ALI culture system offers a better alternative to study host-pathogen interactions. ..
- Fichorova R, Tucker L, Anderson D. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis. 2001;184:418-28 pubmed..Furthermore, this study identifies in vitro and in vivo model systems for monitoring undesirable proinflammatory effects of microbicides and other vaginal products...
- Fichorova R, Bajpai M, Chandra N, Hsiu J, Spangler M, Ratnam V, et al. Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol Reprod. 2004;71:761-9 pubmed..The described evaluation system is a valuable tool in identifying novel vaginal contraceptive microbicides, selecting out candidates that may enhance, rather than decrease, HIV transmission...