Raina Fichorova

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. Fichorova R, Lai J, Schwartz J, Weiner D, Mauck C, Callahan M. Baseline variation and associations between subject characteristics and five cytokine biomarkers of vaginal safety among healthy non-pregnant women in microbicide trials. Cytokine. 2011;55:134-40 pubmed publisher
  2. Fichorova R, Zhou F, Ratnam V, Atanassova V, Jiang S, Strick N, et al. Anti-human immunodeficiency virus type 1 microbicide cellulose acetate 1,2-benzenedicarboxylate in a human in vitro model of vaginal inflammation. Antimicrob Agents Chemother. 2005;49:323-35 pubmed
    ..The described system may be useful for predicting proinflammatory side effects of other microbicide candidates for vaginal application. ..
  3. Fichorova R, Richardson Harman N, Alfano M, Belec L, Carbonneil C, Chen S, et al. Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study. Anal Chem. 2008;80:4741-51 pubmed publisher
    ..This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface. ..
  4. Fichorova R, Mendonca K, Yamamoto H, Murray R, Chandra N, Doncel G. A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation. Toxicol Appl Pharmacol. 2015;285:198-206 pubmed publisher
  5. Fichorova R, Yamamoto H, Fashemi T, Foley E, Ryan S, Beatty N, et al. Trichomonas vaginalis Lipophosphoglycan Exploits Binding to Galectin-1 and -3 to Modulate Epithelial Immunity. J Biol Chem. 2016;291:998-1013 pubmed publisher
    ..These findings suggest novel approaches to control trichomoniasis and warrant further studies of galectin-binding diversity among clinical isolates as a possible source for symptom disparity in parasitic infections. ..
  6. Fichorova R, Chen P, Morrison C, Doncel G, Mendonca K, Kwok C, et al. The Contribution of Cervicovaginal Infections to the Immunomodulatory Effects of Hormonal Contraception. MBio. 2015;6:e00221-15 pubmed publisher
    ..The molecular mechanisms of the vaginal microbiome's simultaneous interactions with hormones and HIV remain to be elucidated. ..
  7. Fichorova R, Buck O, Yamamoto H, Fashemi T, Dawood H, Fashemi B, et al. The villain team-up or how Trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert. Sex Transm Infect. 2013;89:460-6 pubmed publisher
    ..These molecular host-parasite-endosymbiont-bacteria interactions explain epidemiological associations and suggest a revised paradigm for restoring vaginal immunity and preventing BV/TV-attributable inflammatory sequelae in women. ..
  8. Fichorova R. Impact of T. vaginalis infection on innate immune responses and reproductive outcome. J Reprod Immunol. 2009;83:185-9 pubmed publisher
    ..The molecular mechanisms underlying reproductive complications and epidemiologic risks associated with T. vaginalis infection remain to be elucidated...
  9. Fichorova R, Yamamoto H, Delaney M, Onderdonk A, Doncel G. Novel vaginal microflora colonization model providing new insight into microbicide mechanism of action. MBio. 2011;2:e00168-11 pubmed publisher

More Information

Publications14

  1. Fichorova R, Lee Y, Yamamoto H, Takagi Y, Hayes G, Goodman R, et al. Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. PLoS ONE. 2012;7:e48418 pubmed publisher
    ..Metronidazole treatment amplified these proinflammatory responses. Thus, a new paradigm targeting the protozoan viruses along with the protozoan host may prevent trichomoniasis-attributable inflammatory sequelae...
  2. Lee Y, Dizzell S, Leung V, Nazli A, Zahoor M, Fichorova R, et al. Effects of Female Sex Hormones on Susceptibility to HSV-2 in Vaginal Cells Grown in Air-Liquid Interface. Viruses. 2016;8: pubmed publisher
    ..Furthermore, under these conditions P4 was found to confer higher susceptibility to HSV-2 infection in vaginal cells. The vaginal ALI culture system offers a better alternative to study host-pathogen interactions. ..
  3. request reprint
    Fichorova R, Tucker L, Anderson D. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J Infect Dis. 2001;184:418-28 pubmed
    ..Furthermore, this study identifies in vitro and in vivo model systems for monitoring undesirable proinflammatory effects of microbicides and other vaginal products...
  4. request reprint
    Fichorova R, Bajpai M, Chandra N, Hsiu J, Spangler M, Ratnam V, et al. Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives. Biol Reprod. 2004;71:761-9 pubmed
    ..The described evaluation system is a valuable tool in identifying novel vaginal contraceptive microbicides, selecting out candidates that may enhance, rather than decrease, HIV transmission...
  5. Fichorova R, Fraga J, Rappelli P, Fiori P. Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma. Res Microbiol. 2017;168:882-891 pubmed publisher