Yan Feng

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Exo1: a new chemical inhibitor of the exocytic pathway
    Yan Feng
    Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6469-74. 2003
  2. pmc Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Atherosclerosis 196:590-7. 2008
  3. doi request reprint Familial aggregation of metabolic syndrome and its components in a large Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:125-9. 2008
  4. ncbi request reprint Prevalence of metabolic syndrome and its relation to body composition in a Chinese rural population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, FXB 101, Boston, MA 02115, USA
    Obesity (Silver Spring) 14:2089-98. 2006
  5. ncbi request reprint Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
    Lin Wang
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Obstet Gynecol 195:162-71. 2006
  6. ncbi request reprint Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 83:146-54. 2006
  7. pmc Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic
    Thomas J F Nieland
    Harvard Medical School, Department of Cell Biology and The CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston MA, 02115, USA
    Traffic 5:478-92. 2004
  8. pmc Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5
    Howard H Chen
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nanomedicine 8:291-8. 2012
  9. ncbi request reprint Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
    Henry E Pelish
    Department of Cell Biology and The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Chem Biol 2:39-46. 2006
  10. pmc Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance
    Wen Yang
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Pharmacol Exp Ther 339:832-41. 2011

Collaborators

Detail Information

Publications20

  1. pmc Exo1: a new chemical inhibitor of the exocytic pathway
    Yan Feng
    Institute of Chemistry and Cell Biology, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6469-74. 2003
    ..Thus, Exo1 allows the fatty acid exchange activity of Bars50 to be distinguished from ARF1 activity in the control of Golgi tubulation...
  2. pmc Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    Atherosclerosis 196:590-7. 2008
    ..The impact of changes in some metabolic risk factors of cardiovascular disease (CVD) after menopause remains controversial and ageing is an important confounder...
  3. doi request reprint Familial aggregation of metabolic syndrome and its components in a large Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:125-9. 2008
    ..To investigate the familial aggregation of metabolic syndrome (MetS) and its components in the Chinese...
  4. ncbi request reprint Prevalence of metabolic syndrome and its relation to body composition in a Chinese rural population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, FXB 101, Boston, MA 02115, USA
    Obesity (Silver Spring) 14:2089-98. 2006
    ..To investigate the prevalence of metabolic syndrome (MetS) with three different working definitions in a rural Chinese population and to examine its relation to body composition...
  5. ncbi request reprint Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
    Lin Wang
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Obstet Gynecol 195:162-71. 2006
    ..Prolylcarboxypeptidase encodes a lysosomal enzyme and is a regulator for both renin-angiotensin system and the kallikrein-kinin system. There is no published study on prolylcarboxypeptidase gene and preeclampsia...
  6. ncbi request reprint Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 83:146-54. 2006
    ..Higher fat mass may be an independent risk factor for osteoporosis and osteoporotic fractures...
  7. pmc Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic
    Thomas J F Nieland
    Harvard Medical School, Department of Cell Biology and The CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston MA, 02115, USA
    Traffic 5:478-92. 2004
    ..Identification of this novel class of sulfonamide inhibitors provides new chemical tools to better understand the function of organelle pH in membrane traffic and the activity of V-ATPases in particular...
  8. pmc Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5
    Howard H Chen
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nanomedicine 8:291-8. 2012
    ..5 nanoparticles may protect apoptotic cells by cell membrane stabilization and have the potential to become a "theranostic agent" capable of identifying and salvaging early apoptotic cells...
  9. ncbi request reprint Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
    Henry E Pelish
    Department of Cell Biology and The CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Chem Biol 2:39-46. 2006
    ..RhoGDI-dependent Cdc42 inhibition by secramine illustrates a new way to inhibit Rho GTPases with small molecules and provides a new means to study Cdc42, RhoGDI and the cellular processes they mediate...
  10. pmc Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance
    Wen Yang
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Pharmacol Exp Ther 339:832-41. 2011
    ..These data highlight protein farnesyltransferase as a novel potential molecular target to reduce the mortality of patients with sepsis...
  11. ncbi request reprint G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:612-7. 2006
    ..A new asthma susceptibility gene, the G protein-coupled receptor for asthma susceptibility (GPRA, GPR154), has recently been identified and the association was replicated in 2 white populations, but not in a Korean population...
  12. ncbi request reprint Multidimensional drug profiling by automated microscopy
    Zachary E Perlman
    Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 306:1194-8. 2004
    ..Our methods will be useful for discovering the mechanism and predicting the toxicity of new drugs...
  13. pmc Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia
    Ervin Pejo
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA
    Crit Care Med 40:187-92. 2012
    ..The objective of this study was to test the hypothesis that in contrast to etomidate, carboetomidate neither suppresses the adrenocortical response to endotoxemia nor enhances the accompanying production of proinflammatory cytokines...
  14. ncbi request reprint Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, 665 Huntington Avenue, FXB 101, Boston, MA, USA
    Hum Genet 118:568-77. 2006
    ..Our findings suggest that genetic variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are strongly associated with BMD at different skeletal sites in adult men, but not in women...
  15. pmc Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells
    Yan Feng
    Department of Cell Biology, Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    EMBO Rep 5:596-601. 2004
    ..We propose that even in the absence of Exo2 the glycolipid pathway that carries the toxin from plasma membrane into the ER bypasses the Golgi apparatus entirely...
  16. pmc Nonhematopoietic toll-like receptor 2 contributes to neutrophil and cardiac function impairment during polymicrobial sepsis
    Lin Zou
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Shock 36:370-80. 2011
    ..Toll-like receptor 2 also mediates critical ROS production during polymicrobial sepsis...
  17. pmc Toll-like receptors and myocardial inflammation
    Yan Feng
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Inflam 2011:170352. 2011
    ..This paper reviews the animal data on (1) TLRs, TLR ligands, and the signal transduction system and (2) the important role of TLR signaling in these critical cardiac conditions...
  18. pmc Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression
    Natarajan Venkatesh
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:8969-74. 2004
    ....
  19. ncbi request reprint Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7
    Mary Pat Stein
    Methods Enzymol 403:628-49. 2005
    ..Using these methods we demonstrate the requirement for activated Rab7 in the regulation of hVPS34/p150 PtdIns 3-kinase activity on late endosomes in vivo...
  20. pmc The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing
    Jan Cerny
    Department of Cell Biology and The CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    EMBO Rep 5:883-8. 2004
    ..Because cells heal normally in the presence of vacuolin-1, we suggest that lysosomes are dispensable for resealing...