Mark Feinberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
    Mark W Feinberg
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:38247-58. 2005
  2. pmc The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation
    Mark W Feinberg
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 26:4138-48. 2007
  3. ncbi request reprint Role of transforming growth factor-beta1/Smads in regulating vascular inflammation and atherogenesis
    M W Feinberg
    The Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Panminerva Med 47:169-86. 2005
  4. ncbi request reprint Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation
    Mark W Feinberg
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Res 94:601-8. 2004
  5. ncbi request reprint Macrophage-restricted and interferon gamma-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1
    Nicholas E S Sibinga
    Department of Medicine, Cardiovascular Division, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 277:16202-10. 2002
  6. pmc Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
    Manabu Minami
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 283:9692-703. 2008
  7. pmc Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1
    Can Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:408-18. 2004
  8. pmc Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes
    Hiranmoy Das
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6653-8. 2006
  9. ncbi request reprint The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis
    Sucharita Sen Banerjee
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:2581-4. 2003
  10. pmc KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation
    Sucharita SenBanerjee
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Exp Med 199:1305-15. 2004

Research Grants

  1. Inhibition of Macrophage Activation by Smad3
    Mark Feinberg; Fiscal Year: 2005
  2. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2006
  3. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2007
  4. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2009
  5. KLF10, T regulatory cells, and atherogenesis
    Mark Feinberg; Fiscal Year: 2009
  6. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark W Feinberg; Fiscal Year: 2010
  7. KLF10, T regulatory cells, and atherogenesis
    Mark W Feinberg; Fiscal Year: 2010
  8. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
    Mark W Feinberg
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:38247-58. 2005
    ..These findings support an important role for KLF4 as a regulator of key signaling pathways that control macrophage activation...
  2. pmc The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation
    Mark W Feinberg
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 26:4138-48. 2007
    ..1-/- fetal liver cells along the monocytic lineage and can activate the monocytic-specific CD14 promoter. Thus, KLF4 is a critical regulator in the transcriptional network controlling monocyte differentiation...
  3. ncbi request reprint Role of transforming growth factor-beta1/Smads in regulating vascular inflammation and atherogenesis
    M W Feinberg
    The Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Panminerva Med 47:169-86. 2005
    ..These findings are beginning to establish a mechanistic scaffold with which to understand the cell-type specific function of Smads in the development of chronic inflammatory vascular disease states...
  4. ncbi request reprint Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation
    Mark W Feinberg
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Res 94:601-8. 2004
    ....
  5. ncbi request reprint Macrophage-restricted and interferon gamma-inducible expression of the allograft inflammatory factor-1 gene requires Pu.1
    Nicholas E S Sibinga
    Department of Medicine, Cardiovascular Division, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 277:16202-10. 2002
    ..Cooperation between Pu.1 and proteins binding to the interferon regulatory factor element appears to be necessary for both macrophage-specific and interferon gamma-inducible expression of the aif-1 gene...
  6. pmc Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
    Manabu Minami
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 283:9692-703. 2008
    ..Thus, PGE(2)-EP4 signaling augments NF-kappaB1 p105 protein stability through EPRAP after proinflammatory stimulation, limiting macrophage activation...
  7. pmc Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1
    Can Shi
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:408-18. 2004
    ..This represents a new pathway for integrin-dependent modulation of gene expression and control of cellular differentiation...
  8. pmc Kruppel-like factor 2 (KLF2) regulates proinflammatory activation of monocytes
    Hiranmoy Das
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:6653-8. 2006
    ..These observations identify KLF2 as a novel negative regulator of monocytic activation...
  9. ncbi request reprint The Krüppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis
    Sucharita Sen Banerjee
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:2581-4. 2003
    ..These data identify a novel role for KLF2 as a negative regulator of adipogenesis...
  10. pmc KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation
    Sucharita SenBanerjee
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Exp Med 199:1305-15. 2004
    ..These data implicate KLF2 as a novel regulator of endothelial activation in response to proinflammatory stimuli...
  11. ncbi request reprint Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3
    Mark W Feinberg
    Division of Cardiovascular Medicine and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 279:16388-93. 2004
    ..Furthermore, we find that Smad3 prevents the cooperative induction of the iNOS promoter by C/EBP and NF-kappaB. These data demonstrate that Smad3 plays an essential role in mediating TGF-beta1 anti-inflammatory response in VSMCs...
  12. ncbi request reprint The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4
    Susan Gray
    Cardiovascular Division, Brigham and Women s Hospital, Thorn Building, 20 Shattuck Street, Boston, MA 02115, USA
    J Biol Chem 277:34322-8. 2002
    ..Finally, co-immunoprecipitation assays show that KLF15 specifically interacts with MEF2A. These studies indicate that KLF15 is an important regulator of GLUT4 in both adipose and muscle tissues...
  13. ncbi request reprint Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis
    Yoshihisa Okamoto
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 102:218-25. 2008
    ..This study establishes that low levels of adiponectin associated with obesity, the metabolic syndrome, and diabetes favor T-lymphocyte recruitment and contribute to adaptive immune response during atherogenesis...
  14. ncbi request reprint An emerging role for Krüppel-like factors in vascular biology
    Mark W Feinberg
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Trends Cardiovasc Med 14:241-6. 2004
    ..This review examines the current knowledge of this gene family's role in key cell types that critically regulate vessel biology under physiologic and pathologic states...
  15. pmc Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells
    Zhuoxiao Cao
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:24914-24. 2009
    ..Thus, KLF10 is a critical regulator in the transcriptional network controlling TGF-beta1 in both CD4(+)CD25(-) T cells and T regs and plays an important role in regulating atherosclerotic lesion formation in mice...
  16. ncbi request reprint Kruppel-like factor 4 regulates endothelial inflammation
    Anne Hamik
    Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
    J Biol Chem 282:13769-79. 2007
    ..These data implicate Kruppel-like factor 4 as a novel regulator of endothelial activation in response to pro-inflammatory stimuli...

Research Grants9

  1. Inhibition of Macrophage Activation by Smad3
    Mark Feinberg; Fiscal Year: 2005
    ..Insight into the mechanism governing SmadYs role in inflammation may provide potential, therapeutic targets applicable to a number of inflammatory diseases. ..
  2. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2006
    ..The results of these studies are of considerable scientific interest and may serve as the basis for novel therapeutic strategies to modulate TAA and the macrophage response to cytokine stimulation. ..
  3. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2007
    ..The results of these studies are of considerable scientific interest and may serve as the basis for novel therapeutic strategies to modulate TAA and the macrophage response to cytokine stimulation. ..
  4. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2009
    ..The results of these studies are of considerable scientific interest and may serve as the basis for novel therapeutic strategies to modulate TAA and the macrophage response to cytokine stimulation. ..
  5. KLF10, T regulatory cells, and atherogenesis
    Mark Feinberg; Fiscal Year: 2009
    ..The experiments proposed in this study will examine in detail the mechanisms by which KLF10 induces the T regulatory cell suppressive phenotype and its role in experimental atherosclerosis in vivo. ..
  6. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark W Feinberg; Fiscal Year: 2010
    ..The results of these studies are of considerable scientific interest and may serve as the basis for novel therapeutic strategies to modulate TAA and the macrophage response to cytokine stimulation. ..
  7. KLF10, T regulatory cells, and atherogenesis
    Mark W Feinberg; Fiscal Year: 2010
    ..The experiments proposed in this study will examine in detail the mechanisms by which KLF10 induces the T regulatory cell suppressive phenotype and its role in experimental atherosclerosis in vivo. ..
  8. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark Feinberg; Fiscal Year: 2009
    ..The results of these studies are of considerable scientific interest and may serve as the basis for novel therapeutic strategies to modulate TAA and the macrophage response to cytokine stimulation. ..