EDWARD FEENER

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats
    Allen Clermont
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 60:1590-8. 2011
  2. pmc Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein
    Jia Liu
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Nat Med 17:206-10. 2011
  3. pmc Role of plasma kallikrein in diabetes and metabolism
    E P Feener
    Edward P Feener, PhD, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA, Tel 1 617 309 2599, Fax 1 617 309 2637, E mail
    Thromb Haemost 110:434-41. 2013
  4. pmc Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
    Edward P Feener
    Joslin Proteomics Core, Joslin Diabetes Center, 1 Joslin Pl, Boston, MA 02215, USA
    Mol Cell Biol 24:4968-78. 2004
  5. doi request reprint Plasma kallikrein and diabetic macular edema
    Edward P Feener
    Department of Medicine, Harvard Medical School, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 10:270-5. 2010
  6. pmc Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Proteomics 7:2399-409. 2008
  7. doi request reprint Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy
    Ben Bo Gao
    Research Division, Beetham Eye Institute, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Proteome Res 7:2516-25. 2008
  8. ncbi request reprint Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells
    Pedro Geraldes
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Invest Ophthalmol Vis Sci 48:5750-5. 2007
  9. ncbi request reprint Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:181-8. 2007
  10. pmc Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 397:337-44. 2006

Collaborators

  • L P Aiello
  • George King
  • Martin G Myers
  • Q Zhou
  • Morris F White
  • Ben Bo Gao
  • Yasuaki Hata
  • Jørgen F P Wojtaszewski
  • Carol A Witczak
  • Allen Clermont
  • Jia Liu
  • Sukanto Sinha
  • Tamie J Chilcote
  • Eric B Taylor
  • Allen C Clermont
  • Jonas T Treebak
  • Laurie J Goodyear
  • Michael F Hirshman
  • Joanna A Phipps
  • Ding An
  • Jianxin Xie
  • Sven Erik Bursell
  • Jodel Giraud
  • Leah Rider
  • Pedro Geraldes
  • Ryoko Ishida-Takahashi
  • Aileen J McGettrick
  • Zhiheng He
  • Hong Chi Chen
  • Izumi Suzuma
  • Takeshi Kita
  • Priscilla Riva
  • Robert Flaumenhaft
  • Price Blair
  • Taro Toyoda
  • Ho Jin Koh
  • Katja S C Roeckl
  • Nicole Bowles
  • Henning F Kramer
  • Haiyan Yu
  • Nobuharu L Fujii
  • Michael Haas
  • Michiko Yamagata
  • KYLE D COPPS
  • Xiaocheng Dong
  • Sarah L Dunn
  • Maria Diakonova
  • Ronald C Ma
  • Yukio Sassa
  • Leslie Webb
  • Susan L Rook
  • Alla Shatrova
  • Zlatina Stancheva
  • Felicia Rosario
  • Xiaohong Chen
  • Keely Kopp
  • Yusong Gong
  • C Ronald Kahn
  • Joshua A Scott
  • Ronald C W Ma
  • Emi Arikawa
  • Eva Chou
  • Darren M Opland
  • Keiji Isshiki
  • Kerrie J Way
  • Frederick J Schoen
  • Kiyoshi Suzuma
  • Kohjiro Ueki

Detail Information

Publications22

  1. pmc Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats
    Allen Clermont
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 60:1590-8. 2011
    ..In this report, we examined the effects of PK on retinal vascular functions and thickness in diabetic rats...
  2. pmc Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein
    Jia Liu
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Nat Med 17:206-10. 2011
    ..These findings suggest that hyperglycemia augments cerebral hematoma expansion by PK-mediated osmotic-sensitive inhibition of hemostasis...
  3. pmc Role of plasma kallikrein in diabetes and metabolism
    E P Feener
    Edward P Feener, PhD, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA, Tel 1 617 309 2599, Fax 1 617 309 2637, E mail
    Thromb Haemost 110:434-41. 2013
    ..The review summarises the mechanisms that contribute to PK activation and its emerging role in diabetes and metabolism. ..
  4. pmc Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
    Edward P Feener
    Joslin Proteomics Core, Joslin Diabetes Center, 1 Joslin Pl, Boston, MA 02215, USA
    Mol Cell Biol 24:4968-78. 2004
    ..This Tyr(570)-dependent mechanism of Jak2 inhibition likely represents an important mechanism by which cytokine function is regulated...
  5. doi request reprint Plasma kallikrein and diabetic macular edema
    Edward P Feener
    Department of Medicine, Harvard Medical School, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 10:270-5. 2010
    ..Emerging evidence suggests that plasma kallikrein inhibitors may provide a new therapeutic opportunity to reduce retinal vascular permeability...
  6. pmc Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Proteomics 7:2399-409. 2008
    ....
  7. doi request reprint Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy
    Ben Bo Gao
    Research Division, Beetham Eye Institute, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Proteome Res 7:2516-25. 2008
    ..These data provide an in depth analysis of the human vitreous proteome and reveal protein alterations that are associated with PDR...
  8. ncbi request reprint Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells
    Pedro Geraldes
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Invest Ophthalmol Vis Sci 48:5750-5. 2007
    ....
  9. ncbi request reprint Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 13:181-8. 2007
    ..Inhibition of extracellular CA-I and kallikrein-mediated innate inflammation could provide new therapeutic opportunities for the treatment of hemorrhage-induced retinal and cerebral edema...
  10. pmc Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 397:337-44. 2006
    ..Our result suggests that the p70 PDGFR-beta functions as an adapter that recruits PI3K to the membrane upon AT1 receptor stimulation...
  11. ncbi request reprint Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways
    Izumi Suzuma
    Research Division and Beetham Eye Institute, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:1047-57. 2002
    ..This mechanism may play a role in the well documented association of concomitant hypertension with clinical exacerbation of neovascularization and vascular permeability...
  12. pmc Angiotensin AT1 receptor antagonism ameliorates murine retinal proteome changes induced by diabetes
    Ben Bo Gao
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Proteome Res 8:5541-9. 2009
    ..These results provide insight into the effects of diabetes on the retina and the role of the AT1 receptor in modulating this response...
  13. doi request reprint Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability
    Joanna A Phipps
    Department of Medicine, Harvard Medical School, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Hypertension 53:175-81. 2009
    ....
  14. pmc Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling
    Ryoko Ishida-Takahashi
    Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Mol Cell Biol 26:4063-73. 2006
    ..Thus, the phosphorylation of Jak2 on Ser523 inhibits Jak2 activity and represents a novel mechanism for the regulation of Jak2-dependent cytokine signaling...
  15. ncbi request reprint Role of the angiotensin II type 1 receptor in the pathogenesis of diabetic retinopathy: effects of blood pressure control and beyond
    Allen Clermont
    Research Division, Boston, Massachusetts 02215, USA
    J Hypertens Suppl 24:S73-80. 2006
    ..Results from the current DIabetic REtinopathy Candesartan Trials program will evaluate the potential of the AT1-receptor as a therapeutic target for diabetic retinopathy...
  16. pmc Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle
    Eric B Taylor
    The Joslin Diabetes Center Section on Metabolism and Proteomics Core and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    J Biol Chem 283:9787-96. 2008
    ..TBC1D1 is a major PAS immunoreactive protein in skeletal muscle that is phosphorylated in vivo by insulin, AICAR, and contraction. Both Akt and AMPK phosphorylate TBC1D1, but AMPK may be the more robust regulator...
  17. pmc Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle
    Jonas T Treebak
    Joslin Diabetes Center, Section on Metabolism, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Cell Physiol 298:C377-85. 2010
    ..S711 is a novel TBC1D4 phosphorylation site regulated by AMPK in skeletal muscle...
  18. ncbi request reprint Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium
    Zhiheng He
    Research Division, Joslin Diabetes Center, Harvard Medical School and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    J Biol Chem 280:15719-26. 2005
    ....
  19. ncbi request reprint Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation
    Aileen J McGettrick
    Section of Cellular and Molecular Physiology and Joslin Proteomics Core, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:6441-6. 2005
    ....
  20. ncbi request reprint MEK1,2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation
    Hong Chi Chen
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Blood 103:2636-44. 2004
    ..This report identifies the MEK1,2 response element that mediates angiotensin II-stimulated PAI-1 promoter activation and shows that activation of this element requires Sp1 and AP-1 co-activation...
  21. ncbi request reprint Phosphorylation of Irs1 at SER-522 inhibits insulin signaling
    Jodel Giraud
    Howard Hughes Medical Institute, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:2294-302. 2007
    ..Together, these results suggest the phosphatidylinositol 3-kinase-->Akt cascade can inhibit insulin signaling through the phosphorylation of S522(Irs1)...
  22. ncbi request reprint JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions
    Leah Rider
    Department of Biological Sciences, University of Toledo, Toledo, Ohio 43606 3390, USA
    J Biol Chem 282:30985-96. 2007
    ..Our findings indicate that JAK2 phosphorylates PAK1 at these specific tyrosines and that this phosphorylation plays an important role in cell survival and motility...

Research Grants10

  1. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2010
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..
  2. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2002
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..
  3. Role of the kallikrein-kinin system in diabetic retinopathy
    EDWARD FEENER; Fiscal Year: 2009
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..
  4. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2006
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..
  5. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2005
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..
  6. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2004
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..
  7. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2003
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..
  8. Axima-CFR MALDI TOF Mass Spectrometer
    EDWARD FEENER; Fiscal Year: 2003
    ....
  9. Role of the kallikrein-kinin system in diabetic retinopathy
    EDWARD FEENER; Fiscal Year: 2009
    ..These studies could reveal new therapeutic strategies to treat diabetic macular edema, a leading cause of vision loss. ..