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Genomes and GenesSpecies | M FavaSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Folate, vitamin B12, and homocysteine in major depressive disorderM Fava
Depression Clinical and Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
Am J Psychiatry 154:426-8. 1997..The authors examined the relationships between levels of three metabolites (folate, vitamin B12, and homocysteine) and both depressive subtype and response to fluoxetine treatment in depressed patients...- Emergence of adverse events following discontinuation of treatment with extended-release venlafaxineM Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 154:1760-2. 1997..The rate of adverse events following discontinuation of treatment with extended-release venlafaxine was compared with the rate associated with discontinuation of placebo administration... - Hypochondriacal concerns in depressed outpatientsC Demopulos
Depression Research Program, Massachusetts General Hospital, Boston 02114, USA
Psychosom Med 58:314-20. 1996.... - Timing of onset of antidepressant response with fluoxetine treatmentA A Nierenberg
Depression and Clinical Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 157:1423-8. 2000..The purpose of this study was to assess the time until onset of antidepressant response with fluoxetine treatment... - Fluoxetine versus sertraline and paroxetine in major depression: tolerability and efficacy in anxious depressionM Fava
Depression Clinical and Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, WAC 812, 15 Parkman Street, 02114, Boston, MA, USA
J Affect Disord 59:119-26. 2000..For this reason, using head-to-head acute treatment comparison, we compared efficacy and tolerability of fluoxetine, sertraline, and paroxetine among depressed patients with high levels of anxiety... - Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depressionD Mischoulon
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman St, WAC 812, Boston, MA 02114, USA
J Psychosom Res 49:183-7. 2000..We wished to determine whether anemia or macrocytosis predict hypofolatemia, low B12, or refractoriness to antidepressants... 
Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D reportA A Nierenberg
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 40:41-50. 2010..We describe the types and frequency of residual depressive symptoms and their relationship to subsequent depressive relapse after treatment with citalopram in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...- Outcome definitions and predictors in depressionJ Tedlow
Depression Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Psychother Psychosom 67:266-70. 1998..We therefore wanted to investigate possible relationships between baseline severity of depression and anxiety, and different definitions of outcome among outpatients with major depressive disorder undergoing antidepressant treatment... - Efficacy and safety of mirtazapine in major depressive disorder patients after SSRI treatment failure: an open-label trialM Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 62:413-20. 2001..To evaluate the efficacy and safety of mirtazapine in depressed outpatients who have shown nonresponse or intolerance to selective serotonin reuptake inhibitor (SSRI) therapy... - T3 blood levels and treatment outcome in depressionD V Iosifescu
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Psychiatry Med 31:367-73. 2001..CONCLUSION: Abnormal T3-RU levels are rather uncommon in outpatient depression and do not correlate with the response to antidepressant treatment or lack thereof... - Course and treatment of atypical depressionA A Nierenberg
Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 59:5-9. 1998..A review and critique of the relevant literature on atypical depression will be presented... - Treatment resistant depression and axis I co-morbidityT Petersen
Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
Psychol Med 31:1223-9. 2001..In fact, the only statistical difference showed non-TRD patients with higher co-morbidity rates... - Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/dayR H Perlis
Depression Clinical and Research Program, Massachusetts General Hospital, WACC 812, 15 Parkman Street, Boston, MA 02114, USA
Acta Psychiatr Scand 108:432-8. 2003..Factors moderating response to these next-step interventions are not well-studied... 
The importance of irritability as a symptom of major depressive disorder: results from the National Comorbidity Survey ReplicationM Fava
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Mol Psychiatry 15:856-67. 2010..Further investigation is warranted of distinct family aggregation, risk factors and treatment response. Consideration should also be given to including irritability as a nondiagnostic symptom of adult MDD in DSM-V and ICD-11...- Tryptophan depletion in SSRI-recovered depressed outpatientsM K Spillmann
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Psychopharmacology (Berl) 155:123-7. 2001..No other predicting or mediating factors were identified, although the variable "history of response pattern to medication" deserves further study... - Management of major depression in the primary care settingD Mischoulon
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA
Psychother Psychosom 70:103-7. 2001..We wished to determine how PCPs in a community clinic setting initially manage patients newly diagnosed with major depression... - Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatmentM Fava
Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 61:863-7. 2000..Also unknown is whether different agents have differential effects. To examine these questions, we assessed weight changes in patients randomly assigned to long-term treatment with fluoxetine, sertraline, or paroxetine... - New approaches to the treatment of refractory depressionM Fava
Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
J Clin Psychiatry 61:26-32. 2000..The review of treatment options for refractory depression that follows will outline the advantages, disadvantages, and level of support for a number of new treatment strategies... - Fenfluramine challenge in unipolar depression with and without anger attacksM Fava
Depression Clinical and Research Program, WACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Psychiatry Res 94:9-18. 2000.... - Augmentation and combination strategies in treatment-resistant depressionM Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 62:4-11. 2001..Further studies are clearly needed to evaluate the comparative efficacy and tolerability of these different approaches in treatment-resistant depressions... - Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorderD V Iosifescu
Depression Clinical and Research Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Acta Psychiatr Scand 117:271-6. 2008..We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD)... - Continuation cognitive-behavioural therapy maintains attributional style improvement in depressed patients responding acutely to fluoxetineT Petersen
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA, USA
Psychol Med 34:555-61. 2004..The goal of this study was to examine whether CBT would help maintain attributional style changes experienced by patients during acute phase fluoxetine treatment... - Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorderR H Perlis
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Acta Psychiatr Scand 119:282-9. 2009..We examined clinical correlates of irritability in a confirmatory cohort of Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study participants with major depressive disorder (MDD)... - Strategies for managing depression refractory to selective serotonin reuptake inhibitor treatment: a survey of cliniciansD Mischoulon
Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA
Can J Psychiatry 45:476-81. 2000..To examine treatment practices in cases where selective serotonin reuptake inhibitors (SSRIs) are ineffective... - Use of the five-factory inventory in characterizing patients with major depressive disorderT Petersen
Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Compr Psychiatry 42:488-93. 2001..Future studies should examine how such personality factors affect response to treatment and course of illness... - The anxiety sensitivity index: item analysis and suggestions for refinementM A Blais
Inpatient Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Pers Assess 77:272-94. 2001..The 11-item ASI appears to tap 2 primary aspects of anxiety sensitivity: fears of somatic sensations of anxiety and fears of loss of mental control. Suggestions for further development of the ASI are offered... - Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a modelR H Perlis
Depression Clinic and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Psychol Med 42:41-50. 2012..Electronic medical records (EMR) provide a unique opportunity for efficient, large-scale clinical investigation in psychiatry. However, such studies will require development of tools to define treatment outcome... - The potential relationship between levels of perceived stress and subtypes of major depressive disorder (MDD)A H Farabaugh
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA WAC 812, USA
Acta Psychiatr Scand 110:465-70. 2004.... - An open trial of oral sildenafilin antidepressant-induced sexual dysfunctionM Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass 02114, USA
Psychother Psychosom 67:328-31. 1998..The goal of our study was to evaluate its efficacy in a small sample of outpatients with antidepressant-induced sexual dysfunction... - Additional findings on the association between anxiety sensitivity and hypochondriacal concerns: examination of patients with major depressionM W Otto
Cognitive Behavior Therapy Program, Massachusetts General Hospital, Boston 02114, USA
J Anxiety Disord 12:225-32. 1998..Findings are discussed in relation to the role of catastrophic interpretations of somatic symptoms in depression, panic disorder, and hypochondriasis... - Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart reviewJ Sporn
Department of Psychiatry, Massachusetts General Hospital, USA
Ann Clin Psychiatry 12:137-40. 2000..To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting... - Personality disorders and depressionM Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Psychol Med 32:1049-57. 2002..These findings suggest that the lack of stability of PD diagnoses among patients with current MDD may be attributable in part to a direct effect of antidepressant treatment on behaviours and attitudes that comprise PDs... - A detailed examination of cytokine abnormalities in Major Depressive DisorderN M Simon
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Eur Neuropsychopharmacol 18:230-3. 2008..These data support a generalized chronic inflammatory state in MDD, and implicate additional cytokines and chemokines previously linked to cardiovascular disease... - A meta-analysis of clinical trials comparing mirtazapine with selective serotonin reuptake inhibitors for the treatment of major depressive disorderG I Papakostas
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Department of Psychiatry, Boston, MA 02114, USA
J Psychopharmacol 22:843-8. 2008..8; 95% CI: 1.3-2.4; P < 0.0001) during the course of treatment. These results suggest that mirtazapine and the SSRIs differ with respect to their side-effect profile but not their overall efficacy in the treatment of MDD... - Risk of suicidality in depression with serotonergic antidepressantsJ D Matthews
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Ann Clin Psychiatry 12:43-50. 2000..Prescribing inadequate doses of antidepressants is therefore a source of overlooked risk... - Sex- and age-related differences in major depressive disorder with comorbid anxiety treated with fluoxetineP Cassano
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, U S A
Arch Womens Ment Health 7:167-71. 2004..To examine sex- and age-related differences of treatment outcome in a cohort of outpatients with major depressive disorder (MDD), with and without comorbid anxiety, treated with fluoxetine... - Screening for major depression in Asian-Americans: a comparison of the Beck and the Chinese Depression InventoryA Yeung
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
Acta Psychiatr Scand 105:252-7. 2002..This study compares the effectiveness of the Chinese version of the Beck Depression Inventory (CBDI) and the Chinese Depression Inventory (CDI) in screening for depression among Chinese Americans... - Severe depression: is there a best approach?S B Sonawalla
Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
CNS Drugs 15:765-76. 2001..g. renal, cardiac or hepatic disease)... - Psychosocial stressors and the prognosis of major depression: a test of Axis IVS E Gilman
Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA, USA
Psychol Med 43:303-16. 2013..Axis IV is for reporting 'psychosocial and environmental problems that may affect the diagnosis, treatment and prognosis of mental disorders'. No studies have examined the prognostic value of Axis IV in DSM-IV... - BDNF, relative preference, and reward circuitry responses to emotional communicationG P Gasic
Motivation and Emotion Neuroscience Collaboration MENC, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 150:762-81. 2009..This study demonstrates that functional allelic variation in BDNF modulates human brain circuits processing reward/aversion information and relative preference transactions...