Denise Faustman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Islet regeneration during the reversal of autoimmune diabetes in NOD mice
    Shohta Kodama
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 3602, Charlestown, MA 02129, USA
    Science 302:1223-7. 2003
  2. pmc Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2
    Yoshiaki Okubo
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Rm 3602, MGH East, Bldg 149, 13th Street, Boston, MA 02129
    Sci Rep 3:3153. 2013
  3. pmc Novel automated blood separations validate whole cell biomarkers
    Douglas E Burger
    Immunobiology Laboratories, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massaschusetts, United States of America
    PLoS ONE 6:e22430. 2011
  4. doi request reprint Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades
    Denise L Faustman
    Immunobiology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Room 3602, Boston, MA, 02129, USA
    Diabetologia 57:1-3. 2014
  5. pmc Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes
    Denise L Faustman
    The Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41756. 2012
  6. pmc Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay
    Limei Wang
    Immunobiology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:465-70. 2012
  7. doi request reprint Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders
    Denise L Faustman
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Int J Biochem Cell Biol 42:1576-9. 2010
  8. ncbi request reprint Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice
    Denise L Faustman
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Science 314:1243; author reply 1243. 2006
  9. doi request reprint The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies
    Denise L Faustman
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Mol Med (Berl) 87:1173-8. 2009
  10. doi request reprint TNF receptor 2 pathway: drug target for autoimmune diseases
    Denise Faustman
    Immunobiology Laboratory, Room 3602, Building 149, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Drug Discov 9:482-93. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Islet regeneration during the reversal of autoimmune diabetes in NOD mice
    Shohta Kodama
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 3602, Charlestown, MA 02129, USA
    Science 302:1223-7. 2003
    ..Treatment with irradiated splenocytes is also followed by islet regeneration, but at a slower rate. The islets generated in both instances are persistent, functional, and apparent in all NOD hosts with permanent disease reversal...
  2. pmc Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2
    Yoshiaki Okubo
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Rm 3602, MGH East, Bldg 149, 13th Street, Boston, MA 02129
    Sci Rep 3:3153. 2013
    ..Targeting the TNFR2 receptor during ex vivo expansion is a new means for producing homogeneous and potent human T(regs) for clinical opportunities...
  3. pmc Novel automated blood separations validate whole cell biomarkers
    Douglas E Burger
    Immunobiology Laboratories, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massaschusetts, United States of America
    PLoS ONE 6:e22430. 2011
    ..One major obstacle is the inaccuracy of Ficoll density centrifugation, the decades-old method of separating PBLs from the abundant red blood cells (RBCs) of fresh blood samples...
  4. doi request reprint Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades
    Denise L Faustman
    Immunobiology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Room 3602, Boston, MA, 02129, USA
    Diabetologia 57:1-3. 2014
    ..The weight of evidence now makes it clear that a large fraction of patients with long-standing diabetes have low level, but persistent functioning of pancreatic islet cells enduring more than a decade after disease onset...
  5. pmc Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes
    Denise L Faustman
    The Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e41756. 2012
    ..Specifically, it stimulates innate immunity by inducing the host to produce tumor necrosis factor (TNF), which, in turn, kills disease-causing autoimmune cells and restores pancreatic beta-cell function through regeneration...
  6. pmc Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay
    Limei Wang
    Immunobiology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:465-70. 2012
    ..To examine persistence of C-peptide production by ultrasensitive assay years after onset of type 1 diabetes and factors associated with preserving β-cell function...
  7. doi request reprint Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders
    Denise L Faustman
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Int J Biochem Cell Biol 42:1576-9. 2010
    ..Splenic stem cells may have broad pluripotent potential, but unlike iPS cells, possess low oncogenic risk...
  8. ncbi request reprint Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice
    Denise L Faustman
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Science 314:1243; author reply 1243. 2006
    ..We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery...
  9. doi request reprint The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies
    Denise L Faustman
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Mol Med (Berl) 87:1173-8. 2009
    ....
  10. doi request reprint TNF receptor 2 pathway: drug target for autoimmune diseases
    Denise Faustman
    Immunobiology Laboratory, Room 3602, Building 149, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Drug Discov 9:482-93. 2010
    ....
  11. ncbi request reprint Reversal of established autoimmune diabetes by in situ beta-cell regeneration
    Denise L Faustman
    Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149 Room 3601, Thirteenth Street, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 961:40. 2002
  12. ncbi request reprint Cells for repair: breakout session summary
    Denise L Faustman
    Immunology Laboratory, Massachusetts General Hospital, Harvard Medical School, Building 149 Room 3601, Thirteenth Street, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 961:45-7. 2002
  13. ncbi request reprint Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes
    Shohta Kodama
    Harvard Medical School and Massachusetts General Hospital East, Boston, 13th Street, MA 02192, USA
    Pediatr Diabetes 5:38-44. 2004
    ..If the underlying autoimmune defect can be eradicated, stem cells of the spleen, as well as related strategies, can be used in order to regrow islets destroyed by type 1 diabetes...
  14. ncbi request reprint Regenerative medicine: a radical reappraisal of the spleen
    Shohta Kodama
    Harvard Medical School and Massachusetts General Hospital East Immunology Lab, Building 149, 13 th Street, Room 3602, Boston, MA 02193, USA
    Trends Mol Med 11:271-6. 2005
    ..By bringing together findings from diverse disciplines, we propose that the adult spleen is an important source of multi-lineage stem cells for future cellular therapies for diabetes and other diseases...
  15. ncbi request reprint Methods to characterize lymphoid apoptosis in a murine model of autoreactivity
    Willem M Kühtreiber
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, CNY 3601, Charlestown, MA 02129, USA
    J Immunol Methods 306:137-50. 2005
    ..The refined detection of small numbers of lymphoid cell subsets with quantifiable differences in apoptosis provides a possible immune biomarker for monitoring disease activity or treatment interventions...
  16. doi request reprint Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity
    Anna Lonyai
    Immunobiology Laboratories, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 2129, USA
    Immunol Cell Biol 86:301-9. 2008
    ..Taken together, our findings challenge the orthodoxy that autoimmunity is solely caused by a defective immune system...
  17. ncbi request reprint Role of defective apoptosis in type 1 diabetes and other autoimmune diseases
    Takuma Hayashi
    Immunobiology Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Recent Prog Horm Res 58:131-53. 2003
    ..Although no specific genetic defects have been identified in most common forms of human autoimmune disease, functional assays consistently demonstrate heightened apoptosis attributable to multiple death signaling pathways...
  18. ncbi request reprint Characterization of mouse spleen cells by subtractive proteomics
    Francisco J Dieguez-Acuna
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts and the Immunobiology Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Mol Cell Proteomics 4:1459-70. 2005
    ..The CD45- cell subset readily revealed proteins involved in development, suggesting the persistence of a fetal stem cell in an adult animal...
  19. pmc Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism
    Liqin Ban
    Department of Immunobiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 105:13644-9. 2008
    ..This study shows that autoreactive T cells, although rare, can be selectively destroyed in isolated human blood. TNF and a TNFR2 agonist may offer highly targeted therapies, with the latter likely to be less systemically toxic...
  20. pmc Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice
    Elizabeth J Abraham
    Laboratory of Molecular Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Pathol 164:817-30. 2004
    ..We propose that a population of stem/progenitor cells isolated from the islets of the pancreas can cross xenogeneic transplantation immune barriers, induce tissue tolerance, and grow...
  21. ncbi request reprint Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes
    Alfred Penfornis
    Immunobiology Laboratory, Massachusetts General Hospital East and Harvard Medical School, Charlestown 02129, USA
    Hum Immunol 63:61-70. 2002
    ..5%, p = 0.002, p(c) = 0.01). These data are consistent with the existence of susceptibility haplotypes for type I diabetes in the Finnish population consisting of DRB1*04 (*0401 and *0404), DQ8, and TAP2F...
  22. ncbi request reprint Impaired processing and presentation by MHC class II proteins in human diabetic cells
    Gang Yan
    Immunobiology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 170:620-7. 2003
    ..A defect in the expression of Ii p35 may thus result in impairment of Ag presentation by MHC class II molecules and thereby contribute to the development of type 1 diabetes in at-risk genotypes...
  23. ncbi request reprint Diabetes and stem cell researchers turn to the lowly spleen
    Shohta Kodama
    Harvard Medical School and Massachusetts General Hospital East, Boston, MA 02192, USA
    Sci Aging Knowledge Environ 2005:pe2. 2005
    ..This Perspective calls for reappraisal of the lowly spleen for treating diabetes and other diseases of aging...
  24. ncbi request reprint Reversal of type 1 diabetes in mice
    Denise L Faustman
    N Engl J Med 356:311-2. 2007
  25. doi request reprint Immunotherapy on trial for new-onset type 1 diabetes
    Denise L Faustman
    N Engl J Med 359:1956-8. 2008
  26. ncbi request reprint Permanent reversal of diabetes in NOD mice
    Denise L Faustman
    Science 317:196. 2007
  27. pmc Reversal of Sjogren's-like syndrome in non-obese diabetic mice
    Simon D Tran
    McGill University, 3640 University Street, M 43, Montreal, Quebec, Canada H3A 2B2
    Ann Rheum Dis 66:812-4. 2007
    ..Non-obese diabetic (NOD) mice exhibit autoimmune diabetes and Sjögren's-like syndrome...