Research Topics
Genomes and Genes | MICHAEL R FARZANSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entryM Farzan
Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 96:667-76. 1999..CXCR4, another important HIV-1 coreceptor, is also sulfated. Tyrosine sulfation may contribute to the natural function of many 7TMS receptors and may be a modification common to primate immunodeficiency virus coreceptors...- A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entryM Farzan
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
J Biol Chem 275:33516-21. 2000..These data underscore the important role of the N-terminal sulfate moieties of CCR5 in the entry of R5 HIV-1 isolates and localize a critical contact between gp120 and CCR5... 
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor proteinM Farzan
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 97:9712-7. 2000..These data suggest that BACE2 contributes to Abeta production in individuals bearing the Flemish mutation, and that selective inhibition of these highly similar proteases may be feasible and therapeutically advantageous...- Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomainM Farzan
Division of Human Retrovirology, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 72:7620-5. 1998..Disulfide-mediated stabilization of the labile HIV-1 envelope glycoprotein oligomer, which has been suggested to possess advantages as an immunogen, may assist attempts to develop vaccines... 
Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokinesN Bannert
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Exp Med 194:1661-73. 2001....- A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5M Farzan
Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
J Virol 72:1160-4. 1998..These results identify a region of CCR5 that is necessary for the physical association of the gp120 envelope glycoprotein with CCR5 and for HIV-1 infection... - The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolatesH Choe
Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cell 85:1135-48. 1996..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates... - Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replicationP Kolchinsky
Department of Cancer, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 73:8120-6. 1999..Thus, a major function of CD4 binding in the entry of primary HIV-1 isolates can be bypassed by changes in the gp120 V1-V2 elements, which allow the envelope glycoproteins to assume a conformation competent for CCR5 binding... - Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptorT Mirzabekov
Department of Cancer Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Biol Chem 274:28745-50. 1999..The methods described herein contribute to the analysis of CCR5 and are likely to be applicable to many other GPCRs... - Structural interactions between chemokine receptors, gp120 Env and CD4H Choe
Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, 02115, USA
Semin Immunol 10:249-57. 1998..These studies are useful for elucidating the mechanism and molecular determinants of HIV-1 entry, and of inhibitors to that entry... - The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entryC C Bleul
The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 382:829-33. 1996.... - Human Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitroN Bannert
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
J Virol 75:10808-14. 2001..The trafficking of mast cell progenitors to multiple tissues, combined with the long life span of mature mast cells, suggests that they could provide a widespread and persistent HIV reservoir in AIDS... - Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptorM Farzan
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 193:1059-66. 2001..These observations clarify structural and mutagenic studies of the C5a/C5aR association and suggest that related 7TMS receptors are also modified by functionally important sulfate groups on their NH(2)-terminal tyrosines... - CCR3 and CCR5 are co-receptors for HIV-1 infection of microgliaJ He
Division of Human Retrovirology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 385:645-9. 1997..The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1beta, which is a CCR5 ligand. Our results suggest that both CCR3 and CCR5 promote efficient infection of the CNS by HIV-1... - Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infectionM Farzan
Division of Human Retrovirology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Exp Med 186:405-11. 1997..These results underscore the potential diversity of seven-transmembrane segment receptors used as entry cofactors by primate immunodeficiency viruses, and may contribute to an understanding of viral variation and pathogenesis... - Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239L Marcon
Division of Human Retrovirology, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 71:2522-7. 1997..Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor... - Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entryM Cayabyab
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 74:11972-6. 2000....