MICHAEL R FARZAN

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:667-76. 1999
  2. ncbi A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry
    M Farzan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:33516-21. 2000
  3. pmc BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
    M Farzan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9712-7. 2000
  4. pmc Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain
    M Farzan
    Division of Human Retrovirology, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 72:7620-5. 1998
  5. pmc Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines
    N Bannert
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 194:1661-73. 2001
  6. pmc A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 72:1160-4. 1998
  7. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
  8. pmc Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication
    P Kolchinsky
    Department of Cancer, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 73:8120-6. 1999
  9. ncbi Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor
    T Mirzabekov
    Department of Cancer Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 274:28745-50. 1999
  10. ncbi Structural interactions between chemokine receptors, gp120 Env and CD4
    H Choe
    Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, 02115, USA
    Semin Immunol 10:249-57. 1998

Collaborators

Detail Information

Publications17

  1. ncbi Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:667-76. 1999
    ..CXCR4, another important HIV-1 coreceptor, is also sulfated. Tyrosine sulfation may contribute to the natural function of many 7TMS receptors and may be a modification common to primate immunodeficiency virus coreceptors...
  2. ncbi A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry
    M Farzan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:33516-21. 2000
    ..These data underscore the important role of the N-terminal sulfate moieties of CCR5 in the entry of R5 HIV-1 isolates and localize a critical contact between gp120 and CCR5...
  3. pmc BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
    M Farzan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9712-7. 2000
    ..These data suggest that BACE2 contributes to Abeta production in individuals bearing the Flemish mutation, and that selective inhibition of these highly similar proteases may be feasible and therapeutically advantageous...
  4. pmc Stabilization of human immunodeficiency virus type 1 envelope glycoprotein trimers by disulfide bonds introduced into the gp41 glycoprotein ectodomain
    M Farzan
    Division of Human Retrovirology, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 72:7620-5. 1998
    ..Disulfide-mediated stabilization of the labile HIV-1 envelope glycoprotein oligomer, which has been suggested to possess advantages as an immunogen, may assist attempts to develop vaccines...
  5. pmc Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines
    N Bannert
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Exp Med 194:1661-73. 2001
    ....
  6. pmc A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 72:1160-4. 1998
    ..These results identify a region of CCR5 that is necessary for the physical association of the gp120 envelope glycoprotein with CCR5 and for HIV-1 infection...
  7. ncbi The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    H Choe
    Division of Human Retrovirology Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell 85:1135-48. 1996
    ..The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV-1 isolates...
  8. pmc Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication
    P Kolchinsky
    Department of Cancer, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 73:8120-6. 1999
    ..Thus, a major function of CD4 binding in the entry of primary HIV-1 isolates can be bypassed by changes in the gp120 V1-V2 elements, which allow the envelope glycoproteins to assume a conformation competent for CCR5 binding...
  9. ncbi Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor
    T Mirzabekov
    Department of Cancer Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 274:28745-50. 1999
    ..The methods described herein contribute to the analysis of CCR5 and are likely to be applicable to many other GPCRs...
  10. ncbi Structural interactions between chemokine receptors, gp120 Env and CD4
    H Choe
    Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, 02115, USA
    Semin Immunol 10:249-57. 1998
    ..These studies are useful for elucidating the mechanism and molecular determinants of HIV-1 entry, and of inhibitors to that entry...
  11. ncbi The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    C C Bleul
    The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 382:829-33. 1996
    ....
  12. pmc Human Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro
    N Bannert
    Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 75:10808-14. 2001
    ..The trafficking of mast cell progenitors to multiple tissues, combined with the long life span of mature mast cells, suggests that they could provide a widespread and persistent HIV reservoir in AIDS...
  13. pmc Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor
    M Farzan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 193:1059-66. 2001
    ..These observations clarify structural and mutagenic studies of the C5a/C5aR association and suggest that related 7TMS receptors are also modified by functionally important sulfate groups on their NH(2)-terminal tyrosines...
  14. ncbi CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
    J He
    Division of Human Retrovirology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 385:645-9. 1997
    ..The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1beta, which is a CCR5 ligand. Our results suggest that both CCR3 and CCR5 promote efficient infection of the CNS by HIV-1...
  15. pmc Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection
    M Farzan
    Division of Human Retrovirology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Exp Med 186:405-11. 1997
    ..These results underscore the potential diversity of seven-transmembrane segment receptors used as entry cofactors by primate immunodeficiency viruses, and may contribute to an understanding of viral variation and pathogenesis...
  16. pmc Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239
    L Marcon
    Division of Human Retrovirology, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 71:2522-7. 1997
    ..Thus, distantly related immunodeficiency viruses such as SIV and the primary human immunodeficiency virus type 1 isolates can utilize CCR5 as an entry cofactor...
  17. pmc Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry
    M Cayabyab
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 74:11972-6. 2000
    ....