Christian T Farrar

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuro Oncol 12:341-50. 2010
  2. pmc Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    NMR Biomed 21:453-63. 2008
  3. pmc Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model
    Christian T Farrar
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e17228. 2011
  4. pmc Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Stephen E and Catherine Pappas Center for Neuro Oncology, and AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 27:2542-52. 2009
  5. pmc Molecular imaging of fibrin in a breast cancer xenograft mouse model
    Ritika Uppal
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Invest Radiol 47:553-8. 2012
  6. pmc Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging
    Robert M Koffie
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 108:18837-42. 2011
  7. pmc Target-specific contrast agents for magnetic resonance microscopy
    Megan L Blackwell
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129
    Neuroimage 46:382-93. 2009
  8. pmc Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model
    Shuning Huang
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 33:898-905. 2013
  9. ncbi request reprint Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging
    Phillip Zhe Sun
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Magn Reson Med 58:1207-15. 2007
  10. pmc MR contrast probes that trace gene transcripts for cerebral ischemia in live animals
    Christina H Liu
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    FASEB J 21:3004-15. 2007

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuro Oncol 12:341-50. 2010
    ..In addition, preliminary data indicate that the VCI is independent of whether a dynamic susceptibility contrast or SSC measurement method is used...
  2. pmc Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    NMR Biomed 21:453-63. 2008
    ..The optimal performance of ORI will thus likely be seen at low fields, with moderate MION concentrations and with sequences containing very short TEs...
  3. pmc Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model
    Christian T Farrar
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e17228. 2011
    ....
  4. pmc Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Stephen E and Catherine Pappas Center for Neuro Oncology, and AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 27:2542-52. 2009
    ..Our goal was to determine whether alleviation of edema by anti-VEGF agents alone could increase survival in mice...
  5. pmc Molecular imaging of fibrin in a breast cancer xenograft mouse model
    Ritika Uppal
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Invest Radiol 47:553-8. 2012
    ..Fibrin deposition has been indicated within the stroma of a majority of solid tumors. Here we assess the feasibility of using the established fibrin-specific probe EP-2104R for noninvasive imaging of fibrin in the context of breast cancer...
  6. pmc Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging
    Robert M Koffie
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 108:18837-42. 2011
    ..Collectively, these findings highlight the potential of using biodegradable nanocarrier systems to deliver BBB-impermeable targeted molecular probes into the brain for diagnostic neuroimaging...
  7. pmc Target-specific contrast agents for magnetic resonance microscopy
    Megan L Blackwell
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129
    Neuroimage 46:382-93. 2009
    ..Our results suggest target-specific contrast agents will enable more detailed MR images with applications in imaging pathological ex vivo samples and constructing better MR atlases from ex vivo brains...
  8. pmc Cerebral blood volume affects blood-brain barrier integrity in an acute transient stroke model
    Shuning Huang
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 33:898-905. 2013
    ..The low CBV observed for mice with a disrupted BBB, characterized by a high WEI, indicates the importance of CBV restoration for maintaining BBB stability in acute stroke...
  9. ncbi request reprint Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging
    Phillip Zhe Sun
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Magn Reson Med 58:1207-15. 2007
    ..In addition, the proposed algorithm was verified with both numerical simulation and experimental measurements, and showed nearly complete correction of CEST imaging measurement errors caused by moderate field inhomogeneity...
  10. pmc MR contrast probes that trace gene transcripts for cerebral ischemia in live animals
    Christina H Liu
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    FASEB J 21:3004-15. 2007
    ..This study should enable MR detection of mRNA alteration in disease models of the central nervous system...
  11. doi request reprint Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents
    Peter Caravan
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 149 Thirteenth St, Charlestown, MA 02129, USA
    Contrast Media Mol Imaging 4:89-100. 2009
    ..Per ion relaxivities of 80, 45, and 18 mM(-1) s(-1) at 1.5, 3 and 9.4 T, respectively, are feasible for Gd(3+) and Mn(2+) complexes...
  12. pmc Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults
    Amy Fleischman
    Program in Nutritional Metabolism, Massachusetts General Hospital, 55 Fruit St, LON 207, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 292:E1666-73. 2007
    ..Further studies are necessary to determine whether changes in mtDNA resulting from stavudine contribute to effects on insulin sensitivity...
  13. ncbi request reprint Cylindrical meanderline radiofrequency coil for intravascular magnetic resonance studies of atherosclerotic plaque
    Christian T Farrar
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Magn Reson Med 53:226-30. 2005
    ..This radically new RF coil geometry offers the potential to improve the efficiency of MR data acquisition in medical applications in which curved surfaces or slabs contain the material of interest...

Research Grants2