Research Topics
Genomes and Genes
Species | S V FaraoneSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Gender effects on attention-deficit/hyperactivity disorder in adults, revisitedJoseph Biederman
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 55:692-700. 2004..These results bear striking similarities to findings reported in pediatric samples, supporting the validity of ADHD and stressing the importance of identifying and treating the disorder in adulthood...- Meta-analysis of the efficacy of methylphenidate for treating adult attention-deficit/hyperactivity disorderStephen V Faraone
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114 3139, USA
J Clin Psychopharmacol 24:24-9. 2004.... - A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia familiesStephen V Faraone
Department of Psychiatry at Massachusetts General Hospital, Harvard Medical School, 37 Shields Avenue, Boston, MA 02301, USA
Hum Hered 57:59-68. 2004..Such findings help prioritize genes for future case control studies. In addition, we provide a novel permutation method that is useful in future analyses involving a single hypothesis, with multiple candidate genes... - The molecular genetics of schizophrenia: an emerging consensusStephen V Faraone
Harvard Medical School Dept of Psychiatry at the Massachusetts Mental Health Center and Brockton West Roxbury Veterans Affairs Medical Center, 74 Fenwood Rd, Boston, MA 02115, USA
Expert Rev Mol Med 4:1-13. 2002..Molecular genetic studies of specific candidate genes are then reviewed. Some controversies within the literature are examined and possible directions for future research are discussed... - Does stimulant treatment lead to substance use disorders?Stephen V Faraone
Harvard Medical School, and Massachusetts General Hospital, Boston 02114 3139, USA
J Clin Psychiatry 64:9-13. 2003..The implication of this finding is unquestionably one with enormous value both clinically and as a matter of public health... - Genetics of adult attention-deficit/hyperactivity disorderStephen V Faraone
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, WRN 705, 55 Fruit Street, Boston, MA 02114 3139, USA
Psychiatr Clin North Am 27:303-21. 2004..More work from twin and molecular genetic studies is needed to determine if the increased familiality of persistent ADHD reflects the actions of genes or of familial environmental causes... - Attention-deficit/hyperactivity disorder in adults: a survey of current practice in psychiatry and primary careStephen V Faraone
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Intern Med 164:1221-6. 2004..Recognition and treatment of attention-deficit/hyperactivity disorder (ADHD) in adults in psychiatry and primary care have faced many obstacles... - A genome-wide scan of symptom dimensions in bipolar disorder pedigrees of adult probandsStephen V Faraone
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
J Affect Disord 82:S71-8. 2004.... - Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of maniaStephen V Faraone
Department of Psychiatry, Harvard Medical School, Boston, USA
Am J Psychiatry 161:625-30. 2004..Because age at onset may have utility in resolving the complexity and heterogeneity of the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this trait... - Comparative efficacy of Adderall and methylphenidate in attention-deficit/hyperactivity disorder: a meta-analysisStephen V Faraone
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston
J Clin Psychopharmacol 22:468-73. 2002..The effect of Adderall was significant for clinician and parent ratings but not for teacher ratings and was significant for both fixed-dose and best-dose designs... - Linkage of chromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sampleStephen V Faraone
Brockton West Roxbury Veterans Affairs Medical Center, Brockton, Massachusetts, USA
Am J Med Genet 114:598-604. 2002..57; P = 0.01) at 79.0 cM between markers D13S1241 (76.3 cM) and D13S159 (79.5 cM). Both ethnic groups showed a peak in this region. The peak is within 3 cM of the peak reported by Brzustowicz et al. [1999: Am J Hum Genet 65:1096-1103]... - Efficacy of Adderall for Attention-Deficit/Hyperactivity Disorder: a meta-analysisS V Faraone
Harvard Medical School, the Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
J Atten Disord 6:69-75. 2002..Its efficacy was significant for clinician, parent, and teacher ratings, and for both fixed- and best-dose designs... - Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a drug-placebo and drug-drug response curve analysis of a naturalistic studyStephen V Faraone
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Neuropsychopharmacol 5:121-9. 2002..The analyses also highlight an important subgroup of placebo responders, which suggests that future research should focus on how to predict robust placebo response in ADHD patients... - Heterogeneity and the genetics of bipolar disorderStephen V Faraone
Harvard Medical School Department of Psychiatry at the Massachusetts General Hospital, Boston, MA 02114, USA
Am J Med Genet C Semin Med Genet 123:1-9. 2003 - Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sourcesJ Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Am Acad Child Adolesc Psychiatry 38:966-75. 1999..The aim of this study was to examine clinical correlates of ADHD in females using comprehensive assessments in multiple domains of functioning... - Association of neuropsychological vulnerability markers in relatives of schizophrenic patientsR Toomey
Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA, USA
Schizophr Res 31:89-98. 1998..We discuss how the use of multiple risk indicators may help us better identify those relatives that carry the schizophrenia genotype... - A controlled study of behavioral inhibition in children of parents with panic disorder and depressionJ F Rosenbaum
Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
Am J Psychiatry 157:2002-10. 2000..Several lines of evidence suggest that behavioral inhibition is an index of anxiety proneness. The authors sought to replicate prior findings and examine the specificity of the association between behavioral inhibition and anxiety... 
Neurocognitive impairment in unaffected siblings of youth with bipolar disorderA E Doyle
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
Psychol Med 39:1253-63. 2009..The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis...- Family-based tests of association and linkage that use unaffected sibs, covariates, and interactionsK L Lunetta
Department of Biostatistical Science, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Am J Hum Genet 66:605-14. 2000..We apply our methods to a sample of families with attention-deficit/hyperactivity disorder and provide examples of how covariates and gene-environment and gene-gene interactions can be incorporated... - A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidityJ Wozniak
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 40:1079-88. 2010..To estimate the spectrum of familial risk for psychopathology in first-degree relatives of children with unabridged DSM-IV bipolar-I disorder (BP-I)... - Family study of girls with attention deficit hyperactivity disorderS V Faraone
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
Am J Psychiatry 157:1077-83. 2000..To help fill this gap in the literature, the authors assessed the familial transmission of ADHD in families ascertained through girls... - Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probandsW S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817, USA
Psychiatry Res 79:227-40. 1998..Replication with a larger REL-BP sample and with male relatives is needed to evaluate the generalizability of the results... - Suggestive linkage of chromosome 10p to schizophrenia is not due to transmission ratio distortionS V Faraone
Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, Boston, Massachusetts
Am J Med Genet 88:607-8. 1999..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:607-608, 1999... - Further evidence of association between two NET single-nucleotide polymorphisms with ADHDJ W Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Mol Psychiatry 13:624-30. 2008..This is the first time that identical alleles of NET from different studies were implicated, and thus our report provides further evidence that the NET gene is involved in the etiology of ADHD... - Familial transmission of derived phenotypes for molecular genetic studies of substance use disordersStephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Drug Alcohol Depend 92:100-7. 2008..001; cognitive impairment: OR=1.33, p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55, p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD... - Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary studyJoseph Biederman
Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies... - Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depressionJ Biederman
Pediatric Psychopharmacology Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 158:49-57. 2001.... - Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?S V Faraone
Harvard Medical School Department of Psychiatry, Massachusetts Mental Health Center, Boston, USA
Am J Psychiatry 152:1286-90. 1995..However, most of these studies do not address a key measurement question: does the diagnostic accuracy of these spectrum classifications warrant their use in genetic linkage studies of schizophrenia?.. - Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depressionJoseph Biederman
Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
J Affect Disord 82:209-16. 2004..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias... - Phenomenology of childhood psychosis: findings from a large sample of psychiatrically referred youthJoseph Biederman
Clinical Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, USA
J Nerv Ment Dis 192:607-14. 2004..In conclusion, childhood-onset psychosis in referred youth is common and highly morbid. It remains an important topic of research deserving full clinical and scientific attention... 
Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptomsMichael C Monuteaux
Massachusetts General Hospital, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 48:757-64. 2009..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...- Learning disabilities and executive dysfunction in boys with attention-deficit/hyperactivity disorderL J Seidman
Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
Neuropsychology 15:544-56. 2001..These data indicate that comorbid LD, especially arithmetic disability, significantly increases the severity of executive function impairment in ADHD... - Genetic association analysis of behavioral inhibition using candidate loci from mouse modelsJ W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet 105:226-35. 2001..This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders... - Social impairment in girls with ADHD: patterns, gender comparisons, and correlatesR W Greene
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
J Am Acad Child Adolesc Psychiatry 40:704-10. 2001.... - Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot studyDina R Hirshfeld-Becker
Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
Psychiatry Res 145:155-67. 2006..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood... - A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depressionJoseph Biederman
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Psychol Med 36:1141-52. 2006..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence... - Predictors, clinical characteristics, and outcome of conduct disorder in girls with attention-deficit/hyperactivity disorder: a longitudinal studyMichael C Monuteaux
The Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Psychol Med 37:1731-41. 2007..However, it is unclear how these results extend to females. Our aim was to examine the predictors, clinical characteristics, and functional outcome of CD in a sample of female youth with and without ADHD... - Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysisCarter R Petty
Massachusetts General Hospital, Boston, MA 02114, USA
J Psychiatr Res 43:345-52. 2009..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)... - Deficient emotional self-regulation and pediatric attention deficit hyperactivity disorder: a family risk analysisJ Biederman
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA 02114 3139, USA
Psychol Med 42:639-46. 2012..Family studies provide a method of clarifying the co-occurrence of clinical features, but no family studies have yet addressed ADHD and DESR in children... - Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid?S V Faraone
Massachusetts General Hospital, Boston 02114, USA
J Consult Clin Psychol 68:830-42. 2000..They do not support the idea that parents of ADHD children are biased to report ADHD symptoms in themselves because of their exposure to an ADHD child... - Sex differences in self-reported schizotypal traits in relatives of schizophrenic probandsW S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, Sacramento 95817, USA
Schizophr Res 34:27-37. 1998.... - Diagnostic efficiency of neuropsychological test scores for discriminating boys with and without attention deficit-hyperactivity disorderA E Doyle
Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
J Consult Clin Psychol 68:477-88. 2000..The prognostic implications of variable neuropsychological deficits in children with ADHD require further investigation... - Lack of association between parental alcohol or drug addiction and behavioral inhibition in childrenJ Biederman
Department of Psychiatry Unit of Clinical Psychopharmacology, Massachusetts General Hospital, Boston, 02114, USA
Am J Psychiatry 158:1731-3. 2001..CONCLUSIONS: These results are not consistent with the hypothesis linking behavioral inhibition to addictions... - The long-term longitudinal course of oppositional defiant disorder and conduct disorder in ADHD boys: findings from a controlled 10-year prospective longitudinal follow-up studyJ Biederman
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 38:1027-36. 2008.... - Systematic chart review of the pharmacologic treatment of comorbid attention deficit hyperactivity disorder in youth with bipolar disorderJ Biederman
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
J Child Adolesc Psychopharmacol 9:247-56. 1999..Although TCAs can be helpful in the management of ADHD children with manic symptoms, these drugs should be used with caution since they can also have a destabilizing effect on manic symptoms... - Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorderJ Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Pediatrics 104:e20. 1999..To assess the risk for substance use disorders (SUD) associated with previous exposure to psychotropic medication in a longitudinal study of boys with attention-deficit/hyperactivity disorder (ADHD)... - Reduced subcortical brain volumes in nonpsychotic siblings of schizophrenic patients: a pilot magnetic resonance imaging studyL J Seidman
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, Boston 02115, USA
Am J Med Genet 74:507-14. 1997..If replicated in a larger sample including both sexes, these results would suggest that the genetic liability to schizophrenia is also expressed as structural brain abnormalities... - Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 170:199-203. 2009..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD... - Childhood antecedents to panic disorder in referred and nonreferred adultsJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 15:549-61. 2005..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder... - Genome-wide association scan of the time to onset of attention deficit hyperactivity disorderJessica Lasky-Su
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1355-8. 2008..Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene... - Moderating effects of major depression on patterns of comorbidity in patients with panic disorderJoseph Biederman
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
Psychiatry Res 126:143-9. 2004..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults... - Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research ProgramJoseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 53:952-60. 2003..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD... - Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depressionJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
Psychiatry Res 153:245-52. 2007.... - The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal studyMichael C Monuteaux
Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Child Psychol Psychiatry 51:233-41. 2010..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence... - Evidence for the multigenic inheritance of schizophreniaR Freedman
Department of Psychiatry, Denver VA Medical Center and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Med Genet 105:794-800. 2001.... - Intelligence quotient and neuropsychological profiles in patients with schizophrenia and in normal volunteersW S Kremen
Department of Psychiatry, University of California, Davis School of Medicine, 2516 Stockton Boulevard, Sacramento, CA 95817, USA
Biol Psychiatry 50:453-62. 2001..The results strengthen the argument that neurocognitive deficits are core deficits of schizophrenic illness... - A family study of psychiatric comorbidity in girls and boys with attention-deficit/hyperactivity disorderS V Faraone
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
Biol Psychiatry 50:586-92. 2001..Although this is consistent with prior work suggesting more similarities than differences in the nature of psychiatric comorbidity in ADHD boys and girls, we cannot make strong conclusions, owing to the possibility of cohort effects... - Separating attention deficit hyperactivity disorder and learning disabilities in girls: a familial risk analysisA E Doyle
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, 02114, USA
Am J Psychiatry 158:1666-72. 2001.... - Long-term stability of the Child Behavior Checklist in a clinical sample of youth with attention deficit hyperactivity disorderJ Biederman
Harvard Medical School, Massachusetts General Hospital and McLean Hospital, Boston, MA, USA
J Clin Child Psychol 30:492-502. 2001..These results support the informativeness of the CBCL as a useful measure of longitudinal course in clinical samples of youth with ADHD... - Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorderJ Wozniak
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Affect Disord 64:121-31. 2001..Furthermore, they suggest that the comorbid condition of CD+BPD may be a distinct nosological entity. This suggests that clinicians treating CD or BPD children should consider the treatment implications of this comorbid condition... - Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorderJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
Am J Psychiatry 163:1730-8. 2006..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)... - Evidence for genetic association of RORB with bipolar disorderCasey L McGrath
Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
BMC Psychiatry 9:70. 2009..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB... - Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associationsJessica Lasky-Su
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1345-54. 2008..Replication of these results is necessary in order to confirm the proposed genetic variants for ADHD... - Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onsetEric Mick
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 13:453-62. 2003..This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder... - Latent class analysis shows strong heritability of the child behavior checklist-juvenile bipolar phenotypeRobert R Althoff
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 60:903-11. 2006.... - Prevalence and genetic architecture of Child Behavior Checklist-juvenile bipolar disorderJames J Hudziak
Department of Psychiatry, University of Vermont, Burlington 05405, USA
Biol Psychiatry 58:562-8. 2005.... - Antecedents to panic disorder in nonreferred adultsJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:1179-86. 2006..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults... - Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection... - Further evidence of association between behavioral inhibition and social anxiety in childrenJ Biederman
Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
Am J Psychiatry 158:1673-9. 2001..1 versus 50.8). CONCLUSIONS: This study adds to the growing literature suggesting an association between behavioral inhibition and social anxiety disorder and an inverse relationship between inhibition and disruptive behavior disorders... - Current concepts on the neurobiology of Attention-Deficit/Hyperactivity DisorderJ Biederman
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Atten Disord 6:S7-16. 2002.... - Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disordersT J Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
Biol Psychiatry 49:1062-70. 2001..What was previously considered refractory ADHD, oppositionality, aggression, and conduct disorder may respond after mood stabilization. We review these issues in this article... - Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorderJ Lasky-Su
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Ann Hum Genet 71:648-59. 2007..Although definitive conclusions await independent replication, these results suggest that a variant in DRD5 may affect age at onset for ADHD... - Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom typeJ Biederman
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 157:816-8. 2000..Symptom decline in attention deficit hyperactivity disorder (ADHD) was examined with different definitions of remission... - The genetics of schizophreniaM T Tsuang
Harvard Medical School, Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
Curr Psychiatry Rep 1:20-4. 1999..The potential importance of schizotaxia, or similar concepts, for use in genetic studies, is discussed... - Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorderS V Faraone
Pediatric Psychopharmacology Unit, Child Psychiatric Services, Massachusetts General Hospital, Boston 02114, USA
Am J Psychiatry 158:1052-7. 2001..Although several studies have shown an association between ADHD and the 7-repeat allele of the dopamine D(4) receptor gene (DRD4), several studies have not. Thus, the status of the ADHD-DRD4 association is uncertain... - The paradox of normal neuropsychological function in schizophreniaW S Kremen
Department of Psychiatry, University of California, Davis, School of Medicine, 4430 V Street, Sacramento, California 95817, USA
J Abnorm Psychol 109:743-52. 2000..Our results favor the view that even neuropsychologically normal schizophrenia patients have compromised cognitive function relative to their presumed expected or premorbid level of intellectual ability... - New insights into the comorbidity between ADHD and major depression in adolescent and young adult femalesJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:426-34. 2008..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females... - Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorderHamid Mostafavi Abdolmaleky
Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
Hum Mol Genet 15:3132-45. 2006.... - Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disordersJessica A Lasky-Su
Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 133:110-5. 2005..The small but significant effects of the 44-bp insertion/deletion polymorphism for BP is consistent with being one of many genes that contributes to the multi-factorial nature of these psychiatric disorders... - Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3Stephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Am J Psychiatry 163:1760-6. 2006..To address this issue, the authors ascertained 606 Han Chinese families comprising 1,234 affected members... - Familial risk analyses of attention deficit hyperactivity disorder and substance use disordersJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
Am J Psychiatry 165:107-15. 2008..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature... - Association of bipolar and substance use disorders in parents of adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 62:129-34. 2007..We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism... - Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorderJoseph Biederman
Department of Psychiatry, Harvard Medical School, USA
Biol Psychiatry 59:258-64. 2006.... - Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled studyJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
J Affect Disord 94:191-7. 2006..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring... - A naturalistic 10-year prospective study of height and weight in children with attention-deficit hyperactivity disorder grown up: sex and treatment effectsJoseph Biederman
Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
J Pediatr 157:635-40, 640.e1. 2010..To assess the effect of attention-deficit/hyperactivity disorder (ADHD) and its treatment on growth outcomes in children followed into adulthood... - Meta-analysis shows schizophrenia is not associated with the 40-base-pair repeat polymorphism of the dopamine transporter geneF Gamma
Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, MA, USA
Schizophr Res 73:55-8. 2005..The results of these studies have been equivocal due to small sample size and low power. This meta-analysis has the aim to evaluate the collective evidence for an association between the VTNR polymorphism and schizophrenia... - Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescenceJoseph Biederman
Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Dev Neuropsychol 33:44-61. 2008..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence... - The genetics of pediatric-onset bipolar disorderStephen V Faraone
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:970-7. 2003.... - A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorderEric Mick
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:1021-7. 2003..CONCLUSIONS: While there was a significant heterogeneity in estimates between studies, a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression was identified... - Diagnostic threshold for conduct disorder in girls and boysAlysa E Doyle
Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC-725, 15 Parkman Street, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 191:379-86. 2003..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender... - A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizesStephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
J Clin Psychiatry 71:754-63. 2010.... - The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysisJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Yawkey Center, Suite 6A, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 70:732-40. 2009..To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder... - Lack of association between behavioral inhibition and psychosocial adversity factors in children at risk for anxiety disordersDina R Hirshfeld-Becker
Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Cambridge, MA 02138, USA
Am J Psychiatry 161:547-55. 2004..To explore whether this association was mediated by environmental factors, the authors examined associations between psychosocial adversity variables and behavioral inhibition in this group of children... - Presenting ADHD symptoms, subtypes, and comorbid disorders in clinically referred adults with ADHDTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, YAW 6A, 55 Fruit Street, Boston, MA 02114, USA
J Clin Psychiatry 70:1557-62. 2009..Comorbidity among adults with ADHD is also of great interest due to the high rates of psychiatric comorbidity, which can lead to a more persistent ADHD among adults... - Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescentsTimothy E Wilens
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Arch Pediatr Adolesc Med 162:916-21. 2008..To examine the effects of early stimulant treatment on subsequent risk for cigarette smoking and substance use disorders (SUDs) in adolescents with attention-deficit/hyperactivity disorder (ADHD)... - The lifetime impact of attention deficit hyperactivity disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)S Bernardi
Department of Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY, USA
Psychol Med 42:875-87. 2012.... - Efficacy of Adderall and methylphenidate in attention deficit hyperactivity disorder: a reanalysis using drug-placebo and drug-drug response curve methodologyS V Faraone
Pediatric Psychopharmacology Unit, Child Psychiatry Services, Massachusetts General Hospital, Boston 02114, USA
J Child Adolesc Psychopharmacol 11:171-80. 2001..They further suggest that, compared with the Conners Teacher Rating Scale, the Clinical Global Impressions scale may be more sensitive to improvements at the "well end" of the spectrum of functioning... - Cortical abnormalities in schizophrenia identified by structural magnetic resonance imagingJ M Goldstein
Department of Psychiatry, Institute of Psychiatric Epidemiology and Genetics, Massachusetts Mental Health Center, Boston 02115, USA
Arch Gen Psychiatry 56:537-47. 1999..We hypothesized, based on previous empirical and theoretical work, that dorsolateral prefrontal and paralimbic cortices would be significantly volumetrically reduced in patients with schizophrenia compared with normal controls... - Methodological complexities in the diagnosis of major depression in youth: an analysis of mother and youth self-reportsE B Braaten
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
J Child Adolesc Psychopharmacol 11:395-407. 2001..To this end we evaluated whether morbidity and functional correlates on the diagnosis of MDD in youth vary by informant source... - Patterns of remission and symptom decline in conduct disorder: a four-year prospective study of an ADHD sampleJ Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
J Am Acad Child Adolesc Psychiatry 40:290-8. 2001..To evaluate systematically the longitudinal course of conduct disorder (CD) in a sample of youths with attention-deficit hyperactivity disorder (ADHD) to determine the effects of a persistent course on outcome... - Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorderJ W Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:781-90. 2007..We further suggest that co-morbidity with MDD may enhance detection of the association between SNAP-25 and ADHD...