Q R Fan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
    Q R Fan
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 389:96-100. 1997
  2. ncbi Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Nat Immunol 2:452-60. 2001
  3. ncbi Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor
    Q R Fan
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Exp Med 190:113-23. 1999
  4. ncbi A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Eur J Immunol 30:2692-7. 2000
  5. ncbi Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 275:23700-6. 2000
  6. ncbi Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule
    Q R Fan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:7178-83. 1996
  7. ncbi Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    D N Garboczi
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 384:134-41. 1996

Collaborators

Detail Information

Publications7

  1. ncbi Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
    Q R Fan
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 389:96-100. 1997
    ..The topology of the domains and their arrangement relative to each other reveal a relationship to the haematopoietic receptor family, with implications for the signalling mechanism in NK cells...
  2. ncbi Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Nat Immunol 2:452-60. 2001
    ..Most of the amino acids that differ between human and chimpanzee KIRs with HLA-C specificities form solvent-accessible clusters outside the KIR-HLA interface, which suggests undiscovered interactions by KIRs...
  3. ncbi Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor
    Q R Fan
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Exp Med 190:113-23. 1999
    ..The surface of HLA-Cw4 has electrostatic complementarity to the surface of the NK cell inhibitory receptor KIR2D...
  4. ncbi A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Eur J Immunol 30:2692-7. 2000
    ..Furthermore, the covalently-linked KIR2DL1 dimer binds more tightly to HLA-Cw4 than the wild-type monomer, suggesting the occurrence of a second binding event that increases the overall affinity of KIR dimer for HLA-C...
  5. ncbi Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor
    Q R Fan
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    J Biol Chem 275:23700-6. 2000
    ....
  6. ncbi Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule
    Q R Fan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 93:7178-83. 1996
    ..The formation of complexes between soluble, recombinant molecules indicates that HLA-Cw4 is sufficient for specific ligation by the NK receptor and that neither glycoprotein requires carbohydrate for the interaction...
  7. ncbi Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
    D N Garboczi
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 384:134-41. 1996
    ..A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions...