Bao Jian Fan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 13:779-84. 2007
  2. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
  3. ncbi request reprint Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    J Glaucoma 13:377-84. 2004
  4. ncbi request reprint Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Arch Ophthalmol 124:102-6. 2006
  5. ncbi request reprint [Polymorphisms of myocilin and optineurin in primary open angle glaucoma patients]
    Hong yan Yao
    Department of Ophthalmology and Visual Science, Chinese University of Hong Kong, Hong Kong, China
    Zhonghua Yi Xue Za Zhi 86:554-9. 2006
  6. ncbi request reprint A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q
    Chi Pui Pang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 12:85-92. 2006
  7. doi request reprint A genome-wide scan maps a novel high myopia locus to 5p15
    Ching Yan Lam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Invest Ophthalmol Vis Sci 49:3768-78. 2008
  8. ncbi request reprint A genome-wide scan maps a novel juvenile-onset primary open-angle glaucoma locus to 15q
    Dan Yi Wang
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Invest Ophthalmol Vis Sci 47:5315-21. 2006
  9. ncbi request reprint SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 11:625-31. 2005
  10. ncbi request reprint Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population
    Ching Yan Lam
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
    J Glaucoma 15:218-22. 2006

Collaborators

Detail Information

Publications34

  1. pmc Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 13:779-84. 2007
    ..The goal of the present study was to evaluate the role of the NRG2 gene in this JOAG family and unrelated JOAG patients and to refine the critical interval for GLC1M...
  2. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
    ....
  3. ncbi request reprint Polymorphisms in the myocilin promoter unrelated to the risk and severity of primary open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    J Glaucoma 13:377-84. 2004
    ..To investigate the proximal 2.5 kb promoter in the myocilin (MYOC) gene for mutations in Chinese patients with primary open-angle glaucoma (POAG)...
  4. ncbi request reprint Novel myocilin mutation in a Chinese family with juvenile-onset open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Arch Ophthalmol 124:102-6. 2006
    ..To search for the genetic cause of juvenile-onset open-angle glaucoma (JOAG) in a Chinese family...
  5. ncbi request reprint [Polymorphisms of myocilin and optineurin in primary open angle glaucoma patients]
    Hong yan Yao
    Department of Ophthalmology and Visual Science, Chinese University of Hong Kong, Hong Kong, China
    Zhonghua Yi Xue Za Zhi 86:554-9. 2006
    ..To detect the single nucleotide polymorphisms (SNPs) of the myocilin (MYOC) and optineurin (OPTN) genes, and to investigate their associations with high tension glaucoma (HTG) and normal tension glaucoma (NTG)...
  6. ncbi request reprint A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q
    Chi Pui Pang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 12:85-92. 2006
    ..To map the disease-associated locus of a family with autosomal dominant juvenile-onset primary open angle glaucoma (JOAG) and to screen the novel glaucoma gene WD repeat domain 36 (WDR36)...
  7. doi request reprint A genome-wide scan maps a novel high myopia locus to 5p15
    Ching Yan Lam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Invest Ophthalmol Vis Sci 49:3768-78. 2008
    ..This study was conducted to investigate the genetic component of three Chinese pedigrees originating from Hong Kong with autosomal dominant high myopia...
  8. ncbi request reprint A genome-wide scan maps a novel juvenile-onset primary open-angle glaucoma locus to 15q
    Dan Yi Wang
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Invest Ophthalmol Vis Sci 47:5315-21. 2006
    ..To map the disease-associated locus of a family with autosomal dominant juvenile-onset primary open-angle glaucoma (JOAG)...
  9. ncbi request reprint SNPs and interaction analyses of myocilin, optineurin, and apolipoprotein E in primary open angle glaucoma patients
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 11:625-31. 2005
    ..To evaluate the association of myocilin (MYOC), optineurin (OPTN), and apolipoprotein E (APOE) genes and their interactions in primary open angle glaucoma (POAG)...
  10. ncbi request reprint Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population
    Ching Yan Lam
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
    J Glaucoma 15:218-22. 2006
    ..To evaluate the role of apolipoprotein E (APOE) polymorphisms in primary open angle glaucoma (POAG)...
  11. doi request reprint Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, China
    Invest Ophthalmol Vis Sci 49:1886-97. 2008
    ..In this study, the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA in comparison with DEX was investigated...
  12. ncbi request reprint Absence of myocilin and optineurin mutations in a large Philippine family with juvenile onset primary open angle glaucoma
    Dan Yi Wang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 10:851-6. 2004
    ..To analyze the role of the two primary open angle glaucoma (POAG) genes, myocilin (MYOC) and optineurin (OPTN), in a large Philippine family segregating autosomal dominant juvenile onset open angle glaucoma (JOAG)...
  13. pmc AC and AG dinucleotide repeats in the PAX6 P1 promoter are associated with high myopia
    Tsz Kin Ng
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong S A R
    Mol Vis 15:2239-48. 2009
    ..This study investigated the association of PAX6 with high myopia in 379 high myopia patients and 349 controls...
  14. doi request reprint Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Invest Ophthalmol Vis Sci 51:4110-6. 2010
    ..To evaluate the variants of 10 genes for association with primary open-angle glaucoma (POAG) in a Chinese population...
  15. ncbi request reprint Genetic and environmental risk factors for primary open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, Hong Kong, China
    Chin Med J (Engl) 117:706-10. 2004
    ..This study was to investigate the associations of genetic and environmental factors with POAG in a hospital-based Chinese population...
  16. pmc LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:2372-8. 2011
    ..The purpose of this study was to investigate the disease association of LOXL1 variants spanning the gene region, including the 5' and 3' regulatory regions, in a U.S. Caucasian case-control sample...
  17. doi request reprint Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Glaucoma 19:432-6. 2010
    ..To evaluate the elastin gene (ELN) as a secondary risk factor for pseudoexfoliation syndrome (PXFS) and the associated glaucoma pseudoexfoliation glaucoma (PXFG)...
  18. pmc Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 15:646-53. 2009
    ..To determine the distribution of WD repeat domain 36 (WDR36) sequence variants in Chinese patients with primary open-angle glaucoma (POAG)...
  19. ncbi request reprint Different optineurin mutation pattern in primary open-angle glaucoma
    Yuk Fai Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Invest Ophthalmol Vis Sci 44:3880-4. 2003
    ..In this study, sequence alterations in the OPTN gene associated with POAG in Chinese subjects were investigated...
  20. ncbi request reprint [Digenic association of RHO and RP1 genes with retinitis pigmentosa among Chinese population in Hong Kong]
    Dan Yi Wang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Zhonghua Yi Xue Za Zhi 85:1613-7. 2005
    ..To identify the mutation patterns of RHO and RP1 genes in the Chinese patients with retinitis pigmentosa (RP) and to explore their potential interactions in the pathogenesis of RP...
  21. pmc SNP rs1533428 at 2p16.3 as a marker for late-onset primary open-angle glaucoma
    Li Jia Chen
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 18:1629-39. 2012
    ..3, and primary open-angle glaucoma (POAG)...
  22. pmc Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 52:1788-92. 2011
    ..Recent studies have identified SNPs associated with optic nerve area and vertical cup-to-disc ratio (VCDR). The purpose of this study was to evaluate the association between these SNPs and POAG in a US Caucasian case-control sample...
  23. pmc The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    PLoS ONE 7:e45613. 2012
    ..In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field...
  24. ncbi request reprint Gene mapping for primary open angle glaucoma
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, China
    Clin Biochem 39:249-58. 2006
    ..In the near future such comprehensive studies are expected to greatly advance our understanding of the genetic basis of POAG and provide information for effective glaucoma therapy...
  25. pmc EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes
    Haitao Li
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong, China
    Mol Vis 14:1698-704. 2008
    ..We tested the hypothesis that genetic variants in vasoactive and angiogenic factors regulating the retina vasculature contribute to the development of diabetic retinopathy (DR)...
  26. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:971-9. 2010
    ..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)...
  27. ncbi request reprint [Recent progress in molecular genetics and gene therapy for retinitis pigmentosa]
    Dan Yi Wang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Zhonghua Yan Ke Za Zhi 41:188-92. 2005
    ..So far there is no effective treatment for RP. This paper gives an overview on recent advances in molecular genetics of RP with emphasis on the important gene mutations for diagnosis and prognosis, and a review on gene therapy of RP...
  28. ncbi request reprint Growth factor changes in ex vivo expansion of human limbal epithelial cells on human amniotic membrane
    Hin Fai Yam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon
    Cornea 21:101-5. 2002
    ..We determined whether the amniotic basement membrane affects the growth of human limbal epithelial cells through the production of growth factors...
  29. pmc The cytotoxic and stress responses of human trabecular meshwork cells treated with triamcinolone acetonide
    Dan Yi Wang
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Mol Vis 14:105-13. 2008
    ..To evaluate the cytotoxic effect of triamcinolone acetonide (TA) on cultured human trabecular meshwork (TM) cells...
  30. ncbi request reprint The dual role of dexamethasone on anti-inflammation and outflow resistance demonstrated in cultured human trabecular meshwork cells
    Yuk Fai Leung
    Department of Ophthalmology Visual Sciences, The Chinese University of Hong Kong, Hong Kong
    Mol Vis 9:425-39. 2003
    ..In the present work, DEX effects on global gene expressions of an established human TM cell line were studied by microarray...
  31. ncbi request reprint Molecular diagnostics of genetic eye diseases
    Bao Jian Fan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong
    Clin Biochem 39:231-9. 2006
    ..Establishment of ethnic-specific disease databases that contain both clinical and genetic information for identification of genetic markers with diagnostic, prognostic, or pharmacological value is strongly advocated...
  32. pmc Glaucoma: genes, phenotypes, and new directions for therapy
    Bao Jian Fan
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:3064-72. 2010
    ..This review summarizes the human genetics and genomic approaches that have shed light on the complex inheritance of glaucoma genes and the potential for gene-based and cellular therapies that this research makes possible...
  33. ncbi request reprint TGFbeta-induced factor: a candidate gene for high myopia
    Dennis Shun Chiu Lam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 44:1012-5. 2003
    ..To investigate the coding exons of transforming growth factor (TGF)-beta-induced factor (TGIF) for mutations in Chinese patients with high myopia...
  34. pmc Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese
    You Qiang Song
    Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, China
    BMC Med Genet 9:38. 2008
    ..Hence it is a good candidate for genetic studies in DDD...