David T Evans

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
    Bin Jia
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA
    PLoS Pathog 5:e1000429. 2009
  2. pmc Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239
    Bin Jia
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 5:e1000272. 2009
  3. pmc KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif
    Arnaud D Colantonio
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USA
    PLoS Pathog 7:e1001316. 2011
  4. pmc BST-2/tetherin: a new component of the innate immune response to enveloped viruses
    David T Evans
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drives, Southborough, MA 01772, USA
    Trends Microbiol 18:388-96. 2010
  5. pmc Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239
    David T Evans
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102
    J Virol 79:7707-20. 2005
  6. pmc Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge
    Michael D Alpert
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 84:10748-64. 2010
  7. pmc Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1
    Nadine C Salisch
    Division of Immunology, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    J Immunol 184:476-87. 2010
  8. pmc ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge
    Michael D Alpert
    Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 8:e1002890. 2012
  9. ncbi PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation
    Philippe Blancou
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Gen Virol 86:1785-90. 2005
  10. pmc Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system
    David T Evans
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 77:2400-9. 2003

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
    Bin Jia
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA
    PLoS Pathog 5:e1000429. 2009
    ....
  2. pmc Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239
    Bin Jia
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 5:e1000272. 2009
    ....
  3. pmc KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif
    Arnaud D Colantonio
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USA
    PLoS Pathog 7:e1001316. 2011
    ....
  4. pmc BST-2/tetherin: a new component of the innate immune response to enveloped viruses
    David T Evans
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drives, Southborough, MA 01772, USA
    Trends Microbiol 18:388-96. 2010
    ..Here, we review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic...
  5. pmc Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239
    David T Evans
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102
    J Virol 79:7707-20. 2005
    ..Given the extraordinary difficulty in protecting against SIV(mac)239, these results are encouraging and support further evaluation of lentiviruses that are limited to a single cycle of infection as a preclinical AIDS vaccine approach...
  6. pmc Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge
    Michael D Alpert
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 84:10748-64. 2010
    ....
  7. pmc Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1
    Nadine C Salisch
    Division of Immunology, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    J Immunol 184:476-87. 2010
    ....
  8. pmc ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge
    Michael D Alpert
    Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, United States of America
    PLoS Pathog 8:e1002890. 2012
    ....
  9. ncbi PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation
    Philippe Blancou
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Gen Virol 86:1785-90. 2005
    ..However, variation in the levels of PRA1 expression did not influence virion production, infectivity or envelope incorporation under the conditions of these assays...
  10. pmc Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system
    David T Evans
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 77:2400-9. 2003
    ..Nevertheless, this study demonstrates the potential of mucosal priming by the Salmonella type III secretion system to direct SIV-specific cellular immune responses to the gastrointestinal mucosa in a primate model...
  11. pmc Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropism
    M Quinn DeGottardi
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 82:321-34. 2008
    ..These studies reveal differences in the peaks and durations of a single round of productive infection that reflect envelope-specific differences in infectivity, chemokine receptor specificity, and cellular tropism...
  12. pmc Tetherin upregulation in simian immunodeficiency virus-infected macaques
    Andrew R Rahmberg
    Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USA
    J Virol 87:13917-21. 2013
    ..These observations are consistent with a role for tetherin in innate immunity to immunodeficiency virus infection. ..
  13. pmc Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV
    Ruth Serra-Moreno
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Cell Host Microbe 9:46-57. 2011
    ..These results are consistent with HIV-2 Env antagonism of human tetherin and suggest that the ability to oppose tetherin is important for lentiviral pathogenesis...
  14. pmc Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis
    Ruth Serra-Moreno
    Division of Microbiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
    PLoS Pathog 9:e1003487. 2013
    ....
  15. ncbi Adaptation of human and simian immunodeficiency viruses for resistance to tetherin/BST-2
    Ruth Serra-Moreno
    New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Curr HIV Res 10:277-82. 2012
    ....
  16. pmc Flow cytometry based identification of simian immunodeficiency virus Env-specific B lymphocytes
    Ismael Ben F Fofana
    Microbiology Division, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    J Immunol Methods 370:75-85. 2011
    ..These reagents will be useful for analyzing development of Env-specific B cell responses in preclinical studies using SIV-infected or vaccinated rhesus macaques...
  17. pmc Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2
    M Quinn DeGottardi
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Virol 82:3139-46. 2008
    ..Thus, selective major histocompatibility complex class I downregulation is a conserved mechanism of immune evasion for pathogenic SIV infection of rhesus macaques and nonpathogenic SIV infection of sooty mangabeys...
  18. pmc Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor
    David T Evans
    New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 9102, USA
    J Virol 76:327-37. 2002
    ..Thus, PRA1 associates with envelope glycoproteins from widely divergent lentiviruses...
  19. pmc A novel approach for producing lentiviruses that are limited to a single cycle of infection
    David T Evans
    New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
    J Virol 78:11715-25. 2004
    ..Single-cycle SIV produced by this approach will be useful for addressing questions relating to viral dynamics and viral pathogenesis and for evaluation as an experimental AIDS vaccine in rhesus macaques...
  20. pmc Nonhuman primate models in AIDS research
    David T Evans
    New England National Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
    Curr Opin HIV AIDS 8:255-61. 2013
    ..However, several challenges remain, including the absence of a vaccine that can reliably prevent virus acquisition, and the inability of current ART regimens to eradicate the infection...
  21. pmc A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- or SIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays
    Michael D Alpert
    Department of Microbiology and Immunobiology, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts, USA
    J Virol 86:12039-52. 2012
    ....
  22. pmc Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependent cell-mediated cytotoxicity
    Juan F Arias
    Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772
    Proc Natl Acad Sci U S A 111:6425-30. 2014
    ..By serving as link between innate and adaptive immunity, the antiviral activity of tetherin may be augmented by virus-specific antibodies, and hence much greater than previously appreciated. ..
  23. ncbi Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03: 04 and modulate primary natural killer cell function
    Nienke H van Teijlingen
    aRagon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA bExperimental Immunology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands cDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston dDivision of Microbiology, New England Primate Research Center, Southborough, Massachusetts, USA eIrsicaixa AIDS Research Institute HIVACAT, Autonomous University of Barcelona, Badalona and Institució Catalana de Recerca i Estudis Avancats ICREA, Barcelona, Spain fCancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick, Inc, Frederick National Laboratories for Cancer Research, Frederick, Maryland gDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA hLaboratory for Translational Immunology, University Medical Center Utrecht, Utrecht iCenter for Infectious Disease Control, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands jHeinrich Pette Institut, Leibniz Institute for Experimental Virology, Hamburg, Germany Nienke H van Teijlingen and Angelique Hölzemer have contributed equally to the writing of the manuscript
    AIDS 28:1399-408. 2014
    ..The aim of this study was to assess the consequence of sequence variations in HLA-C03:04-presented HIV-1 p24 Gag epitopes on binding of the inhibitory natural killer (NK) cell receptor KIR2DL2 to HLA-C03:04...
  24. ncbi Reversion of CTL escape-variant immunodeficiency viruses in vivo
    Thomas C Friedrich
    Wisconsin National Primate Research Center, Madison, Wisconsin 53715, USA
    Nat Med 10:275-81. 2004
    ..In the absence of selective pressure upon transmission to new hosts, these original escape mutations can be lost. This suggests that some HIV CTL epitopes will be maintained in human populations...
  25. ncbi Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
    Anke Specht
    Institute of Virology, Universitatsklinikum, 89081 Ulm, Germany
    Virology 373:229-37. 2008
    ....

Research Grants6

  1. Single-Cycle SIV as a Novel AIDS Vaccine Approach
    David Evans; Fiscal Year: 2005
    ..Associations between immune responses elicited by scSIV and the outcome of challenge will be analyzed for each specific aim to reveal potential mechanisms of protection. ..
  2. Single-Cycle SIV as a Non-Replicating Vaccine Strain
    David Evans; Fiscal Year: 2004
    ..Macaques immunized with single-cycle viruses will be challenged with wild type SIV by mucosal routes to assess protection. ..
  3. Single-Cycle SIV as a Novel AIDS Vaccine Approach
    David Evans; Fiscal Year: 2007
    ..Associations between immune responses elicited by scSIV and the outcome of challenge will be analyzed for each specific aim to reveal potential mechanisms of protection. ..
  4. Single-Cycle SIV as a Novel AIDS Vaccine Approach
    David Evans; Fiscal Year: 2006
    ..Associations between immune responses elicited by scSIV and the outcome of challenge will be analyzed for each specific aim to reveal potential mechanisms of protection. ..