Research Topics
Genomes and Genes
| Joel K ElmquistSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Neuroscience. The fat-brain axis enters a new dimensionJoel K Elmquist
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Science 304:63-4. 2004- Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptorToshiro Kishi
Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 482:217-43. 2005..These observations are consistent with the proposed roles of the central NPY/Y1-R system in energy homeostasis... - Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasisJoel K Elmquist
Department of Medicine and Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 493:63-71. 2005..Finally, although these studies have been illustrative, they also underscore our relative lack of knowledge and highlight the need for more definitive approaches to unravel the functional significance of these pathways... - Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophagesJ K Elmquist
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
J Comp Neurol 381:119-29. 1997.... 
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nucleiJ K Elmquist
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
Proc Natl Acad Sci U S A 95:741-6. 1998..Our results demonstrate that a discrete set of hypothalamic pathways may underlie leptin's autonomic, endocrine, and behavioral effects...- Distributions of leptin receptor mRNA isoforms in the rat brainJ K Elmquist
Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 395:535-47. 1998..Leptin receptors localized in nonneuronal cells in the meninges, choroid plexus, and blood vessels may be involved in transport of leptin into the brain and in the clearance of leptin from the cerebrospinal fluid... - Unraveling the central nervous system pathways underlying responses to leptinJ K Elmquist
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Neurosci 1:445-50. 1998..We describe neural circuits that are downstream of leptin receptors and propose a model linking populations of leptin-responsive neurons with effector neurons underlying leptin's endocrine, autonomic and behavioral effects... - Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenesCarl De Luca
Department of Medicine, Division of Preventative Medicine, Columbia University, New York, New York, USA
J Clin Invest 115:3484-93. 2005..In summary, we show that brain-specific leptin signaling is sufficient to reverse the obesity, diabetes, and infertility of db/db mice... - Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasisHarveen Dhillon
Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Neuron 49:191-203. 2006..These results reveal a critical role for leptin action on VMH neurons... - Mice lacking ghrelin receptors resist the development of diet-induced obesityJeffrey M Zigman
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 115:3564-72. 2005..Moreover, our data suggest that ghrelin signaling is required for development of the full phenotype of diet-induced obesity... - The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activityRoberto Coppari
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Cell Metab 1:63-72. 2005..These data demonstrate that leptin signaling in the ARH is sufficient for mediating leptin's effects on glucose homeostasis and locomotor activity... - Leptin receptor signaling in POMC neurons is required for normal body weight homeostasisNina Balthasar
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
Neuron 42:983-91. 2004..In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis... - Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balanceQingchun Tong
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
Nat Neurosci 11:998-1000. 2008..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance... - Central serotonin and melanocortin pathways regulating energy homeostasisLora K Heisler
Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 994:169-74. 2003..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus... - Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone miceHiralben R Patel
University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
Diabetes 55:3091-8. 2006..Insulin, leptin, and triglyceride levels increase with adiposity in both wild-type and NPYko mice... - Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesityLaura E Parton
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Nature 449:228-32. 2007..We conclude that obesity-induced, UCP2-mediated loss of glucose sensing in glucose-excited neurons might have a pathogenic role in the development of type 2 diabetes... - Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemiaQingchun Tong
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
Cell Metab 5:383-93. 2007..Thus, glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia... - Divergence of melanocortin pathways in the control of food intake and energy expenditureNina Balthasar
Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
Cell 123:493-505. 2005..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance... - Expression of ghrelin receptor mRNA in the rat and the mouse brainJeffrey M Zigman
Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 494:528-48. 2006.... - Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in miceTomoaki Morioka
Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
J Clin Invest 117:2860-8. 2007.... - Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brainJoseph F Kelly
Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
Diabetes 53:911-20. 2004..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin... - Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cellsPaul Kievit
Division of Endocrinology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
Cell Metab 4:123-32. 2006..These studies demonstrate that Socs-3 within POMC neurons regulates leptin sensitivity and glucose homeostasis, and plays a key role in linking high-fat diet to disordered metabolism... - Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic miceTakatoshi Mochizuki
Department of Neurology and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:4471-6. 2011..These observations demonstrate that the tuberomammillary region plays an essential role in the wake-promoting effects of orexins, but orexins must stabilize sleep through other targets... - Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sitesHiroshi Yamamoto
Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Neurosci 23:2939-46. 2003..These findings suggest that catecholamine neurons in the AP link peripheral GLP-1 and central autonomic control sites that mediate the diverse neuroendocrine and autonomic actions of peripheral GLP-1... - Minireview: From anorexia to obesity--the yin and yang of body weight controlJeffrey M Zigman
Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Endocrinology 144:3749-56. 2003..Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia... - Expression of melanocortin 4 receptor mRNA in the central nervous system of the ratToshiro Kishi
Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 457:213-35. 2003..The distribution of MC4-R mRNA is consistent with the proposed roles of central melanocortin systems in feeding and autonomic regulation... - Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brainYi Hong Zhang
Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 463:3-12. 2003..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J... - PTP1B regulates leptin signal transduction in vivoJanice M Zabolotny
Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Department of Medicine, Boston, MA, USA
Dev Cell 2:489-95. 2002..Our data indicate that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. PTP1B may be a novel target to treat leptin resistance in obesity... - Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in miceHiroaki Masuzaki
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 112:83-90. 2003..The potential role of adipose 11beta-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder... - The need to feed: homeostatic and hedonic control of eatingClifford B Saper
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neuron 36:199-211. 2002..We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition... - Activation of central melanocortin pathways by fenfluramineLora K Heisler
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Science 297:609-11. 2002..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments... - "AMPing up" our understanding of the hypothalamic control of energy balanceKevin W Williams
Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 85390 9051, USA
J Clin Invest 117:2089-92. 2007..These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis... - VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fastingSeung Hahm
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurosci 22:6929-38. 2002.... - Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathwaysLigang Zhou
Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
Cell Metab 6:398-405. 2007.... - Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in miceJennifer W Hill
Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Clin Invest 118:1796-805. 2008.... - Rethinking the central causes of diabetesJoel K Elmquist
Nat Med 9:645-7. 2003 
Hypothalamic pathways linking energy balance and reproductionJennifer W Hill
Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Am J Physiol Endocrinol Metab 294:E827-32. 2008..The nature of the interplay between these elements of the metabolic and reproductive systems presents a fascinating puzzle, whose pieces are just beginning to fall into place...- The orexigenic hormone ghrelin defends against depressive symptoms of chronic stressMichael Lutter
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9077, USA
Nat Neurosci 11:752-3. 2008..Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress... - Brain SIRT1: anatomical distribution and regulation by energy availabilityGiorgio Ramadori
Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
J Neurosci 28:9989-96. 2008..Collectively, our findings establish the distribution of Sirt1 mRNA throughout the neuraxis and suggest a previously unrecognized role of brain SIRT1 in regulating energy homeostasis... - Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processesJon T Willie
Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Neuron 38:715-30. 2003.... - A good night's sleep: future antidote to the obesity epidemic?Jeffrey S Flier
Ann Intern Med 141:885-6. 2004 - The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and miceJennifer L Lachey
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237 0559, USA
Endocrinology 146:458-62. 2005..Such species differences are an important consideration when comparing results from rat and mouse studies... - Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like proteinAndrea M Haqq
Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
Biochem J 376:595-605. 2003.... - Physiology: do neural signals remodel bone?Joel K Elmquist
Nature 434:447-8. 2005 - Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoterHongyan Liu
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
J Neurosci 23:7143-54. 2003..The transgenic mouse line should be useful for future studies on the role of melanocortin signaling in regulating feeding behavior and autonomic homeostasis... - Movin' on up: adipocytes become regulators of nutrient homeostasisRoger H Unger
Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell Metab 3:147-8. 2006..2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities... - Orexin neurons and the TASK of glucosensingMichael M Scott
Center for Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Neuron 50:665-7. 2006..The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses... - Serotonin reciprocally regulates melanocortin neurons to modulate food intakeLora K Heisler
Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
Neuron 51:239-49. 2006.... - In search of an effective obesity treatment: a shot in the dark or a shot in the arm?Jeffrey M Zigman
Department of Internal Medicine, Division of Endocrinology and Metabolism, Center for Hypothalamic Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390 9077, USA
Proc Natl Acad Sci U S A 103:12961-2. 2006