Joel K Elmquist

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Neuroscience. The fat-brain axis enters a new dimension
    Joel K Elmquist
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 304:63-4. 2004
  2. ncbi Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 482:217-43. 2005
  3. ncbi Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
    Joel K Elmquist
    Department of Medicine and Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:63-71. 2005
  4. ncbi Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
    J K Elmquist
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 381:119-29. 1997
  5. pmc Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Proc Natl Acad Sci U S A 95:741-6. 1998
  6. ncbi Distributions of leptin receptor mRNA isoforms in the rat brain
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 395:535-47. 1998
  7. ncbi Unraveling the central nervous system pathways underlying responses to leptin
    J K Elmquist
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Neurosci 1:445-50. 1998
  8. pmc Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
    Carl De Luca
    Department of Medicine, Division of Preventative Medicine, Columbia University, New York, New York, USA
    J Clin Invest 115:3484-93. 2005
  9. ncbi Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
  10. pmc Mice lacking ghrelin receptors resist the development of diet-induced obesity
    Jeffrey M Zigman
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:3564-72. 2005

Detail Information

Publications49

  1. ncbi Neuroscience. The fat-brain axis enters a new dimension
    Joel K Elmquist
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 304:63-4. 2004
  2. ncbi Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 482:217-43. 2005
    ..These observations are consistent with the proposed roles of the central NPY/Y1-R system in energy homeostasis...
  3. ncbi Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
    Joel K Elmquist
    Department of Medicine and Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:63-71. 2005
    ..Finally, although these studies have been illustrative, they also underscore our relative lack of knowledge and highlight the need for more definitive approaches to unravel the functional significance of these pathways...
  4. ncbi Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
    J K Elmquist
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 381:119-29. 1997
    ....
  5. pmc Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Proc Natl Acad Sci U S A 95:741-6. 1998
    ..Our results demonstrate that a discrete set of hypothalamic pathways may underlie leptin's autonomic, endocrine, and behavioral effects...
  6. ncbi Distributions of leptin receptor mRNA isoforms in the rat brain
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 395:535-47. 1998
    ..Leptin receptors localized in nonneuronal cells in the meninges, choroid plexus, and blood vessels may be involved in transport of leptin into the brain and in the clearance of leptin from the cerebrospinal fluid...
  7. ncbi Unraveling the central nervous system pathways underlying responses to leptin
    J K Elmquist
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Neurosci 1:445-50. 1998
    ..We describe neural circuits that are downstream of leptin receptors and propose a model linking populations of leptin-responsive neurons with effector neurons underlying leptin's endocrine, autonomic and behavioral effects...
  8. pmc Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
    Carl De Luca
    Department of Medicine, Division of Preventative Medicine, Columbia University, New York, New York, USA
    J Clin Invest 115:3484-93. 2005
    ..In summary, we show that brain-specific leptin signaling is sufficient to reverse the obesity, diabetes, and infertility of db/db mice...
  9. ncbi Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
    ..These results reveal a critical role for leptin action on VMH neurons...
  10. pmc Mice lacking ghrelin receptors resist the development of diet-induced obesity
    Jeffrey M Zigman
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:3564-72. 2005
    ..Moreover, our data suggest that ghrelin signaling is required for development of the full phenotype of diet-induced obesity...
  11. ncbi The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    Roberto Coppari
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell Metab 1:63-72. 2005
    ..These data demonstrate that leptin signaling in the ARH is sufficient for mediating leptin's effects on glucose homeostasis and locomotor activity...
  12. pmc Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
    Nat Neurosci 11:998-1000. 2008
    ..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance...
  13. ncbi Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
    ..In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis...
  14. ncbi Central serotonin and melanocortin pathways regulating energy homeostasis
    Lora K Heisler
    Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 994:169-74. 2003
    ..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus...
  15. ncbi Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice
    Hiralben R Patel
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:3091-8. 2006
    ..Insulin, leptin, and triglyceride levels increase with adiposity in both wild-type and NPYko mice...
  16. pmc Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:383-93. 2007
    ..Thus, glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia...
  17. ncbi Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    Laura E Parton
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 449:228-32. 2007
    ..We conclude that obesity-induced, UCP2-mediated loss of glucose sensing in glucose-excited neurons might have a pathogenic role in the development of type 2 diabetes...
  18. ncbi Divergence of melanocortin pathways in the control of food intake and energy expenditure
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell 123:493-505. 2005
    ..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance...
  19. ncbi Expression of ghrelin receptor mRNA in the rat and the mouse brain
    Jeffrey M Zigman
    Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 494:528-48. 2006
    ....
  20. pmc Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice
    Tomoaki Morioka
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Clin Invest 117:2860-8. 2007
    ....
  21. ncbi Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    Paul Kievit
    Division of Endocrinology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 4:123-32. 2006
    ..These studies demonstrate that Socs-3 within POMC neurons regulates leptin sensitivity and glucose homeostasis, and plays a key role in linking high-fat diet to disordered metabolism...
  22. ncbi Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain
    Joseph F Kelly
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 53:911-20. 2004
    ..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin...
  23. pmc Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
    Takatoshi Mochizuki
    Department of Neurology and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:4471-6. 2011
    ..These observations demonstrate that the tuberomammillary region plays an essential role in the wake-promoting effects of orexins, but orexins must stabilize sleep through other targets...
  24. ncbi Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    Hiroshi Yamamoto
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 23:2939-46. 2003
    ..These findings suggest that catecholamine neurons in the AP link peripheral GLP-1 and central autonomic control sites that mediate the diverse neuroendocrine and autonomic actions of peripheral GLP-1...
  25. ncbi Minireview: From anorexia to obesity--the yin and yang of body weight control
    Jeffrey M Zigman
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:3749-56. 2003
    ..Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia...
  26. ncbi Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 457:213-35. 2003
    ..The distribution of MC4-R mRNA is consistent with the proposed roles of central melanocortin systems in feeding and autonomic regulation...
  27. ncbi Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  28. ncbi PTP1B regulates leptin signal transduction in vivo
    Janice M Zabolotny
    Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Department of Medicine, Boston, MA, USA
    Dev Cell 2:489-95. 2002
    ..Our data indicate that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. PTP1B may be a novel target to treat leptin resistance in obesity...
  29. pmc Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    Hiroaki Masuzaki
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 112:83-90. 2003
    ..The potential role of adipose 11beta-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder...
  30. ncbi The need to feed: homeostatic and hedonic control of eating
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 36:199-211. 2002
    ..We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition...
  31. ncbi Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  32. pmc "AMPing up" our understanding of the hypothalamic control of energy balance
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 85390 9051, USA
    J Clin Invest 117:2089-92. 2007
    ..These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis...
  33. ncbi VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting
    Seung Hahm
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 22:6929-38. 2002
    ....
  34. pmc Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Cell Metab 6:398-405. 2007
    ....
  35. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
    ....
  36. ncbi Rethinking the central causes of diabetes
    Joel K Elmquist
    Nat Med 9:645-7. 2003
  37. doi Hypothalamic pathways linking energy balance and reproduction
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Physiol Endocrinol Metab 294:E827-32. 2008
    ..The nature of the interplay between these elements of the metabolic and reproductive systems presents a fascinating puzzle, whose pieces are just beginning to fall into place...
  38. pmc The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9077, USA
    Nat Neurosci 11:752-3. 2008
    ..Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress...
  39. pmc Brain SIRT1: anatomical distribution and regulation by energy availability
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:9989-96. 2008
    ..Collectively, our findings establish the distribution of Sirt1 mRNA throughout the neuraxis and suggest a previously unrecognized role of brain SIRT1 in regulating energy homeostasis...
  40. ncbi Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    Jon T Willie
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 38:715-30. 2003
    ....
  41. ncbi A good night's sleep: future antidote to the obesity epidemic?
    Jeffrey S Flier
    Ann Intern Med 141:885-6. 2004
  42. ncbi The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice
    Jennifer L Lachey
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237 0559, USA
    Endocrinology 146:458-62. 2005
    ..Such species differences are an important consideration when comparing results from rat and mouse studies...
  43. pmc Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein
    Andrea M Haqq
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem J 376:595-605. 2003
    ....
  44. ncbi Physiology: do neural signals remodel bone?
    Joel K Elmquist
    Nature 434:447-8. 2005
  45. ncbi Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
    Hongyan Liu
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 23:7143-54. 2003
    ..The transgenic mouse line should be useful for future studies on the role of melanocortin signaling in regulating feeding behavior and autonomic homeostasis...
  46. ncbi Movin' on up: adipocytes become regulators of nutrient homeostasis
    Roger H Unger
    Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:147-8. 2006
    ..2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities...
  47. ncbi Orexin neurons and the TASK of glucosensing
    Michael M Scott
    Center for Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Neuron 50:665-7. 2006
    ..The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses...
  48. ncbi Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
    Neuron 51:239-49. 2006
    ....
  49. pmc In search of an effective obesity treatment: a shot in the dark or a shot in the arm?
    Jeffrey M Zigman
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Center for Hypothalamic Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390 9077, USA
    Proc Natl Acad Sci U S A 103:12961-2. 2006