Joel K Elmquist

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
    J K Elmquist
    Department of Neurology, Division of Endocrinology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Int J Obes Relat Metab Disord 25:S78-82. 2001
  2. ncbi request reprint Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, 325 Research North, 99 Brookline Avenue, Boston, MA 02215, USA
    Physiol Behav 74:703-8. 2001
  3. ncbi request reprint Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
  4. ncbi request reprint The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    Roberto Coppari
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell Metab 1:63-72. 2005
  5. pmc Mice lacking ghrelin receptors resist the development of diet-induced obesity
    Jeffrey M Zigman
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:3564-72. 2005
  6. pmc Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
    Nat Neurosci 11:998-1000. 2008
  7. ncbi request reprint Central serotonin and melanocortin pathways regulating energy homeostasis
    Lora K Heisler
    Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 994:169-74. 2003
  8. ncbi request reprint Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
  9. ncbi request reprint Neuroscience. The fat-brain axis enters a new dimension
    Joel K Elmquist
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 304:63-4. 2004
  10. pmc Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:383-93. 2007

Detail Information

Publications62

  1. ncbi request reprint Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
    J K Elmquist
    Department of Neurology, Division of Endocrinology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Int J Obes Relat Metab Disord 25:S78-82. 2001
    ..These results provide a neuroanatomic framework explaining the endocrine, autonomic and behavioral effects of leptin...
  2. ncbi request reprint Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, 325 Research North, 99 Brookline Avenue, Boston, MA 02215, USA
    Physiol Behav 74:703-8. 2001
    ..These projections link circulating leptin and neurons that regulate feeding behavior, energy expenditure, and body weight homeostasis...
  3. ncbi request reprint Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
    ..These results reveal a critical role for leptin action on VMH neurons...
  4. ncbi request reprint The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    Roberto Coppari
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell Metab 1:63-72. 2005
    ..These data demonstrate that leptin signaling in the ARH is sufficient for mediating leptin's effects on glucose homeostasis and locomotor activity...
  5. pmc Mice lacking ghrelin receptors resist the development of diet-induced obesity
    Jeffrey M Zigman
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 115:3564-72. 2005
    ..Moreover, our data suggest that ghrelin signaling is required for development of the full phenotype of diet-induced obesity...
  6. pmc Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave, Boston, Massachusetts 02215, USA
    Nat Neurosci 11:998-1000. 2008
    ..These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance...
  7. ncbi request reprint Central serotonin and melanocortin pathways regulating energy homeostasis
    Lora K Heisler
    Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 994:169-74. 2003
    ..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus...
  8. ncbi request reprint Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
    ..In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis...
  9. ncbi request reprint Neuroscience. The fat-brain axis enters a new dimension
    Joel K Elmquist
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 304:63-4. 2004
  10. pmc Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:383-93. 2007
    ..Thus, glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia...
  11. ncbi request reprint Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice
    Hiralben R Patel
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:3091-8. 2006
    ..Insulin, leptin, and triglyceride levels increase with adiposity in both wild-type and NPYko mice...
  12. ncbi request reprint Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    Laura E Parton
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 449:228-32. 2007
    ..We conclude that obesity-induced, UCP2-mediated loss of glucose sensing in glucose-excited neurons might have a pathogenic role in the development of type 2 diabetes...
  13. ncbi request reprint Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
    Joel K Elmquist
    Department of Medicine and Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 493:63-71. 2005
    ..Finally, although these studies have been illustrative, they also underscore our relative lack of knowledge and highlight the need for more definitive approaches to unravel the functional significance of these pathways...
  14. ncbi request reprint Divergence of melanocortin pathways in the control of food intake and energy expenditure
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell 123:493-505. 2005
    ..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance...
  15. ncbi request reprint Expression of ghrelin receptor mRNA in the rat and the mouse brain
    Jeffrey M Zigman
    Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 494:528-48. 2006
    ....
  16. ncbi request reprint Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 482:217-43. 2005
    ..These observations are consistent with the proposed roles of the central NPY/Y1-R system in energy homeostasis...
  17. ncbi request reprint Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    Paul Kievit
    Division of Endocrinology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 4:123-32. 2006
    ..These studies demonstrate that Socs-3 within POMC neurons regulates leptin sensitivity and glucose homeostasis, and plays a key role in linking high-fat diet to disordered metabolism...
  18. pmc Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice
    Tomoaki Morioka
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Clin Invest 117:2860-8. 2007
    ....
  19. ncbi request reprint Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain
    Joseph F Kelly
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 53:911-20. 2004
    ..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin...
  20. pmc A neurohistochemical blueprint for pain-induced loss of appetite
    A Malick
    Department of Neurobiology and the Program in Neuroscience, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9930-5. 2001
    ..Based on these findings, we suggest that at least one of several groups of hypothalamic neurons that normally inhibit appetite in response to metabolic cues is positioned to mediate the suppression of food intake by pain signals...
  21. ncbi request reprint Characterization of CART neurons in the rat and human hypothalamus
    C F Elias
    Department of Neurology, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Comp Neurol 432:1-19. 2001
    ..The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans...
  22. pmc Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
    Takatoshi Mochizuki
    Department of Neurology and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:4471-6. 2011
    ..These observations demonstrate that the tuberomammillary region plays an essential role in the wake-promoting effects of orexins, but orexins must stabilize sleep through other targets...
  23. ncbi request reprint Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites
    Hiroshi Yamamoto
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 23:2939-46. 2003
    ..These findings suggest that catecholamine neurons in the AP link peripheral GLP-1 and central autonomic control sites that mediate the diverse neuroendocrine and autonomic actions of peripheral GLP-1...
  24. ncbi request reprint Orexin (hypocretin) neurons contain dynorphin
    T C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:RC168. 2001
    ..These findings suggest that dynorphin-A may play an important role in the function of the orexin neurons...
  25. ncbi request reprint Identification of SOCS-3 as a potential mediator of central leptin resistance
    C Bjørbaek
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 1:619-25. 1998
    ..In conclusion, SOCS-3 is a leptin-inducible inhibitor of leptin signaling, and a potential mediator of leptin resistance in obesity...
  26. ncbi request reprint Minireview: From anorexia to obesity--the yin and yang of body weight control
    Jeffrey M Zigman
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 144:3749-56. 2003
    ..Our model predicts that overstimulation or understimulation of these central pathways can result in obesity, anorexia, or cachexia...
  27. ncbi request reprint Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide
    J K Elmquist
    Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 374:315-31. 1996
    ..Our results are consistent with the hypothesis that the PVH plays a key role in integrating diverse physiological cues into the varied manifestations that constitute the cerebral component of the acute phase response...
  28. ncbi request reprint Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration
    J K Elmquist
    Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 371:85-103. 1996
    ....
  29. ncbi request reprint Distributions of leptin receptor mRNA isoforms in the rat brain
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 395:535-47. 1998
    ..Leptin receptors localized in nonneuronal cells in the meninges, choroid plexus, and blood vessels may be involved in transport of leptin into the brain and in the clearance of leptin from the cerebrospinal fluid...
  30. ncbi request reprint Leptin activates neurons in ventrobasal hypothalamus and brainstem
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Endocrinology 138:839-42. 1997
    ..These findings indicate that circulating leptin activates specific nuclear groups in the hypothalamus and brainstem known to regulate complex physiological responses during times of substrate availability...
  31. ncbi request reprint Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
    J K Elmquist
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 381:119-29. 1997
    ....
  32. pmc Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Proc Natl Acad Sci U S A 95:741-6. 1998
    ..Our results demonstrate that a discrete set of hypothalamic pathways may underlie leptin's autonomic, endocrine, and behavioral effects...
  33. ncbi request reprint Unraveling the central nervous system pathways underlying responses to leptin
    J K Elmquist
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Neurosci 1:445-50. 1998
    ..We describe neural circuits that are downstream of leptin receptors and propose a model linking populations of leptin-responsive neurons with effector neurons underlying leptin's endocrine, autonomic and behavioral effects...
  34. pmc Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation
    J Lu
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:4864-74. 2001
    ....
  35. ncbi request reprint Differential expression of orexin receptors 1 and 2 in the rat brain
    J N Marcus
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 435:6-25. 2001
    ..The differential distribution of orexin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX(2)R receptor in regulating sleep state stability...
  36. ncbi request reprint Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  37. ncbi request reprint Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 457:213-35. 2003
    ..The distribution of MC4-R mRNA is consistent with the proposed roles of central melanocortin systems in feeding and autonomic regulation...
  38. pmc Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    Hiroaki Masuzaki
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 112:83-90. 2003
    ..The potential role of adipose 11beta-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder...
  39. pmc Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling
    M Harris
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 107:111-20. 2001
    ..Indeed, a novel Stat-response element in the TRH promoter is necessary for leptin's effect. Thus, the TRH promoter is an ideal target for further characterizing the integration of transcriptional pathways through which leptin acts...
  40. pmc Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons
    E D Abel
    Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine 15 North 2030 East, Building 533, Room 3410B, Salt Lake City, UT 84112, USA
    J Clin Invest 107:1017-23. 2001
    ..Thus TR-beta2 is the key TR isoform responsible for T(3)-mediated negative-feedback regulation by hypophysiotropic TRH neurons...
  41. ncbi request reprint The need to feed: homeostatic and hedonic control of eating
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 36:199-211. 2002
    ..We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition...
  42. ncbi request reprint Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  43. ncbi request reprint PTP1B regulates leptin signal transduction in vivo
    Janice M Zabolotny
    Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Department of Medicine, Boston, MA, USA
    Dev Cell 2:489-95. 2002
    ..Our data indicate that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2. PTP1B may be a novel target to treat leptin resistance in obesity...
  44. pmc "AMPing up" our understanding of the hypothalamic control of energy balance
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 85390 9051, USA
    J Clin Invest 117:2089-92. 2007
    ..These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis...
  45. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
    ....
  46. pmc Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Cell Metab 6:398-405. 2007
    ....
  47. ncbi request reprint Rethinking the central causes of diabetes
    Joel K Elmquist
    Nat Med 9:645-7. 2003
  48. pmc Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
    Carl De Luca
    Department of Medicine, Division of Preventative Medicine, Columbia University, New York, New York, USA
    J Clin Invest 115:3484-93. 2005
    ..In summary, we show that brain-specific leptin signaling is sufficient to reverse the obesity, diabetes, and infertility of db/db mice...
  49. ncbi request reprint VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting
    Seung Hahm
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 22:6929-38. 2002
    ....
  50. ncbi request reprint Orexin neurons and the TASK of glucosensing
    Michael M Scott
    Center for Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Neuron 50:665-7. 2006
    ..The findings may shed light on the mechanisms that link hypoglycemia and coordinated arousal and autonomic responses...
  51. ncbi request reprint Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter
    Hongyan Liu
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 23:7143-54. 2003
    ..The transgenic mouse line should be useful for future studies on the role of melanocortin signaling in regulating feeding behavior and autonomic homeostasis...
  52. pmc Brain SIRT1: anatomical distribution and regulation by energy availability
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:9989-96. 2008
    ..Collectively, our findings establish the distribution of Sirt1 mRNA throughout the neuraxis and suggest a previously unrecognized role of brain SIRT1 in regulating energy homeostasis...
  53. pmc The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 9077, USA
    Nat Neurosci 11:752-3. 2008
    ..Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress...
  54. pmc Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein
    Andrea M Haqq
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem J 376:595-605. 2003
    ....
  55. doi request reprint Hypothalamic pathways linking energy balance and reproduction
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Physiol Endocrinol Metab 294:E827-32. 2008
    ..The nature of the interplay between these elements of the metabolic and reproductive systems presents a fascinating puzzle, whose pieces are just beginning to fall into place...
  56. ncbi request reprint The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice
    Jennifer L Lachey
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237 0559, USA
    Endocrinology 146:458-62. 2005
    ..Such species differences are an important consideration when comparing results from rat and mouse studies...
  57. ncbi request reprint A good night's sleep: future antidote to the obesity epidemic?
    Jeffrey S Flier
    Ann Intern Med 141:885-6. 2004
  58. ncbi request reprint Physiology: do neural signals remodel bone?
    Joel K Elmquist
    Nature 434:447-8. 2005
  59. ncbi request reprint Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    Jon T Willie
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 38:715-30. 2003
    ....
  60. pmc In search of an effective obesity treatment: a shot in the dark or a shot in the arm?
    Jeffrey M Zigman
    Department of Internal Medicine, Division of Endocrinology and Metabolism, Center for Hypothalamic Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, 75390 9077, USA
    Proc Natl Acad Sci U S A 103:12961-2. 2006
  61. ncbi request reprint Movin' on up: adipocytes become regulators of nutrient homeostasis
    Roger H Unger
    Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:147-8. 2006
    ..2006[this issue of Cell Metabolism]) unexpectedly induce leptin sensitivity with hypophagia and improvement in abnormal glucose and lipid abnormalities...
  62. ncbi request reprint Serotonin reciprocally regulates melanocortin neurons to modulate food intake
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 2QQ, United Kingdom
    Neuron 51:239-49. 2006
    ....