Research Topics
| I ElmanSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Effects of risperidone on the peripheral noradrenegic system in patients with schizophrenia: a comparison with clozapine and placeboIgor Elman
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Neuropsychopharmacology 27:293-300. 2002..Our data suggest that both risperidone and clozapine elevate plasma NE levels via enhanced neurotransmitter spillover, with risperidone producing a smaller effect...- Ultrarapid opioid detoxification: effects on cardiopulmonary physiology, stress hormones and clinical outcomesI Elman
Addiction Services, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
Drug Alcohol Depend 61:163-72. 2001..Further research is needed on the efficacy, safety, mechanisms and neurobiological sequelae of the procedure... - The validity of self-reported drug use in non-treatment seeking individuals with cocaine dependence: correlation with biochemical assaysI Elman
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Am J Addict 9:216-21. 2000..These results suggest that self-reported substance use in non-treatment seeking research subjects is generally valid... - Gender differences in cocaine craving among non-treatment-seeking individuals with cocaine dependenceI Elman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Am J Drug Alcohol Abuse 27:193-202. 2001.... - Depressive symptomatology and cocaine-induced pituitary-adrenal axis activation in individuals with cocaine dependenceI Elman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Drug Alcohol Depend 56:39-45. 1999..These results suggest that the HPA axis may be involved in affective disturbances associated with the use of cocaine. Implications of these data for the pathophysiology of cocaine dependence are discussed... - The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteersI Elman
Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Brain Res 815:243-9. 1999.... - Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependenceIgor Elman
Department of Psychiatry, Motivation and Emotion Neuroscience Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Psychopharmacol 16:163-7. 2002.... - Effect of acute metabolic stress on pituitary-adrenal axis activation in patients with schizophreniaI Elman
Experimental Therapeutics Branch, NIMH, National Institutes of Health, Bethesda, MD, USA
Am J Psychiatry 155:979-81. 1998..The authors examined the effects of acute metabolic stress induced by 2-deoxy-D-glucose (2-DG) on pituitary-adrenal axis activation... - Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy menI Elman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Life Sci 68:1889-98. 2001..Our results suggest that adrenomedullary activation may be involved in stress-induced testosterone effects. The implications of these data for the understanding of the role of catecholamines in glucoprivic stress response are discussed... - Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approachA Breier
Experimental Therapeutics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Synapse 29:142-7. 1998..The implications of this brain imaging method for studies of schizophrenia and the mechanism of action of antipsychotic drugs are discussed... - Clozapine and risperidone in chronic schizophrenia: effects on symptoms, parkinsonian side effects, and neuroendocrine responseA F Breier
Experimental Therapeutics Branch, Division of Intramural Research Programs, NIMH, Bethesda, MD, USA
Am J Psychiatry 156:294-8. 1999.... - Clinical outcomes following cocaine infusion in nontreatment-seeking individuals with cocaine dependenceI Elman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 49:553-5. 2001..In a time-related trend analysis, both groups showed significant reductions in frequency of cocaine use. CONCLUSIONS: Laboratory-based cocaine administration can be a safe paradigm even in individuals who are not engaged in treatment... - Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophreniaC M Adler
Experimental Therapeutics Branch, NIMH, Bethesda, MD, USA
Am J Psychiatry 156:1646-9. 1999..This study sought to determine whether thought disorder induced in healthy volunteers by the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine resembles the thought disorder found in patients with schizophrenia... - Effects of acute metabolic stress on plasma progesterone and testosterone in male subjects: relationship to pituitary-adrenocortical axis activationI Elman
Experimental Therapeutics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1380, USA
Life Sci 61:1705-12. 1997..The implications of these data for the understanding of the role of sex steroids in the stress response is discussed... - Dopamine D2 receptor density and personal detachment in healthy subjectsA Breier
Experimental Therapeutics Branch, NIMH, Bethesda, MD, USA
Am J Psychiatry 155:1440-2. 1998..The purpose of this study was to examine the relationship between the personality trait involving personal detachment and dopamine D2 receptor specific binding in healthy subjects... - Effects of acute cortisol and cocaine administration on attention, recall and recognition task performance in individuals with cocaine dependenceJ W Hopper
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, MA, USA
Hum Psychopharmacol 19:511-6. 2004.... - Reward-aversion circuitry in analgesia and pain: implications for psychiatric disordersDavid Borsook
PAIN Group, Department of Psychiatry, Brain Imaging Center, McLean Hospital and Harvard Medical School, Belmont MA 02748, United States
Eur J Pain 11:7-20. 2007..These underlying features have implications for understanding the neurobiology of functional illnesses such as depression and anxiety and for the development and evaluation of novel therapeutic interventions... - Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agentsIgor Elman
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 31:2091-120. 2006..These effects can further deteriorate eating patterns. Pathophysiological and therapeutic implications of these insights need further validation via prospective clinical trials and neuroimaging studies... - Effects of cortisol and cocaine on plasma prolactin and growth hormone levels in cocaine-dependent volunteersIgor Elman
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
Addict Behav 30:859-64. 2005..These different neuroendocrine response profiles point to important differences between dopaminergic effects of cortisol and cocaine... 
Effects of perceived cocaine availability on subjective and objective responses to the drugRINAH T YAMAMOTO
Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA, USA
Subst Abuse Treat Prev Policy 2:30. 2007..Several lines of evidence suggest that cocaine expectancy and craving are two related phenomena. The present study assessed this potential link by contrasting reactions to varying degrees of the drug's perceived availability...- Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophreniaIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 176:369-75. 2004..Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function... - Acute cortisol administration triggers craving in individuals with cocaine dependenceIgor Elman
Behavioral Psychopharmacology Research Laboratory, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
Psychopharmacol Bull 37:84-9. 2003..These pilot data suggest that cortisol can induce a state that is associated with drug abuse... - Psychosocial stress and the duration of cocaine use in non-treatment seeking individuals with cocaine dependenceKatherine H Karlsgodt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Drug Alcohol Abuse 29:539-51. 2003.... - Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cuesDaniel D Langleben
Department of Psychiatry, University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
Am J Psychiatry 165:390-4. 2008..The authors sought to identify the functional neuroanatomy of the brain response to visual heroin-related stimuli in methadone maintenance patients... - Amphetamine-induced dopamine release and post-synaptic specific binding in patients with mild tardive dyskinesiaCaleb M Adler
Experimental Therapeutics Branch, National Institute of Mental Health/NIH, Bethesda, MD, USA
Neuropsychopharmacology 26:295-300. 2002..More research is needed to unravel the neurobiology of this debilitating disorder... - Probing reward function in post-traumatic stress disorder with beautiful facial imagesIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychiatry Res 135:179-83. 2005..There were no significant group differences in the attractiveness ratings. However, PTSD patients expended less effort to extend the viewing time of the beautiful female faces. These findings suggest a reward deficit in PTSD... - Decreased absolute amygdala volume in cocaine addictsNikos Makris
Motivation and Emotion Neuroscience Collaboration, Department of Radiology, Harvard Medical School, Boston, MA 02129, USA
Neuron 44:729-40. 2004..These findings argue for a condition that predisposes the individual to cocaine dependence by affecting the amygdala, or a primary event early in the course of cocaine use... - Effects of acute metabolic stress on the peripheral vasopressinergic system in schizophreniaIgor Elman
Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
J Psychopharmacol 17:317-23. 2003.... - Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and lossesJames W Hopper
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
J Psychiatr Res 42:802-7. 2008..Posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. The present study assessed for such dysfunction in both the expectancy and outcome phases of reward processing...