E A Elion

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Pheromone response, mating and cell biology
    E A Elion
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Microbiol 3:573-81. 2000
  2. pmc Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p
    V Cherkasova
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 151:989-1004. 1999
  3. pmc The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae
    D M Lyons
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:4095-106. 1996
  4. ncbi request reprint Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11
    Y Feng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 8:267-78. 1998
  5. ncbi request reprint Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
    S K Mahanty
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:501-12. 1999
  6. pmc Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity
    K Y Choi
    Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, Massachusetts 02115 5701, USA
    Mol Biol Cell 10:1553-68. 1999
  7. ncbi request reprint The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5
    J E Kranz
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:313-27. 1994
  8. pmc The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components
    B N Lee
    Department of Biological Chemistry, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:12679-84. 1999
  9. pmc Relative dependence of different outputs of the Saccharomyces cerevisiae pheromone response pathway on the MAP kinase Fus3p
    F W Farley
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 151:1425-44. 1999
  10. pmc FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1
    E A Elion
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Biol Cell 4:495-510. 1993

Collaborators

  • Y Wang
  • Y Feng
  • K S Park
  • V Cherkasova
  • S K Mahanty
  • K Y Choi
  • F W Farley
  • D M Lyons
  • B N Lee
  • M A Leza
  • J E Kranz
  • B Satterberg
  • E J Goldsmith
  • J A Brill
  • M Manandhar
  • G R Fink

Detail Information

Publications18

  1. ncbi request reprint Pheromone response, mating and cell biology
    E A Elion
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Microbiol 3:573-81. 2000
    ..Far1 and Cdc24 also undergo nuclear shuttling and the nuclear pool of Far1 may temporally regulate access of Cdc24 to the cell cortex...
  2. pmc Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p
    V Cherkasova
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 151:989-1004. 1999
    ..Thus, Fus3p and Kss1p control G1 arrest through a balance of arrest functions that inhibit the Cdc28p machinery and proliferative functions that bypass this inhibition...
  3. pmc The SH3-domain protein Bem1 coordinates mitogen-activated protein kinase cascade activation with cell cycle control in Saccharomyces cerevisiae
    D M Lyons
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:4095-106. 1996
    ..These and other results suggest that Bem1 may cross-link the Ste5-MAPK cascade complex to upstream activators and specific downstream substrates at the shmoo tip, thus enabling efficient circuitry for G1 arrest and mating...
  4. ncbi request reprint Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11
    Y Feng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Curr Biol 8:267-78. 1998
    ..Ste5 is thought to associate with Gbeta in a pheromone-independent manner, but it is not known if this interaction affects signaling...
  5. ncbi request reprint Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
    S K Mahanty
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:501-12. 1999
    ..This novel regulatory scheme may ensure that cytoplasmic Ste5 does not activate downstream kinases in the absence of pheromone and could be applicable to other membrane-recruited signaling proteins...
  6. pmc Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity
    K Y Choi
    Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School, Boston, Massachusetts 02115 5701, USA
    Mol Biol Cell 10:1553-68. 1999
    ..Collectively, these results support Ste5's role as a tether and suggest that association of Fus3 in complexes in the presence of pheromone may prevent inactivation in addition to enhancing activation...
  7. ncbi request reprint The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5
    J E Kranz
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:313-27. 1994
    ..These observations suggest the possibility that Ste5 promotes signal transduction by tethering Fus3 to its activating protein kinase(s)...
  8. pmc The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components
    B N Lee
    Department of Biological Chemistry, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:12679-84. 1999
    ..We predict that general proliferative functions may also exist for other MAPK cascades thought only to perform specialized functions...
  9. pmc Relative dependence of different outputs of the Saccharomyces cerevisiae pheromone response pathway on the MAP kinase Fus3p
    F W Farley
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 151:1425-44. 1999
    ..Finally, suppression analysis argues that Kss1p contributes to the overall pheromone response in a wild-type strain, but that Fus3p is the critical kinase for all of the outputs tested...
  10. pmc FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1
    E A Elion
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Biol Cell 4:495-510. 1993
    ..These data support a model in which FUS3 mediates transcription and G1 arrest by direct activation of STE12 and FAR1 and phosphorylates many other proteins involved in the response to pheromone...
  11. ncbi request reprint far4, far5, and far6 define three genes required for efficient activation of MAPKs Fus3 and Kss1 and accumulation of glycogen
    V Cherkasova
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Curr Genet 40:13-26. 2001
    ..Finally, BIM1 and BIK1 have been identified as CEN suppressors of far5, suggesting that the microtubule apparatus may regulate the ability of the pheromone response pathway to promote G1 arrest...
  12. pmc POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2
    M A Leza
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 151:531-43. 1999
    ..These and other results suggest that POG1 may regulate additional genes during vegetative growth and recovery...
  13. ncbi request reprint Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
    K Y Choi
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Cell 78:499-512. 1994
    ..Ste5 also increases the amount of Ste11 complexed to Ste7 and Fus3 and is required for Ste11 to function. These results substantiate a novel signal transduction component that physically links multiple kinases within a single cascade...
  14. ncbi request reprint The Ste5p scaffold
    E A Elion
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    J Cell Sci 114:3967-78. 2001
    ....
  15. pmc A role for autophosphorylation revealed by activated alleles of FUS3, the yeast MAP kinase homolog
    J A Brill
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Mol Biol Cell 5:297-312. 1994
    ..Furthermore, these results imply that the degree of autophosphorylation of a MAP kinase determines its threshold of sensitivity to upstream signals...
  16. pmc Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation
    E A Elion
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Cell Biol 130:1283-96. 1995
    ..These, and other results suggest that Fus2 defines a novel cell fusion function and subcellular structure that is also required for the alignment of parental nuclei before nuclear fusion...
  17. pmc FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction
    E A Elion
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Proc Natl Acad Sci U S A 88:9392-6. 1991
    ..The diverse roles for FUS3 suggest that the FUS3 protein kinase has multiple substrates, some of which may be shared with KSS1...
  18. ncbi request reprint FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation
    E A Elion
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142
    Cell 60:649-64. 1990
    ..The predicted FUS3 protein is 35% identical to the cdc2+/CDC28 kinases and 52% identical to the KSS1 predicted kinase...