Research Topics
Genomes and GenesSpecies | Stefan EhrlichSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia nervosaStefan Ehrlich
Charite Universitatsmedizin Berlin, CVK, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Berlin, Germany
J Psychiatr Res 44:827-33. 2010..This may represent a counterregulatory mechanism as part of the crosstalk between the immune and neuroendocrine systems...
The 5-HTTLPR polymorphism, platelet serotonin transporter activity and platelet serotonin content in underweight and weight-recovered females with anorexia nervosaStefan Ehrlich
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charite, Universitatsmedizin Berlin, CVK, Berlin, Germany
Eur Arch Psychiatry Clin Neurosci 260:483-90. 2010..Changes in platelet 5-HT transporter activity were related to the stage of the illness but not to 5-HTTLPR genotype. Increased V (max) and K (m) in recovered AN patients might mirror adaptive modulations of the 5-HT system...
Cumulative genetic risk and prefrontal activity in patients with schizophreniaEsther Walton
To whom correspondence should be addressed Translational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, 01307 Dresden, Germany tel 49 0 351 458 2244, fax 49 0 351 458 57 54, E mail
Schizophr Bull 39:703-11. 2013..The GRS approach could provide an advantage over studying single genes in studies focusing on the genetic basis of polygenic conditions such as neuropsychiatric disorders...
Trajectories of agouti-related protein and leptin levels during antipsychotic-associated weight gain in patients with schizophreniaStefan Ehrlich
Translational Developmental Neuroscience Section, Department of Child and Adolescent Psychiatry, Dresden, Germany
J Clin Psychopharmacol 32:767-72. 2012..The hypothalamic mediator Agouti-related protein (AGRP) is inhibited by leptin and was shown to increase food intake. The aim of the present study was to investigate the trajectory of AGRP levels during antipsychotic-induced weight gain...
Smoking, but not malnutrition, influences promoter-specific DNA methylation of the proopiomelanocortin gene in patients with and without anorexia nervosaStefan Ehrlich
Dresden University of Technology, Department of Child and Adolescent Psychiatry, Translational Developmental Neuroscience Section, Dresden, Germany
Can J Psychiatry 57:168-76. 2012..Our pilot study evaluates the impact of environmental factors, such as nutrition and smoking status, on epigenetic patterns in a disease-associated gene...
Associations of cortical thickness and cognition in patients with schizophrenia and healthy controlsStefan Ehrlich
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2000, USA
Schizophr Bull 38:1050-62. 2012..In line with the prefrontal inefficiency hypothesis, schizophrenia patients may engage a larger compensatory network of brain regions other than frontal cortex to recall and manipulate verbal material in working memory...
Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosaStefan Ehrlich
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
J Psychiatry Neurosci 34:323-9. 2009..To control for secondary effects of acute malnutrition, we assessed acutely underweight patients with anorexia nervosa (acAN) in comparison to long-term weight-recovered patients with the disorder (recAN) and healthy controls...
The role of leptin and cortisol in hyperactivity in patients with acute and weight-recovered anorexia nervosaStefan Ehrlich
Charite Universitatsmedizin Berlin, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, CVK, Augustenburger Platz 1, 13353 Berlin, Germany
Prog Neuropsychopharmacol Biol Psychiatry 33:658-62. 2009..In this study, we assessed the relationships between PA and both, cortisol and leptin levels at the same time in patients with acute anorexia nervosa (acAN) in comparison to recovered patients (recAN)...
The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adultsStefan Ehrlich
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
Neuroimage 53:992-1000. 2010..Taken together with previous work, our data support a model in which lower COMT activity, and a resulting elevation in extracellular dopamine levels, stimulates growth of medial temporal lobe structures...
S100B in underweight and weight-recovered patients with anorexia nervosaStefan Ehrlich
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charite Universitatsmedizin Berlin, CVK, Augustenburger Platz 1, Berlin 13353, Germany
Psychoneuroendocrinology 33:782-8. 2008..Together they do not support hypotheses comprising the degeneration of glial or neuronal cells to explain common signs of brain atrophy in patients with acute AN...
Preproenkephalin expression in peripheral blood mononuclear cells of acutely underweight and recovered patients with anorexia nervosaDeike Weiss
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Berlin, Berlin, Germany
Neuropsychobiology 62:151-7. 2010..We hypothesized that ppE expression in AN patients may vary depending on the state of the disorder and the extent of malnutrition...
Aromatic amino acids in weight-recovered females with anorexia nervosaStefan Ehrlich
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charite Universitatsmedizin Berlin, Berlin, Germany
Int J Eat Disord 42:166-72. 2009..The present study assessed the availability of aromatic amino acids in the plasma of weight-recovered outpatients with AN (recAN) in comparison to acutely underweight AN patients (acAN) and healthy control woman (HCW)...
DISC1 is associated with cortical thickness and neural efficiencyStefan Brauns
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129 2000, USA
Neuroimage 57:1591-600. 2011..Here, we investigated the effects of variation in DISC1 on cortical thickness. In a subsequent analysis we tested whether the identified DISC1 risk variant is also associated with neural activity during working memory functioning...
Glial and neuronal damage markers in patients with anorexia nervosaStefan Ehrlich
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charite, Universitatsmedizin Berlin, CVK, Augustenburger Platz 1, Berlin, Germany
J Neural Transm 115:921-7. 2008....
Leptin and its associations with measures of psychopathology in patients with anorexia nervosaStefan Ehrlich
Department of Child and Adolescent Psychiatry, Universitatsmedizin Berlin, CVK, Augustenburger Platz 1, 13353, Berlin, Germany
J Neural Transm 116:109-15. 2009..e. the absence of sexual desire and intimate relationships. Our results are in accordance with recent animal experiments linking low leptin levels with decreased sexual interest irrespective of body weight...
Correspondence between self-reported and parent-reported psychopathology in adolescents with eating disordersHarriet Salbach-Andrae
Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Psychopathology 41:307-12. 2008..This study examined parent/youth self-report agreement on emotional and behavioral symptoms among adolescents with eating disorders (ED)...
Cognitive flexibility and Agouti-related protein in adolescent patients with anorexia nervosaLea Sarrar
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Psychoneuroendocrinology 36:1396-406. 2011....
Genetic variation in GAD1 is associated with cortical thickness in the parahippocampal gyrusStefan Brauns
Department of Child and Adolescent Psychiatry, TU Dresden, Germany MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA Department of Psychiatry, Charite University Medicine, Berlin, Germany
J Psychiatr Res 47:872-9. 2013..Our findings point to the importance of the GABAergic system in the pathogenesis of schizophrenia...
COMT Val108/158Met genotype modulates human sensory gatingTomislav Majic
Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
Neuroimage 55:818-24. 2011..It is however unclear if COMT genotype as a predictor of prefrontal efficiency modulates sensory gating on the level of the auditory cortex, i.e. the gating of the auditory evoked P50 and N100 components...
Factitious disorder in children and adolescents: a retrospective studyStefan Ehrlich
Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Klinik fur Psychiatrie, Psychosomatik, und Psychotherapie des Kindes und Jugendalters, Berlin, Germany
Psychosomatics 49:392-8. 2008..Factitious disorder (FD) presumably manifests at an early age, but epidemiological and clinical data about pediatric FD are still lacking...
Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomyAnastasia Yendiki
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA
Front Neuroinform 5:23. 2011....
Influence of age and movement complexity on kinematic hand movement parameters in childhood and adolescenceStefan Mark Rueckriegel
Pediatric Neurooncology Program, Department of Pediatric Oncology and Hematology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Int J Dev Neurosci 26:655-63. 2008..Furthermore, differences were observed in the maturation of different task complexities, the complex fine motor function reaching maturity later than basic and repetitive movement patterns...
