Kathleen M Egan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Active and passive smoking in breast cancer: prospective results from the Nurses' Health Study
    Kathleen M Egan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:138-45. 2002
  2. pmc Dietary carotenoids and the risk of invasive breast cancer
    Laura I Mignone
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 124:2929-37. 2009
  3. doi request reprint Meat consumption, heterocyclic amines, NAT2, and the risk of breast cancer
    Laura I Mignone
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nutr Cancer 61:36-46. 2009
  4. pmc Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality
    Hazel B Nichols
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 18:1403-9. 2009
  5. ncbi request reprint Dietary fat consumption and primary open-angle glaucoma
    Jae H Kang
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 79:755-64. 2004
  6. pmc Exposure to breast milk in infancy and risk of breast cancer
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
    Cancer Causes Control 20:1083-90. 2009
  7. pmc Bilateral oophorectomy in relation to risk of postmenopausal breast cancer: confounding by nonmalignant indications for surgery?
    Hazel B Nichols
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, E6139, Baltimore, MD 21205, USA
    Am J Epidemiol 173:1111-20. 2011
  8. ncbi request reprint Prospective study of cigarette smoking and the risk of primary open-angle glaucoma
    Jae H Kang
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Ophthalmol 121:1762-8. 2003
  9. doi request reprint Mortality after diagnosis of small melanocytic lesions of the choroid
    Anne Marie Lane
    Massachusetts Eye and Ear Infirmary, Boston, USA
    Arch Ophthalmol 128:996-1000. 2010
  10. pmc Postoophorectomy estrogen use and breast cancer risk
    Hazel B Nichols
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Obstet Gynecol 120:27-36. 2012

Detail Information

Publications50

  1. ncbi request reprint Active and passive smoking in breast cancer: prospective results from the Nurses' Health Study
    Kathleen M Egan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:138-45. 2002
    ..The role of active and passive smoking in breast cancer remains controversial...
  2. pmc Dietary carotenoids and the risk of invasive breast cancer
    Laura I Mignone
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 124:2929-37. 2009
    ..Results from this study are comparable to previous prospective studies, and suggest that a high consumption of carotenoids may reduce the risk of premenopausal but not postmenopausal breast cancer, particularly among smokers...
  3. doi request reprint Meat consumption, heterocyclic amines, NAT2, and the risk of breast cancer
    Laura I Mignone
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nutr Cancer 61:36-46. 2009
    ..There were no statistically significant interactions with NAT2 genotype. Results do not support an important association of HCAs with breast cancer risk, although potential biases in case-control studies should be considered...
  4. pmc Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality
    Hazel B Nichols
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 18:1403-9. 2009
    ..Factors related to improving outcomes in breast cancer survivors are of increasing public health significance. We examined postdiagnosis weight change in relation to mortality risk in a cohort of breast cancer survivors...
  5. ncbi request reprint Dietary fat consumption and primary open-angle glaucoma
    Jae H Kang
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 79:755-64. 2004
    ..Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure...
  6. pmc Exposure to breast milk in infancy and risk of breast cancer
    Lauren A Wise
    Slone Epidemiology Center, Boston University, Boston, MA 02215, USA
    Cancer Causes Control 20:1083-90. 2009
    ..Likewise, we found no association between breastfeeding duration and risk of breast cancer. Our results did not support the hypothesis that exposure to breast milk in infancy influences the risk of adult breast cancer...
  7. pmc Bilateral oophorectomy in relation to risk of postmenopausal breast cancer: confounding by nonmalignant indications for surgery?
    Hazel B Nichols
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, E6139, Baltimore, MD 21205, USA
    Am J Epidemiol 173:1111-20. 2011
    ..Results indicate that breast cancer risk reductions conferred by bilateral oophorectomy are not strongly confounded by failure to account for nonmalignant indications for surgery...
  8. ncbi request reprint Prospective study of cigarette smoking and the risk of primary open-angle glaucoma
    Jae H Kang
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Ophthalmol 121:1762-8. 2003
    ..To examine the association between cigarette smoking and incident primary open-angle glaucoma (POAG)...
  9. doi request reprint Mortality after diagnosis of small melanocytic lesions of the choroid
    Anne Marie Lane
    Massachusetts Eye and Ear Infirmary, Boston, USA
    Arch Ophthalmol 128:996-1000. 2010
    ..To evaluate the risk of dying of metastatic choroidal melanoma in patients with small, indeterminate, pigmented lesions of the uveal tract...
  10. pmc Postoophorectomy estrogen use and breast cancer risk
    Hazel B Nichols
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Obstet Gynecol 120:27-36. 2012
    ..To estimate whether the protective effect of premenopausal bilateral oophorectomy on breast cancer risk is mitigated by estrogen therapy use after surgery...
  11. ncbi request reprint Statin use and risk of breast cancer
    Gaia Pocobelli
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Cancer 112:27-33. 2008
    ..We analyzed data from a population-based case-control study to evaluate the association between the use of statins and breast cancer risk...
  12. doi request reprint Lifetime tobacco smoke exposure and breast cancer incidence
    Thomas P Ahern
    Department of Epidemiology, Boston University School of Public Health, 715 Albany Street T3E, Boston, MA 02118, USA
    Cancer Causes Control 20:1837-44. 2009
    ..We analyzed data from a case-control study to assess the association between lifetime tobacco smoke exposure and breast cancer incidence...
  13. ncbi request reprint Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
    Teresa T Fung
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:110-5. 2003
    ..No evidence was found that vitamins A, C and E; folate; or carotenoids play an important protective role against incident SCC...
  14. doi request reprint Adjuvant interferon therapy for patients with uveal melanoma at high risk of metastasis
    Anne Marie Lane
    Retina Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 116:2206-12. 2009
    ..To examine whether interferon (IFN)-alfa-2a treatment after radiation or enucleation reduces death rates in patients with uveal melanoma...
  15. pmc Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma
    Evangelos S Gragoudas
    Clinical Research Unit, Retina Service, Massachusetts Eye and Ear Infirmary, Boston, USA
    Trans Am Ophthalmol Soc 100:43-8; discussion 48-9. 2002
    ..To quantitate long-term risk of local treatment failure after proton irradiation of choroidal/ciliary body melanomas and to evaluate risk of metastasis-related deaths after local failure...
  16. ncbi request reprint Evidence-based estimates of outcome in patients irradiated for intraocular melanoma
    Evangelos Gragoudas
    Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 120:1665-71. 2002
    ..Until radiation therapy gained wide acceptance in the 1980s, enucleation was the standard treatment for the tumor. Long-term results after proton beam irradiation are now available...
  17. doi request reprint Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanoma
    Ivana K Kim
    Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 117:1617-22. 2010
    ..To evaluate the natural history of radiation papillopathy after proton beam irradiation of parapapillary choroidal melanoma...
  18. ncbi request reprint Tumor basal area and metastatic death after proton beam irradiation for choroidal melanoma
    Wenjun Li
    Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
    Arch Ophthalmol 121:68-72. 2003
    ..Tumor dimension is an established prognostic factor for metastasis-related death after radiotherapy for uveal melanoma...
  19. ncbi request reprint Conservation treatment of the eye: Conformal proton reirradiation for recurrent uveal melanoma
    Laura Marucci
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 64:1018-22. 2006
    ..To evaluate the outcomes of a second course of proton beam radiation therapy (PBRT) in patients with recurrent uveal melanoma...
  20. ncbi request reprint Antioxidant intake and primary open-angle glaucoma: a prospective study
    Jae H Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 158:337-46. 2003
    ..97 (95% CI: 0.62, 1.52) for vitamin E, and 1.11 (95% CI: 0.82, 1.51) for vitamin A. In conclusion, the authors did not observe any strong associations between antioxidant consumption and the risk of primary open-angle glaucoma...
  21. ncbi request reprint Early life risk factors in cancer: the relation of birth weight to adult obesity
    Nicole M Leong
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Int J Cancer 103:789-91. 2003
    ..76). These data suggest that both low and high birth weights are associated with higher adult BMI and support the hypothesis that fetal experience may influence adult obesity with potential consequences for risk of several major cancers...
  22. ncbi request reprint Cigarette smoking and risk of breast carcinoma in situ
    Amy Trentham-Dietz
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, Wisconsin 53726, USA
    Epidemiology 18:629-38. 2007
    ..Although the associations with cigarette smoking have been explored extensively for invasive breast cancer, the relation to in situ cancer has not previously been examined in depth...
  23. ncbi request reprint Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United States
    Jane A McElroy
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Madison, WI 53726, USA
    J Occup Environ Med 49:266-74. 2007
    ..Our objective was to evaluate women who were occupationally exposed to electromagnetic fields (EMF) and breast cancer risk...
  24. pmc Prediagnostic use of hormone therapy and mortality after breast cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 17:864-71. 2008
    ..Due to the high prevalence of past and current hormone use, it is important to investigate whether these preparations are related to breast cancer mortality...
  25. pmc Proportion of invasive breast cancer attributable to risk factors modifiable after menopause
    Brian L Sprague
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
    Am J Epidemiol 168:404-11. 2008
    ..3%. These findings suggest that a substantial fraction of postmenopausal breast cancer may be avoided by purposeful changes in lifestyle later in life...
  26. ncbi request reprint Postmenopausal estrogen and progestin use in relation to breast cancer risk
    Polly A Newcomb
    University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53706, USA
    Cancer Epidemiol Biomarkers Prev 11:593-600. 2002
    ..09; 95% CI, 1.07-4.07 for ever use versus nonuse). Estrogen-progestin use, both sequential and continuous, appears to be more strongly associated with risk of breast cancer than use of estrogen alone...
  27. ncbi request reprint Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Pharmacogenet Genomics 16:237-43. 2006
    ....
  28. ncbi request reprint Association of NAT2 and smoking in relation to breast cancer incidence in a population-based case-control study (United States)
    Kathleen M Egan
    Division of General Internal Medicine and the Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, 37232, USA
    Cancer Causes Control 14:43-51. 2003
    ..To evaluate the potential interaction between N-acetyltransferase 2 (NAT2) and smoking in breast cancer incidence...
  29. ncbi request reprint Genetic polymorphisms in GSTM1, GSTP1, and GSTT1 and the risk for breast cancer: results from the Shanghai Breast Cancer Study and meta-analysis
    Kathleen M Egan
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 27232 8300, USA
    Cancer Epidemiol Biomarkers Prev 13:197-204. 2004
    ....
  30. ncbi request reprint Sunlight and reduced risk of cancer: is the real story vitamin D?
    Kathleen M Egan
    J Natl Cancer Inst 97:161-3. 2005
  31. pmc Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women
    Hui Cai
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37203 1738, USA
    Pharmacogenet Genomics 18:657-64. 2008
    ..We investigated the associations of genetic polymorphisms in CYP19A1, a critical gene involved in estrogen synthesis, with plasma levels of sex hormones among postmenopausal Chinese women...
  32. ncbi request reprint Early life factors in relation to breast cancer risk in postmenopausal women
    Linda Titus-Ernstoff
    Norris Cotton Cancer Center and the Department of Community and Family Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Cancer Epidemiol Biomarkers Prev 11:207-10. 2002
    ..Overall, our results are consistent with previous studies and suggest that these early life factors have a modest influence on breast cancer risk in postmenopausal women...
  33. pmc Timing is everything: methodologic issues locating and recruiting medically underserved women for abnormal mammography follow-up research
    Alecia Malin Fair
    Department of Surgery, Meharry Medical College, 1005 Dr D B Todd Boulevard, Nashville, TN 37208, USA
    Contemp Clin Trials 29:537-46. 2008
    ..We present our experience attempting to locate and recruit minority and medically underserved women identified in a Nashville, Tennessee public hospital for a mammography follow-up study...
  34. doi request reprint Physical activity and survival after diagnosis of invasive breast cancer
    Crystal N Holick
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 17:379-86. 2008
    ..This study provides support for reduced overall mortality and mortality from breast cancer among women who engage in physical activity after breast cancer diagnosis...
  35. ncbi request reprint Oral contraceptive use and risk of breast carcinoma in situ
    Hazel B Nichols
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53726, USA
    Cancer Epidemiol Biomarkers Prev 16:2262-8. 2007
    ..16; 95% CI, 1.01-1.32 for ever versus never use). Consistent with invasive breast cancer, these results suggest that oral contraceptive use is at most a minor contributor to BCIS risk...
  36. ncbi request reprint Vitamin D receptor polymorphism and breast cancer risk
    Polly A Newcomb
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:1503-4. 2002
  37. ncbi request reprint MnSOD polymorphism and breast cancer in a population-based case-control study
    Kathleen M Egan
    Department of Medicine, Vanderbilt University Medical Center, Suite 6000 Medical Center East, Nashville, TN 37232 8300, USA
    Cancer Lett 199:27-33. 2003
    ..91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer...
  38. ncbi request reprint STK15 polymorphism and breast cancer risk in a population-based study
    Kathleen M Egan
    Vanderbilt University Medical Center, Suite 6000, MCE, Nashville, TN 37232 8300, USA
    Carcinogenesis 25:2149-53. 2004
    ..79). No interaction was detected between STK15 variants and estrogenic risk factors, although the power of these analyses was limited. These results suggest that STK15 may represent a low penetrance type breast cancer susceptibility gene...
  39. ncbi request reprint Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 7076, Rockville, MD 20952 7234, USA
    Hum Genet 119:376-88. 2006
    ..Evaluation of potential underlying gene-gene interactions or associations in population subgroups will require even larger sample sizes...
  40. ncbi request reprint Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer
    Yawei Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:353-8. 2006
    ..6; 95% CI, 1.1-2.4; P = 0.02). In conclusion, our results do not support that the polymorphisms evaluated in six BER pathway genes play a major role in breast carcinogenesis, particularly in Caucasian populations...
  41. ncbi request reprint Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States)
    Neeraja B Peterson
    Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University School of Medicine, Medical Center East, Suite 6000, Nashville, TN 37232 8300, USA
    Cancer Causes Control 17:459-67. 2006
    ..To examine the relationship between anthropometric measures and ovarian cancer by menopausal status...
  42. ncbi request reprint Duration of sleep and breast cancer risk in a large population-based case-control study
    Jane A McElroy
    University of Wisconsin Comprehensive Cancer Center, Madison, 53726, USA
    J Sleep Res 15:241-9. 2006
    ..In contrast, short duration of sleep (<7 h/night) is not substantially associated with increased risk. Further research in this area is warranted...
  43. ncbi request reprint Alcohol consumption and ovarian cancer risk in a population-based case-control study
    Neeraja B Peterson
    Center for Health Services Research, Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 8300, USA
    Int J Cancer 119:2423-7. 2006
    ..30), though results for other subtypes were based on sparse data and results were imprecise. In this study, neither total alcohol consumption as a young adult nor recently was associated with an increase in the risk of ovarian cancer...
  44. ncbi request reprint Familial relative risk estimates for use in epidemiologic analyses
    Yutaka Yasui
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Am J Epidemiol 164:697-705. 2006
    ....
  45. ncbi request reprint From menarche to menopause: trends among US Women born from 1912 to 1969
    Hazel B Nichols
    University of Wisconsin Comprehensive Cancer Center, Madison, WI 53726, USA
    Am J Epidemiol 164:1003-11. 2006
    ..1 years among women born between 1915 and 1919 to 37.7 years among the 1935-1939 cohort (p = 0.0001). These findings have implications for women's lifetime exposure to circulating endogenous hormones...
  46. ncbi request reprint Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Hum Genet 121:483-90. 2007
    ..Additional studies are required to replicate these findings and to determine whether rs361525 is a causative SNP or is a marker of a causative SNP...
  47. ncbi request reprint Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer
    Brian L Sprague
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin 53726, USA
    Cancer Epidemiol Biomarkers Prev 16:236-43. 2007
    ..Lifetime strenuous occupational activity was not associated with invasive breast cancer risk. These results provide further evidence that, for most women, physical activity may reduce the risk of invasive breast cancer...
  48. ncbi request reprint Genetic variation in TP53 and risk of breast cancer in a population-based case control study
    Brian L Sprague
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, WI 53726, USA
    Carcinogenesis 28:1680-6. 2007
    ..03). These results indicate that common variation in the TP53 gene could modify the risk of invasive breast cancer...
  49. ncbi request reprint Whole-genome amplification of oral rinse self-collected DNA in a population-based case-control study of breast cancer
    Xueying Liang
    Center for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 16:1610-4. 2007
    ..Whole-genome amplification may introduce substantial allele amplification bias in gDNA collected using a common protocol in population-based epidemiologic studies...
  50. ncbi request reprint Recreational physical activity and ovarian cancer in a population-based case-control study
    Elizabeth R Bertone
    Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 9304, USA
    Int J Cancer 99:431-6. 2002
    ..70; 95% CI = 0.36-1.35; p for trend = 0.41). Overall, our results provide only limited support for an inverse association between recreational physical activity and risk of ovarian cancer...