Danny J Eckert

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Div of Sleep Medicine, Sleep Disorders Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 111:1644-53. 2011
  2. pmc Pathophysiology of adult obstructive sleep apnea
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, and Havard Medical School, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:144-53. 2008
  3. pmc Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, Harvard Medical School, Boston, MA 02115, USA
    J Clin Sleep Med 3:570-3. 2007
  4. pmc Genioglossus reflex inhibition to upper-airway negative-pressure stimuli during wakefulness and sleep in healthy males
    Danny J Eckert
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, and School of Molecular and Biomedical Science, Discipline of Physiology, University of Adelaide, South Australia, Australia
    J Physiol 581:1193-205. 2007
  5. pmc Central sleep apnea: Pathophysiology and treatment
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 131:595-607. 2007
  6. pmc Mechanisms of apnea
    Danny J Eckert
    Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Program and Harvard Medical School, Boston, MA, USA
    Prog Cardiovasc Dis 51:313-23. 2009
  7. pmc The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, 221 Longwood Avenue, Boston, MA 02115, USA
    Chest 135:957-64. 2009
  8. pmc A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure
    Danny J Eckert
    Sleep Disorders Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:1619-24. 2010
  9. pmc Alcohol alters sensory processing to respiratory stimuli in healthy men and women during wakefulness
    Danny J Eckert
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, SA, Australia
    Sleep 33:1389-95. 2010
  10. pmc Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold
    Danny J Eckert
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Sci (Lond) 120:505-14. 2011

Detail Information

Publications34

  1. pmc Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Div of Sleep Medicine, Sleep Disorders Program, Boston, MA 02115, USA
    J Appl Physiol (1985) 111:1644-53. 2011
    ..However, OSA patients may be vulnerable to fatigue of upper-airway dilator muscles, which could contribute to disease progression...
  2. pmc Pathophysiology of adult obstructive sleep apnea
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, and Havard Medical School, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:144-53. 2008
    ..Finally, the potential for novel treatment strategies, based on an improved understanding of the underlying pathophysiology, is also discussed with the ultimate aim of stimulating research ideas in areas where knowledge is lacking...
  3. pmc Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, Harvard Medical School, Boston, MA 02115, USA
    J Clin Sleep Med 3:570-3. 2007
    ..Thus, future studies should carefully explore the functional consequences of UAM abnormalities and define which patients, if any, are susceptible to these potentially detrimental effects...
  4. pmc Genioglossus reflex inhibition to upper-airway negative-pressure stimuli during wakefulness and sleep in healthy males
    Danny J Eckert
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, and School of Molecular and Biomedical Science, Discipline of Physiology, University of Adelaide, South Australia, Australia
    J Physiol 581:1193-205. 2007
    ..These data indicate there are both excitatory and inhibitory components to the genioglossus negative-pressure reflex which are differentially affected by state...
  5. pmc Central sleep apnea: Pathophysiology and treatment
    Danny J Eckert
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 131:595-607. 2007
    ..The clinical implications of improved CSA pathophysiology knowledge and the potential for novel therapeutic treatment approaches are also discussed...
  6. pmc Mechanisms of apnea
    Danny J Eckert
    Division of Sleep Medicine, Brigham and Women s Hospital, Sleep Disorders Program and Harvard Medical School, Boston, MA, USA
    Prog Cardiovasc Dis 51:313-23. 2009
    ....
  7. pmc The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program, 221 Longwood Avenue, Boston, MA 02115, USA
    Chest 135:957-64. 2009
    ....
  8. pmc A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure
    Danny J Eckert
    Sleep Disorders Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:1619-24. 2010
    ..These differential responses support the hypothesis that GG reflex suppression may be mediated via inhibition of respiratory-related premotor input...
  9. pmc Alcohol alters sensory processing to respiratory stimuli in healthy men and women during wakefulness
    Danny J Eckert
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, SA, Australia
    Sleep 33:1389-95. 2010
    ..Using respiratory-related evoked potentials (RREPs) during wakefulness, this study aimed to test the hypothesis that alcohol impairs respiratory-load sensory processing and to explore potential sex differences...
  10. pmc Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold
    Danny J Eckert
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Sci (Lond) 120:505-14. 2011
    ..However, additional treatment strategies are probably required to achieve elimination of apnoea...
  11. ncbi Effects of hypoxia on genioglossus and scalene reflex responses to brief pulses of negative upper-airway pressure during wakefulness and sleep in healthy men
    Danny J Eckert
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA, USA
    J Appl Physiol (1985) 104:1426-35. 2008
    ..38 +/- 6 ms, P = 0.006). These results indicate differential sensitivity to the depressive effects of hypoxia in the reflex responsiveness to sudden respiratory loads to breathing between these two respiratory muscles...
  12. pmc A method for measuring and modeling the physiological traits causing obstructive sleep apnea
    Andrew Wellman
    221 Longwood Ave, 036 BLI, Boston, MA 02115, USA
    J Appl Physiol (1985) 110:1627-37. 2011
    ..This technique could conceivably be used clinically to define a patient's physiology and guide therapy based on the traits...
  13. pmc The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility
    Robert L Owens
    Sleep Disorders Research Program, Div of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Appl Physiol (1985) 108:445-51. 2010
    ..Changes in lung volume alter Pcrit substantially. This work supports a role for lung volume in the pathogenesis of OSA, and lung volume changes should be a consideration during assessment of pharyngeal mechanics...
  14. pmc Recruitment and rate-coding strategies of the human genioglossus muscle
    Julian P Saboisky
    Division of Sleep Medicine, Sleep Disorders Program, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 109:1939-49. 2010
    ..Understanding upper airway muscle recruitment/derecruitment may yield therapeutic targets for maintenance of pharyngeal patency...
  15. pmc Termination of respiratory events with and without cortical arousal in obstructive sleep apnea
    Amy S Jordan
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 184:1183-91. 2011
    ..Arousals are thought to predispose to further events by promoting hyperventilation, hypocapnia, and upper-airway dilator muscle hypotonia. Therefore, events terminated without arousal may promote stable breathing...
  16. pmc Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea
    Amy S Jordan
    Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
    Sleep 32:361-8. 2009
    ....
  17. pmc Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 113:691-9. 2012
    ..These results also highlight the importance of inspiratory collapse in OSA pathogenesis. The cause of negative effort dependence within and across breaths is not known and requires further study...
  18. pmc Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea
    Bradley A Edwards
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Physiol 590:1199-211. 2012
    ..Identification of patients who may benefit from reductions in LG alone or in combination with other therapies to alter the remaining traits may facilitate pharmacological resolution of OSA in the future...
  19. ncbi Hypoxia impairs the arousal response to external resistive loading and airway occlusion during sleep
    Michael C Hlavac
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia, Australia
    Sleep 29:624-31. 2006
    ..The aim of this study was to assess the effects of sustained hypoxia on arousal from sleep in normal subjects...
  20. ncbi Sustained hypoxia depresses sensory processing of respiratory resistive loads
    Danny J Eckert
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia
    Am J Respir Crit Care Med 172:1047-54. 2005
    ..Hypoxia has been shown to inhibit respiratory load perception in healthy and asthmatic subjects, and could contribute to treatment delays and impaired function of protective reflexes...
  21. ncbi The effects of hypoxia on load compensation during sustained incremental resistive loading in patients with obstructive sleep apnea
    Michael C Hlavac
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia
    J Appl Physiol (1985) 103:234-9. 2007
    ..001). These results suggest that ventilation during incremental resistive loading is preserved in OSA patients and that it appears relatively impervious to the effects of hypoxia...
  22. pmc Sitting and supine esophageal pressures in overweight and obese subjects
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:2354-60. 2012
    ..These data indicate that mediastinal weight and postural effects on P(Es) are within a clinically acceptable range, and suggest that esophageal manometry can be used to inform clinical decision making across wide range of body types...
  23. pmc The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway
    Robert L Owens
    Sleep Disorders Research Program, Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    J Appl Physiol (1985) 116:1105-12. 2014
    ..In contrast to the classical Starling resistor model, the upper airway exhibits marked NED in some subjects. ..
  24. pmc Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets
    Danny J Eckert
    1 Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Respir Crit Care Med 188:996-1004. 2013
    ..The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized...
  25. pmc Neurogenic changes in the upper airway of patients with obstructive sleep apnea
    Julian P Saboisky
    Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 185:322-9. 2012
    ..Controversy persists regarding the presence and importance of hypoglossal nerve dysfunction in obstructive sleep apnea (OSA)...
  26. ncbi Acute sustained hypoxia suppresses the cough reflex in healthy subjects
    Danny J Eckert
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia, Australia, 5041
    Am J Respir Crit Care Med 173:506-11. 2006
    ..Hypoxia is common in respiratory disorders and has been shown to have depressant effects on respiratory sensation and ventilation. We hypothesized that it might also suppress the cough reflex...
  27. ncbi Obstructive Sleep Apnea in Older Adults is a Distinctly Different Physiological Phenotype
    Bradley A Edwards
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Sleep 37:1227-36. 2014
    ..However, previous studies examining individual physiological traits known to contribute to OSA pathogenesis have been assessed in isolation, primarily in healthy individuals...
  28. pmc Pathophysiology & genetics of obstructive sleep apnoea
    Lisa Campana
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program and Harvard Medical School Boston, MA, USA
    Indian J Med Res 131:176-87. 2010
    ..We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits...
  29. pmc Changes in respiration in NREM sleep in hypercapnic chronic obstructive pulmonary disease
    Fergal J O'Donoghue
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia 5041, Australia
    J Physiol 559:663-73. 2004
    ..48(4.69) to 15.02(4.57) cm H2O s(-1), P=0.01) were all reduced. This suggests respiratory drive alters to maintain a preset VI in sleep, irrespective of load, at least while the fatigue threshold of respiratory muscles is not exceeded...
  30. pmc Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature
    Robert L Owens
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pulm Med 14:519-24. 2008
    ..However, recent work has focused on the function, rather than structure alone, of the upper airway...
  31. ncbi Hypoxia suppresses symptom perception in asthma
    Danny J Eckert
    Adelaide Institute for Sleep Health and Department of Respiratory Medicine, Repatriation General Hospital, Daw Park, South Australia, Australia
    Am J Respir Crit Care Med 169:1224-30. 2004
    ..We conclude that 30 minutes of sustained hypoxia and possibly hypercapnia impair sensations of respiratory load and that the effects of hypoxia persist for at least 10 minutes after returning to normoxia...
  32. ncbi Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women
    Amy S Jordan
    Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia, Australia
    Am J Respir Crit Care Med 168:1512-9. 2003
    ..These results suggest that male sex and supine position are associated with greater ventilatory instability after arousal from sleep...
  33. pmc Trazodone increases the respiratory arousal threshold in patients with obstructive sleep apnea and a low arousal threshold
    Danny J Eckert
    Brigham and Women s Hospital, Division of Sleep Medicine, Sleep Disorders Program and Harvard Medical School, Boston, MA Neuroscience Research Australia NeuRA, and the School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Sleep 37:811-9. 2014
    ..Secondary aims were to examine the effects of trazodone on upper airway dilator muscle activity, upper airway collapsibility, and breathing during sleep...
  34. ncbi Cardiac changes during arousals from non-REM sleep in healthy volunteers
    Eugene Nalivaiko
    Department of Human Physiology, Flinders Medical Centre, Bedford Park, SA 5042, Australia
    Am J Physiol Regul Integr Comp Physiol 292:R1320-7. 2007
    ..Whether prolonged atrio-ventricular conductance associated with increased sympathetic outflow to the ventricular myocardium contributes to arrhythmogenesis during sudden arousal from sleep remains to be evaluated...