Affiliation: Harvard University
Miles W, Lembo A, Volorio A, Brachtel E, Tian B, Sgroi D, et al
. Alternative Polyadenylation in Triple-Negative Breast Tumors Allows NRAS and c-JUN to Bypass PUMILIO Posttranscriptional Regulation. Cancer Res. 2016;76:7231-7241 pubmed
..Cancer Res; 76(24); 7231-41. Â©2016 AACR. ..
Sanidas I, Morris R, Fella K, Rumde P, Boukhali M, Tai E, et al
. A Code of Mono-phosphorylation Modulates the Function of RB. Mol Cell. 2019;: pubmed publisher
..These results indicate that RB activation signals are integrated in a phosphorylation code that determines the diversity of RB activity. ..
Sanidas I, Dyson N. pRB Takes an EZ Path to a Repetitive Task. Mol Cell. 2016;64:1015-1017 pubmed publisher
..Repetitive DNA elements are essential for genome function; in this issue of Molecular Cell, Ishak et al. (2016) describe a novel mechanism of epigenetic repression at these elements that requires pRB-dependent recruitment of EZH2. ..
Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998;12:2245-62 pubmed
Manning A, Yazinski S, Nicolay B, Bryll A, Zou L, Dyson N. Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell. 2014;53:993-1004 pubmed publisher
..These data explain how loss of pRB undermines genomic integrity. Given the frequent functional inactivation of pRB in cancer, conditions that increase cohesion may provide a general strategy to suppress CIN. ..
Korenjak M, Kwon E, Morris R, Anderssen E, Amzallag A, Ramaswamy S, et al
. dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes. Nucleic Acids Res. 2014;42:8939-53 pubmed publisher
..These findings suggest that dREAM functions in the organization of transcriptional domains. ..
Miles W, Korenjak M, Griffiths L, Dyer M, Provero P, Dyson N. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells. EMBO J. 2014;33:2201-15 pubmed publisher
..Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE). ..
Guarner A, Morris R, Korenjak M, Boukhali M, Zappia M, Van Rechem C, et al
. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Dev Cell. 2017;43:689-703.e5 pubmed publisher
..These results show that, in some cellular contexts, dE2F/dDP-dependent suppression of DNA damage signaling is key for cell-cycle control and needed for normal development. ..