Research Topics
Genomes and Genes | J DworkinSummaryAffiliation: Harvard University Country: USA Publications
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Publications
A protein-induced DNA bend increases the specificity of a prokaryotic enhancer-binding proteinJ Dworkin
Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
Genes Dev 12:894-900. 1998..These opposite effects have the consequence of increasing the specificity of activation of a promoter that is susceptible to regulation by proteins bound to a distal site...
Role of upstream activation sequences and integration host factor in transcriptional activation by the constitutively active prokaryotic enhancer-binding protein PspFJ Dworkin
Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
J Mol Biol 273:377-88. 1997..These data, taken together, support the model that a precise promoter geometry is necessary for IHF to positively regulate transcription and that IHF may act to prevent activation from inappropriately spaced upstream sites...
The Escherichia coli phage-shock-protein (psp) operonP Model
The Rockefeller University, New York, New York 10021, USA
Mol Microbiol 24:255-61. 1997..The major product of the operon, PspA, may also serve as a negative regulator of an unusual porin, OmpG...
The PspA protein of Escherichia coli is a negative regulator of sigma(54)-dependent transcriptionJ Dworkin
Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
J Bacteriol 182:311-9. 2000..We describe here the in vivo and in vitro properties of the PspA protein of Escherichia coli, which negatively regulates expression of the pspA promoter without binding DNA directly...
Autogenous control of PspF, a constitutively active enhancer-binding protein of Escherichia coliG Jovanovic
Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
J Bacteriol 179:5232-7. 1997..PspF production is independent of PspA (the negative regulator of the pspA to -E operon) and of PspB and -C (positive regulators)...
Differential gene expression governed by chromosomal spatial asymmetryJ Dworkin
Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
Cell 107:339-46. 2001..Supporting this idea, transposition of spoIIAB to sites present in the forespore at the time of division impaired sporulation when a second pathway that participates in sigmaF activation was disabled...
