Andrew K Dunn

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
  2. ncbi Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Andrew K Dunn
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 27:279-90. 2005
  3. pmc Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:1631-42. 2007
  4. pmc Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
    Phill B Jones
    Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:044007. 2008
  5. pmc Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation
    Elizabeth M C Hillman
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 35:89-104. 2007
  6. pmc A time domain fluorescence tomography system for small animal imaging
    Anand T N Kumar
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 27:1152-63. 2008
  7. pmc Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex
    Anna Devor
    Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14347-57. 2008
  8. pmc Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity
    Anna Devor
    Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:3822-7. 2005
  9. ncbi Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
    Shuai Yuan
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1823-30. 2005
  10. ncbi Pronounced hypoperfusion during spreading depression in mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    J Cereb Blood Flow Metab 24:1172-82. 2004

Collaborators

Detail Information

Publications24

  1. ncbi Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
    ..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...
  2. ncbi Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Andrew K Dunn
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 27:279-90. 2005
    ..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes...
  3. pmc Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:1631-42. 2007
    ..Our data show that normobaric hyperoxia increases tissue O2 delivery, and that novel mechanisms such as CBF augmentation, and suppression of PIDs may afford neuroprotection during hyperoxia...
  4. pmc Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
    Phill B Jones
    Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:044007. 2008
    ....
  5. pmc Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation
    Elizabeth M C Hillman
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 35:89-104. 2007
    ....
  6. pmc A time domain fluorescence tomography system for small animal imaging
    Anand T N Kumar
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 27:1152-63. 2008
    ..These results suggest the practical feasibility and advantages of a time domain approach for whole body small animal fluorescence molecular imaging, particularly with the use of lifetime as a contrast mechanism...
  7. pmc Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex
    Anna Devor
    Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14347-57. 2008
    ..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus...
  8. pmc Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity
    Anna Devor
    Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:3822-7. 2005
    ..The surround "negative" hemodynamic activity did not correspond to observable changes in neuronal activity. The complex spatial integration of the hemodynamic response should be considered when interpreting fMRI data...
  9. ncbi Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
    Shuai Yuan
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1823-30. 2005
    ..Our results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents...
  10. ncbi Pronounced hypoperfusion during spreading depression in mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    J Cereb Blood Flow Metab 24:1172-82. 2004
    ..The differences in CBF response between species may be in part caused by an increased sensitivity of mouse cerebral vessels to elevated extracellular K+...
  11. ncbi Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
    Anna Devor
    Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuron 39:353-9. 2003
    ....
  12. ncbi Fluorescence-lifetime-based tomography for turbid media
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 30:3347-9. 2005
    ....
  13. ncbi Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 24:744-55. 2004
    ..In summary, LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution...
  14. pmc Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
    ..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology...
  15. ncbi Vasoconstrictive neurovascular coupling during focal ischemic depolarizations
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 26:1018-30. 2006
    ..Mitigating the vasoconstrictive neurovascular coupling during intense ischemic depolarizations may provide a novel hemodynamic mechanism of neuroprotection by inhibitors of CSD...
  16. ncbi Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    Hayrunnisa Bolay
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:136-42. 2002
    ....
  17. ncbi Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media
    Elizabeth M C Hillman
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:1650-2. 2004
    ..System design and image reconstruction techniques are described, along with simulation and phantom results that demonstrate the characteristics and limitations of system accuracy and resolution...
  18. ncbi Microvascular oxygen quantification using two-photon microscopy
    Arnold D Estrada
    Biomedical Engineering Department, University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712 0238, USA
    Opt Lett 33:1038-40. 2008
    ....
  19. ncbi Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortex
    Anthony J Strong
    King s College London, Department of Clinical Neurosciences Neurosurgery, UK
    Brain 130:995-1008. 2007
    ..The findings suggest that such events play a central rather than a subsidiary role in cerebral infarction in the gyrencephalic brain...
  20. ncbi Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisations
    Anthony J Strong
    King s College London, Department of Clinical Neurosciences Neurosurgery, London, UK
    J Cereb Blood Flow Metab 26:645-53. 2006
    ....
  21. ncbi Computational microscopy in embryo imaging
    Joseph L Hollmann
    Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts 02115, USA
    Opt Lett 29:2267-9. 2004
    ..After a description of the algorithm, sample results are presented, followed by a discussion of future plans and applications...
  22. ncbi Cortical blood flow assessment with frequency-domain laser Doppler microscopy
    Michael Atlan
    Universite Pierre et Marie Curie, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, Laboratoire d Optique, CNRS UPR A0005, 10 rue Vauquelin, F 75231 Paris Cedex 05, France
    J Biomed Opt 12:024019. 2007
    ..The quadratic mean of the measured frequency shift is used as an indicator of CBF. We observe a significant variability of this indicator in an experiment designed to induce blood flow changes...
  23. ncbi Robust flow measurement with multi-exposure speckle imaging
    Ashwin B Parthasarathy
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA
    Opt Express 16:1975-89. 2008
    ..We also show that the new speckle model used with the MESI instrument can maintain the linearity of relative flow measurements in the presence of static scatterers...
  24. ncbi Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells
    Jaesook Park
    Department of Biomedical Engineering, The University of Texas at Austin, Texas 78712, USA
    Opt Express 16:1590-9. 2008
    ..To demonstrate the potential application of this bright two-photon-induced photoluminescence (TPIP) signal for biological imaging, we imaged the 3D distribution of gold nanoshells targeted to murine tumors...