Research Topics
| Andrew K DunnSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activationAndrew K Dunn
Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
Opt Lett 28:28-30. 2003..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...- Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortexAndrew K Dunn
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 27:279-90. 2005..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes... 
Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemiaHwa Kyoung Shin
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Brain 130:1631-42. 2007..Our data show that normobaric hyperoxia increases tissue O2 delivery, and that novel mechanisms such as CBF augmentation, and suppression of PIDs may afford neuroprotection during hyperoxia...- Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemiaPhill B Jones
Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 13:044007. 2008.... - Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulationElizabeth M C Hillman
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuroimage 35:89-104. 2007.... - A time domain fluorescence tomography system for small animal imagingAnand T N Kumar
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
IEEE Trans Med Imaging 27:1152-63. 2008..These results suggest the practical feasibility and advantages of a time domain approach for whole body small animal fluorescence molecular imaging, particularly with the use of lifetime as a contrast mechanism... - Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortexAnna Devor
Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
J Neurosci 28:14347-57. 2008..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus... - Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activityAnna Devor
Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:3822-7. 2005..The surround "negative" hemodynamic activity did not correspond to observable changes in neuronal activity. The complex spatial integration of the hemodynamic response should be considered when interpreting fMRI data... - Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imagingShuai Yuan
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
Appl Opt 44:1823-30. 2005..Our results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents... - Pronounced hypoperfusion during spreading depression in mouse cortexCenk Ayata
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
J Cereb Blood Flow Metab 24:1172-82. 2004..The differences in CBF response between species may be in part caused by an increased sensitivity of mouse cerebral vessels to elevated extracellular K+... - Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortexAnna Devor
Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
Neuron 39:353-9. 2003.... - Fluorescence-lifetime-based tomography for turbid mediaAnand T N Kumar
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 30:3347-9. 2005.... - Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortexCenk Ayata
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 24:744-55. 2004..In summary, LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution... - Laser speckle contrast imaging in biomedical opticsDavid A Boas
Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 15:011109. 2010..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology... - Vasoconstrictive neurovascular coupling during focal ischemic depolarizationsHwa Kyoung Shin
Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 26:1018-30. 2006..Mitigating the vasoconstrictive neurovascular coupling during intense ischemic depolarizations may provide a novel hemodynamic mechanism of neuroprotection by inhibitors of CSD... - Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine modelHayrunnisa Bolay
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:136-42. 2002.... - Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid mediaElizabeth M C Hillman
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:1650-2. 2004..System design and image reconstruction techniques are described, along with simulation and phantom results that demonstrate the characteristics and limitations of system accuracy and resolution... - Microvascular oxygen quantification using two-photon microscopyArnold D Estrada
Biomedical Engineering Department, University of Texas at Austin, 1 University Station, C0800, Austin, TX 78712 0238, USA
Opt Lett 33:1038-40. 2008.... - Peri-infarct depolarizations lead to loss of perfusion in ischaemic gyrencephalic cerebral cortexAnthony J Strong
King s College London, Department of Clinical Neurosciences Neurosurgery, UK
Brain 130:995-1008. 2007..The findings suggest that such events play a central rather than a subsidiary role in cerebral infarction in the gyrencephalic brain... - Evaluation of laser speckle flowmetry for imaging cortical perfusion in experimental stroke studies: quantitation of perfusion and detection of peri-infarct depolarisationsAnthony J Strong
King s College London, Department of Clinical Neurosciences Neurosurgery, London, UK
J Cereb Blood Flow Metab 26:645-53. 2006.... - Computational microscopy in embryo imagingJoseph L Hollmann
Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts 02115, USA
Opt Lett 29:2267-9. 2004..After a description of the algorithm, sample results are presented, followed by a discussion of future plans and applications... - Cortical blood flow assessment with frequency-domain laser Doppler microscopyMichael Atlan
Universite Pierre et Marie Curie, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, Laboratoire d Optique, CNRS UPR A0005, 10 rue Vauquelin, F 75231 Paris Cedex 05, France
J Biomed Opt 12:024019. 2007..The quadratic mean of the measured frequency shift is used as an indicator of CBF. We observe a significant variability of this indicator in an experiment designed to induce blood flow changes... - Robust flow measurement with multi-exposure speckle imagingAshwin B Parthasarathy
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA
Opt Express 16:1975-89. 2008..We also show that the new speckle model used with the MESI instrument can maintain the linearity of relative flow measurements in the presence of static scatterers... - Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshellsJaesook Park
Department of Biomedical Engineering, The University of Texas at Austin, Texas 78712, USA
Opt Express 16:1590-9. 2008..To demonstrate the potential application of this bright two-photon-induced photoluminescence (TPIP) signal for biological imaging, we imaged the 3D distribution of gold nanoshells targeted to murine tumors...