Catherine G Dulac

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
    Hayan Yoon
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 123:669-82. 2005
  2. pmc The activity-dependent histone variant H2BE modulates the life span of olfactory neurons
    Stephen W Santoro
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States
    elife 1:e00070. 2012
  3. pmc Molecular organization of vomeronasal chemoreception
    Yoh Isogai
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 478:241-5. 2011
  4. pmc Members of the miRNA-200 family regulate olfactory neurogenesis
    Philip S Choi
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 57:41-55. 2008
  5. pmc Brain function and chromatin plasticity
    Catherine Dulac
    Howard Hughes Medical Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 465:728-35. 2010
  6. pmc Neural mechanisms underlying sex-specific behaviors in vertebrates
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 17:675-83. 2007
  7. ncbi request reprint Neuroscience. Charting olfactory maps
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Science 314:606-7. 2006
  8. ncbi request reprint Genetic analysis of brain circuits underlying pheromone signaling
    C Dulac
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Genet 40:449-67. 2006
  9. ncbi request reprint Expression of candidate pheromone receptor genes in vomeronasal neurons
    C Dulac
    Howard Hughes Medical Institute, Cambridge, MA, USA
    Chem Senses 23:467-75. 1998
  10. ncbi request reprint Molecular detection of pheromone signals in mammals: from genes to behaviour
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 4:551-62. 2003

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
    Hayan Yoon
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 123:669-82. 2005
    ..Further visualization of afferents to LHRH neurons across the brain offers a unique opportunity to uncover complex polysynaptic circuits modulating reproduction and fertility...
  2. pmc The activity-dependent histone variant H2BE modulates the life span of olfactory neurons
    Stephen W Santoro
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States
    elife 1:e00070. 2012
    ..We propose a physiological function for H2be in modulating olfactory neuron population dynamics to adapt the OR repertoire to the environment.DOI:http://dx.doi.org/10.7554/eLife.00070.001...
  3. pmc Molecular organization of vomeronasal chemoreception
    Yoh Isogai
    Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 478:241-5. 2011
    ....
  4. pmc Members of the miRNA-200 family regulate olfactory neurogenesis
    Philip S Choi
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 57:41-55. 2008
    ....
  5. pmc Brain function and chromatin plasticity
    Catherine Dulac
    Howard Hughes Medical Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 465:728-35. 2010
    ..Recent advances in chromatin biology offer new avenues to investigate regulatory mechanisms underlying long-lasting changes in neurons, with direct implications for the study of brain function, behaviour and diseases...
  6. pmc Neural mechanisms underlying sex-specific behaviors in vertebrates
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 17:675-83. 2007
    ....
  7. ncbi request reprint Neuroscience. Charting olfactory maps
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Science 314:606-7. 2006
  8. ncbi request reprint Genetic analysis of brain circuits underlying pheromone signaling
    C Dulac
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Genet 40:449-67. 2006
    ..We will review and discuss the specific contribution of each of the two chemosensory systems that ensure specific behavioral responses to conspecific animals...
  9. ncbi request reprint Expression of candidate pheromone receptor genes in vomeronasal neurons
    C Dulac
    Howard Hughes Medical Institute, Cambridge, MA, USA
    Chem Senses 23:467-75. 1998
    ....
  10. ncbi request reprint Molecular detection of pheromone signals in mammals: from genes to behaviour
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 4:551-62. 2003
  11. ncbi request reprint Sensory coding of pheromone signals in mammals
    C Dulac
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 10:511-8. 2000
    ..Identification of these genes, which include putative pheromone receptor genes, has offered a new opportunity to uncover basic principles of pheromone sensory processing and important aspects of vomeronasal development...
  12. pmc Sex-specific parent-of-origin allelic expression in the mouse brain
    Christopher Gregg
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 329:682-5. 2010
    ..Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease...
  13. pmc High-resolution analysis of parent-of-origin allelic expression in the mouse brain
    Christopher Gregg
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 329:643-8. 2010
    ..Thus, parental expression bias emerges as a major mode of epigenetic regulation in the brain...
  14. ncbi request reprint Loss of sex discrimination and male-male aggression in mice deficient for TRP2
    Lisa Stowers
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:1493-500. 2002
    ..Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior...
  15. ncbi request reprint A functional circuit underlying male sexual behaviour in the female mouse brain
    Tali Kimchi
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 448:1009-14. 2007
    ..Moreover, they imply that functional neuronal circuits underlying male-specific behaviours exist in the normal female mouse brain...
  16. ncbi request reprint Molecular architecture of pheromone sensing in mammals
    Catherine Dulac
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Novartis Found Symp 268:100-7; discussion 107-10, 167-70. 2005
    ....
  17. ncbi request reprint Single-cell transcriptional profiles and spatial patterning of the mammalian olfactory epithelium
    Ian Tietjen
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA, USA
    Int J Dev Biol 49:201-7. 2005
    ....
  18. ncbi request reprint MHC homologs in the nervous system--they haven't lost their groove
    Rich Olson
    Division of Biology, Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Curr Opin Neurobiol 16:351-7. 2006
    ..Instead of presenting MHC-binding peptides, M10s might function as molecular chaperones to V2R receptors or more generally as modulators of neuronal function, as demonstrated elsewhere in the brain for classical MHC molecules...
  19. ncbi request reprint Single-cell transcriptional analysis of neuronal progenitors
    Ian Tietjen
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Neuron 38:161-75. 2003
    ..Finally, we show that regional differences in gene expression can be predicted from transcriptional analysis of single neuronal precursors isolated by laser capture from defined areas of the developing brain...
  20. ncbi request reprint Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear
    Gleb P Shumyatsky
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 111:905-18. 2002
    ..These experiments provide genetic evidence that GRP and its neural circuitry operate as a negative feedback regulating fear and establish a causal relationship between Grpr gene expression, LTP, and amygdala-dependent memory for fear...
  21. ncbi request reprint Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules
    Jennifer Loconto
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Cell 112:607-18. 2003
    ..The functional characterization of M10 highlights an unexpected role for MHC molecules in pheromone detection by mammalian VNO neurons...
  22. ncbi request reprint Sparse encoding of natural scents
    Catherine Dulac
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuron 50:816-8. 2006
    ..In a paper in this issue of Neuron, Lin et al. combined gas chromatography and intrinsic signal imaging to examine the responses of individual olfactory bulb glomeruli in the mouse to natural odors and their component parts...

Research Grants13

  1. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 1999
    ..This will allow the functional dissection of signal transduction pathways that translate pheromone signals into neural activity, leading to the generation of stereotyped behaviors and neuroendocrine changes. ..
  2. Genetic analysis of brain circuits underlying pheromone signaling
    Catherine Dulac; Fiscal Year: 2009
    ....
  3. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2007
    ....
  4. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2006
    ....
  5. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2005
    ....
  6. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2004
    ....
  7. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2003
    ..This will allow the functional dissection of signal transduction pathways that translate pheromone signals into neural activity, leading to the generation of stereotyped behaviors and neuroendocrine changes. ..
  8. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2002
    ..This will allow the functional dissection of signal transduction pathways that translate pheromone signals into neural activity, leading to the generation of stereotyped behaviors and neuroendocrine changes. ..
  9. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2000
    ..This will allow the functional dissection of signal transduction pathways that translate pheromone signals into neural activity, leading to the generation of stereotyped behaviors and neuroendocrine changes. ..
  10. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2001
    ..This will allow the functional dissection of signal transduction pathways that translate pheromone signals into neural activity, leading to the generation of stereotyped behaviors and neuroendocrine changes. ..
  11. SIGNAL TRANSDUCTION COMPONENTS IN THE VOMERONASAL ORGAN
    Catherine Dulac; Fiscal Year: 2000
    ..This will allow the functional dissection of signal transduction pathways that translate pheromone signals into neural activity, leading to the generation of stereotyped behaviors and neuroendocrine changes. ..
  12. Genetic analysis of brain circuits underlying pheromone signaling
    Catherine G Dulac; Fiscal Year: 2010
    ....