Research Topics
| Christopher P DugganSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Multiple micronutrient supplementation in Tanzanian infants born to HIV-infected mothers: a randomized, double-blind, placebo-controlled clinical trialChristopher Duggan
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 96:1437-46. 2012..Multiple micronutrients (vitamin B complex and vitamins C and E) were effective at reducing infectious disease morbidity, HIV disease progression, and poor pregnancy outcomes in HIV-infected women...
Growth and nutritional status in infants with short-bowel syndrome after the serial transverse enteroplasty procedureChristopher Duggan
Division of Gastroenterology and Nutrition, Children s Hospital, Boston, Massachusetts 02115, USA
Clin Gastroenterol Hepatol 4:1237-41. 2006..The aim of this study was to describe the long-term nutritional outcomes of 4 patients with short bowel syndrome (SBS) who underwent a newly described bowel-lengthening procedure, the serial transverse enteroplasty (STEP) procedure...- Glutamine supplementation in infants with gastrointestinal disease: a randomized, placebo-controlled pilot trialChristopher Duggan
Children s Hospital, Boston, MA 02115, USA
Nutrition 20:752-6. 2004..We evaluated the effects of enteral supplementation with Gln in infants undergoing surgery for congenital or acquired gastrointestinal disease... - Scientific rationale for a change in the composition of oral rehydration solutionChristopher Duggan
Division of Gastroenterology and Nutrition, Children's Hospital Boston, Boston, Mass 02115, USA
JAMA 291:2628-31. 2004 - Serial transverse enteroplasty is associated with successful short-term outcomes in infants with short bowel syndromePatrick J Javid
Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 40:1019-23; discussion 1023-4. 2005..CONCLUSION: The STEP procedure is a simple bowel-lengthening procedure with promising early surgical and nutritional outcomes. Further data from a multicenter registry are needed to demonstrate its long-term efficacy... 
Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver diseaseKathleen M Gura
Department of Pharmacy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Pediatrics 121:e678-86. 2008..Parenteral nutrition-associated liver disease can be a progressive and fatal entity in children with short-bowel syndrome. Soybean-fat emulsions provided as part of standard parenteral nutrition may contribute to its pathophysiology...- Nutritional practices and their relationship to clinical outcomes in critically ill children--an international multicenter cohort study*Nilesh M Mehta
Division of Critical Care Medicine, Department of Anesthesiology, Pain and Perioperative Medicine at Children s Hospital Boston, Boston, MA, USA
Crit Care Med 40:2204-11. 2012..To examine factors influencing the adequacy of energy and protein intake in the pediatric intensive care unit and to describe their relationship to clinical outcomes in mechanically ventilated children... - The role of enteral nutrition in the reversal of parenteral nutrition-associated liver dysfunction in infantsPatrick J Javid
Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 40:1015-8. 2005..These findings support the aggressive weaning of PN to enteral nutrition in infants with short bowel syndrome... - Weekly measurements accurately represent trends in resting energy expenditure in children undergoing hematopoietic stem cell transplantationDebora Duro
Children s Hospital Boston, Boston, MA 02115, USA
JPEN J Parenter Enteral Nutr 32:427-32. 2008..The goal of this study was to determine if weekly REE measurements could accurately represent changes in REE in the peritransplant period compared with a more frequent standard of daily measurements... - Improved survival in a multidisciplinary short bowel syndrome programBiren P Modi
Center for Advanced Intestinal Rehabilitation CAIR, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 43:20-4. 2008..In 1999, we initiated a multidisciplinary pediatric intestinal rehabilitation program. The purpose of this study was to determine if the multidisciplinary approach was associated with improved survival in this patient population... - Stunting and wasting are associated with poorer psychomotor and mental development in HIV-exposed Tanzanian infantsChristine M McDonald
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
J Nutr 143:204-14. 2013..Strategies to lower mother-to-child transmission of HIV, prevent preterm birth, and enhance child growth could contribute to improved child psychomotor and mental development... - Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future managementKathleen M Gura
Department of Pharmacy, Children's Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
Pediatrics 118:e197-201. 2006..A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition-associated liver disease... - Multiple micronutrient deficiencies in a child with short bowel syndrome and normal somatic growthDebora Duro
Division of Gastroenterology and Nutrition, Children's Hospital Boston, MA 02115, USA
J Pediatr Gastroenterol Nutr 46:461-4. 2008 - High diagnostic yield of gastrointestinal endoscopy in children with intestinal failureY Avery Ching
Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02215, USA
J Pediatr Surg 43:906-10. 2008..The use of endoscopic assessment of these symptoms has not been previously reported. This report evaluates the diagnostic yield of GI endoscopy in the setting of IF... - Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injuryMark Puder
Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
Ann Surg 250:395-402. 2009..The objective was to determine the safety and efficacy of a fish oil-based intravenous lipid emulsion (ILE) in the treatment of parenteral nutrition-associated liver disease (PNALD)... - Relationship between biopsy-proven parenteralnutrition-associated liver fibrosis and biochemical cholestasis in children with short bowel syndromeShimae C Fitzgibbons
Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 45:95-9; discussion 99. 2010.... - Overview of pediatric short bowel syndromeDebora Duro
Division of Gastroenterology and Nutrition and Center for Advanced Intestinal Rehabilitation at Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Pediatr Gastroenterol Nutr 47:S33-6. 2008..Intestinal transplantation is an emerging treatment that may be considered when intestinal failure is irreversible and children are experiencing serious complications related to TPN administration... - Challenges to optimal enteral nutrition in a multidisciplinary pediatric intensive care unitNilesh M Mehta
Division of Critical Care, Department of Anesthesia, Department of Nursing, Division of Gastroenterology, and Nutrition and Clinical Research Program, Biostatistics Core, at Children s Hospital Boston, Boston, Massachusetts 02115, USA
JPEN J Parenter Enteral Nutr 34:38-45. 2010..Clinical characteristics, time to reach caloric goal, and parenteral nutrition (PN) use were compared between patients with and without avoidable interruptions to EN... - Cumulative energy imbalance in the pediatric intensive care unit: role of targeted indirect calorimetryNilesh M Mehta
Divisions of Critical Care Medicine and Gastroenterology and Nutrition, Children s Hospital, Boston, MA, USA
JPEN J Parenter Enteral Nutr 33:336-44. 2009..Failure to accurately estimate energy requirements may result in underfeeding or overfeeding. In this study, a dedicated multidisciplinary nutrition team measured energy expenditure in critically ill children... - Patterns and predictors of CD4 T-cell counts among children born to HIV-infected women in TanzaniaRoland Kupka
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
J Trop Pediatr 55:290-6. 2009..5 g/dl among HIV-uninfected children. The maternal and child predictors described may serve as intervention targets among HIV-exposed children... - Novel intravenous (13)C-methionine breath test as a measure of liver function in children with short bowel syndromeDebora Duro
Harvard Medical School, Children s Hospital Boston, MA 02115, USA
J Pediatr Surg 44:236-40; discussion 240. 2009..We hypothesized that the (13)C-methionine breath test ((13)C-MBT) could be a safe, noninvasive, and valid measure of hepatic mitochondrial function in children with SBS and PNALD... - Patterns of postnatal growth in HIV-infected and HIV-exposed childrenSheila Isanaka
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nutr Rev 67:343-59. 2009..Timely growth monitoring may be used to improve the clinical course and quality of life of these children... - Macronutrient supplementation and food prices in HIV treatmentKevin A Sztam
Children s Hospital Boston, Division of Pediatric Gastroenterology and Nutrition, Boston, MA 02115, USA
J Nutr 140:213S-23S. 2010..HIV treatment programs may struggle to meet the needs of patients with potential increased rates of malnutrition and food insecurity in the setting of high food prices... - Changes in resting energy expenditure among children undergoing allogeneic stem cell transplantationChristopher Duggan
Clinical Nutrition Service, Division of GI Nutrition, Children s Hospital, Boston, MA 02115, USA
Am J Clin Nutr 78:104-9. 2003..The energy and nutrient needs of these patients have not been well studied... - Effectiveness of a clinical practice guideline for parenteral nutrition: a 5-year follow-up study in a pediatric teaching hospitalChristopher Duggan
Division of Gastroenterology and Nutrition, Children s Hospital, Boston, Massachusetts 02115, USA
JPEN J Parenter Enteral Nutr 26:377-81. 2002..To determine the effectiveness of a clinical practice guideline (CPG) on the use of parenteral nutrition (PN) at a tertiary care pediatric hospital... - Use of a fish oil-based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutritionKathleen M Gura
Department of Pharmacy, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Clin Nutr 24:839-47. 2005.... - Predictors of bone mineral density in human immunodeficiency virus-1 infected childrenDenise L Jacobson
Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
J Pediatr Gastroenterol Nutr 41:339-46. 2005..Dietary intake of calcium and vitamin D were not associated with bone loss, but most children had suboptimal intake. However, multivitamin use was strongly associated with better bone mineral density... - Protective nutrients and functional foods for the gastrointestinal tractChristopher Duggan
Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts General Hospital, and Division of Nutrition, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 75:789-808. 2002..Regulatory changes in the way in which health claims can be made for dietary supplements should also be encouraged... - Growth and correlates of nutritional status among infants with hypoplastic left heart syndrome (HLHS) after stage 1 Norwood procedureDeanne K Kelleher
Division of GI/Nutrition, Children's Hospital Boston, Boston, Massachusetts, USA
Nutrition 22:237-44. 2006..Aggressive parenteral and enteral nutritional therapy might help reduce the prevalence of growth faltering in infants who have HLHS... - Update on micronutrients: iron and zincEmily Oken
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Pediatr 14:350-3. 2002..Although breakthroughs in micronutrient research have generally come from populations in developing countries, children in industrialized countries also benefit from increasing knowledge about nutritional requirements and interventions... - Severe weight loss and hypermetabolic paroxysmal dysautonomia following hypoxic ischemic brain injury: the role of indirect calorimetry in the intensive care unitNilesh M Mehta
Division of Critical Care Medicine Children s Hospital, Boston, MA 02115, USA
JPEN J Parenter Enteral Nutr 32:281-4. 2008..In hospitalized patients with metabolic fluctuations, accurate measurement of energy requirements by indirect calorimetry allows serial monitoring of energy balance and may guide nutrition intake to prevent cumulative energy deficits... - Risk factors for intestinal failure in infants with necrotizing enterocolitis: a Glaser Pediatric Research Network studyDebora Duro
Division of Gastroenterology and Nutrition, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Pediatr 157:203-208.e1. 2010..To determine risk factors for intestinal failure (IF) in infants undergoing surgery for necrotizing enterocolitis (NEC)... - Persistent alanine aminotransferase elevations in children with parenteral nutrition-associated liver diseaseChi Fu Jeffrey Yang
Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 44:1084-7; discussion 1087-8. 2009..The aim of this study was to longitudinally assess serum alanine aminotransferase (ALT), a marker for hepatocyte injury, in enterally fed children with PNALD... - The effect of insulin infusion upon protein metabolism in neonates on extracorporeal life supportMichael S D Agus
Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA
Ann Surg 244:536-44. 2006..Insulin administration significantly improves net protein balance only in those ECLS neonates in whom adequate dietary protein is provided... - Long-term nutritional and clinical outcomes after serial transverse enteroplasty at a single institutionY Avery Ching
Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 44:939-43. 2009..Our aim was to assess clinical and nutritional outcomes after the STEP procedure... - Oligofructose-supplemented infant cereal: 2 randomized, blinded, community-based trials in Peruvian infantsChristopher Duggan
Children's Hospital, Boston, USA
Am J Clin Nutr 77:937-42. 2003..influenzae type B immunization. Infants and young children who continue to breast-feed may not benefit from prebiotic supplementation... - Serial transverse enteroplasty for management of refractory D-lactic acidosis in short-bowel syndromeBiren P Modi
Department of Surgery, Children's Hospital Boston, Boston, MA 02115, USA
J Pediatr Gastroenterol Nutr 43:395-7. 2006 - Prognostic factors in the resumption of oral dietary intake after allogeneic hematopoietic stem cell transplantation (HSCT) in childrenLori J Bechard
Children s Hospital Boston, Boston, Massachusetts 02115, USA
JPEN J Parenter Enteral Nutr 31:295-301. 2007..The objective of this study was to identify demographic, clinical, and nutrition factors associated with the resumption of oral dietary intake following HSCT... - Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndromeShimae Fitzgibbons
Department of Surgery, Children s Hospital Boston, Boston, MA 02115, USA
J Pediatr Surg 44:928-32. 2009..Plasma citrulline (CIT) levels have been proposed as surrogate markers for bowel length and function. We sought to evaluate the relationship between CIT and parenteral nutrition (PN) independence in children with SBS... - First report of the international serial transverse enteroplasty data registry: indications, efficacy, and complicationsBiren P Modi
Center for Advanced Intestinal Rehabilitation, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Am Coll Surg 204:365-71. 2007..This report describes patient characteristics, operative parameters, and early results of STEP in the first 38 patients enrolled in the International STEP Data Registry... - A multiagent strategy to decrease regimen-related toxicity in children undergoing allogeneic hematopoietic stem cell transplantationIan Thornley
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Biol Blood Marrow Transplant 10:635-44. 2004..The decreased RRT observed in comparison to historical controls suggests that combination approaches deserve exploration as a means of reducing the morbidity of HSCT... - Nutritional deficiencies during critical illnessNilesh M Mehta
Division of Critical Care Medicine, Department of Anesthesia, Bader 634, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Clin North Am 56:1143-60. 2009.... - Efficacy of ethanol locks in reducing central venous catheter infections in pediatric patients with intestinal failureBrian A Jones
Center for Advanced Intestinal Rehabilitation CAIR, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr Surg 45:1287-93. 2010..We sought to determine whether a regimen of 70% ethanol locks could reduce the rate of central venous catheter (CVC) infections in parenteral nutrition-dependent children with intestinal failure... - Serial transverse enteroplasty for short bowel syndrome: a case reportHeung Bae Kim
Department of Pediatric Surgery and Gastroenterology and Nutrition, Children's Hospital Boston, MA 02115, USA
J Pediatr Surg 38:881-5. 2003..The STEP procedure should be considered a surgical option for children with short bowel syndrome... - Plasma zinc concentrations are depressed during the acute phase response in children with falciparum malariaChristopher Duggan
Division of Gastroenterology and Nutrition, Children's Hospital, Boston, MA, USA
J Nutr 135:802-7. 2005..In children whose age, diet, and/or nutritional status place them at risk of zinc deficiency, those with low plasma zinc levels should be supplemented with oral zinc and followed for clinical and/or biochemical response... - Update on pediatric nutrition: breastfeeding, infant nutrition, and growthJill Fulhan
Clinical Nutrition Service, Division of Gastroenterology and Nutrition, Children's Hospital, Boston, MA 02115, USA
Curr Opin Pediatr 15:323-32. 2003.... - Nutrition for the pediatric office: update on vitamins, infant feeding and food allergiesSharon Collier
Clinical Nutrition Service, Division of GI/Nutrition, Children's Hospital, Boston, Harvard Medical School, Massachusetts 02115, USA
Curr Opin Pediatr 16:314-20. 2004..SUMMARY: Regular supplementation with vitamin D, and newborn provision of vitamin K, are important nutritional interventions for infants and children... - A new formulation of ORS for children is warrantedChristopher Duggan
J Pediatr Gastroenterol Nutr 34:251-2. 2002 - Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapyCaleb K King
University of North Carolina Chapel Hill, North Carolina, USA
MMWR Recomm Rep 52:1-16. 2003..In the United States, adoption of these updated recommendations could substantially reduce medical costs and childhood hospitalizations and deaths caused by diarrhea... - Changes in macronutrient intake among HIV-infected children between 1995 and 2004Tanvi S Sharma
Divisions of Infectious Diseases and Gastroenterology, Golisano Children s Hospital at Strong, University of Rochester School of Medicine, Rochester, NY, USA
Am J Clin Nutr 88:384-91. 2008..Nutritional concerns in HIV-infected children have evolved, from wasting to obesity and insulin resistance. However, little is known about the diet of these children during this evolution... - Gastrointestinal and nutritional complications of human immunodeficiency virus infectionTracie L Miller
Department of Pediatrics, Division of Pediatric Clinical Research, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
J Pediatr Gastroenterol Nutr 47:247-53. 2008 - Impact of permethrin-treated bed nets on growth, nutritional status, and body composition of primary school children in western KenyaJennifer F Friedman
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 68:78-85. 2003..2%; P = 0.04). This may be consequent to reduced exposure to malaria with subsequent reduced elaboration of pro-inflammatory cytokines known to promote muscle wasting...
Research Grants
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher Duggan; Fiscal Year: 2007..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
- A Trial of Zinc and Micronutrients in Tanzanian ChildrenChristopher P Duggan; Fiscal Year: 2010..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..