Research Topics
Genomes and Genes | JEREMY DUFFIELDSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cellsTakaharu Ichimura
Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
J Clin Invest 118:1657-68. 2008..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes...
The inflammatory macrophage: a story of Jekyll and HydeJeremy S Duffield
Medical Research Council Centre for Inflammation Research, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
Clin Sci (Lond) 104:27-38. 2003..Recent insights into the mechanisms by which apoptotic cells signal the change of function to the Mphi offer the prospect of novel targets for manipulation of Mphis in the inflamed tissue...- Resolvin D series and protectin D1 mitigate acute kidney injuryJeremy S Duffield
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 177:5902-11. 2006..These data may also have therapeutic implications for potentiation of recovery from acute kidney injury... - Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosisJonathan A Fallowfield
Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
J Immunol 178:5288-95. 2007..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver... 
Intrinsic epithelial cells repair the kidney after injuryBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
Cell Stem Cell 2:284-91. 2008..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney...- PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosisJeremy S Duffield
Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Drug News Perspect 23:305-15. 2010.... - Macrophages and immunologic inflammation of the kidneyJeremy S Duffield
Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Semin Nephrol 30:234-54. 2010..This article advances the case that targeting macrophage activation and phenotype is leading to new therapies in the treatment of many acute and chronic kidney diseases... - Conditional ablation of macrophages halts progression of crescentic glomerulonephritisJeremy S Duffield
Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 167:1207-19. 2005..This study demonstrates that macrophages are key effectors of disease progression in crescentic GN, acting to regulate parenchymal cell populations by modulating both cell proliferation and apoptosis... - Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injuryJeremy S Duffield
Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Kidney Int 68:1956-61. 2005..Analysis of the phenotype of interstitial and vascular cells following I/R injury revealed small numbers of peritubular endothelial cells to be derived from bone marrow cells that may serve in the repair process... - Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repairJeremy S Duffield
Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
J Clin Invest 115:56-65. 2005..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring... - Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosisBenjamin D Humphreys
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 176:85-97. 2010..These data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease... - Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cellsJeremy S Duffield
Renal Division and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Invest 115:1743-55. 2005..It is likely that intrinsic tubular cell proliferation accounts for functionally significant replenishment of the tubular epithelium after ischemia... - Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidneyShuei Liong Lin
Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 173:1617-27. 2008..Therefore, our results serve to refocus fibrosis research to injury of the vasculature rather than injury to the epithelium... - Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injuryBing Li
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 121:2211-20. 2010..We studied the capacity of human CD34(+) hematopoietic stem/progenitor cells (HSPCs) to promote kidney repair and regeneration using an established ischemia/reperfusion injury model in mice, with particular focus on the microvasculature... - Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populationsShuei Liong Lin
Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 183:6733-43. 2009.... - Resolved: EMT produces fibroblasts in the kidneyMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Soc Nephrol 21:1247-53. 2010..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate... - Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivoAna P Castano
Laboratory of Inflammation Research, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
Sci Transl Med 1:5ra13. 2009..These studies uncover previously unidentified roles for Fc gamma receptors in sterile inflammation and highlight serum amyloid P as a potential antifibrotic therapy through local generation of interleukin-10... - Macrophage Wnt7b is critical for kidney repair and regenerationShuei Liong Lin
Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:4194-9. 2010.... - The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repairBing Li
Laboratory of Inflammation Research, Brigham and Womens Hospital and Harvard Medical School, Boston, MA 02115, USA
FASEB J 24:4767-81. 2010..Therefore, Gpnmb is a novel prorepair gene that is necessary for crosstalk between the macroautophagic degradation pathway and phagocytosis... - Quantitative morphometry of lupus nephritis: the significance of collagen, tubular space, and inflammatory infiltrateMichael G Hunter
MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
Kidney Int 67:94-102. 2005..CONCLUSION: A simple automated system for objectively scoring biopsies of lupus nephritis predicts renal survival and may provide a useful adjunct to guide patient management... - Endothelial activation markers in anemic non-dialysis chronic kidney disease patientsTejas V Patel
Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Nephron Clin Pract 110:c244-50. 2008..We explored the relationship between anemia and markers of inflammation and endothelial activation in non-dialysis chronic kidney disease (ND-CKD) patients to understand this mechanism...
Research Grants
- DEFINING INJURIOUS & REPARATIVE MACROPHAGES IN KIDNEY INJURY AND REPAIRJEREMY DUFFIELD; Fiscal Year: 2007..It is proposed that the reason for this paradox is that there are two distinct types of tissue macrophage. My goal is to define these two types of macrophage so that novel therapies can be developed to target one type over another. ..
- The role of Macrophage Delivered WNT Signaling in kidney injury and repairJEREMY DUFFIELD; Fiscal Year: 2009..We will study the molecular components of this complex cell-cell signaling pathway to discover new targets that may lead to new therapies for patients with kidney disease. ..