JEREMY DUFFIELD

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
  2. ncbi The inflammatory macrophage: a story of Jekyll and Hyde
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Clin Sci (Lond) 104:27-38. 2003
  3. ncbi Resolvin D series and protectin D1 mitigate acute kidney injury
    Jeremy S Duffield
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:5902-11. 2006
  4. ncbi Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
  5. doi Intrinsic epithelial cells repair the kidney after injury
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Cell Stem Cell 2:284-91. 2008
  6. doi PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis
    Jeremy S Duffield
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Drug News Perspect 23:305-15. 2010
  7. pmc Macrophages and immunologic inflammation of the kidney
    Jeremy S Duffield
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Semin Nephrol 30:234-54. 2010
  8. pmc Conditional ablation of macrophages halts progression of crescentic glomerulonephritis
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 167:1207-19. 2005
  9. pmc Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury
    Jeremy S Duffield
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Kidney Int 68:1956-61. 2005
  10. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005

Collaborators

Detail Information

Publications21

  1. pmc Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
    ..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes...
  2. ncbi The inflammatory macrophage: a story of Jekyll and Hyde
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, Medical School, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Clin Sci (Lond) 104:27-38. 2003
    ..Recent insights into the mechanisms by which apoptotic cells signal the change of function to the Mphi offer the prospect of novel targets for manipulation of Mphis in the inflamed tissue...
  3. ncbi Resolvin D series and protectin D1 mitigate acute kidney injury
    Jeremy S Duffield
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:5902-11. 2006
    ..These data may also have therapeutic implications for potentiation of recovery from acute kidney injury...
  4. ncbi Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
    ..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver...
  5. doi Intrinsic epithelial cells repair the kidney after injury
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Cell Stem Cell 2:284-91. 2008
    ..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney...
  6. doi PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis
    Jeremy S Duffield
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Drug News Perspect 23:305-15. 2010
    ....
  7. pmc Macrophages and immunologic inflammation of the kidney
    Jeremy S Duffield
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Semin Nephrol 30:234-54. 2010
    ..This article advances the case that targeting macrophage activation and phenotype is leading to new therapies in the treatment of many acute and chronic kidney diseases...
  8. pmc Conditional ablation of macrophages halts progression of crescentic glomerulonephritis
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 167:1207-19. 2005
    ..This study demonstrates that macrophages are key effectors of disease progression in crescentic GN, acting to regulate parenchymal cell populations by modulating both cell proliferation and apoptosis...
  9. pmc Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury
    Jeremy S Duffield
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Kidney Int 68:1956-61. 2005
    ..Analysis of the phenotype of interstitial and vascular cells following I/R injury revealed small numbers of peritubular endothelial cells to be derived from bone marrow cells that may serve in the repair process...
  10. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophages play critical roles in both the injury and recovery phases of inflammatory scarring...
  11. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
    ..These data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease...
  12. pmc Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    Jeremy S Duffield
    Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 115:1743-55. 2005
    ..It is likely that intrinsic tubular cell proliferation accounts for functionally significant replenishment of the tubular epithelium after ischemia...
  13. pmc Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    Shuei Liong Lin
    Laboratory of Inflammation Research, Renal Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 173:1617-27. 2008
    ..Therefore, our results serve to refocus fibrosis research to injury of the vasculature rather than injury to the epithelium...
  14. pmc Mobilized human hematopoietic stem/progenitor cells promote kidney repair after ischemia/reperfusion injury
    Bing Li
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 121:2211-20. 2010
    ..We studied the capacity of human CD34(+) hematopoietic stem/progenitor cells (HSPCs) to promote kidney repair and regeneration using an established ischemia/reperfusion injury model in mice, with particular focus on the microvasculature...
  15. doi Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations
    Shuei Liong Lin
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:6733-43. 2009
    ....
  16. doi Resolved: EMT produces fibroblasts in the kidney
    Michael Zeisberg
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Soc Nephrol 21:1247-53. 2010
    ..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate...
  17. pmc Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo
    Ana P Castano
    Laboratory of Inflammation Research, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Sci Transl Med 1:5ra13. 2009
    ..These studies uncover previously unidentified roles for Fc gamma receptors in sterile inflammation and highlight serum amyloid P as a potential antifibrotic therapy through local generation of interleukin-10...
  18. pmc Macrophage Wnt7b is critical for kidney repair and regeneration
    Shuei Liong Lin
    Laboratory of Inflammation Research, Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:4194-9. 2010
    ....
  19. pmc The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair
    Bing Li
    Laboratory of Inflammation Research, Brigham and Womens Hospital and Harvard Medical School, Boston, MA 02115, USA
    FASEB J 24:4767-81. 2010
    ..Therefore, Gpnmb is a novel prorepair gene that is necessary for crosstalk between the macroautophagic degradation pathway and phagocytosis...
  20. ncbi Quantitative morphometry of lupus nephritis: the significance of collagen, tubular space, and inflammatory infiltrate
    Michael G Hunter
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Kidney Int 67:94-102. 2005
    ..Lupus nephritis encompasses a wide range of parenchymal injuries and severity. Better predictors of outcome are needed for patients newly diagnosed with lupus nephritis, so that an appropriate management strategy may be selected...
  21. pmc Endothelial activation markers in anemic non-dialysis chronic kidney disease patients
    Tejas V Patel
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nephron Clin Pract 110:c244-50. 2008
    ..We explored the relationship between anemia and markers of inflammation and endothelial activation in non-dialysis chronic kidney disease (ND-CKD) patients to understand this mechanism...

Research Grants3

  1. DEFINING INJURIOUS & REPARATIVE MACROPHAGES IN KIDNEY INJURY AND REPAIR
    JEREMY DUFFIELD; Fiscal Year: 2007
    ..It is proposed that the reason for this paradox is that there are two distinct types of tissue macrophage. My goal is to define these two types of macrophage so that novel therapies can be developed to target one type over another. ..
  2. The role of Macrophage Delivered WNT Signaling in kidney injury and repair
    JEREMY DUFFIELD; Fiscal Year: 2009
    ..We will study the molecular components of this complex cell-cell signaling pathway to discover new targets that may lead to new therapies for patients with kidney disease. ..